Phenpromethamine + Estramustine Phosphate Sodium
Estramustine Phosphate Sodium brand name: Emcyt.
We found no known interaction between Phenpromethamine and Estramustine Phosphate Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Phenpromethamine and Estramustine Phosphate Sodium
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Estramustine Phosphate Sodium and Phenpromethamine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Phenpromethamine safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Estramustine Phosphate Sodium
Interactions in our licensed database are recorded against drug classes, not just single drug names. Estramustine Phosphate Sodium is filed under 2 classifications — alkylating agents, oral drugs. Phenpromethamine has documented interactions with 1 drug class — the most serious being stimulant drugs (moderate) — and none of Estramustine Phosphate Sodium’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Phenpromethamine Does Interact With Other Medications
Phenpromethamine has 172 moderate known drug interactions in our database — Estramustine Phosphate Sodium isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Phenpromethamine
We haven’t checked that one against Phenpromethamine yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Phenpromethamine. Pick one to open its full report.
Phenpromethamine in Pregnancy & Breastfeeding
When used orally. Certain stimulants, especially when used in combination with other stimulants or intensive exercise, have been associated with cardiovascular events such as stroke and cardiac arrest. Avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Estramustine Phosphate Sodium
This page covers Phenpromethamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Estramustine Phosphate Sodium page lists 24 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Acerola (moderate), Alpha-lipoic Acid (moderate), Coenzyme Q10 (moderate) and Coffee Charcoal (moderate).
By severity: 1 major · 14 moderate · 9 minor.
From our pharmacist’s overview on the Estramustine Phosphate Sodium page
“Estramustine phosphate sodium (Emcyt) is an oral chemotherapy for advanced prostate cancer, so supplements that weaken it carry real weight, and this list of 24 ingredients warrants genuine care. Nearly everything here does one of two things: fiber-heavy products like psyllium and various gums can keep the capsule from being absorbed p…”
Reviewed by 2 · Jul 18, 2026
Where Phenpromethamine and Estramustine Phosphate Sodium Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,235 of 1,452 supplements looked up here in the last 7 days
#1,174 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phenpromethamine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Phenpromethamine and Estramustine Phosphate Sodium records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Phenpromethamine
What is Phenpromethamine?
- Nasal decongestion (historical)
- Stimulant effects (misuse)
- Pre-workout 'energy' (illegally added to some products)
Phenpromethamine is a synthetic stimulant drug, not a herb or legitimate dietary supplement. It has been found illegally added to some sports and weight-loss supplements, and it is not approved for use in the United States. You should avoid any product that lists it as an ingredient and talk to a pharmacist or doctor.
Not applicable; phenpromethamine is a synthetic chemical, not a plant part · Historically found as a nasal inhaler; not a legitimate dietary supplement ingredient
An interaction check asks whether these two react with each other — it does not ask whether Phenpromethamine is a good idea for someone in your situation. Here is what our Phenpromethamine record says about it on its own.
Phenpromethamine: dosing
There is no established or recommended dose of phenpromethamine for supplement use. It is not an approved supplement ingredient, and any amount found in products is unregulated and potentially unsafe.Because the amount in spiked products is unknown and uncontrolled, no dose can be considered safe. The best advice is to avoid products that contain it entirely.
From our Phenpromethamine monograph — the full record covers uses, side effects and every documented interaction.
About Estramustine
What Is Estramustine Used For?
Brand name: Emcyt
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Estramustine is used to treat prostate cancer that has worsened or has spread to other parts of the body. Estramustine is in a class of medications called antimicrotubule agents. It works by stopping the growth and spread of cancer cells.
Other Drugs & Phenpromethamine
Browse every other medication we’ve checked against Phenpromethamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
172 interactions
- Phentermine ›
- Methylphenidate ›
- Phenylpropanolamine ›
- Nicotine ›
- Phenylephrine ›
- Pseudoephedrine ›
- Amphetamine ›
- Diethylpropion ›
- Caffeine (otc Drug) ›
- Modafinil ›
- Oxymetazoline Hydrochloride ›
- Amphetamine Sulfate ›
- Caffeine (prescription Drug) ›
- Cocaine Hydrochloride (prescription Drug) ›
- Ephedrine Sulfate ›
- Methylphenidate Hydrochloride ›
- Pemoline ›
- Pseudoephedrine Sulfate ›
- Ambenonium Chloride ›
- Armodafinil ›
- Dexamfetamine ›
- Dexmethylphenidate ›
- Dextroamphetamine ›
- Dextroamphetamine (patch) ›
- Dextroamphetamine Sulphate ›
- Ecstasy ›
- Ephedrine Hydrochloride (prescription Drug) ›
- Ephedrine Sulfate (prescription Drug) ›
- Hethylphenidate Hcl ›
- Lisdexamfetamine ›
- Mephentermine ›
- Methamphetamine ›
- Methoxyamphetamine ›
- Methylphenidate Transdermal System ›
- Psuedoephedrine Hydrochloride ›
- Sibutramine ›
- Solriamfetol ›
- Guaifenesin, Pseudoephedrine ›
- Chlorpheniramine, Pseudoephedrine ›
- Brompheniramine, Pseudoephedrine ›
- Chlorpheniramine, Methscopolamine, Phenylephrine ›
- Pheniramine, Phenylpropanolamine, Phenyltoloxamine, Pyrilamine ›
- Acetaminophen, Pseudoephedrine ›
- Carbinoxamine, Pseudoephedrine ›
- Dextromethorphan, Guaifenesin, Pseudoephedrine ›
- Acetaminophen, Chlorpheniramine, Pseudoephedrine ›
- Acetaminophen, Butalbital, Caffeine ›
- Acetaminophen, Caffeine, Codeine ›
- Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate ›
- Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine ›
- Chlorpheniramine, Phenylpropanolamine ›
- Guaifenesin, Phenylephrine ›
- Guaifenesin, Phenylpropanolamine ›
- Aspirin, Caffeine, Orphenadrine ›
- Acetaminophen, Dextromethorphan, Pseudoephedrine ›
- Chlorpheniramine, Phenylephrine, Phenyltoloxamine ›
- Acetaminophen, Chlorpheniramine, Phenylpropanolamine ›
- Acetaminophen, Dichloralantipyrine, Isometheptene ›
- Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine ›
- Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate ›
Showing 60 of 172 moderate interactions — see all 172 on the Phenpromethamine page.
No interaction 2,657 drugs checked — show the list
We also checked Phenpromethamine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Clonazepam ›
- Quetiapine ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
- Candesartan Cilexetil ›
- Acetaminophen, Oxycodone ›
- Amoxicillin, Clavulanate Potassium ›
Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full Phenpromethamine list.
Phenpromethamine References
The 2 references that drive our Phenpromethamine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Venhuis B, Keizers P, van Riel A, de Kaste D. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. Drug Test Anal. 2014 Jun;6(6):578-81. doi: 10.1002/dta.1664. Epub 2014 May 6. PubMed
- Cohen PA, Travis JC, Vanhee C, Ohana D, Venhuis BJ. Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMA
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Estramustine Phosphate Sodium Is Linked to Lower Levels of One Nutrient
Natural Medicines records Estramustine Phosphate Sodium as a medicine that can lower these. This is not an interaction with Phenpromethamine — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Estramustine Phosphate Sodium nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Phenpromethamine and Estramustine Phosphate Sodium Together: Common Questions
Is it safe to take Phenpromethamine with Estramustine Phosphate Sodium?
How was the Phenpromethamine and Estramustine Phosphate Sodium combination checked?
Does Phenpromethamine interact with any other medications?
Does Estramustine Phosphate Sodium interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.