Phenpromethamine + Peginterferon alfa-2b
Peginterferon alfa-2b brand names: Peg-Intron, ViraferonPeg.
We found no known interaction between Phenpromethamine and Peginterferon alfa-2b in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Phenpromethamine and Peginterferon alfa-2b
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Peginterferon alfa-2b and Phenpromethamine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Phenpromethamine safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Peginterferon alfa-2b
Interactions in our licensed database are recorded against drug classes, not just single drug names. Peginterferon alfa-2b is filed under a single classification — hepatotoxic drugs. Phenpromethamine has documented interactions with 1 drug class — the most serious being stimulant drugs (moderate) — and none of Peginterferon alfa-2b’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Phenpromethamine Does Interact With Other Medications
Phenpromethamine has 172 moderate known drug interactions in our database — Peginterferon alfa-2b isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Phenpromethamine
We haven’t checked that one against Phenpromethamine yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Phenpromethamine. Pick one to open its full report.
Phenpromethamine in Pregnancy & Breastfeeding
When used orally. Certain stimulants, especially when used in combination with other stimulants or intensive exercise, have been associated with cardiovascular events such as stroke and cardiac arrest. Avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Peginterferon alfa-2b
This page covers Phenpromethamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Peginterferon alfa-2b page lists 38 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Ashwagandha (moderate) and Black Cohosh (moderate).
By severity: 3 major · 35 moderate.
From our pharmacist’s overview on the Peginterferon alfa-2b page
“Someone taking peginterferon alfa-2b (Peg-Intron) is usually treating hepatitis C, so the liver is already the organ under strain, and all 38 supplement interactions on file for this drug pile additional liver stress on top of it. That earns genuine caution.”
Reviewed by 2 · Jul 18, 2026
Where Phenpromethamine and Peginterferon alfa-2b Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,437 of 1,452 supplements looked up here in the last 7 days
#1,839 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phenpromethamine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Phenpromethamine and Peginterferon alfa-2b records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Phenpromethamine
What is Phenpromethamine?
- Nasal decongestion (historical)
- Stimulant effects (misuse)
- Pre-workout 'energy' (illegally added to some products)
Phenpromethamine is a synthetic stimulant drug, not a herb or legitimate dietary supplement. It has been found illegally added to some sports and weight-loss supplements, and it is not approved for use in the United States. You should avoid any product that lists it as an ingredient and talk to a pharmacist or doctor.
Not applicable; phenpromethamine is a synthetic chemical, not a plant part · Historically found as a nasal inhaler; not a legitimate dietary supplement ingredient
An interaction check asks whether these two react with each other — it does not ask whether Phenpromethamine is a good idea for someone in your situation. Here is what our Phenpromethamine record says about it on its own.
Phenpromethamine: dosing
There is no established or recommended dose of phenpromethamine for supplement use. It is not an approved supplement ingredient, and any amount found in products is unregulated and potentially unsafe.Because the amount in spiked products is unknown and uncontrolled, no dose can be considered safe. The best advice is to avoid products that contain it entirely.
From our Phenpromethamine monograph — the full record covers uses, side effects and every documented interaction.
About Peginterferon Alfa-2b (PEG-Intron)
What Is Peginterferon Alfa-2b (PEG-Intron) Used For?
Brand names: Peg-Intron, ViraferonPeg
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Peginterferon alfa-2b is used alone or in combination with ribavirin (a medication) to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus) in people who show signs of liver damage and who have not been treated with interferon alpha (medication similar to peginterferon alfa-2b) in the past. Peginterferon alfa-2b is in a class of medications called interferons. Peginterferon alfa-2b is a combination of interferon and polyethylene glycol, which helps the interferon stay active in your body for a longer period of time. Peginterferon alpha-2b works by decreasing the amount of hepatitis C virus (HCV) in the body. Peginterferon alfa-2b may not cure hepatitis C or prevent you from developing complications of hepatitis C such as cirrhosis (scarring) of the liver, liver failure, or liver cancer. Peginterferon alfa-2b may not prevent the spread of hepatitis C to other people.
Other Drugs & Phenpromethamine
Browse every other medication we’ve checked against Phenpromethamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
172 interactions
- Phentermine ›
- Methylphenidate ›
- Phenylpropanolamine ›
- Nicotine ›
- Phenylephrine ›
- Pseudoephedrine ›
- Amphetamine ›
- Diethylpropion ›
- Caffeine (otc Drug) ›
- Modafinil ›
- Oxymetazoline Hydrochloride ›
- Amphetamine Sulfate ›
- Caffeine (prescription Drug) ›
- Cocaine Hydrochloride (prescription Drug) ›
- Ephedrine Sulfate ›
- Methylphenidate Hydrochloride ›
- Pemoline ›
- Pseudoephedrine Sulfate ›
- Ambenonium Chloride ›
- Armodafinil ›
- Dexamfetamine ›
- Dexmethylphenidate ›
- Dextroamphetamine ›
- Dextroamphetamine (patch) ›
- Dextroamphetamine Sulphate ›
- Ecstasy ›
- Ephedrine Hydrochloride (prescription Drug) ›
- Ephedrine Sulfate (prescription Drug) ›
- Hethylphenidate Hcl ›
- Lisdexamfetamine ›
- Mephentermine ›
- Methamphetamine ›
- Methoxyamphetamine ›
- Methylphenidate Transdermal System ›
- Psuedoephedrine Hydrochloride ›
- Sibutramine ›
- Solriamfetol ›
- Guaifenesin, Pseudoephedrine ›
- Chlorpheniramine, Pseudoephedrine ›
- Brompheniramine, Pseudoephedrine ›
- Chlorpheniramine, Methscopolamine, Phenylephrine ›
- Pheniramine, Phenylpropanolamine, Phenyltoloxamine, Pyrilamine ›
- Acetaminophen, Pseudoephedrine ›
- Carbinoxamine, Pseudoephedrine ›
- Dextromethorphan, Guaifenesin, Pseudoephedrine ›
- Acetaminophen, Chlorpheniramine, Pseudoephedrine ›
- Acetaminophen, Butalbital, Caffeine ›
- Acetaminophen, Caffeine, Codeine ›
- Chlorpheniramine Tannate, Phenylephrine Tannate, Pyrilamine Tannate ›
- Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Phenyltoloxamine ›
- Chlorpheniramine, Phenylpropanolamine ›
- Guaifenesin, Phenylephrine ›
- Guaifenesin, Phenylpropanolamine ›
- Aspirin, Caffeine, Orphenadrine ›
- Acetaminophen, Dextromethorphan, Pseudoephedrine ›
- Chlorpheniramine, Phenylephrine, Phenyltoloxamine ›
- Acetaminophen, Chlorpheniramine, Phenylpropanolamine ›
- Acetaminophen, Dichloralantipyrine, Isometheptene ›
- Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine ›
- Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate ›
Showing 60 of 172 moderate interactions — see all 172 on the Phenpromethamine page.
No interaction 2,657 drugs checked — show the list
We also checked Phenpromethamine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Tadalafil ›
- Clopidogrel ›
- Abemaciclib ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Ibuprofen ›
- Tirzepatide ›
- Semaglutide ›
- Warfarin Sodium ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Metformin ›
- Lisinopril ›
- Bupropion ›
- Amoxicillin ›
- Bendamustine ›
- Amitriptyline ›
- Acyclovir ›
- Methotrexate ›
- Doxycycline ›
- Fluoxetine ›
- Lamotrigine ›
- Pregabalin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Gabapentin ›
- Isotretinoin ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Amlodipine Besylate ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
- Diazepam ›
- Dapsone ›
Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full Phenpromethamine list.
Phenpromethamine References
The 2 references that drive our Phenpromethamine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Venhuis B, Keizers P, van Riel A, de Kaste D. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. Drug Test Anal. 2014 Jun;6(6):578-81. doi: 10.1002/dta.1664. Epub 2014 May 6. PubMed
- Cohen PA, Travis JC, Vanhee C, Ohana D, Venhuis BJ. Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMA
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Phenpromethamine and Peginterferon alfa-2b Together: Common Questions
Is it safe to take Phenpromethamine with Peginterferon alfa-2b?
How was the Phenpromethamine and Peginterferon alfa-2b combination checked?
Does Phenpromethamine interact with any other medications?
Does Peginterferon alfa-2b interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.