Medication interaction hub

What Supplements Interact with Peginterferon alfa-2b?

Peginterferon alfa-2b brand names: Peg-Intron, ViraferonPeg. Every interaction below applies to the brands too.

38 Interactions 3 Major 35 Moderate
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Peginterferon alfa-2b? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Peginterferon alfa-2b against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Someone taking peginterferon alfa-2b (Peg-Intron) is usually treating hepatitis C, so the liver is already the organ under strain, and all 38 supplement interactions on file for this drug pile additional liver stress on top of it. That earns genuine caution. Three entries carry a major rating, and two of them are simply alcohol in the form of beer and wine; the third, Siberian cocklebur, has been linked to outright liver failure.

The remaining 35 are rated moderate, and they tell the same story from different angles: herbs with their own record of liver injury, from kava and ashwagandha, which sit in plenty of cabinets for stress and sleep, to comfrey and greater celandine. When both the disease and its treatment lean on one organ, the safer default is skipping herbal extras until your pharmacist or liver specialist has reviewed the full list below.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 35 No known interaction 1,414

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Peginterferon alfa-2b: Top Interactions at a Glance

The most significant Peginterferon alfa-2b supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 38 interacting ingredients — plus 1,414 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Peginterferon alfa-2b + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Peginterferon alfa-2bi

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Probable Beer + Peginterferon alfa-2bi

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable Wine + Peginterferon alfa-2bi

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Peginterferon alfa-2b

All 1,452 ingredients in our database, ranked by severity — 38 with a Peginterferon alfa-2b interaction on file and 1,414 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Peginterferon alfa-2b?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Saigon Cinnamon with Peginterferon alfa-2b?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Saigon Cinnamon + Peginterferon alfa-2b answer

Can you take Green Tea with Peginterferon alfa-2b?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Green Tea + Peginterferon alfa-2b answer

Can you take Siberian Cocklebur with Peginterferon alfa-2b?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Siberian cocklebur can adversely affect the liver.

Full Siberian Cocklebur + Peginterferon alfa-2b answer

Can you take Beer with Peginterferon alfa-2b?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Full Beer + Peginterferon alfa-2b answer

Can you take Wine with Peginterferon alfa-2b?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Full Wine + Peginterferon alfa-2b answer

Can you take Ashwagandha with Peginterferon alfa-2b?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.

Full Ashwagandha + Peginterferon alfa-2b answer

Can you take Black Cohosh with Peginterferon alfa-2b?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.

Full Black Cohosh + Peginterferon alfa-2b answer

Can you take Boldo with Peginterferon alfa-2b?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.

Full Boldo + Peginterferon alfa-2b answer

Can you take Buchu with Peginterferon alfa-2b?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu contains pulegone, a known hepatotoxin.

Full Buchu + Peginterferon alfa-2b answer

Can you take Camphor with Peginterferon alfa-2b?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of camphor with other hepatotoxic drugs might increase the risk of liver damage.

Full Camphor + Peginterferon alfa-2b answer

Can you take Cassia Cinnamon with Peginterferon alfa-2b?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Cassia Cinnamon + Peginterferon alfa-2b answer

Can you take Chaparral with Peginterferon alfa-2b?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Chaparral + Peginterferon alfa-2b answer

Can you take Comfrey with Peginterferon alfa-2b?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, comfrey might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Comfrey + Peginterferon alfa-2b answer

Can you take Ephedra with Peginterferon alfa-2b?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Ephedra + Peginterferon alfa-2b answer

Can you take Epistane with Peginterferon alfa-2b?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Epistane + Peginterferon alfa-2b answer

Can you take Fo-ti with Peginterferon alfa-2b?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Fo-ti + Peginterferon alfa-2b answer

Can you take Garcinia with Peginterferon alfa-2b?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.

Full Garcinia + Peginterferon alfa-2b answer

Can you take Gotu Kola with Peginterferon alfa-2b?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.

Full Gotu Kola + Peginterferon alfa-2b answer

Can you take Greater Celandine with Peginterferon alfa-2b?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that greater celandine can adversely affect the liver.

Full Greater Celandine + Peginterferon alfa-2b answer

Can you take Hemp Agrimony with Peginterferon alfa-2b?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA).

Full Hemp Agrimony + Peginterferon alfa-2b answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Peginterferon alfa-2b is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Peginterferon alfa-2b, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Peginterferon alfa-2b sits in 1 interaction category. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Peginterferon alfa-2b through this category.

About Peginterferon alfa-2b

Peginterferon alfa-2b is a prescription medication also sold under the brand names Peg-Intron, ViraferonPeg. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Peginterferon alfa-2b  ·  Brand names: Peg-Intron, ViraferonPeg.

See the full Peginterferon Alfa-2b (PEG-Intron) drug information
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Take a Supplement Product? Check the Whole Bottle Against Peginterferon alfa-2b

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Peginterferon alfa-2b.

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Pharmacist Counseling Corner

Peginterferon alfa-2b & Supplements: Common Questions

What supplements interact with Peginterferon alfa-2b?
Our database currently documents 38 ingredients with a known Peginterferon alfa-2b interaction (3 major, 35 moderate, 0 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 38. The highest-ranked right now: Siberian Cocklebur, Beer, Wine.
Which Peginterferon alfa-2b supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Beer and Wine. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Peginterferon alfa-2b?
Plenty of supplements coexist fine with Peginterferon alfa-2b; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Peg-Intron have the same supplement interactions as Peginterferon alfa-2b?
Yes — Peg-Intron, ViraferonPeg all contain Peginterferon alfa-2b, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Peginterferon alfa-2b and my other medications?
This page covers Peginterferon alfa-2b against supplements and herbal ingredients. Checking Peginterferon alfa-2b against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Peginterferon Alfa-2b (PEG-Intron) drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.