Masterwort + Peginterferon alfa-2b
Peginterferon alfa-2b brand names: Peg-Intron, ViraferonPeg.
We found no known interaction between Masterwort and Peginterferon alfa-2b in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Masterwort and Peginterferon alfa-2b
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Peginterferon alfa-2b and Masterwort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Masterwort safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Peginterferon alfa-2b
Interactions in our licensed database are recorded against drug classes, not just single drug names. Peginterferon alfa-2b is filed under a single classification — hepatotoxic drugs. Masterwort has documented interactions with 1 drug class — the most serious being photosensitizing drugs (moderate) — and none of Peginterferon alfa-2b’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Masterwort Does Interact With Other Medications
Masterwort has 335 moderate known drug interactions in our database — Peginterferon alfa-2b isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Masterwort
We haven’t checked that one against Masterwort yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Masterwort. Pick one to open its full report.
See Every Supplement That Interacts With Peginterferon alfa-2b
This page covers Masterwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Peginterferon alfa-2b page lists 38 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Ashwagandha (moderate) and Black Cohosh (moderate).
By severity: 3 major · 35 moderate.
From our pharmacist’s overview on the Peginterferon alfa-2b page
“Someone taking peginterferon alfa-2b (Peg-Intron) is usually treating hepatitis C, so the liver is already the organ under strain, and all 38 supplement interactions on file for this drug pile additional liver stress on top of it. That earns genuine caution.”
Reviewed by 2 · Jul 18, 2026
Where Masterwort and Peginterferon alfa-2b Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#394 of 1,452 supplements looked up here in the last 7 days
#2,821 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Masterwort reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Masterwort and Peginterferon alfa-2b records this page draws on were last updated June 20, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Masterwort
What is Masterwort?
- Digestive upset
- Mild anxiety and tension
- Skin complaints
- Respiratory and cough relief
- Traditional tonic
Masterwort (Heracleum sphondylium), a plant in the carrot family, has a long folk-medicine history for digestion, nerves, and skin. Modern scientific evidence to support these uses is very limited, and the plant can cause skin reactions to sunlight, so use it cautiously and talk with your pharmacist or doctor first.
Heracleum sphondylium · Apiaceae · Root, leaves, seeds, and aerial parts · Tea, tincture, dried herb, essential oil
An interaction check asks whether these two react with each other — it does not ask whether Masterwort is a good idea for someone in your situation. Here is what our Masterwort record says about it on its own.
Masterwort: dosing
There is no standardized, well-established dose for masterwort. Traditional preparations vary widely, and product strengths are not consistent.If you choose to use a commercial product, follow the directions on the label and do not exceed the suggested amount.
From our Masterwort monograph — the full record covers uses, side effects and every documented interaction.
About Peginterferon Alfa-2b (PEG-Intron)
What Is Peginterferon Alfa-2b (PEG-Intron) Used For?
Brand names: Peg-Intron, ViraferonPeg
-
Peginterferon alfa-2b is used alone or in combination with ribavirin (a medication) to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus) in people who show signs of liver damage and who have not been treated with interferon alpha (medication similar to peginterferon alfa-2b) in the past. Peginterferon alfa-2b is in a class of medications called interferons. Peginterferon alfa-2b is a combination of interferon and polyethylene glycol, which helps the interferon stay active in your body for a longer period of time. Peginterferon alpha-2b works by decreasing the amount of hepatitis C virus (HCV) in the body. Peginterferon alfa-2b may not cure hepatitis C or prevent you from developing complications of hepatitis C such as cirrhosis (scarring) of the liver, liver failure, or liver cancer. Peginterferon alfa-2b may not prevent the spread of hepatitis C to other people.
Other Drugs & Masterwort
Browse every other medication we’ve checked against Masterwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
335 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Diphenhydramine ›
- Naproxen ›
- Doxycycline ›
- Minocycline ›
- Tetracycline ›
- Hydrochlorothiazide ›
- Quinidine ›
- Glyburide ›
- Ciprofloxacin ›
- Flurbiprofen ›
- Isotretinoin ›
- Carbamazepine ›
- Diclofenac Potassium ›
- Tazarotene ›
- Trimipramine ›
- Etodolac ›
- Griseofulvin ›
- Ketoprofen ›
- Lofepramine ›
- Meloxicam ›
- Nortriptyline ›
- Ofloxacin ›
- Selegiline ›
- Topiramate ›
- Tretinoin ›
- Trichlormethiazide ›
- Aripiprazole ›
- Azithromycin ›
- Bendroflumethiazide ›
- Dapsone ›
- Desipramine ›
- Doxepin ›
- Doxycycline Hyclate ›
- Fluphenazine ›
- Hydroxyzine ›
- Interferon Alfa-2b ›
- Interferon Beta-1b ›
- Levofloxacin ›
- Lisinopril ›
- Metolazone ›
- Paroxetine ›
- Sulfasalazine ›
- Valproic Acid ›
- Acetazolamide ›
- Aminolevulinic Acid Hydrochloride ›
- Amiodarone ›
- Aripiprazole Lauroxil ›
- Brompheniramine ›
- Captopril ›
- Celecoxib ›
- Chlorpheniramine ›
- Chlorpromazine ›
- Chlorpropamide ›
- Chlorthalidone ›
- Clomipramine ›
- Clozapine ›
Showing 60 of 335 moderate interactions — see all 335 on the Masterwort page.
No interaction 2,494 drugs checked — show the list
We also checked Masterwort against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Testosterone ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Atorvastatin ›
- Valacyclovir ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Semaglutide ›
- Sumatriptan ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Bupropion ›
- Metformin ›
- Acyclovir ›
- Amoxicillin ›
- Bendamustine ›
- Lamotrigine ›
- Methotrexate ›
- Gabapentin ›
- Pregabalin ›
- Amphetamine ›
- Acetaminophen, Codeine ›
- Dextroamphetamine ›
- Clonazepam ›
- Omeprazole ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
- Diazepam ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Mannitol ›
- Cephalexin ›
- Roxithromycin ›
- Atorvastatin Calcium ›
- Pegunigalsidase Alfa-iwxj ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Daptomycin ›
Showing the 60 most looked-up of 2,494 medications checked with no known interaction — see the full Masterwort list.
Masterwort References
The 1 references that drive our Masterwort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Masterwort and Peginterferon alfa-2b Together: Common Questions
Is it safe to take Masterwort with Peginterferon alfa-2b?
How was the Masterwort and Peginterferon alfa-2b combination checked?
Does Masterwort interact with any other medications?
Does Peginterferon alfa-2b interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.