Rehmannia + Peginterferon alfa-2b
Peginterferon alfa-2b brand names: Peg-Intron, ViraferonPeg.
We found no known interaction between Rehmannia and Peginterferon alfa-2b in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Rehmannia and Peginterferon alfa-2b
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Peginterferon alfa-2b and Rehmannia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Rehmannia safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Peginterferon alfa-2b
Interactions in our licensed database are recorded against drug classes, not just single drug names. Peginterferon alfa-2b is filed under a single classification — hepatotoxic drugs. Rehmannia has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and antihypertensive drugs (moderate) — and none of Peginterferon alfa-2b’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Rehmannia Does Interact With Other Medications
Rehmannia has 258 moderate known drug interactions in our database — Peginterferon alfa-2b isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Rehmannia
We haven’t checked that one against Rehmannia yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Rehmannia. Pick one to open its full report.
See Every Supplement That Interacts With Peginterferon alfa-2b
This page covers Rehmannia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Peginterferon alfa-2b page lists 38 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Ashwagandha (moderate) and Black Cohosh (moderate).
By severity: 3 major · 35 moderate.
From our pharmacist’s overview on the Peginterferon alfa-2b page
“Someone taking peginterferon alfa-2b (Peg-Intron) is usually treating hepatitis C, so the liver is already the organ under strain, and all 38 supplement interactions on file for this drug pile additional liver stress on top of it. That earns genuine caution.”
Reviewed by 2 · Jul 18, 2026
Taking Rehmannia as Part of a Dietary Supplement Product? Check It for Interactions
We hold 861 real supplement products containing Rehmannia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rehmannia. Even though Rehmannia itself has no known interaction with Peginterferon alfa-2b, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Rehmannia and Peginterferon alfa-2b Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#272 of 1,452 supplements looked up here in the last 7 days
#1,975 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rehmannia reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Rehmannia and Peginterferon alfa-2b records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Rehmannia
What is Rehmannia?
- Kidney and adrenal support
- Anemia and blood building (traditional)
- Inflammatory conditions
- Allergies
- Fatigue and aging-related complaints
Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health. Human evidence for most modern uses is limited, so it should be viewed as unproven rather than reliable. Talk with a pharmacist or doctor before trying it, especially if you are pregnant, breastfeeding, or take other medicines.
Rehmannia glutinosa · Orobanchaceae · Root (raw or steam-prepared) · Dried root, decoctions/teas, capsules, tinctures, and ingredient in multi-herb formulas
An interaction check asks whether these two react with each other — it does not ask whether Rehmannia is a good idea for someone in your situation. Here is what our Rehmannia record says about it on its own.
Rehmannia: dosing
There is no official, well-established standardized dose for Rehmannia. Traditional use varies widely depending on the form (raw versus prepared root), whether it is a tea, capsule, or tincture, and whether it is part of a larger herbal formula.The safest approach is to follow the directions on the product label and not exceed them.
From our Rehmannia monograph — the full record covers uses, side effects and every documented interaction.
About Peginterferon Alfa-2b (PEG-Intron)
What Is Peginterferon Alfa-2b (PEG-Intron) Used For?
Brand names: Peg-Intron, ViraferonPeg
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Peginterferon alfa-2b is used alone or in combination with ribavirin (a medication) to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus) in people who show signs of liver damage and who have not been treated with interferon alpha (medication similar to peginterferon alfa-2b) in the past. Peginterferon alfa-2b is in a class of medications called interferons. Peginterferon alfa-2b is a combination of interferon and polyethylene glycol, which helps the interferon stay active in your body for a longer period of time. Peginterferon alpha-2b works by decreasing the amount of hepatitis C virus (HCV) in the body. Peginterferon alfa-2b may not cure hepatitis C or prevent you from developing complications of hepatitis C such as cirrhosis (scarring) of the liver, liver failure, or liver cancer. Peginterferon alfa-2b may not prevent the spread of hepatitis C to other people.
Other Drugs & Rehmannia
Browse every other medication we’ve checked against Rehmannia — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
258 interactions
- Diltiazem ›
- Nifedipine ›
- Insulin (rdna) ›
- Propranolol ›
- Hydrochlorothiazide ›
- Verapamil ›
- Glyburide ›
- Insulin (pork) ›
- Hydralazine ›
- Insulin (human) ›
- Trichlormethiazide ›
- Acarbose ›
- Bendroflumethiazide ›
- Insulin Glargine ›
- Lisinopril ›
- Metolazone ›
- Minoxidil ›
- Nicardipine ›
- Prazosin ›
- Semaglutide ›
- Spironolactone ›
- Timolol ›
- Acebutolol ›
- Acetazolamide ›
- Ambrisentan ›
- Amiloride ›
- Atenolol ›
- Betaxolol ›
- Candesartan Cilexetil ›
- Captopril ›
- Carteolol ›
- Carvedilol ›
- Chlorpropamide ›
- Chlorthalidone ›
- Cyclothiazide ›
- Enalapril Maleate ›
- Exenatide ›
- Felodipine ›
- Glipizide ›
- Glucagon ›
- Guanethidine Monosulfate ›
- Iloprost ›
- Indapamide ›
- Insulin Lispro ›
- Irbesartan ›
- Labetalol ›
- Mannitol ›
- Metformin ›
- Methyclothiazide ›
- Methyldopa ›
- Metoprolol ›
- Nadolol ›
- Nebivolol ›
- Nimodipine ›
- Olmesartan Medoxomil ›
- Oxprenolol ›
- Pindolol ›
- Quinapril ›
- Repaglinide ›
- Reserpine ›
Showing 60 of 258 moderate interactions — see all 258 on the Rehmannia page.
No interaction 2,571 drugs checked — show the list
We also checked Rehmannia against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Warfarin Sodium ›
- Prednisone ›
- Lisdexamfetamine ›
- Bupropion ›
- Amoxicillin ›
- Acyclovir ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Fluoxetine ›
- Lamotrigine ›
- Acetaminophen, Codeine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Dextroamphetamine ›
- Azithromycin ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Methylene Blue ›
- Quetiapine ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
- Dapsone ›
- Diazepam ›
- Cyclopentolate ›
- Cephalexin ›
- Roxithromycin ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Atorvastatin Calcium ›
Showing the 60 most looked-up of 2,571 medications checked with no known interaction — see the full Rehmannia list.
Rehmannia References
The 3 references that drive our Rehmannia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Zhang R, Zhou J, Jia Z, et al. Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism. J Ethnopharmacol 2004;90:39-43. PubMed
- Zhang RX, Li MX, Jia ZP. Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol 2008;117(2):199-214. PubMed
- Chao CH, Hsu JL, Chen MF, et al. Anti-hypertensive effects of Radix Rehmanniae and its active ingredients. Nat Prod Res. 2020;34(11):1547-1552.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Rehmannia and Peginterferon alfa-2b Together: Common Questions
Is it safe to take Rehmannia with Peginterferon alfa-2b?
How was the Rehmannia and Peginterferon alfa-2b combination checked?
Does Rehmannia interact with any other medications?
Does Peginterferon alfa-2b interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.