Drug & supplement interaction

Picrorhiza + Dextromethorphan, Guaifenesin, Psuedoephedrine

Dextromethorphan, Guaifenesin, Psuedoephedrine brand name: Aquatab C.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Oct 4, 2026

The bottom line No known interaction

We found no known interaction between Picrorhiza and Dextromethorphan, Guaifenesin, Psuedoephedrine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Picrorhiza and Dextromethorphan, Guaifenesin, Psuedoephedrine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dextromethorphan, Guaifenesin, Psuedoephedrine and Picrorhiza in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Picrorhiza safety at a glance

Picrorhiza overall Use caution Generally used in traditional medicine, but human safety data are limited, so use with care.

Pregnancy Avoid Not enough safety information; avoid use during pregnancy.

Breastfeeding Avoid Not enough safety information; avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Dextromethorphan, Guaifenesin, Psuedoephedrine and Picrorhiza? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Dextromethorphan, Guaifenesin, Psuedoephedrine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Dextromethorphan, Guaifenesin, Psuedoephedrine is filed under 8 classifications — including alpha-adrenergic agonists, stimulant drugs, serotonergic drugs. Picrorhiza has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and immunosuppressants (moderate) — and none of Dextromethorphan, Guaifenesin, Psuedoephedrine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Picrorhiza Does Interact With Other Medications

Picrorhiza has 207 moderate known drug interactions in our database — Dextromethorphan, Guaifenesin, Psuedoephedrine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 207 No known interaction 2,623 (incl. Dextromethorphan, Guaifenesin, Psuedoephedrine)

Taking anything else?

Check Another of Your Medications Against Picrorhiza

Covers the 2,830 medications we’ve checked against Picrorhiza. Pick one to open its full report.

What to actually watch for

What Picrorhiza Itself Has Been Linked To

This is not an interaction — nothing below involves Dextromethorphan, Guaifenesin, Psuedoephedrine. It is the side-effect record for Picrorhiza on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Picrorhiza, this list is the first place to look.

Reduced appetite / Diarrhea / Vomiting Additional detail
“Orally, picrorhiza may cause vomiting, rash, anorexia, diarrhea, itching, and giddiness.”

Picrorhiza · Natural Medicines adverse-effect record, reported in anorexia.
1 source cited

11858. Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med 1983;29:89-95.
“Orally, picrorhiza may cause vomiting, anorexia, and diarrhea.”

Picrorhiza · Natural Medicines adverse-effect record, reported in anorexia.
1 source cited

11858. Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med 1983;29:89-95.
Itching / A skin rash Additional detail
“Orally, picrorhiza may cause rash and itching.”

Picrorhiza · Natural Medicines adverse-effect record, reported in pruritus.
1 source cited

11858. Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med 1983;29:89-95.

Everything above comes from the Natural Medicines adverse-effect record for Picrorhiza — expand a row for the licensed statement it rests on. We haven’t matched Dextromethorphan, Guaifenesin, Psuedoephedrine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Dextromethorphan, Guaifenesin, Psuedoephedrine.

Everything else you take

See Every Supplement That Interacts With Dextromethorphan, Guaifenesin, Psuedoephedrine

This page covers Picrorhiza only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dextromethorphan, Guaifenesin, Psuedoephedrine page lists 197 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Grapefruit (major), Lithium (major) and Peyote (major).

By severity: 8 major · 148 moderate · 41 minor.

From our pharmacist’s overview on the Dextromethorphan, Guaifenesin, Psuedoephedrine page

“A cold and congestion remedy sounds low stakes, but Aquatab C (dextromethorphan, guaifenesin, and pseudoephedrine) earns real caution. Eight of the 197 supplements and herbs on file carry a major rating, and those deserve your attention first.”

Reviewed by 2 · Jul 18, 2026

Open the Dextromethorphan, Guaifenesin, Psuedoephedrine interaction page

One more smart check

Taking Picrorhiza as Part of a Dietary Supplement Product? Check It for Interactions

We hold 177 real supplement products containing Picrorhiza, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Picrorhiza. Even though Picrorhiza itself has no known interaction with Dextromethorphan, Guaifenesin, Psuedoephedrine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Picrorhiza and Dextromethorphan, Guaifenesin, Psuedoephedrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Picrorhiza

Top half

#557 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Dextromethorphan, Guaifenesin, Psuedoephedrine

Top 5%

#135 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Picrorhiza reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Picrorhiza and Dextromethorphan, Guaifenesin, Psuedoephedrine records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Picrorhiza

What is Picrorhiza?

Liver support
Digestive complaints
Asthma and breathing problems
Skin conditions
Fever
Immune support

Picrorhiza (Picrorhiza kurroa) is a bitter Himalayan herb used in Ayurvedic medicine, mainly for liver and digestive complaints. Early lab and small human studies suggest possible liver-protective and anti-inflammatory effects, but high-quality evidence is limited. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Picrorhiza kurroa · Plantaginaceae · Roots and rhizomes · Capsules, tablets, powder (churna), liquid extracts, and traditional herbal formulas

An interaction check asks whether these two react with each other — it does not ask whether Picrorhiza is a good idea for someone in your situation. Here is what our Picrorhiza record says about it on its own.

Picrorhiza: dosing

There is no well-established standard dose of Picrorhiza. The amount used can vary widely depending on the form (powder, capsule, or extract) and how concentrated the product is.The safest approach is to follow the dosing directions on the product label and not to exceed them.

From our Picrorhiza monograph — the full record covers uses, side effects and every documented interaction.

Read the full Picrorhiza monograph & all interactions

Keep checking

Other Drugs & Picrorhiza

Browse every other medication we’ve checked against Picrorhiza — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

207Moderate

0Minor

2,622No known interaction

207 Moderate 2,622 No interaction

Moderate

207 interactions

Showing 60 of 207 moderate interactions — see all 207 on the Picrorhiza page.

No interaction 2,622 drugs checked — show the list

We also checked Picrorhiza against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,622 medications checked with no known interaction — see the full Picrorhiza list.

See the full Picrorhiza interactions page

See every supplement checked against Dextromethorphan, Guaifenesin, Psuedoephedrine, ranked by severity

Evidence & sources

Picrorhiza References

The 7 references that drive our Picrorhiza monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Sharma ML, Rao CS, Duda PL. Immunostimulatory activity of Picrorhiza kurroa leaf extract. J Ethnopharmacol 1994;41:185-92. PubMed
Bedi KL, Zutshi U, Chopra CL, Amla V. Picrorhiza kurroa, an ayurvedic herb, may potentiate photochemotherapy in vitiligo. J Ethnopharmacol 1989;27:347-52. PubMed
Vaidya AB, Antarkar DS, Doshi JC, et al. Picrorhiza kurroa (Kutaki) Royle ex Benth as a hepatoprotective agent--experimental & clinical studies. J Postgrad Med 1996;42:105-8.
Baruah CC, Gupta PP, Nath A, et al. Anti-allergic and anti-anaphylactic activity of picroliv--a standardised iridoid glycoside fraction of Picrorhiza kurroa. Pharmacol Res 1998;38:487-92.
Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med 1983;29:89-95.
Joy, K. L. and Kuttan, R. Anti-diabetic activity of Picrorrhiza kurroa extract. J Ethnopharmacol 11-1-1999;67(2):143-148. PubMed
Brockwell C, Ampikaipakan S, Sexton DW, Price D, Freeman D, Thomas M, Ali M, Wilson AM. Adjunctive treatment with oral AKL1, a botanical nutraceutical, in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2014;9:715-21. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Picrorhiza and Dextromethorphan, Guaifenesin, Psuedoephedrine Together: Common Questions

Is it safe to take Picrorhiza with Dextromethorphan, Guaifenesin, Psuedoephedrine?

We do not list a known interaction between Picrorhiza and Dextromethorphan, Guaifenesin, Psuedoephedrine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Picrorhiza and Dextromethorphan, Guaifenesin, Psuedoephedrine combination checked?

Interactions in our licensed database are recorded against drug classes. Dextromethorphan, Guaifenesin, Psuedoephedrine is filed under 8 classifications, and Picrorhiza has documented interactions with 2 drug classes — none of Dextromethorphan, Guaifenesin, Psuedoephedrine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Picrorhiza interact with any other medications?

Yes. Picrorhiza has 207 documented drug interactions in our database — Dextromethorphan, Guaifenesin, Psuedoephedrine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Dextromethorphan, Guaifenesin, Psuedoephedrine interact with any supplements?

Yes. Dextromethorphan, Guaifenesin, Psuedoephedrine has documented interactions with 197 supplements in our database — Picrorhiza is not one of them. The Dextromethorphan, Guaifenesin, Psuedoephedrine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Picrorhiza monograph Uses, safety profile, and every drug interaction in one place Dextromethorphan, Guaifenesin, Psuedoephedrine supplement interactions Every supplement checked against Dextromethorphan, Guaifenesin, Psuedoephedrine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Dextromethorphan, Guaifenesin, Psuedoephedrine and Picrorhiza?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.