Drug & supplement interaction

Picrorhiza + Timothy Grass Pollen Allergen Extract

Timothy Grass Pollen Allergen Extract brand name: Grastek.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Picrorhiza and Timothy Grass Pollen Allergen Extract in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Picrorhiza and Timothy Grass Pollen Allergen Extract

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Timothy Grass Pollen Allergen Extract and Picrorhiza in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Picrorhiza safety at a glance

Picrorhiza overall Use caution Generally used in traditional medicine, but human safety data are limited, so use with care.

Pregnancy Avoid Not enough safety information; avoid use during pregnancy.

Breastfeeding Avoid Not enough safety information; avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Timothy Grass Pollen Allergen Extract and Picrorhiza? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Timothy Grass Pollen Allergen Extract

Interactions in our licensed database are recorded against drug classes, not just single drug names. Timothy Grass Pollen Allergen Extract is filed under a single classification — oral drugs. Picrorhiza has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and immunosuppressants (moderate) — and none of Timothy Grass Pollen Allergen Extract’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Picrorhiza Does Interact With Other Medications

Picrorhiza has 207 moderate known drug interactions in our database — Timothy Grass Pollen Allergen Extract isn’t one of them. If you take anything else, check it against the full list below.

Moderate 207 No known interaction 2,623 (incl. Timothy Grass Pollen Allergen Extract)

Taking anything else?

Check Another of Your Medications Against Picrorhiza

Covers the 2,830 medications we’ve checked against Picrorhiza. Pick one to open its full report.

What to actually watch for

What Picrorhiza Itself Has Been Linked To

This is not an interaction — nothing below involves Timothy Grass Pollen Allergen Extract. It is the side-effect record for Picrorhiza on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Picrorhiza, this list is the first place to look.

Reduced appetite / Diarrhea / Vomiting Additional detail
“Orally, picrorhiza may cause vomiting, rash, anorexia, diarrhea, itching, and giddiness.”

Picrorhiza · Natural Medicines adverse-effect record, reported in anorexia.
1 source cited

11858. Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med 1983;29:89-95.
“Orally, picrorhiza may cause vomiting, anorexia, and diarrhea.”

Picrorhiza · Natural Medicines adverse-effect record, reported in anorexia.
1 source cited

11858. Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med 1983;29:89-95.
Itching / A skin rash Additional detail
“Orally, picrorhiza may cause rash and itching.”

Picrorhiza · Natural Medicines adverse-effect record, reported in pruritus.
1 source cited

11858. Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med 1983;29:89-95.

Everything above comes from the Natural Medicines adverse-effect record for Picrorhiza — expand a row for the licensed statement it rests on. We haven’t matched Timothy Grass Pollen Allergen Extract to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Timothy Grass Pollen Allergen Extract.

Everything else you take

See Every Supplement That Interacts With Timothy Grass Pollen Allergen Extract

This page covers Picrorhiza only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Timothy Grass Pollen Allergen Extract page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Timothy Grass Pollen Allergen Extract page

“A daily under-the-tongue allergy tablet might seem like an odd match for supplement trouble, but timothy grass pollen allergen extract (Grastek) has 17 herbal and supplement ingredients flagged against it, and this is a list that earns real caution, mainly for one entry. Activated charcoal, the sole major-rated interaction, binds many…”

Reviewed by 2 · Jul 18, 2026

Open the Timothy Grass Pollen Allergen Extract interaction page

One more smart check

Taking Picrorhiza as Part of a Dietary Supplement Product? Check It for Interactions

We hold 177 real supplement products containing Picrorhiza, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Picrorhiza. Even though Picrorhiza itself has no known interaction with Timothy Grass Pollen Allergen Extract, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Picrorhiza and Timothy Grass Pollen Allergen Extract Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Picrorhiza

Top half

#384 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Timothy Grass Pollen Allergen Extract

Top 25%

#337 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Picrorhiza reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Picrorhiza and Timothy Grass Pollen Allergen Extract records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Picrorhiza

What is Picrorhiza?

Liver support
Digestive complaints
Asthma and breathing problems
Skin conditions
Fever
Immune support

Picrorhiza (Picrorhiza kurroa) is a bitter Himalayan herb used in Ayurvedic medicine, mainly for liver and digestive complaints. Early lab and small human studies suggest possible liver-protective and anti-inflammatory effects, but high-quality evidence is limited. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Picrorhiza kurroa · Plantaginaceae · Roots and rhizomes · Capsules, tablets, powder (churna), liquid extracts, and traditional herbal formulas

An interaction check asks whether these two react with each other — it does not ask whether Picrorhiza is a good idea for someone in your situation. Here is what our Picrorhiza record says about it on its own.

Picrorhiza: dosing

There is no well-established standard dose of Picrorhiza. The amount used can vary widely depending on the form (powder, capsule, or extract) and how concentrated the product is.The safest approach is to follow the dosing directions on the product label and not to exceed them.

From our Picrorhiza monograph — the full record covers uses, side effects and every documented interaction.

Read the full Picrorhiza monograph & all interactions

Keep checking

Other Drugs & Picrorhiza

Browse every other medication we’ve checked against Picrorhiza — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

207Moderate

0Minor

2,622No known interaction

207 Moderate 2,622 No interaction

Moderate

207 interactions

Showing 60 of 207 moderate interactions — see all 207 on the Picrorhiza page.

No interaction 2,622 drugs checked — show the list

We also checked Picrorhiza against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,622 medications checked with no known interaction — see the full Picrorhiza list.

See the full Picrorhiza interactions page

See every supplement checked against Timothy Grass Pollen Allergen Extract, ranked by severity

Evidence & sources

Picrorhiza References

The 7 references that drive our Picrorhiza monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Sharma ML, Rao CS, Duda PL. Immunostimulatory activity of Picrorhiza kurroa leaf extract. J Ethnopharmacol 1994;41:185-92. PubMed
Bedi KL, Zutshi U, Chopra CL, Amla V. Picrorhiza kurroa, an ayurvedic herb, may potentiate photochemotherapy in vitiligo. J Ethnopharmacol 1989;27:347-52. PubMed
Vaidya AB, Antarkar DS, Doshi JC, et al. Picrorhiza kurroa (Kutaki) Royle ex Benth as a hepatoprotective agent--experimental & clinical studies. J Postgrad Med 1996;42:105-8.
Baruah CC, Gupta PP, Nath A, et al. Anti-allergic and anti-anaphylactic activity of picroliv--a standardised iridoid glycoside fraction of Picrorhiza kurroa. Pharmacol Res 1998;38:487-92.
Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med 1983;29:89-95.
Joy, K. L. and Kuttan, R. Anti-diabetic activity of Picrorrhiza kurroa extract. J Ethnopharmacol 11-1-1999;67(2):143-148. PubMed
Brockwell C, Ampikaipakan S, Sexton DW, Price D, Freeman D, Thomas M, Ali M, Wilson AM. Adjunctive treatment with oral AKL1, a botanical nutraceutical, in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2014;9:715-21. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Picrorhiza and Timothy Grass Pollen Allergen Extract Together: Common Questions

Is it safe to take Picrorhiza with Timothy Grass Pollen Allergen Extract?

We do not list a known interaction between Picrorhiza and Timothy Grass Pollen Allergen Extract. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Picrorhiza and Timothy Grass Pollen Allergen Extract combination checked?

Interactions in our licensed database are recorded against drug classes. Timothy Grass Pollen Allergen Extract is filed under 1 classification, and Picrorhiza has documented interactions with 2 drug classes — none of Timothy Grass Pollen Allergen Extract's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Picrorhiza interact with any other medications?

Yes. Picrorhiza has 207 documented drug interactions in our database — Timothy Grass Pollen Allergen Extract is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Timothy Grass Pollen Allergen Extract interact with any supplements?

Yes. Timothy Grass Pollen Allergen Extract has documented interactions with 17 supplements in our database — Picrorhiza is not one of them. The Timothy Grass Pollen Allergen Extract interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Picrorhiza monograph Uses, safety profile, and every drug interaction in one place Timothy Grass Pollen Allergen Extract supplement interactions Every supplement checked against Timothy Grass Pollen Allergen Extract, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Timothy Grass Pollen Allergen Extract and Picrorhiza?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.