Drug & supplement interaction

Policosanol + Doxepin

Doxepin brand names: Sinequan, Doxepin, Zonalon.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Policosanol and Doxepin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Policosanol and Doxepin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Doxepin and Policosanol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Policosanol safety at a glance

Policosanol overall Use caution Generally well tolerated in studies, but its real-world benefit is uncertain and quality varies between products.
Pregnancy Avoid There is not enough safety information, so it is best to avoid use during pregnancy.
Breastfeeding Avoid There is not enough safety information, so it is best to avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Doxepin and Policosanol? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Doxepin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Doxepin is filed under 10 classifications — including tricyclic antidepressants (tcas), antidepressant drugs, qt interval-prolonging drugs. Policosanol has documented interactions with 6 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and beta-blockers (moderate) — and none of Doxepin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Policosanol Does Interact With Other Medications

Policosanol has 242 moderate known drug interactions in our database — Doxepin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 242 No known interaction 2,588 (incl. Doxepin)
Taking anything else?

Check Another of Your Medications Against Policosanol

Covers the 2,830 medications we’ve checked against Policosanol. Pick one to open its full report.

What to actually watch for

What Policosanol Itself Has Been Linked To

This is not an interaction — nothing below involves Doxepin. It is the side-effect record for Policosanol on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Policosanol, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Pain or burning when passing urine Worth acting on Additional detail

    “Orally, policosanol is usually well-tolerated.

    Most Common Adverse Effects:

    Orally: Dysuria, headache, insomnia, polyphagia, pruritis, skin rash, somnolence, upset stomach, vertigo, weight loss.”

    Policosanol · Natural Medicines adverse-effect record, reported in cluster headache.

  • Bleeding or bruising Worth acting on Additional detail

    “A case gum bleeding has been reported in a patient taking policosanol 20 mg and aspirin 100 mg daily for 7 days.”

    Policosanol · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 2937. Arruzazabala ML, Valdes S, Mas R, et al. Comparative study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy volunteers. Pharmacol Res 1997;36:293-7. PubMed
  • Weight loss Additional detail

    “Orally, policosanol has been associated with weight loss. However, evidence from a post-market surveillance study of patients taking policosanol 5-15 mg daily shows that this adverse event is uncommon.”

    Policosanol · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 95375. Fernandez L, Mas R, Illnait J, Fernandez JC. Policosanol: results of a postmarketing surveillance study of 27,879 patients. Curr Ther Res 1998;59(10):717-22. DOI
  • Mood changes or irritability Additional detail

    “Orally, policosanol may cause headache, mild vertigo, somnolence, irritability, or insomnia but these events are uncommon. In one clinical study, 1 out of 44 subjects receiving policosanol 20 mg daily 12 weeks experienced mild vertigo and 2 out of 44 experienced mild headache. In another study, 2 out of 70 patients taking policosanol 10 mg daily for 8 weeks experienced headache.”

    Policosanol · Natural Medicines adverse-effect record, reported in cluster headache.

    3 sources cited
    1. 14404. Greyling A, De Witt C, Oosthuizen W, Jerling JC. Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects. Br J Nutr 2006;95:968-75. PubMed
    2. 69119. Francini-Pesenti F, Brocadello F, Beltramolli D, et al. Sugar cane policosanol failed to lower plasma cholesterol in primitive, diet-resistant hypercholesterolaemia: A double blind, controlled study. Complement Ther Med 2008;16:61-65. PubMed
    3. 95374. Castaño G, Fernández L, Mas R, Illnait J, Mesa M, Fernández JC. Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus. Clin Drug Investig. 2003;23(10 PubMed
  • Drowsiness / Trouble sleeping / Dizziness Additional detail

    Recorded for Policosanol in the same Natural Medicines adverse-effect record shown under Pain or burning when passing urine above.

  • Stomach upset Additional detail

    Recorded for Policosanol in the same Natural Medicines adverse-effect record shown under Pain or burning when passing urine above.

  • Itching Additional detail

    “Orally, policosanol can cause pruritus or skin rash, but these events appear to be uncommon. In one clinical trial that included over 50 patients, one case of policosanol-associated skin rash was reported. In another study, 1 out of 40 patients treated with policosanol 10 mg daily reported pruritus.”

    Policosanol · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    3 sources cited
    1. 65369. Castano G, Fernandez L, Mas R, et al. Comparison of the efficacy, safety and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II hypercholesterolemia. Int.J.Clin.Pharmacol.Res. 2002;22:5
    2. 95374. Castaño G, Fernández L, Mas R, Illnait J, Mesa M, Fernández JC. Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus. Clin Drug Investig. 2003;23(10 PubMed
    3. 100178. Wang HY, Jiao QP, Chen SY, et al. Efficacy and safety of policosanol plus fenofibrate combination therapy in elderly patients with mixed dyslipidemia: A randomized, controlled clinical study. Am J Med Sci. 2018;356(3):254-261. PubMed
  • A skin rash Additional detail

    Recorded for Policosanol in the same Natural Medicines adverse-effect record shown under Pain or burning when passing urine above.

Showing the 10 most notable of 11 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Policosanol — expand a row for the licensed statement it rests on. We haven’t matched Doxepin to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Doxepin.

Everything else you take

See Every Supplement That Interacts With Doxepin

This page covers Policosanol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Doxepin page lists 186 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), American Hellebore (major), Arsenic (major) and Beer (major).

By severity: 15 major · 145 moderate · 26 minor.

From our pharmacist’s overview on the Doxepin page

“Doxepin is a sedating tricyclic prescribed for depression, anxiety, and often sleep itself, and the people taking it tend to shop the same shelf where the trouble sits. Of the 186 supplements on file, 78 deepen its drowsiness, with alcohol (beer and wine carry major, well-documented ratings) and kava the clearest examples, and I would…”

Reviewed by 2 · Jul 18, 2026

Open the Doxepin interaction page

One more smart check

Taking Policosanol as Part of a Dietary Supplement Product? Check It for Interactions

We hold 479 real supplement products containing Policosanol, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Policosanol. Even though Policosanol itself has no known interaction with Doxepin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Policosanol and Doxepin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Policosanol
Top 25%

#348 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Doxepin
Top half

#893 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Policosanol reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Policosanol and Doxepin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Policosanol

What is Policosanol?

Policosanol
  • High cholesterol
  • Heart and blood vessel health
  • Leg pain from poor circulation (intermittent claudication)
  • Physical stamina and energy

Policosanol is a mix of waxy alcohols (mostly octacosanol) made from sugar cane or other plant waxes, and it is often marketed as a natural way to lower cholesterol. Early studies from Cuba showed strong cholesterol-lowering effects, but independent studies in other countries have mostly failed to confirm these benefits. Talk with your pharmacist or doctor before using it, especially if you take cholesterol medicine.

Wax extracted from sugar cane, beeswax, rice bran, or wheat germ · Tablets, capsules

An interaction check asks whether these two react with each other — it does not ask whether Policosanol is a good idea for someone in your situation. Here is what our Policosanol record says about it on its own.

Policosanol: dosing

There is no official or universally agreed-upon dose for policosanol. The amounts used in studies have varied, and the source of the wax can change how a product behaves. They can help you decide if it is appropriate for you and whether your cholesterol or heart condition needs proven treatment instead.

From our Policosanol monograph — the full record covers uses, side effects and every documented interaction.

Read the full Policosanol monograph & all interactions
Medication

About Doxepin (Insomnia)

What Is Doxepin (Insomnia) Used For?

Brand names: Sinequan, Doxepin, Zonalon

This product is marketed to temporarily relieve occasional trouble sleeping when it's brought on by anxiety, restlessness, stress, or sensitivity to caffeine.

It is a homeopathic remedy — meaning its claims are based on traditional homeopathic practice, not accepted medical evidence, and it has not been evaluated by the FDA for effectiveness.

Most-Reported Side Effects for Doxepin

From FAERS, the FDA’s public side-effect reporting system (12,553 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Toxicity to various agents 988 reports
Completed suicide 828 reports
Fatigue 793 reports
Nausea 679 reports
Headache 642 reports
See full Doxepin (Insomnia) drug information
Keep checking

Other Drugs & Policosanol

Browse every other medication we’ve checked against Policosanol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
242Moderate
0Minor
2,587No known interaction
242 Moderate 2,587 No interaction
Moderate

242 interactions

Showing 60 of 242 moderate interactions — see all 242 on the Policosanol page.

No interaction 2,587 drugs checked — show the list

We also checked Policosanol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,587 medications checked with no known interaction — see the full Policosanol list.

See the full Policosanol interactions page
See every supplement checked against Doxepin, ranked by severity
Evidence & sources

Policosanol References

The 15 references that drive our Policosanol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Carbajal D, Arruzazabala ML, Valdes S, Mas R. Effect of policosanol on platelet aggregation and serum levels of arachidonic acid metabolites in healthy volunteers. Prostaglandins Leukot Essent Fatty Acids 1998;58:61-4.
  2. Arruzazabala ML, Valdes S, Mas R, et al. Comparative study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy volunteers. Pharmacol Res 1997;36:293-7. PubMed
  3. Valdes S, Arruzazabala ML, Fernandez L. Effect of policosanol on platelet aggregation in healthy volunteers. Int J Clin Pharmacol Res 1996;16:67-72.
  4. Greyling A, De Witt C, Oosthuizen W, Jerling JC. Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects. Br J Nutr 2006;95:968-75. PubMed
  5. Abdul MI, Jiang X, Williams KM, et al. Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. Br J Clin.Pharmacol. 2010;69:508-15. PubMed
  6. Molina, Cuevas, V, Arruzazabala, M. L., Carbajal, Quintana D., Mas, Ferreiro R., and Valdes, Garcia S. Effect of policosanol on arterial blood pressure in rats. Study of the pharmacological interaction with nifedipine and propranolol. Arch Med Res 1998;29
  7. Castano G, Fernandez L, Mas R, et al. Comparison of the efficacy, safety and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II hypercholesterolemia. Int.J.Clin.Pharmacol.Res. 2002;22:5
  8. Arruzazabala, M. L., Carbajal, D., Mas, R., Valdes, S., and Molina, V. Pharmacological Interaction Between Policosanol and Nitroprusside in Rats. J Med Food 2001;4(2):67-70. PubMed
  9. Castano G, Mas R, Gamez R, et al. Concomitant use of policosanol and beta-blockers in older patients. Int J Clin Pharmacol.Res 2004;24:65-77.
  10. Francini-Pesenti F, Brocadello F, Beltramolli D, et al. Sugar cane policosanol failed to lower plasma cholesterol in primitive, diet-resistant hypercholesterolaemia: A double blind, controlled study. Complement Ther Med 2008;16:61-65. PubMed
  11. Castaño G, Fernández L, Mas R, Illnait J, Mesa M, Fernández JC. Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus. Clin Drug Investig. 2003;23(10 PubMed
  12. Fernandez L, Mas R, Illnait J, Fernandez JC. Policosanol: results of a postmarketing surveillance study of 27,879 patients. Curr Ther Res 1998;59(10):717-22. DOI
  13. Wang HY, Jiao QP, Chen SY, et al. Efficacy and safety of policosanol plus fenofibrate combination therapy in elderly patients with mixed dyslipidemia: A randomized, controlled clinical study. Am J Med Sci. 2018;356(3):254-261. PubMed
  14. Xu K, Liu X, Li Y, Wang Y, Zang H, Guo L, et al. Safety and efficacy of policosanol in patients with high on-treatment platelet reactivity after drug-eluting stent implantation: two-year follow-up results. Cardiovasc Ther. 2016 Oct;34(5):337-42. doi: 10.1 PubMed
  15. Li C, Ding Y, Si Q, Li K, Xu K. Multiple functions of policosanol in elderly patients with dyslipidemia. J Int Med Res. 2020;48(7):300060520936082. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Policosanol and Doxepin Together: Common Questions

Is it safe to take Policosanol with Doxepin?
We do not list a known interaction between Policosanol and Doxepin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Policosanol and Doxepin combination checked?
Interactions in our licensed database are recorded against drug classes. Doxepin is filed under 10 classifications, and Policosanol has documented interactions with 6 drug classes — none of Doxepin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Policosanol interact with any other medications?
Yes. Policosanol has 242 documented drug interactions in our database — Doxepin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Doxepin interact with any supplements?
Yes. Doxepin has documented interactions with 186 supplements in our database — Policosanol is not one of them. The Doxepin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Policosanol monograph Uses, safety profile, and every drug interaction in one place Doxepin (Insomnia) drug information The full plain-English guide to this medication Doxepin supplement interactions Every supplement checked against Doxepin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 15 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Doxepin and Policosanol?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.