Drug & supplement interaction

Polypodium Leucotomos + Pasireotide Diaspartate

Pasireotide Diaspartate brand name: Signifor.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Polypodium Leucotomos and Pasireotide Diaspartate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Polypodium Leucotomos and Pasireotide Diaspartate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pasireotide Diaspartate and Polypodium Leucotomos in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Polypodium Leucotomos safety at a glance

Polypodium Leucoto... overall Use caution Generally well tolerated in studies, but long-term safety is not well established.
Pregnancy Avoid There is not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoidance is the safer choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pasireotide Diaspartate and Polypodium Leucotomos? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Pasireotide Diaspartate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pasireotide Diaspartate is filed under a single classification — qt interval-prolonging drugs. Polypodium Leucotomos has documented interactions with 1 drug class — the most serious being cytochrome p450 3a4 (cyp3a4) substrates (minor) — and none of Pasireotide Diaspartate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Polypodium Leucotomos Does Interact With Other Medications

Polypodium Leucotomos has 643 minor known drug interactions in our database — Pasireotide Diaspartate isn’t one of them. If you take anything else, check it against the full list below.

Minor 643 No known interaction 2,187 (incl. Pasireotide Diaspartate)
Taking anything else?

Check Another of Your Medications Against Polypodium Leucotomos

Covers the 2,830 medications we’ve checked against Polypodium Leucotomos. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Polypodium Leucotomos and Pasireotide Diaspartate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Itching Additional detail

    Polypodium Leucotomos

    “Orally, Polypodium leucotomos has rarely been associated with pruritus.”

    Polypodium Leucotomos · Natural Medicines adverse-effect record, reported in pruritus.

    1 source cited
    1. 101470. Goh CL, Chuah SY, Tien S, Thng G, Vitale MA, Delgado-Rubin A. Double-blind, placebo-controlled trial to evaluate the effectiveness of Polypodium leucotomos extract in the treatment of melasma in Asian skin: a pilot study. J Clin Aesthet Dermatol 2018;11(3

    Pasireotide Diaspartate

    Listed in the ADVERSE REACTIONS section of the FDA label for Pasireotide Diaspartate. Read the label on DailyMed ›

Effects for Pasireotide Diaspartate come from the ADVERSE REACTIONS section of its FDA label; effects for Polypodium Leucotomos come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Pasireotide Diaspartate

This page covers Polypodium Leucotomos only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pasireotide Diaspartate page lists 13 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: American Hellebore (major), Arsenic (major), Cesium (major), Ephedra (major) and Grapefruit (major).

By severity: 6 major · 7 moderate.

From our pharmacist’s overview on the Pasireotide Diaspartate page

“All 13 supplements on this page raise the same concern with pasireotide (Signifor), a drug for Cushing's disease that can itself lengthen the QT interval, the electrical reset time between heartbeats. Stack another QT-prolonging ingredient on top and the risk of a dangerous heart rhythm goes up, so treat these combinations with real care.”

Reviewed by 2 · Jul 18, 2026

Open the Pasireotide Diaspartate interaction page

One more smart check

Taking Polypodium Leucotomos as Part of a Dietary Supplement Product? Check It for Interactions

We hold 26 real supplement products containing Polypodium Leucotomos, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Polypodium Leucotomos. Even though Polypodium Leucotomos itself has no known interaction with Pasireotide Diaspartate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Polypodium Leucotomos and Pasireotide Diaspartate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Polypodium Leucotomos
Steady interest

#814 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pasireotide Diaspartate
Top half

#1,363 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Polypodium Leucotomos reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Polypodium Leucotomos and Pasireotide Diaspartate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Polypodium Leucotomos

What is Polypodium Leucotomos?

  • Sun sensitivity and sunburn protection
  • Skin conditions like vitiligo and melasma
  • Polymorphic light eruption
  • Skin aging and photoaging
  • Atopic dermatitis support

Polypodium leucotomos is a fern extract taken by mouth, mostly studied as an add-on to (not a replacement for) sunscreen and for certain light-triggered skin conditions. Some early research is promising for reducing sun sensitivity, but the evidence is still limited and it should not replace standard sun protection. Talk with your pharmacist or doctor before starting it.

Polypodium leucotomos · Polypodiaceae · Leaves (fronds) and rhizome extract · Capsules, tablets, oral supplements

An interaction check asks whether these two react with each other — it does not ask whether Polypodium Leucotomos is a good idea for someone in your situation. Here is what our Polypodium Leucotomos record says about it on its own.

Polypodium Leucotomos: dosing

There is no official or standardized dose for Polypodium leucotomos. Do not assume that taking more will give better or faster results.

From our Polypodium Leucotomos monograph — the full record covers uses, side effects and every documented interaction.

Read the full Polypodium Leucotomos monograph & all interactions
Medication

About Pasireotide Injection

What Is Pasireotide Injection Used For?

Brand name: Signifor

Signifor (pasireotide subcutaneous injection) is used to treat Cushing's disease — a condition caused by a pituitary tumor that makes the body produce too much cortisol — in patients for whom pituitary surgery is not an option or did not cure the disease.

Signifor LAR (a long-acting intramuscular form of pasireotide) is approved to treat both acromegaly (a condition where the pituitary gland makes too much growth hormone) and Cushing's disease, in patients who have had an inadequate response to surgery or for whom surgery is not an option.

See full Pasireotide Injection drug information
Keep checking

Other Drugs & Polypodium Leucotomos

Browse every other medication we’ve checked against Polypodium Leucotomos — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
643Minor
2,186No known interaction
643 Minor 2,186 No interaction
Minor

643 interactions

Showing 60 of 643 minor interactions — see all 643 on the Polypodium Leucotomos page.

No interaction 2,186 drugs checked — show the list

We also checked Polypodium Leucotomos against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,186 medications checked with no known interaction — see the full Polypodium Leucotomos list.

See the full Polypodium Leucotomos interactions page
See every supplement checked against Pasireotide Diaspartate, ranked by severity
Evidence & sources

Polypodium Leucotomos References

The 2 references that drive our Polypodium Leucotomos monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Goh CL, Chuah SY, Tien S, Thng G, Vitale MA, Delgado-Rubin A. Double-blind, placebo-controlled trial to evaluate the effectiveness of Polypodium leucotomos extract in the treatment of melasma in Asian skin: a pilot study. J Clin Aesthet Dermatol 2018;11(3
  2. Shinya K, Nishimura Y, Ryu K, et al. Short-term administration of Polypodium leucotomos extract does not inhibit CYP3A4-mediated metabolism of midazolam in healthy subjects: an open-label, two-period, fixed-sequence study. Int J Dermatol 2022.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Polypodium Leucotomos and Pasireotide Diaspartate Together: Common Questions

Is it safe to take Polypodium Leucotomos with Pasireotide Diaspartate?
We do not list a known interaction between Polypodium Leucotomos and Pasireotide Diaspartate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Polypodium Leucotomos and Pasireotide Diaspartate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Polypodium Leucotomos and Pasireotide Diaspartate combination checked?
Interactions in our licensed database are recorded against drug classes. Pasireotide Diaspartate is filed under 1 classification, and Polypodium Leucotomos has documented interactions with 1 drug class — none of Pasireotide Diaspartate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Polypodium Leucotomos interact with any other medications?
Yes. Polypodium Leucotomos has 643 documented drug interactions in our database — Pasireotide Diaspartate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Pasireotide Diaspartate interact with any supplements?
Yes. Pasireotide Diaspartate has documented interactions with 13 supplements in our database — Polypodium Leucotomos is not one of them. The Pasireotide Diaspartate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Polypodium Leucotomos monograph Uses, safety profile, and every drug interaction in one place Pasireotide Injection drug information The full plain-English guide to this medication Pasireotide Diaspartate supplement interactions Every supplement checked against Pasireotide Diaspartate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.