Drug & supplement interaction

Propolis + Hethylphenidate HCl

Hethylphenidate HCl brand name: Hethylphenidate HCl.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Propolis and Hethylphenidate HCl in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Propolis and Hethylphenidate HCl

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Hethylphenidate HCl and Propolis in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Propolis safety at a glance

Propolis overall Use caution Generally well tolerated short term, but allergic reactions are possible, especially in people sensitive to bee products.
Pregnancy Avoid Not enough reliable safety information, so it is best avoided during pregnancy.
Breastfeeding Possibly Safe When used orally and appropriately during lactation. Propolis 300 mg daily has been used for 4-10 months in one clinical study with no apparent adverse effects... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Hethylphenidate HCl and Propolis? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Hethylphenidate HCl

Interactions in our licensed database are recorded against drug classes, not just single drug names. Hethylphenidate HCl is filed under 3 classifications — amphetamines, stimulant drugs, oral drugs. Propolis has documented interactions with 8 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), cytochrome p450 1a2 (cyp1a2) substrates (moderate) and cytochrome p450 2c19 (cyp2c19) substrates (moderate) — and none of Hethylphenidate HCl’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Propolis Does Interact With Other Medications

Propolis has 921 moderate known drug interactions in our database — Hethylphenidate HCl isn’t one of them. If you take anything else, check it against the full list below.

Moderate 921 No known interaction 1,909 (incl. Hethylphenidate HCl)
Taking anything else?

Check Another of Your Medications Against Propolis

Covers the 2,830 medications we’ve checked against Propolis. Pick one to open its full report.

What to actually watch for

What Propolis Itself Has Been Linked To

This is not an interaction — nothing below involves Hethylphenidate HCl. It is the side-effect record for Propolis on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Propolis, this list is the first place to look. 4 entries are worth acting on rather than waiting out — marked below.

  • A severe skin reaction Worth acting on Additional detail

    “Propolis can cause allergic reactions and acute oral mucositis with ulceration from the use of the propolis-containing lozenges.

    Topically, propolis-containing products, including some cosmetics, can cause eczematous contact dermatitis, erythema multiforme-like contact dermatitis, or allergic contact cheilitis.

    Patients allergic to bees or bee products may be more likely to experience allergic reactions to propolis.”

    Propolis · Natural Medicines adverse-effect record, reported in dermatitis.

    6 sources cited
    1. 2632. Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol 1990;70:584-6. PubMed
    2. 15647. Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006;55:312-3. PubMed
    3. 92796. Matos D, Serrano P, Brandao FM. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis 2015;72(1):59-60. PubMed
    4. 92798. Nyman G, Hagvall L. A case of allergic contact cheilitis caused by propolis and honey. Contact Dermatitis 2016;74(3):186-7. PubMed
    5. 95878. Lamoureux A, Meharon M, Durand AL, Darrigade AS, Doutre MS, Milpied B. A first case of erythema multiforme-like contact dermatitis caused by propolis. Contact Dermatitis. 2017;77(4):263-264. PubMed
    6. 95882. Piredda M, Facchinetti G, Biagioli V, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6). PubMed
  • Kidney problems Worth acting on Additional detail

    “In one case report, a 59-year-old male with cholangiocarcinoma developed acute kidney failure requiring hemodialysis after taking a Brazilian preparation of propolis 5 mL three times daily for 2 weeks. Renal function improved when propolis was discontinued. The patient restarted taking propolis and symptoms developed again and the patient again required hemodialysis.”

    Propolis · Natural Medicines adverse-effect record, reported in kidney failure.

    1 source cited
    1. 14300. Li YJ, Lin JL, Yang CW, Yu CC. Acute renal failure induced by a Brazilian variety of propolis. Am J Kidney Dis 2005;46:e125-9. PubMed
  • A severe allergic reaction Worth acting on Additional detail

    “In one case report, a 36-year-old female developed severe erythematous papules and patches with edema of the face, neck, arms, abdomen, and thighs after consuming propolis solution for a few weeks. After symptom resolution, a patch test showed an extreme positive reaction to propolis.”

    Propolis · Natural Medicines adverse-effect record, reported in dermatitis.

    6 sources cited
    1. 106443. Cho E, Lee JD, Cho SH. Systemic contact dermatitis from propolis ingestion. Ann Dermatol. 2011;23(1):85-88. PubMed
    2. 70063. Hsu, C. Y., Chiang, W. C., Weng, T. I., Chen, W. J., and Yuan, A. Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis. Am J Emerg.Med 2004;22(5):432-433. PubMed
    3. 15647. Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006;55:312-3. PubMed
    4. 92796. Matos D, Serrano P, Brandao FM. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis 2015;72(1):59-60. PubMed
    5. 92798. Nyman G, Hagvall L. A case of allergic contact cheilitis caused by propolis and honey. Contact Dermatitis 2016;74(3):186-7. PubMed
    6. 102517. Nyman GSA, Tang M, Inerot A, Osmancevic A, Malmberg P, Hagvall L. Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. Contact Dermatitis 2019;81(2):110-6. PubMed
  • An allergic reaction Worth acting on Additional detail

    “Orally and topically, propolis seems to be well tolerated.

    Most Common Adverse Effects:

    Orally: Headache.

    Topically: Contact cheilitis and contact dermatitis in sensitive individuals.

    Serious Adverse Effects (Rare):

    Orally: Severe allergic reactions in sensitive individuals.”

    Propolis · Natural Medicines adverse-effect record, reported in cluster headache.

  • Sore throat Additional detail

    “Orally, propolis may cause an increase in liver enzymes when used long-term at high doses. In one case, a 30-year-old male presented with persistent abnormal liver enzymes for six months. With other causes ruled out, the patient disclosed using more than 10 propolis lozenges per day for several months to treat a sore throat. Upon discontinuation of the propolis lozenges, liver enzymes returned to normal.”

    Propolis · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    3 sources cited
    1. 105788. D'Ercole MC. Prolonged use of propolis can increase liver enzymes. J Gastrointestin Liver Dis 2020;29(3):468-9. PubMed
    2. 108521. Hallajzadeh J, Milajerdi A, Amirani E, Attari VE, Maghsoudi H, Mirhashemi SM. Effects of propolis supplementation on glycemic status, lipid profiles, inflammation and oxidative stress, liver enzymes, and body weight: a systematic review and meta-analysis
    3. 108522. Gheflati A, Dehnavi Z, Ghannadzadeh Yazdi A, Khorasanchi Z, Raeisi-Dehkordi H, Ranjbar G. The effects of propolis supplementation on metabolic parameters: a systematic review and meta-analysis of randomized controlled clinical trials. Avicenna J Phytomed
  • Swelling Additional detail

    Recorded for Propolis in the same Natural Medicines adverse-effect record shown under A severe allergic reaction above.

  • A skin rash Additional detail

    Recorded for Propolis in the same Natural Medicines adverse-effect record shown under An allergic reaction above.

  • Headache Additional detail

    “Orally, propolis may cause headache in some patients. In one clinical trial, around 7% of patients taking propolis 250 mg twice daily for 4 months reported mild headache.”

    Propolis · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 105786. Soleimani D, Rezaie M, Rajabzadeh F, et al. Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real-time two-dimensional shear wave elastography: a randomized clinical

Everything above comes from the Natural Medicines adverse-effect record for Propolis — expand a row for the licensed statement it rests on. We haven’t matched Hethylphenidate HCl to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Hethylphenidate HCl.

Special populations

Propolis in Pregnancy & Breastfeeding

Lactation Possibly Safe

When used orally and appropriately during lactation. Propolis 300 mg daily has been used for 4-10 months in one clinical study with no apparent adverse effects to nursing infants.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Hethylphenidate HCl

This page covers Propolis only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hethylphenidate HCl page lists 65 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Peyote (major), Rauvolfia Vomitoria (major) and Sida Cordifolia (major).

By severity: 5 major · 47 moderate · 13 minor.

From our pharmacist’s overview on the Hethylphenidate HCl page

“Hethylphenidate HCl is a stimulant medication, which is exactly why this list deserves genuine care rather than a quick skim. Of the 65 supplement and herbal ingredients with an interaction on file, 44 pile more stimulant effect on top of the drug, raising blood pressure, heart rate, and cardiovascular risk.”

Reviewed by 2 · Jul 18, 2026

Open the Hethylphenidate HCl interaction page

One more smart check

Taking Propolis as Part of a Dietary Supplement Product? Check It for Interactions

We hold 723 real supplement products containing Propolis, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Propolis. Even though Propolis itself has no known interaction with Hethylphenidate HCl, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Propolis and Hethylphenidate HCl Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Propolis
Top 25%

#251 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hethylphenidate HCl
Top 5%

#95 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Propolis reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Propolis and Hethylphenidate HCl records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Propolis

What is Propolis?

Propolis
  • Cold sores and herpes lesions (topical)
  • Sore throat and mouth sores
  • Wound and skin healing
  • Immune support
  • Oral and gum health

Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research suggests it may help with cold sores, mouth sores, and minor wounds, but high-quality evidence is limited for most uses. It is generally well tolerated, but allergic reactions can occur, especially in people allergic to bee products.

Resinous hive material collected by bees from tree buds and bark · Capsules, tablets, lozenges, throat sprays, tinctures, liquid extracts, mouthwash, creams, ointments, and toothpaste

An interaction check asks whether these two react with each other — it does not ask whether Propolis is a good idea for someone in your situation. Here is what our Propolis record says about it on its own.

Propolis: dosing

There is no standard, well-established dose for propolis. Products vary widely in strength and in the actual amount of active compounds they contain, partly because propolis composition depends on where the bees collected it.Because of this, the best advice is to follow the directions on the product label and not exceed the recommended amount.

From our Propolis monograph — the full record covers uses, side effects and every documented interaction.

Read the full Propolis monograph & all interactions
Keep checking

Other Drugs & Propolis

Browse every other medication we’ve checked against Propolis — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
921Moderate
0Minor
1,908No known interaction
921 Moderate 1,908 No interaction
Moderate

921 interactions

Showing 60 of 921 moderate interactions — see all 921 on the Propolis page.

No interaction 1,908 drugs checked — show the list

We also checked Propolis against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,908 medications checked with no known interaction — see the full Propolis list.

See the full Propolis interactions page
See every supplement checked against Hethylphenidate HCl, ranked by severity
Evidence & sources

Propolis References

The 21 references that drive our Propolis monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol 1990;70:584-6. PubMed
  2. Li YJ, Lin JL, Yang CW, Yu CC. Acute renal failure induced by a Brazilian variety of propolis. Am J Kidney Dis 2005;46:e125-9. PubMed
  3. Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006;55:312-3. PubMed
  4. Chen, T. G., Lee, J. J., Lin, K. H., Shen, C. H., Chou, D. S., and Sheu, J. R. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol 6-30-2007;50(3):121-126.
  5. Hsu, C. Y., Chiang, W. C., Weng, T. I., Chen, W. J., and Yuan, A. Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis. Am J Emerg.Med 2004;22(5):432-433. PubMed
  6. Black, R. J. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp.Dermatol. 2005;30(1):91-92. PubMed
  7. Matos D, Serrano P, Brandao FM. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis 2015;72(1):59-60. PubMed
  8. Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
  9. Nyman G, Hagvall L. A case of allergic contact cheilitis caused by propolis and honey. Contact Dermatitis 2016;74(3):186-7. PubMed
  10. Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
  11. Akbay E, Özenirler Ç, Çelemli ÖG, Durukan AB, Onur MA, Sorkun K. Effects of propolis on warfarin efficacy. Kardiochir Torakochirurgia Pol. 2017;14(1):43-46. PubMed
  12. Lamoureux A, Meharon M, Durand AL, Darrigade AS, Doutre MS, Milpied B. A first case of erythema multiforme-like contact dermatitis caused by propolis. Contact Dermatitis. 2017;77(4):263-264. PubMed
  13. Piredda M, Facchinetti G, Biagioli V, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6). PubMed
  14. Zhang YX, Yang TT, Xia L, Zhang WF, Wang JF, Wu YP. Inhibitory Effect of Propolis on Platelet Aggregation In Vitro. J Healthc Eng. 2017;2017:3050895. PubMed
  15. Nyman GSA, Tang M, Inerot A, Osmancevic A, Malmberg P, Hagvall L. Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. Contact Dermatitis 2019;81(2):110-6. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Propolis and Hethylphenidate HCl Together: Common Questions

Is it safe to take Propolis with Hethylphenidate HCl?
We do not list a known interaction between Propolis and Hethylphenidate HCl. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Propolis and Hethylphenidate HCl combination checked?
Interactions in our licensed database are recorded against drug classes. Hethylphenidate HCl is filed under 3 classifications, and Propolis has documented interactions with 8 drug classes — none of Hethylphenidate HCl's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Propolis interact with any other medications?
Yes. Propolis has 921 documented drug interactions in our database — Hethylphenidate HCl is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Hethylphenidate HCl interact with any supplements?
Yes. Hethylphenidate HCl has documented interactions with 65 supplements in our database — Propolis is not one of them. The Hethylphenidate HCl interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Propolis monograph Uses, safety profile, and every drug interaction in one place Hethylphenidate HCl supplement interactions Every supplement checked against Hethylphenidate HCl, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 21 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Hethylphenidate HCl and Propolis?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.