Quercetin + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide
Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide brand name: Ascriptin Codeine #3.
Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide falls into 3 drug categories that Quercetin can interact with; the most serious is rated moderate. Theoretically, concomitant use might increase the effects and adverse effects of OAT3 substrates.
Read the full interaction reportQuercetin and Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Quercetin interacts with whole categories of medication. Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide falls into 3 of those categories, so it can interact with Quercetin in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES
1 of 3Why this applies to Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide
Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide falls under ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES — the group Quercetin interacts with.
In vitro research shows that quercetin is a strong non-competitive inhibitor of OAT3, with half-maximal inhibitory concentration (IC50) values as low as 0.75 mcM. So far, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combination product packs a lot in, but the piece that matters here is the aspirin. Your kidneys use a little doorway called OAT3 to help clear aspirin out of your body. In lab dishes, quercetin blocks that doorway pretty strongly. In theory, that could let aspirin linger a bit longer and nudge up its effects, including things like stomach upset, heartburn, or a higher chance of bleeding or bruising.
The important caveat: this has only been seen in test-tube studies, never reported in real people. So I wouldn't lose sleep over it, especially with food amounts of quercetin. If you take high-dose quercetin supplements regularly, it's worth a quick chat with your pharmacist or doctor first.
- Li C, Wang X, Bi Y, et al. Potent Inhibitors of Organic Anion Transporters 1 and 3 From Natural Compounds and Their Protective Effect on Aristolochic Acid Nephropathy. Toxicol Sci. 2020;175(2):279-291. PubMed
- Ni Y, Duan Z, Zhou D, et al. Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids. Front Pharmacol. 2020;11:802. PubMed
ORGANIC ANION TRANSPORTER 1 (OAT1) SUBSTRATES
2 of 3Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide also falls under ORGANIC ANION TRANSPORTER 1 (OAT1) SUBSTRATES.
In vitro research shows that quercetin is a strong non-competitive inhibitor of OAT1, with half-maximal inhibitory concentration (IC50) values less than 10 mcM. So far, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combination product contains aspirin, codeine, and two antacids (aluminum and magnesium hydroxide). The piece that matters here is the aspirin, because your kidneys use a transporter called OAT1 to help clear salicylate (the active part of aspirin) out of your body. In lab dish studies, quercetin blocks that transporter. In theory, that could slow aspirin's removal and let a bit more linger, which might nudge up side effects like stomach upset, heartburn, or ringing in the ears.
The important caveat: this has only been seen in test-tube research, never in actual people, so the real-world risk is likely small. Food amounts of quercetin are very unlikely to matter. If you take high-dose quercetin supplements regularly, just mention it to your pharmacist or doctor first.
- Ni Y, Duan Z, Zhou D, et al. Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids. Front Pharmacol. 2020;11:802. PubMed
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
3 of 3Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide also falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES.
In vitro research show that quercetin inhibits CYP2D6. This effect has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here is the part of this combination pill that matters for quercetin: the codeine. Codeine is actually a prodrug, which means it does nothing for pain on its own. Your body uses an enzyme called CYP2D6 to convert codeine into morphine, the active pain reliever. In lab studies, quercetin appears to block that same enzyme.
So in theory, high-dose quercetin could mean less codeine gets turned into morphine, giving you weaker pain relief rather than more side effects. I want to stress this is only test-tube data and has not been shown in real people, so it is theoretical. Food amounts of quercetin are very unlikely to matter. If you take concentrated supplements, just mention it to your pharmacist or doctor.
- Obach RS. Inhibition of human cytochrome P450 enzymes by constituents of St. John's wort, an herbal preparation used in the treatment of depression. J Pharmacol Exp Ther 2000;294:88-95. DOI
- DiCenzo R, Frerichs V, Larppanichpoonphol P, et al. Effect of quercetin on the plasma and intracellular concentrations of saquinavir in healthy adults. Pharmacotherapy 2006;26:1255-61. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Quercetin Also Interacts With Other Medications
Quercetin has 1,168 moderate known drug interactions in our database — the Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Quercetin
We haven’t checked that one against Quercetin yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Quercetin. Pick one to open its full report.
See Every Supplement That Interacts With Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide
This page covers Quercetin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide page lists 293 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).
By severity: 8 major · 246 moderate · 39 minor.
From our pharmacist’s overview on the Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide page
“Bleeding dominates the supplement list for Ascriptin Codeine #3, which pairs aspirin and codeine with two antacid ingredients. Of 293 interactions on file, 8 are rated major, and this combination pill earns real caution.”
Reviewed by 2 · Jul 18, 2026
Open the Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interaction page
Taking Quercetin as Part of a Dietary Supplement Product? Check It for Interactions
We hold 4,589 real supplement products containing Quercetin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Quercetin. Your product may carry other ingredients that interact with Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide too, on top of Quercetin — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Quercetin and Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#47 of 1,452 supplements looked up here in the last 7 days
#843 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Quercetin
What is Quercetin?
- Seasonal allergies
- Antioxidant support
- Heart and blood pressure health
- Anti-inflammatory support
- Immune support
- Exercise recovery
Quercetin is a plant flavonoid with antioxidant and anti-inflammatory properties found in many common foods and sold as a supplement. While early research is interesting for allergies, blood pressure, and inflammation, strong human evidence is limited for most uses. It is generally well tolerated in food amounts, but talk to your pharmacist or doctor before taking high-dose supplements.
Other Drugs & Quercetin
Browse every other medication we’ve checked against Quercetin — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,168 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Aspirin ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Naproxen ›
- Doxycycline ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Tetracycline ›
- Lidocaine ›
- Ranitidine ›
- Hydrochlorothiazide ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Ciprofloxacin ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Isotretinoin ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Apomorphine ›
- Budesonide ›
- Carbamazepine ›
- Ceftazidime ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Hydralazine ›
- Indomethacin ›
- Insulin (human) ›
- Miconazole ›
- Morphine Sulfate ›
- Salsalate ›
- Trimipramine ›
- Acyclovir ›
- Amphetamine ›
Showing 60 of 1,168 moderate interactions — see all 1,168 on the Quercetin page.
No interaction 1,661 drugs checked — show the list
We also checked Quercetin against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Docusate ›
- Hydroxyurea ›
- Sumatriptan ›
- Amoxicillin ›
- Bupropion ›
- Bendamustine ›
- Lamotrigine ›
- Pregabalin ›
- Azithromycin ›
- Gabapentin ›
- Methylene Blue ›
- Levothyroxine, Liothyronine ›
- Cyclopentolate ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Roxithromycin ›
- Pegunigalsidase Alfa-iwxj ›
- Levetiracetam ›
- Daptomycin ›
- Levothyroxine Sodium ›
- Ezetimibe ›
- Dexmethylphenidate ›
- Amoxicillin, Clavulanate Potassium ›
- Hexobarbitone ›
- Phentermine, Topiramate ›
- Thyroid Hormone ›
- Carbidopa, Levodopa ›
- Factor 7a ›
- Levodopa ›
- Lenvatinib ›
- Mitomycin ›
- Hethylphenidate Hcl ›
- Azelaic Acid ›
- Phenylephrine ›
- Hydroxychloroquine ›
- Tenecteplase ›
- Vancomycin ›
- Bentoquatam ›
- Pizotifen ›
- Triptorelin ›
- Pentobarbitone ›
- Dirithromycin ›
- Procainamide ›
- Dextrothyroxine ›
- Tocainide ›
- Sodium Valproate ›
- Rocuronium ›
- Mitomycin C ›
- Digitoxin ›
- Paracetamol ›
- Lomustine ›
- Chenodiol ›
- Lorazepam ›
- Gestodene ›
- Desflurane ›
- Salbutamol Sulfate ›
Showing the 60 most looked-up of 1,661 medications checked with no known interaction — see the full Quercetin list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide Is Linked to Lower Levels of 7 Nutrients
Natural Medicines records Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide as a medicine that can lower these. This is not an interaction with Quercetin — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Quercetin and Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide Together: Common Questions
Can you take Quercetin with Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide?
Why are there 3 interactions listed for Quercetin and Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide?
How serious is the Quercetin and Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.