Quercetin + Diclofenac Sodium, Misoprostol
Diclofenac Sodium, Misoprostol brand names: Arthrotec 50, Arthrotec 75.
Diclofenac Sodium, Misoprostol falls into 4 drug categories that Quercetin can interact with; the most serious is rated moderate. Theoretically, concomitant use might increase the effects and adverse effects of OAT3 substrates.
Read the full interaction reportQuercetin and Diclofenac Sodium, Misoprostol
These two interact in 4 distinct ways. Each one is explained separately below.
Why Are There 4 Interactions?
Quercetin interacts with whole categories of medication. Diclofenac Sodium, Misoprostol falls into 4 of those categories, so it can interact with Quercetin in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES
1 of 4Why this applies to Diclofenac Sodium, Misoprostol
Diclofenac Sodium, Misoprostol falls under ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES — the group Quercetin interacts with.
In vitro research shows that quercetin is a strong non-competitive inhibitor of OAT3, with half-maximal inhibitory concentration (IC50) values as low as 0.75 mcM. So far, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Arthrotec is a combo of diclofenac (an anti-inflammatory pain reliever) and misoprostol (added to protect your stomach). Your kidneys help clear diclofenac partly through a transporter called OAT3. In test-tube studies, quercetin blocks that transporter pretty strongly. The idea is that if OAT3 is slowed down, a bit more diclofenac could hang around in your body, which could nudge up its effects and side effects like stomach upset, fluid retention, higher blood pressure, or kidney strain.
Here's the honest part: this is only based on lab work, and it hasn't actually been seen in real people. Food amounts of quercetin are very unlikely to matter. If you're thinking about high-dose quercetin supplements alongside Arthrotec, just run it by your pharmacist or doctor first.
- Li C, Wang X, Bi Y, et al. Potent Inhibitors of Organic Anion Transporters 1 and 3 From Natural Compounds and Their Protective Effect on Aristolochic Acid Nephropathy. Toxicol Sci. 2020;175(2):279-291. PubMed
- Ni Y, Duan Z, Zhou D, et al. Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids. Front Pharmacol. 2020;11:802. PubMed
ORGANIC ANION TRANSPORTER 1 (OAT1) SUBSTRATES
2 of 4Diclofenac Sodium, Misoprostol also falls under ORGANIC ANION TRANSPORTER 1 (OAT1) SUBSTRATES.
In vitro research shows that quercetin is a strong non-competitive inhibitor of OAT1, with half-maximal inhibitory concentration (IC50) values less than 10 mcM. So far, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Arthrotec is a combo pill: diclofenac (an anti-inflammatory pain reliever) paired with misoprostol to protect your stomach. The concern here is with the diclofenac part. Your kidneys use a transporter called OAT1 to help clear diclofenac from your body. In lab dish studies, quercetin blocks that transporter. In theory, if diclofenac is cleared a little slower, more could linger in your system, which could nudge up its usual side effects like stomach upset, swelling, raised blood pressure, or stress on the kidneys.
I want to be honest about the strength of this: it is only test-tube data and has never actually been seen in people. Food amounts of quercetin are very unlikely to matter. Before adding a high-dose supplement, just run it by your pharmacist or doctor.
- Ni Y, Duan Z, Zhou D, et al. Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids. Front Pharmacol. 2020;11:802. PubMed
CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES
3 of 4Diclofenac Sodium, Misoprostol also falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES.
A small clinical study in healthy volunteers shows that taking quercetin 500 mg twice daily for 10 days prior to taking diclofenac, a CYP2C9 substrate, increases diclofenac plasma levels by 75% and prolongs the half-life by 32.5%. Animal research also shows that pretreatment with quercetin increases plasma levels and prolongs the half-life of losartan (Cozaar), a substrate of CYP2C9. Furthermore, laboratory research shows that quercetin inhibits CYP2C9.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Arthrotec is a combo pill: diclofenac (an anti-inflammatory pain reliever) plus misoprostol (which protects your stomach). The piece that matters here is the diclofenac, since your liver clears it using an enzyme called CYP2C9. Quercetin appears to slow that enzyme down, so the diclofenac can clear out more slowly and build up. In one small study, high-dose quercetin (500 mg twice daily) raised diclofenac blood levels by about 75 percent.
In plain terms, more diclofenac in your system could mean more of its usual side effects, like stomach upset, heartburn, fluid retention, higher blood pressure, or kidney strain. This is a moderate, theoretical concern from limited research, and food amounts of quercetin are unlikely to matter. Before adding a concentrated supplement, please check with your pharmacist or doctor.
- Obach RS. Inhibition of human cytochrome P450 enzymes by constituents of St. John's wort, an herbal preparation used in the treatment of depression. J Pharmacol Exp Ther 2000;294:88-95. DOI
- DiCenzo R, Frerichs V, Larppanichpoonphol P, et al. Effect of quercetin on the plasma and intracellular concentrations of saquinavir in healthy adults. Pharmacotherapy 2006;26:1255-61. PubMed
- Bedada SK, Neerati P. Evaluation of the effect of quercetin treatment on CYP2C9 enzyme activity of diclofenac in healthy human volunteers. Phytother Res. 2018 Feb;32(2):305-311. doi: 10.1002/ptr.5978. PubMed
- Zhao Q, Wei J, Zhang H. Effects of quercetin on the pharmacokinetics of losartan and its metabolite EXP3174 in rats. Xenobiotica 2019;49(5):563-8. PubMed
DICLOFENAC (Voltaren, others)
4 of 4A small clinical study in healthy volunteers shows that taking quercetin 500 mg twice daily for 10 days prior to taking diclofenac increases diclofenac plasma levels by 75% and prolongs the half-life by 32.5%. This is thought to be due to inhibition of CYP2C9 by quercetin.
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
Arthrotec is a combo pill: diclofenac (an anti-inflammatory pain reliever) paired with misoprostol (added to protect your stomach). The diclofenac part is cleared from your body by a liver enzyme called CYP2C9. Quercetin in concentrated supplement doses appears to slow that enzyme down, so the diclofenac doesn't get broken down as fast and can build up. In one small study, quercetin pushed diclofenac blood levels up by about 75 percent.
In real terms, more diclofenac in your system can mean more of its usual downsides: stomach upset or irritation, a higher risk of ulcers or bleeding, fluid retention, and added strain on the kidneys. The amounts in everyday foods aren't likely to matter much, but high-dose supplements could. Please check with your pharmacist or doctor before pairing the two.
- Bedada SK, Neerati P. Evaluation of the effect of quercetin treatment on CYP2C9 enzyme activity of diclofenac in healthy human volunteers. Phytother Res. 2018 Feb;32(2):305-311. doi: 10.1002/ptr.5978. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Quercetin Also Interacts With Other Medications
Quercetin has 1,168 moderate known drug interactions in our database — the Diclofenac Sodium, Misoprostol one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Quercetin
We haven’t checked that one against Quercetin yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Quercetin. Pick one to open its full report.
See Every Supplement That Interacts With Diclofenac Sodium, Misoprostol
This page covers Quercetin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diclofenac Sodium, Misoprostol page lists 306 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).
By severity: 7 major · 265 moderate · 34 minor.
From our pharmacist’s overview on the Diclofenac Sodium, Misoprostol page
“Alcohol is the plainest hazard on this list. Beer and wine both carry major ratings with Arthrotec (diclofenac sodium and misoprostol) because mixing an NSAID with alcohol raises the risk of stomach bleeding, and bleeding is the thread running through most of these 306 entries.”
Reviewed by 2 · Jul 18, 2026
Taking Quercetin as Part of a Dietary Supplement Product? Check It for Interactions
We hold 4,589 real supplement products containing Quercetin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Quercetin. Your product may carry other ingredients that interact with Diclofenac Sodium, Misoprostol too, on top of Quercetin — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Quercetin and Diclofenac Sodium, Misoprostol Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#44 of 1,452 supplements looked up here in the last 7 days
#266 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Quercetin
What is Quercetin?
- Seasonal allergies
- Antioxidant support
- Heart and blood pressure health
- Anti-inflammatory support
- Immune support
- Exercise recovery
Quercetin is a plant flavonoid with antioxidant and anti-inflammatory properties found in many common foods and sold as a supplement. While early research is interesting for allergies, blood pressure, and inflammation, strong human evidence is limited for most uses. It is generally well tolerated in food amounts, but talk to your pharmacist or doctor before taking high-dose supplements.
Other Drugs & Quercetin
Browse every other medication we’ve checked against Quercetin — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,168 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Aspirin ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Naproxen ›
- Doxycycline ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Tetracycline ›
- Lidocaine ›
- Ranitidine ›
- Hydrochlorothiazide ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Ciprofloxacin ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Isotretinoin ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Apomorphine ›
- Budesonide ›
- Carbamazepine ›
- Ceftazidime ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Hydralazine ›
- Indomethacin ›
- Insulin (human) ›
- Miconazole ›
- Morphine Sulfate ›
- Salsalate ›
- Trimipramine ›
- Acyclovir ›
- Amphetamine ›
Showing 60 of 1,168 moderate interactions — see all 1,168 on the Quercetin page.
No interaction 1,661 drugs checked — show the list
We also checked Quercetin against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Acetaminophen ›
- Rosuvastatin ›
- Escitalopram ›
- Docusate ›
- Sumatriptan ›
- Hydroxyurea ›
- Amoxicillin ›
- Bupropion ›
- Bendamustine ›
- Azithromycin ›
- Pregabalin ›
- Gabapentin ›
- Lamotrigine ›
- Levothyroxine, Liothyronine ›
- Methylene Blue ›
- Amoxicillin, Clavulanate Potassium ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Cyclopentolate ›
- Ezetimibe ›
- Thyroid Hormone ›
- Carbidopa, Levodopa ›
- Levetiracetam ›
- Roxithromycin ›
- Phentermine, Topiramate ›
- Levodopa ›
- Levothyroxine Sodium ›
- Dexmethylphenidate ›
- Mitomycin ›
- Acetaminophen, Brompheniramine, Phenylpropanolamine ›
- Pizotifen ›
- Daptomycin ›
- Hydroxychloroquine ›
- Magnesium Hydroxide (otc Drug) ›
- Pegunigalsidase Alfa-iwxj ›
- Acenocoumarol ›
- Hexobarbitone ›
- Alginic Acid, Aluminum Hydroxide ›
- Bentoquatam ›
- Amobarbital, Ephedrine Sulfate ›
- Salbutamol Sulfate ›
- Lenvatinib ›
- Casanthranol, Docusate ›
- Birth Control Pills ›
- Succinylcholine ›
- Factor 7a ›
- Paracetamol ›
- Flutemetamol F-18 ›
- Triptorelin ›
- Vancomycin ›
- Hethylphenidate Hcl ›
- Alglucosidase Alpha ›
- Azelaic Acid ›
- Tocainide ›
- Cyproheptadine ›
- Phenylephrine ›
- Mitomycin C ›
- Articaine, Epinephrine ›
- Chenodiol ›
Showing the 60 most looked-up of 1,661 medications checked with no known interaction — see the full Quercetin list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Diclofenac Sodium, Misoprostol Is Linked to Lower Levels of One Nutrient
Natural Medicines records Diclofenac Sodium, Misoprostol as a medicine that can lower these. This is not an interaction with Quercetin — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Diclofenac Sodium, Misoprostol nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Quercetin and Diclofenac Sodium, Misoprostol Together: Common Questions
Can you take Quercetin with Diclofenac Sodium, Misoprostol?
Why are there 4 interactions listed for Quercetin and Diclofenac Sodium, Misoprostol?
How serious is the Quercetin and Diclofenac Sodium, Misoprostol interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Diclofenac Sodium, Misoprostol and Quercetin?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.