Medication interaction hub

What Supplements Interact with Diclofenac Sodium, Misoprostol?

Diclofenac Sodium, Misoprostol brand names: Arthrotec 50, Arthrotec 75. Every interaction below applies to the brands too.

306 Interactions 7 Major 265 Moderate 34 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Diclofenac Sodium, Misoprostol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Diclofenac Sodium, Misoprostol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Alcohol is the plainest hazard on this list. Beer and wine both carry major ratings with Arthrotec (diclofenac sodium and misoprostol) because mixing an NSAID with alcohol raises the risk of stomach bleeding, and bleeding is the thread running through most of these 306 entries. Fully 202 of the ingredients can thin the blood or hamper platelets, stacking onto a risk diclofenac already carries on its own. Seven interactions rate major, and I would want anyone on this medication to understand those seven before anything else here.

The other 265 moderate and 34 minor entries follow a few patterns. Herbs like Siberian cocklebur can strain the kidneys, an organ diclofenac already taxes, and activated charcoal can trap the tablet before it absorbs, so space the two well apart. A third group slows how the body clears the drug; quercetin raised diclofenac blood levels by 75% in one small study, enough to amplify side effects.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 265 Minor 34 No known interaction 1,146

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Diclofenac Sodium, Misoprostol: Top Interactions at a Glance

The Diclofenac Sodium, Misoprostol supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 306 interacting ingredients — plus 1,146 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Diclofenac Sodium, Misoprostol Combinations Today

The Diclofenac Sodium, Misoprostol + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Gamma-hydroxybutyrate (ghb) + Diclofenac Sodium, Misoprostoli

Diclofenac might decrease the levels and clinical effects of GHB.

Read the full interaction Moderate Likelihood Possible Cannabis + Diclofenac Sodium, Misoprostoli

Theoretically, cannabis might increase the levels and adverse effects of CYP2C9 substrates.

Read the full interaction Moderate Likelihood Possible Red Yeast Rice + Diclofenac Sodium, Misoprostoli

Theoretically, concomitant use might increase the risk of liver damage.

Read the full interaction Moderate Likelihood Possible Fo-ti + Diclofenac Sodium, Misoprostoli

Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.

Read the full interaction Moderate Likelihood Possible Summer Savory + Diclofenac Sodium, Misoprostoli

In vitro research suggests that summer savory extract inhibits platelet aggregation and adhesion.

Read the full interaction Moderate Likelihood Possible Lycopene + Diclofenac Sodium, Misoprostoli

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full interaction
The complete list

Every Supplement Checked Against Diclofenac Sodium, Misoprostol

All 1,452 ingredients in our database, ranked by severity — 306 with a Diclofenac Sodium, Misoprostol interaction on file and 1,146 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Diclofenac Sodium, Misoprostol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Gamma-hydroxybutyrate (ghb) with Diclofenac Sodium, Misoprostol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Diclofenac might decrease the levels and clinical effects of GHB.

Full Gamma-hydroxybutyrate (ghb) + Diclofenac Sodium, Misoprostol answer

Can you take Cannabis with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might increase the levels and adverse effects of CYP2C9 substrates.

Full Cannabis + Diclofenac Sodium, Misoprostol answer

Can you take Red Yeast Rice with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of liver damage.

Full Red Yeast Rice + Diclofenac Sodium, Misoprostol answer

Can you take Fo-ti with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Fo-ti + Diclofenac Sodium, Misoprostol answer

Can you take Summer Savory with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that summer savory extract inhibits platelet aggregation and adhesion.

Full Summer Savory + Diclofenac Sodium, Misoprostol answer

Can you take Black Currant with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black currant seed oil might increase the risk of bleeding if used in combination with anticoagulant or antiplatelet drugs.

Full Black Currant + Diclofenac Sodium, Misoprostol answer

Can you take Black Pepper with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.

Full Black Pepper + Diclofenac Sodium, Misoprostol answer

Can you take Black Seed with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.

Full Black Seed + Diclofenac Sodium, Misoprostol answer

Can you take Black Tea with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Black Tea + Diclofenac Sodium, Misoprostol answer

Can you take Blood Irradiation Therapy with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary clinical research suggests that blood irradiation therapy might reduce platelet aggregation.

Full Blood Irradiation Therapy + Diclofenac Sodium, Misoprostol answer

Can you take Boldo with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.

Full Boldo + Diclofenac Sodium, Misoprostol answer

Can you take Borage with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Borage + Diclofenac Sodium, Misoprostol answer

Can you take Boswellia Serrata with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.

Full Boswellia Serrata + Diclofenac Sodium, Misoprostol answer

Can you take Breadfruit with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with anticoagulant/antiplatelet drugs might increase the risk of bleeding.

Full Breadfruit + Diclofenac Sodium, Misoprostol answer

Can you take Bromelain with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Bromelain + Diclofenac Sodium, Misoprostol answer

Can you take Buchu with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu contains pulegone, a known hepatotoxin.

Full Buchu + Diclofenac Sodium, Misoprostol answer

Can you take Bulbine Natalensis with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP2C9 substrates.

Full Bulbine Natalensis + Diclofenac Sodium, Misoprostol answer

Can you take Bupleurum with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bupleurum might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Bupleurum + Diclofenac Sodium, Misoprostol answer

Can you take Burdock with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Full Burdock + Diclofenac Sodium, Misoprostol answer

Can you take Caffeic Acid with Diclofenac Sodium, Misoprostol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeic acid might increase the levels and clinical effects of OAT3 substrates.

Full Caffeic Acid + Diclofenac Sodium, Misoprostol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Diclofenac Sodium, Misoprostol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Diclofenac Sodium, Misoprostol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Diclofenac Sodium, Misoprostol sits in 10 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Diclofenac Sodium, Misoprostol through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Diclofenac Sodium, Misoprostol through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Diclofenac Sodium, Misoprostol through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Diclofenac Sodium, Misoprostol through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Diclofenac Sodium, Misoprostol through this category.

Diclofenac (Voltaren, Others) 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Diclofenac Sodium, Misoprostol through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Diclofenac Sodium, Misoprostol through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Diclofenac Sodium, Misoprostol through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Diclofenac Sodium, Misoprostol through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Diclofenac Sodium, Misoprostol through this category.

Related: does Diclofenac Sodium, Misoprostol deplete any nutrients?

Diclofenac Sodium, Misoprostol has 2 reported nutrient associations in the research literature — see the Diclofenac Sodium, Misoprostol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Diclofenac Sodium, Misoprostol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Diclofenac Sodium, Misoprostol.

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Pharmacist Counseling Corner

Diclofenac Sodium, Misoprostol & Supplements: Common Questions

What supplements interact with Diclofenac Sodium, Misoprostol?
Our database currently documents 306 ingredients with a known Diclofenac Sodium, Misoprostol interaction (7 major, 265 moderate, 34 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 306. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Diclofenac Sodium, Misoprostol supplement interactions are the most serious?
The 7 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Beer, Danshen and Piracetam — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Diclofenac Sodium, Misoprostol?
Plenty of supplements coexist fine with Diclofenac Sodium, Misoprostol; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Arthrotec 50 have the same supplement interactions as Diclofenac Sodium, Misoprostol?
Yes — Arthrotec 50, Arthrotec 75 all contain Diclofenac Sodium, Misoprostol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Diclofenac Sodium, Misoprostol deplete any vitamins or nutrients?
It might — Diclofenac Sodium, Misoprostol has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Diclofenac Sodium, Misoprostol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Diclofenac Sodium, Misoprostol and my other medications?
This page covers Diclofenac Sodium, Misoprostol against supplements and herbal ingredients. Checking Diclofenac Sodium, Misoprostol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.