Quercetin + Diphenhydramine Hydrochloride, Naproxen Sodium
Diphenhydramine Hydrochloride, Naproxen Sodium brand name: Aleve PM.
Diphenhydramine Hydrochloride, Naproxen Sodium falls into 3 drug categories that Quercetin can interact with; the most serious is rated moderate. Theoretically, concomitant use might increase the effects and adverse effects of OAT3 substrates.
Read the full interaction reportQuercetin and Diphenhydramine Hydrochloride, Naproxen Sodium
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Quercetin interacts with whole categories of medication. Diphenhydramine Hydrochloride, Naproxen Sodium falls into 3 of those categories, so it can interact with Quercetin in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES
1 of 3Why this applies to Diphenhydramine Hydrochloride, Naproxen Sodium
Diphenhydramine Hydrochloride, Naproxen Sodium falls under ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES — the group Quercetin interacts with.
In vitro research shows that quercetin is a strong non-competitive inhibitor of OAT3, with half-maximal inhibitory concentration (IC50) values as low as 0.75 mcM. So far, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Aleve PM pairs naproxen (an anti-inflammatory pain reliever) with diphenhydramine (a sedating antihistamine). One of the ways your kidneys clear naproxen is through a transporter called OAT3. Lab studies suggest quercetin can block that transporter, which could in theory slow how naproxen leaves your body and let a little more build up. That might nudge up naproxen's usual side effects, like stomach upset, heartburn, fluid retention, or, with regular use, stress on the kidneys.
The important word here is theoretical. This comes from test-tube research only and hasn't been seen in real people, so I wouldn't lose sleep over it, especially with quercetin from foods. If you take high-dose quercetin supplements, just run it by your pharmacist or doctor first.
- Li C, Wang X, Bi Y, et al. Potent Inhibitors of Organic Anion Transporters 1 and 3 From Natural Compounds and Their Protective Effect on Aristolochic Acid Nephropathy. Toxicol Sci. 2020;175(2):279-291. PubMed
- Ni Y, Duan Z, Zhou D, et al. Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids. Front Pharmacol. 2020;11:802. PubMed
ORGANIC ANION TRANSPORTER 1 (OAT1) SUBSTRATES
2 of 3Diphenhydramine Hydrochloride, Naproxen Sodium also falls under ORGANIC ANION TRANSPORTER 1 (OAT1) SUBSTRATES.
In vitro research shows that quercetin is a strong non-competitive inhibitor of OAT1, with half-maximal inhibitory concentration (IC50) values less than 10 mcM. So far, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Aleve PM combines naproxen (a pain and inflammation reliever) with diphenhydramine (a sedating antihistamine for sleep). Your kidneys help clear medicines like naproxen, partly using a transporter called OAT1. In lab dish studies, quercetin blocks that transporter, which could in theory slow the removal of naproxen and let a bit more linger in your body. That might mean stronger effects and a slightly higher chance of side effects like stomach upset, heartburn, fluid retention, or, with the diphenhydramine, extra drowsiness or grogginess.
Here's the honest part: this is only seen in test-tube research, never reported in real people, so the worry is small, especially with food amounts of quercetin. If you take a concentrated quercetin supplement regularly, just check with your pharmacist or doctor first.
- Ni Y, Duan Z, Zhou D, et al. Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids. Front Pharmacol. 2020;11:802. PubMed
CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES
3 of 3Diphenhydramine Hydrochloride, Naproxen Sodium also falls under CYTOCHROME P450 2C9 (CYP2C9) SUBSTRATES.
A small clinical study in healthy volunteers shows that taking quercetin 500 mg twice daily for 10 days prior to taking diclofenac, a CYP2C9 substrate, increases diclofenac plasma levels by 75% and prolongs the half-life by 32.5%. Animal research also shows that pretreatment with quercetin increases plasma levels and prolongs the half-life of losartan (Cozaar), a substrate of CYP2C9. Furthermore, laboratory research shows that quercetin inhibits CYP2C9.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Aleve PM combines naproxen (an anti-inflammatory pain reliever) with diphenhydramine (a sedating antihistamine). The naproxen part is cleared partly by a liver enzyme called CYP2C9, and quercetin can slow that enzyme down. So in theory, high-dose quercetin supplements could let naproxen build up a bit higher and linger longer in your body.
What that might look like in real life is more of naproxen's usual side effects: stomach upset, heartburn, a higher chance of stomach irritation or bleeding, and fluid retention. Keep in mind this is mostly based on lab work and a small study with a different drug, so it's a theoretical concern, not a proven one. Quercetin from foods is very unlikely to matter; concentrated supplements are the question. Please run it by your pharmacist or doctor first.
- Obach RS. Inhibition of human cytochrome P450 enzymes by constituents of St. John's wort, an herbal preparation used in the treatment of depression. J Pharmacol Exp Ther 2000;294:88-95. DOI
- DiCenzo R, Frerichs V, Larppanichpoonphol P, et al. Effect of quercetin on the plasma and intracellular concentrations of saquinavir in healthy adults. Pharmacotherapy 2006;26:1255-61. PubMed
- Bedada SK, Neerati P. Evaluation of the effect of quercetin treatment on CYP2C9 enzyme activity of diclofenac in healthy human volunteers. Phytother Res. 2018 Feb;32(2):305-311. doi: 10.1002/ptr.5978. PubMed
- Zhao Q, Wei J, Zhang H. Effects of quercetin on the pharmacokinetics of losartan and its metabolite EXP3174 in rats. Xenobiotica 2019;49(5):563-8. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Quercetin Also Interacts With Other Medications
Quercetin has 1,169 moderate known drug interactions in our database — the Diphenhydramine Hydrochloride, Naproxen Sodium one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Quercetin
We haven’t checked that one against Quercetin yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Quercetin. Pick one to open its full report.
See Every Supplement That Interacts With Diphenhydramine Hydrochloride, Naproxen Sodium
This page covers Quercetin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diphenhydramine Hydrochloride, Naproxen Sodium page lists 378 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).
By severity: 13 major · 320 moderate · 45 minor.
From our pharmacist’s overview on the Diphenhydramine Hydrochloride, Naproxen Sodium page
“Aleve PM combines naproxen, an NSAID, with the sedating antihistamine diphenhydramine, and its supplement list earns genuine care rather than a quick skim. Thirteen of the 378 ingredients on file rate major, and the two largest themes track the pill's two halves.”
Reviewed by 2 · Jul 18, 2026
Open the Diphenhydramine Hydrochloride, Naproxen Sodium interaction page
Taking Quercetin as Part of a Dietary Supplement Product? Check It for Interactions
We hold 4,589 real supplement products containing Quercetin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Quercetin. Your product may carry other ingredients that interact with Diphenhydramine Hydrochloride, Naproxen Sodium too, on top of Quercetin — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Quercetin and Diphenhydramine Hydrochloride, Naproxen Sodium Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#41 of 1,452 supplements looked up here in the last 7 days
#73 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Quercetin
What is Quercetin?
- Seasonal allergies
- Antioxidant support
- Heart and blood pressure health
- Anti-inflammatory support
- Immune support
- Exercise recovery
Quercetin is a plant flavonoid with antioxidant and anti-inflammatory properties found in many common foods and sold as a supplement. While early research is interesting for allergies, blood pressure, and inflammation, strong human evidence is limited for most uses. It is generally well tolerated in food amounts, but talk to your pharmacist or doctor before taking high-dose supplements.
Other Drugs & Quercetin
Browse every other medication we’ve checked against Quercetin — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,169 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Aspirin ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Naproxen ›
- Doxycycline ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Tetracycline ›
- Lidocaine ›
- Ranitidine ›
- Hydrochlorothiazide ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Ciprofloxacin ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Isotretinoin ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Apomorphine ›
- Budesonide ›
- Carbamazepine ›
- Ceftazidime ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Hydralazine ›
- Indomethacin ›
- Insulin (human) ›
- Miconazole ›
- Morphine Sulfate ›
- Salsalate ›
- Trimipramine ›
- Acyclovir ›
- Amphetamine ›
Showing 60 of 1,169 moderate interactions — see all 1,169 on the Quercetin page.
No interaction 1,660 drugs checked — show the list
We also checked Quercetin against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Rosuvastatin ›
- Acetaminophen ›
- Levothyroxine, Liothyronine ›
- Docusate ›
- Sumatriptan ›
- Amoxicillin ›
- Hydroxyurea ›
- Bupropion ›
- Azithromycin ›
- Pregabalin ›
- Gabapentin ›
- Lamotrigine ›
- Methylene Blue ›
- Bendamustine ›
- Amoxicillin, Clavulanate Potassium ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Aminophylline, Amobarbital, Ephedrine ›
- Acetaminophen, Dichloralphenazone, Isometheptene ›
- Bismuth Subcarbonate, Calcium Carbonate, Opium ›
- Ezetimibe ›
- Ephedrine, Phenobarbital, Theophylline ›
- Acetaminophen, Brompheniramine, Phenylpropanolamine ›
- Levetiracetam ›
- Daunorubicin, Cytarabine ›
- Carbidopa, Levodopa ›
- Levodopa ›
- Ephedrine Sulfate, Hydroxyzine, Theophylline ›
- Hydrocortisone, Clioquinol, Pramoxine ›
- Sodium Bicarbonate (otc Drug) ›
- Atropine Methyl Nitrate, Digestive Enzymes ›
- Cytomegalovirus Immune Globulin ›
- Cyclopentolate ›
- Efgartigimod Alfa-fcab ›
- Ceftolozane Sulfate, Tazobactam Sodium ›
- Amobarbital, Ephedrine Sulfate ›
- Thyroid Hormone ›
- Measles, Mumps, Rubella Virus Live ›
- Aminolevulinic Acid Hydrochloride ›
- Alginic Acid, Aluminum Hydroxide ›
- Pyrilamine Maleate ›
- Vestronidase Alfa-vjbk ›
- Acetaminophen, Phenylpropanolamine, Phenyltoloxamine ›
- Glycerol Phenylbutyrate ›
- Psyllium , Senna (otc Drug) ›
- Neomycin, Polymyxin B, Gramicidin ›
- Lonapegsomatropin-tcgd ›
- Tubocurarine ›
- Acetaminophen, Butalbital ›
- Human Papillomavirus Vaccine ›
- Acetaminophen, Phenyltoloxamine, Salicylamide ›
- Levothyroxine Sodium ›
- Magnesium Hydroxide (otc Drug) ›
- Sulfadiazine, Trimethoprim ›
- Daxibotulinumtoxina-lanm ›
- Delafloxacin (oral) ›
- Peginterferon Alfa-2a, Ribavirin ›
- Imipenem, Cilastatin, Relebactam ›
- Docusate Sodium, Sennosides (otc Drug) ›
Showing the 60 most looked-up of 1,660 medications checked with no known interaction — see the full Quercetin list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Diphenhydramine Hydrochloride, Naproxen Sodium Is Linked to Lower Levels of One Nutrient
Natural Medicines records Diphenhydramine Hydrochloride, Naproxen Sodium as a medicine that can lower these. This is not an interaction with Quercetin — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Diphenhydramine Hydrochloride, Naproxen Sodium nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Quercetin and Diphenhydramine Hydrochloride, Naproxen Sodium Together: Common Questions
Can you take Quercetin with Diphenhydramine Hydrochloride, Naproxen Sodium?
Why are there 3 interactions listed for Quercetin and Diphenhydramine Hydrochloride, Naproxen Sodium?
How serious is the Quercetin and Diphenhydramine Hydrochloride, Naproxen Sodium interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Diphenhydramine Hydrochloride, Naproxen Sodium and Quercetin?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.