Quercetin + Hydrochlorothiazide, Propranolol
Hydrochlorothiazide, Propranolol brand name: Inderide.
Hydrochlorothiazide, Propranolol falls into 4 drug categories that Quercetin can interact with; the most serious is rated moderate. Theoretically, taking quercetin with antihypertensive drugs might increase the risk of hypotension.
Read the full interaction reportQuercetin and Hydrochlorothiazide, Propranolol
These two interact in 4 distinct ways. Each one is explained separately below.
Why Are There 4 Interactions?
Quercetin interacts with whole categories of medication. Hydrochlorothiazide, Propranolol falls into 4 of those categories, so it can interact with Quercetin in 4 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
ANTIHYPERTENSIVE DRUGS
1 of 4Why this applies to Hydrochlorothiazide, Propranolol
Hydrochlorothiazide, Propranolol falls under ANTIHYPERTENSIVE DRUGS — the group Quercetin interacts with.
Quercetin can modestly decrease blood pressure in people with mild hypertension. Theoretically, it might have additive blood pressure lowering effects when used with antihypertensive drugs.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Inderide combines two blood pressure medicines: hydrochlorothiazide (a water pill) and propranolol (a beta-blocker). Both work to bring your blood pressure down. Quercetin isn't changing how your body breaks these drugs down here. Instead, the concern is simpler addition: some studies suggest quercetin can modestly lower blood pressure on its own, so stacking it on top of your medicine could nudge your numbers a little lower than expected.
If that happens, you might notice dizziness, lightheadedness, feeling faint when you stand up, or unusual tiredness. This is a theoretical, modest effect based on limited evidence, and food amounts of quercetin are unlikely to matter. Still, if you take a high-dose supplement, mention it to your pharmacist or doctor so they can keep an eye on your readings.
- Edwards RL, Lyon T, Litwin SE, et al. Quercetin reduces blood pressure in hypertensive subjects. J Nutr 2007;137:2405-11.
- Larson A, Witman MA, Guo Y, et al. Acute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin-1: nitric oxide. Nutr Res. 2012;32(8):557-64. PubMed
ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES
2 of 4Hydrochlorothiazide, Propranolol also falls under ORGANIC ANION TRANSPORTER 3 (OAT3) SUBSTRATES.
In vitro research shows that quercetin is a strong non-competitive inhibitor of OAT3, with half-maximal inhibitory concentration (IC50) values as low as 0.75 mcM. So far, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Inderide combines two blood pressure medicines: hydrochlorothiazide (a water pill) and propranolol (a beta blocker). Your kidneys use a transporter called OAT3 to help clear the hydrochlorothiazide part. In lab and animal studies, quercetin can block that transporter, which in theory could let a bit more of the drug linger in your body and slightly strengthen its effects.
If that happened, you might notice more of the usual effects, like extra dizziness, lightheadedness when standing, a slower heartbeat, or more frequent urination. The good news: this is only test-tube evidence and has not been seen in real people, and everyday food amounts of quercetin are very unlikely to matter. Before adding a concentrated supplement, just run it by your pharmacist or doctor.
- Li C, Wang X, Bi Y, et al. Potent Inhibitors of Organic Anion Transporters 1 and 3 From Natural Compounds and Their Protective Effect on Aristolochic Acid Nephropathy. Toxicol Sci. 2020;175(2):279-291. PubMed
- Ni Y, Duan Z, Zhou D, et al. Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids. Front Pharmacol. 2020;11:802. PubMed
ORGANIC ANION TRANSPORTER 1 (OAT1) SUBSTRATES
3 of 4Hydrochlorothiazide, Propranolol also falls under ORGANIC ANION TRANSPORTER 1 (OAT1) SUBSTRATES.
In vitro research shows that quercetin is a strong non-competitive inhibitor of OAT1, with half-maximal inhibitory concentration (IC50) values less than 10 mcM. So far, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Inderide combines two blood pressure medicines: hydrochlorothiazide (a water pill) and propranolol (a beta blocker). The piece that matters here is the hydrochlorothiazide, which your kidneys clear partly through a transporter called OAT1. In test-tube studies, quercetin blocks that transporter, so in theory it could slow how your body removes the diuretic and let more of it hang around. That might mean a bit more of its usual effects, like extra urination, lightheadedness, dehydration, or low potassium or sodium.
Here's the important part: this is only lab-based evidence and has never actually been seen in people. Food amounts of quercetin are very unlikely to matter. If you're considering high-dose supplements, just run it by your pharmacist or doctor first.
- Ni Y, Duan Z, Zhou D, et al. Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids. Front Pharmacol. 2020;11:802. PubMed
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
4 of 4Hydrochlorothiazide, Propranolol also falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES.
In vitro research show that quercetin inhibits CYP2D6. This effect has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Your combo pill, Inderide, contains two medicines. The part to watch here is propranolol, a beta-blocker that your body partly clears using an enzyme called CYP2D6. In test-tube studies, quercetin can slow down that enzyme. If that happened in real life, propranolol could build up a bit and lead to stronger effects like a slower heart rate, lower blood pressure, dizziness, or feeling unusually tired. The hydrochlorothiazide (the water pill) part isn't really affected by this.
Here's the reassuring part: this is only seen in the lab, not in actual people, so it's theoretical. Food amounts of quercetin are very unlikely to matter. If you're considering high-dose supplements, just check with your pharmacist or doctor first.
- Obach RS. Inhibition of human cytochrome P450 enzymes by constituents of St. John's wort, an herbal preparation used in the treatment of depression. J Pharmacol Exp Ther 2000;294:88-95. DOI
- DiCenzo R, Frerichs V, Larppanichpoonphol P, et al. Effect of quercetin on the plasma and intracellular concentrations of saquinavir in healthy adults. Pharmacotherapy 2006;26:1255-61. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Quercetin Also Interacts With Other Medications
Quercetin has 1,168 moderate known drug interactions in our database — the Hydrochlorothiazide, Propranolol one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Quercetin
We haven’t checked that one against Quercetin yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Quercetin. Pick one to open its full report.
See Every Supplement That Interacts With Hydrochlorothiazide, Propranolol
This page covers Quercetin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydrochlorothiazide, Propranolol page lists 324 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).
By severity: 11 major · 273 moderate · 40 minor.
From our pharmacist’s overview on the Hydrochlorothiazide, Propranolol page
“Inderide combines hydrochlorothiazide, a water pill, with propranolol, a beta blocker, so a supplement that also lowers blood pressure or pulls potassium out of the body hits the drug on its own turf. That describes most of this list, and I'd approach it with genuine care.”
Reviewed by 2 · Jul 18, 2026
Taking Quercetin as Part of a Dietary Supplement Product? Check It for Interactions
We hold 4,589 real supplement products containing Quercetin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Quercetin. Your product may carry other ingredients that interact with Hydrochlorothiazide, Propranolol too, on top of Quercetin — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Quercetin and Hydrochlorothiazide, Propranolol Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#48 of 1,452 supplements looked up here in the last 7 days
#1,593 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Quercetin
What is Quercetin?
- Seasonal allergies
- Antioxidant support
- Heart and blood pressure health
- Anti-inflammatory support
- Immune support
- Exercise recovery
Quercetin is a plant flavonoid with antioxidant and anti-inflammatory properties found in many common foods and sold as a supplement. While early research is interesting for allergies, blood pressure, and inflammation, strong human evidence is limited for most uses. It is generally well tolerated in food amounts, but talk to your pharmacist or doctor before taking high-dose supplements.
Other Drugs & Quercetin
Browse every other medication we’ve checked against Quercetin — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,168 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Aspirin ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Naproxen ›
- Doxycycline ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Tetracycline ›
- Lidocaine ›
- Ranitidine ›
- Hydrochlorothiazide ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Ciprofloxacin ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Isotretinoin ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Apomorphine ›
- Budesonide ›
- Carbamazepine ›
- Ceftazidime ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Hydralazine ›
- Indomethacin ›
- Insulin (human) ›
- Miconazole ›
- Morphine Sulfate ›
- Salsalate ›
- Trimipramine ›
- Acyclovir ›
- Amphetamine ›
Showing 60 of 1,168 moderate interactions — see all 1,168 on the Quercetin page.
No interaction 1,661 drugs checked — show the list
We also checked Quercetin against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Docusate ›
- Hydroxyurea ›
- Sumatriptan ›
- Bupropion ›
- Amoxicillin ›
- Bendamustine ›
- Lamotrigine ›
- Gabapentin ›
- Pregabalin ›
- Azithromycin ›
- Methylene Blue ›
- Levothyroxine, Liothyronine ›
- Cyclopentolate ›
- Roxithromycin ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Pegunigalsidase Alfa-iwxj ›
- Daptomycin ›
- Hexobarbitone ›
- Levothyroxine Sodium ›
- Levetiracetam ›
- Dexmethylphenidate ›
- Factor 7a ›
- Carbidopa, Levodopa ›
- Thyroid Hormone ›
- Mitomycin ›
- Levodopa ›
- Ezetimibe ›
- Lenvatinib ›
- Phenylephrine ›
- Vancomycin ›
- Hethylphenidate Hcl ›
- Phentermine, Topiramate ›
- Bentoquatam ›
- Dirithromycin ›
- Procainamide ›
- Tenecteplase ›
- Hydroxychloroquine ›
- Amoxicillin, Clavulanate Potassium ›
- Azelaic Acid ›
- Dextrothyroxine ›
- Triptorelin ›
- Lomustine ›
- Sodium Valproate ›
- Tocainide ›
- Pentobarbitone ›
- Pizotifen ›
- Rocuronium ›
- Succimer ›
- Mitomycin C ›
- Lorazepam ›
- Paracetamol ›
- Gestodene ›
- Halothane ›
- Chenodiol ›
- Desflurane ›
Showing the 60 most looked-up of 1,661 medications checked with no known interaction — see the full Quercetin list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Hydrochlorothiazide, Propranolol Is Linked to Lower Levels of 8 Nutrients
Natural Medicines records Hydrochlorothiazide, Propranolol as a medicine that can lower these. This is not an interaction with Quercetin — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Hydrochlorothiazide, Propranolol nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Quercetin and Hydrochlorothiazide, Propranolol Together: Common Questions
Can you take Quercetin with Hydrochlorothiazide, Propranolol?
Why are there 4 interactions listed for Quercetin and Hydrochlorothiazide, Propranolol?
How serious is the Quercetin and Hydrochlorothiazide, Propranolol interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Hydrochlorothiazide, Propranolol and Quercetin?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.