Drug & supplement interaction

Raspberry Ketone + Clomipramine

Clomipramine brand names: Anafranil, Anafranil SR.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Raspberry Ketone and Clomipramine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Clomipramine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Raspberry Ketone and Clomipramine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Clomipramine and Raspberry Ketone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Raspberry Ketone safety at a glance

Raspberry Ketone overall Use caution Used in foods safely, but human safety data for high supplement doses is very limited.
Pregnancy Avoid Not enough safety information; avoid concentrated supplements during pregnancy.
Breastfeeding Avoid Not enough safety information; avoid supplement use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Clomipramine and Raspberry Ketone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Clomipramine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Clomipramine is filed under 13 classifications — including tricyclic antidepressants (tcas), antidepressant drugs, cytochrome p450 2c19 (cyp2c19) substrates. Raspberry Ketone has documented interactions with 2 drug classes — the most serious being stimulant drugs (moderate) and warfarin (coumadin) (moderate) — and none of Clomipramine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Raspberry Ketone Does Interact With Other Medications

Raspberry Ketone has 174 moderate known drug interactions in our database — Clomipramine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 174 No known interaction 2,656 (incl. Clomipramine)
Taking anything else?

Check Another of Your Medications Against Raspberry Ketone

Covers the 2,830 medications we’ve checked against Raspberry Ketone. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Raspberry Ketone and Clomipramine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An irregular heartbeat Worth acting on Additional detail

    Raspberry Ketone

    “Structurally, raspberry ketone resembles synephrine, a known stimulant agent. Although not well studied in humans, stimulant-related side effects are possible. Orally, cases of heart palpitations, tachycardia, elevated blood pressure, coronary vasospasm are reported after taking raspberry ketone.”

    Raspberry Ketone · Natural Medicines adverse-effect record, reported in arrhythmia.

    3 sources cited
    1. 17961. Adverse Event Report. Raspberry Ketone. Natural MedWatch, April 27, 2012.
    2. 112386. Ansari SA, Patel F, Ashouri D, Dhaliwal JSS, Desai A. Resistant Polymorphic Ventricular Tachycardia in a Patient Taking Raspberry Ketones Weight Loss Supplement. Cureus 2022;14(12):e33089. PubMed
    3. 112400. Khattar A, Beeton I. Coronary vasospasm and raspberry ketones weight-loss supplement: Is there a connection? Anatol J Cardiol. 2020;24(3):205-208.

    Clomipramine

    Listed in the ADVERSE REACTIONS section of the FDA label for Clomipramine. Read the label on DailyMed ›

  • Tremor or shakiness / Sweating / Diarrhea Additional detail

    Raspberry Ketone

    “Structurally, raspberry ketone resembles synephrine, a known stimulant agent. Although not well studied in humans, stimulant-related side effects are possible. Two case reports describe symptoms of sweating, diarrhea, and feelings of shakiness after oral use of raspberry ketone.”

    Raspberry Ketone · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 17961. Adverse Event Report. Raspberry Ketone. Natural MedWatch, April 27, 2012.
    2. 112400. Khattar A, Beeton I. Coronary vasospasm and raspberry ketones weight-loss supplement: Is there a connection? Anatol J Cardiol. 2020;24(3):205-208.

    Clomipramine

    Listed in the ADVERSE REACTIONS section of the FDA label for Clomipramine. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    Raspberry Ketone

    Recorded for Raspberry Ketone in the same Natural Medicines adverse-effect record shown under An irregular heartbeat above.

    Clomipramine

    Listed in the ADVERSE REACTIONS section of the FDA label for Clomipramine. Read the label on DailyMed ›

Reported for Raspberry Ketone but not commonly for Clomipramine: raised blood pressure.

Effects for Clomipramine come from the ADVERSE REACTIONS section of its FDA label; effects for Raspberry Ketone come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Clomipramine Products Have a Food Rule — Raspberry Ketone Should Not Break It

At least one FDA label for a product containing Clomipramine says to take it with food. If you take Raspberry Ketone on an empty stomach out of habit, keep them separate — and take Clomipramine with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Clomipramine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

During initial titration, Anafranil should be given in divided doses with meals to reduce gastrointestinal side effects.

From the Dosage and Administration section of the FDA label we read for Clomipramine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Raspberry Ketone or Clomipramine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Raspberry Ketone or Clomipramine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Clomipramine

This page covers Raspberry Ketone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Clomipramine page lists 236 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Henbane (major), Scopolia (major) and St. John's Wort (major).

By severity: 5 major · 179 moderate · 52 minor.

From our pharmacist’s overview on the Clomipramine page

“A tricyclic antidepressant used mostly for OCD, clomipramine (Anafranil) is unforgiving of shifts in its blood level, which is why its 236 supplement interactions deserve genuine wariness. Most of the list involves metabolism: herbs that speed up or slow down the liver enzymes handling clomipramine can drag its level too low or push it…”

Reviewed by 2 · Jul 18, 2026

Open the Clomipramine interaction page

One more smart check

Taking Raspberry Ketone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 682 real supplement products containing Raspberry Ketone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Raspberry Ketone. Even though Raspberry Ketone itself has no known interaction with Clomipramine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Raspberry Ketone and Clomipramine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Raspberry Ketone
Top 25%

#239 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Clomipramine
Steady interest

#1,782 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Raspberry Ketone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Raspberry Ketone and Clomipramine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Raspberry Ketone

What is Raspberry Ketone?

Raspberry Ketone
  • Weight loss
  • Fat burning
  • Boosting metabolism
  • Appetite support
  • General 'fat-burner' supplement

Raspberry ketone is a natural aroma compound found in red raspberries that is heavily marketed for weight loss, but there is no good human evidence that it helps people lose weight. Most claims come from lab and animal studies using doses far higher than what you could get from food or typical supplements. If you choose to try it, talk to your pharmacist or doctor first.

Fruit-derived aromatic compound (4-(4-hydroxyphenyl)butan-2-one) · Capsules, tablets, softgels, powders, often combined with other weight-loss ingredients

An interaction check asks whether these two react with each other — it does not ask whether Raspberry Ketone is a good idea for someone in your situation. Here is what our Raspberry Ketone record says about it on its own.

Raspberry Ketone: dosing

There is no established or proven effective dose of raspberry ketone for weight loss or any other use. The amounts found in supplements vary widely from product to product.If you decide to try it, follow the directions on the product label and do not take more than recommended. Because supplements are not tightly regulated, the actual amount in a product may differ from what is listed, and quality can vary between brands.Before starting, it is a good idea to review the full ingredient list with your pharmacist, especially since many products contain caffeine or other added stimulants.

From our Raspberry Ketone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Raspberry Ketone monograph & all interactions
Medication

About Clomipramine

What Is Clomipramine Used For?

Brand names: Anafranil, Anafranil SR

Clomipramine — sold as Anafranil and under the generic name Clomipramine Hydrochloride — is approved to treat obsessions and compulsions in people with Obsessive-Compulsive Disorder (OCD). This includes adults and children/adolescents ages 10 to 17.

To qualify for treatment, the obsessions or compulsions must cause significant distress, take up a lot of time, or noticeably interfere with work, school, or social life.

See full Clomipramine drug information
Keep checking

Other Drugs & Raspberry Ketone

Browse every other medication we’ve checked against Raspberry Ketone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
174Moderate
0Minor
2,655No known interaction
174 Moderate 2,655 No interaction
Moderate

174 interactions

Showing 60 of 174 moderate interactions — see all 174 on the Raspberry Ketone page.

No interaction 2,655 drugs checked — show the list

We also checked Raspberry Ketone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,655 medications checked with no known interaction — see the full Raspberry Ketone list.

See the full Raspberry Ketone interactions page
See every supplement checked against Clomipramine, ranked by severity
Evidence & sources

Raspberry Ketone References

The 4 references that drive our Raspberry Ketone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Adverse Event Report. Raspberry Ketone. Natural MedWatch, April 27, 2012.
  2. Adverse Event Report. Raspberry Ketone. Natural MedWatch, September 18, 2011.
  3. Ansari SA, Patel F, Ashouri D, Dhaliwal JSS, Desai A. Resistant Polymorphic Ventricular Tachycardia in a Patient Taking Raspberry Ketones Weight Loss Supplement. Cureus 2022;14(12):e33089. PubMed
  4. Khattar A, Beeton I. Coronary vasospasm and raspberry ketones weight-loss supplement: Is there a connection? Anatol J Cardiol. 2020;24(3):205-208.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Raspberry Ketone and Clomipramine Together: Common Questions

Is it safe to take Raspberry Ketone with Clomipramine?
We do not list a known interaction between Raspberry Ketone and Clomipramine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Raspberry Ketone and Clomipramine have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Raspberry Ketone and Clomipramine at the same time of day?
At least one FDA label for a product containing Clomipramine says to take it with food. If you take Raspberry Ketone on an empty stomach out of habit, keep them separate and take Clomipramine with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Clomipramine products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Raspberry Ketone and Clomipramine combination checked?
Interactions in our licensed database are recorded against drug classes. Clomipramine is filed under 13 classifications, and Raspberry Ketone has documented interactions with 2 drug classes — none of Clomipramine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Raspberry Ketone interact with any other medications?
Yes. Raspberry Ketone has 174 documented drug interactions in our database — Clomipramine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Clomipramine interact with any supplements?
Yes. Clomipramine has documented interactions with 236 supplements in our database — Raspberry Ketone is not one of them. The Clomipramine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Raspberry Ketone monograph Uses, safety profile, and every drug interaction in one place Clomipramine drug information The full plain-English guide to this medication Clomipramine supplement interactions Every supplement checked against Clomipramine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Clomipramine and Raspberry Ketone?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.