Drug & supplement interaction

Rue + Mineral Oil

Mineral Oil brand name: Kondremul Plain.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Rue and Mineral Oil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Mineral Oil states a food rule worth keeping to.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Rue and Mineral Oil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mineral Oil and Rue in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rue safety at a glance

Rue overall Use caution Rue can be toxic in higher doses and the oil is especially risky, so use it cautiously if at all.
Pregnancy Likely Unsafe When used orally. Rue has uterine stimulant and abortifacient effects; avoid using. Deaths have been reported in women who used rue as an abortifacient. Read the full pregnancy detail
Breastfeeding Avoid Safety is not established and potentially toxic compounds may pass to the baby, so avoid use.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mineral Oil and Rue? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Mineral Oil

Interactions in our licensed database are recorded against drug classes, not just single drug names. Mineral Oil is filed under a single classification — oral drugs. Rue has documented interactions with 1 drug class — the most serious being photosensitizing drugs (moderate) — and none of Mineral Oil’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Rue Does Interact With Other Medications

Rue has 335 moderate known drug interactions in our database — Mineral Oil isn’t one of them. If you take anything else, check it against the full list below.

Moderate 335 No known interaction 2,495 (incl. Mineral Oil)
Taking anything else?

Check Another of Your Medications Against Rue

Covers the 2,830 medications we’ve checked against Rue. Pick one to open its full report.

What to actually watch for

What Rue Itself Has Been Linked To

This is not an interaction — nothing below involves Mineral Oil. It is the side-effect record for Rue on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Rue, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • Confusion / Seizures Worth acting on Additional detail

    “Orally, therapeutic doses of rue can cause tremor, dizziness, drowsiness, sleep disorders, and depression. High doses can cause vertigo, seizures, and delirium (2,12,18).”

    Rue · Natural Medicines adverse-effect record, reported in depression.

    3 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    3. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • Low mood Worth acting on Additional detail

    “Orally, rue is well tolerated when taken in the amounts found in foods. The dried herb seems to be generally well tolerated when taken in medicinal doses; however, a thorough evaluation of safety outcomes has not been conducted.”

    Rue · Natural Medicines adverse-effect record, reported in depression.

  • Shortness of breath Worth acting on Additional detail

    “Orally, high doses of rue can cause respiratory distress (2,12,18).”

    Rue · Natural Medicines adverse-effect record, reported in acute respiratory distress syndrome (ards).

    3 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    3. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • Tremor or shakiness Additional detail

    Recorded for Rue in the same Natural Medicines adverse-effect record shown under Confusion / Seizures above.

  • Drowsiness / Dizziness Additional detail

    Recorded for Rue in the same Natural Medicines adverse-effect record shown under Low mood above.

  • Trouble sleeping Additional detail

    Recorded for Rue in the same Natural Medicines adverse-effect record shown under Low mood above.

  • Itching Additional detail

    “Topically, rue can cause contact dermatitis (2). Exposure to the fresh rue plant followed by sun exposure within 48 hours can lead to severe phototoxic reactions (2,6). Multiple case reports describe patients who developed pruritus, erythema, and severe blistering on the back of the hands and wrists, equivalent to a partial thickness burn, after contact with the fresh plant leaves and exposure to sunlight.”

    Rue · Natural Medicines adverse-effect record, reported in dermatitis.

    4 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    3. 104119. Radotra I, Gardiner S, Barnes D. A phytophototoxic injury at a burns unit: the ungraceful after-effects of the "common rue" plant. J Burn Care Res. 2018;39(6):1064-6. PubMed
    4. 107948. Avallone G, Mastorino L, Agostini A, et al. Ruta graveolens phytophotodermatitis. Dermatol Online J 2021;27(7). PubMed
  • Stomach pain Additional detail

    “Orally, rue can cause gastrointestinal irritation and cramps at therapeutic doses (2,12). When taken in large doses, it causes severe abdominal pain and vomiting (2,12,18).”

    Rue · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    3 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    3. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Showing the 10 most notable of 12 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Rue — expand a row for the licensed statement it rests on. We haven’t matched Mineral Oil to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Mineral Oil.

Special populations

Rue in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Rue has uterine stimulant and abortifacient effects; avoid using. Deaths have been reported in women who used rue as an abortifacient.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Mineral Oil Products Have a Food Rule — Rue Should Not Break It

At least one FDA label for a product containing Mineral Oil says to take it with food. If you take Rue on an empty stomach out of habit, keep them separate — and take Mineral Oil with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Mineral Oil products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Directions: * Do not take with meals.

From the Dosage and Administration section of the FDA label we read for Mineral Oil — where that label names a specific product, the instruction is that product's. See the Mineral Oil drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Mineral Oil

This page covers Rue only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mineral Oil page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Mineral Oil page

“Everything on record for mineral oil (Kondremul Plain) comes down to one theme, absorption in the gut, and it deserves genuine care, chiefly because of activated charcoal. Charcoal binds a wide array of medicines and can sharply cut how much of them the body actually takes in, and it carries this list's only major rating, so understand…”

Reviewed by 2 · Jul 18, 2026

Open the Mineral Oil interaction page

One more smart check

Taking Rue as Part of a Dietary Supplement Product? Check It for Interactions

We hold 47 real supplement products containing Rue, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Rue. Even though Rue itself has no known interaction with Mineral Oil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Rue and Mineral Oil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rue
Top half

#552 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mineral Oil
Top half

#712 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rue reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Rue and Mineral Oil records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rue

What is Rue?

Rue
  • Menstrual cramps
  • Digestive upset
  • Muscle spasms and pain
  • Headache
  • Insect repellent (topical)
  • Traditional folk remedy

Rue is a strong-smelling herb from southern Europe with a long history in folk medicine, but there is very little reliable human research to support its health uses. It can be toxic in larger amounts and is considered unsafe during pregnancy, so most people should avoid it or use it only under professional guidance.

Ruta graveolens · Rutaceae · Aerial parts (leaves and flowering tops) and essential oil · Tea, tincture, dried herb, essential oil, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Rue is a good idea for someone in your situation. Here is what our Rue record says about it on its own.

Rue: dosing

There is no well-established or standardized safe dose of rue. Because the plant can be toxic and the amount of active compounds varies widely between products, it is hard to know what amount is safe.If you choose to use a commercial rue product, follow the directions on the label exactly and do not exceed them. The essential oil should not be taken internally.

From our Rue monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rue monograph & all interactions
Medication

About Mineral Oil

What Is Mineral Oil Used For?

Brand name: Kondremul Plain

Most mineral oil products are used to relieve occasional constipation. Rectal enema products — including Fleet, Leader Ready to Use Mineral Oil, Foster and Thrive Ready to Use Mineral oil, Enema, and Enema Mineral Oil — are also used for relief of fecal impaction (stool that is stuck and won't pass) and to remove residue left in the bowel after a barium procedure.

Humco Mineral Oil Light topical liquid is used to help treat and prevent diaper rash, protect chafed skin, and seal out wetness. HANHOO BlemishPatch is applied directly to skin concerns as a topical patch.

See full Mineral Oil drug information
Keep checking

Other Drugs & Rue

Browse every other medication we’ve checked against Rue — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
335Moderate
0Minor
2,494No known interaction
335 Moderate 2,494 No interaction
Moderate

335 interactions

Showing 60 of 335 moderate interactions — see all 335 on the Rue page.

No interaction 2,494 drugs checked — show the list

We also checked Rue against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,494 medications checked with no known interaction — see the full Rue list.

See the full Rue interactions page
See every supplement checked against Mineral Oil, ranked by severity
Evidence & sources

Rue References

The 8 references that drive our Rue monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  6. Puig L. Pharmacodynamic interaction with phototoxic plants during PUVA therapy. Br J Dermatol 1997;136:973-4. PubMed
  7. Radotra I, Gardiner S, Barnes D. A phytophototoxic injury at a burns unit: the ungraceful after-effects of the "common rue" plant. J Burn Care Res. 2018;39(6):1064-6. PubMed
  8. Avallone G, Mastorino L, Agostini A, et al. Ruta graveolens phytophotodermatitis. Dermatol Online J 2021;27(7). PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rue and Mineral Oil Together: Common Questions

Is it safe to take Rue with Mineral Oil?
We do not list a known interaction between Rue and Mineral Oil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Rue and Mineral Oil at the same time of day?
At least one FDA label for a product containing Mineral Oil says to take it with food. If you take Rue on an empty stomach out of habit, keep them separate and take Mineral Oil with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Mineral Oil products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Rue and Mineral Oil combination checked?
Interactions in our licensed database are recorded against drug classes. Mineral Oil is filed under 1 classification, and Rue has documented interactions with 1 drug class — none of Mineral Oil's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Rue interact with any other medications?
Yes. Rue has 335 documented drug interactions in our database — Mineral Oil is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Mineral Oil interact with any supplements?
Yes. Mineral Oil has documented interactions with 17 supplements in our database — Rue is not one of them. The Mineral Oil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Rue monograph Uses, safety profile, and every drug interaction in one place Mineral Oil drug information The full plain-English guide to this medication Mineral Oil supplement interactions Every supplement checked against Mineral Oil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mineral Oil and Rue?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.