Drug & supplement interaction

Same + Nadolol

Nadolol brand names: Corgard, Nadolol.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Same and Nadolol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Same and Nadolol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Nadolol and Same in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Same safety at a glance

Same overall Use caution Often well tolerated short-term, but it can cause stomach upset and may trigger mania in people with bipolar disorder.
Pregnancy Possibly Safe When used intravenously short-term during the third trimester of pregnancy. In two small-scale trials, SAMe 800 mg daily was used intravenously for 14-20 days d... Read the full pregnancy detail
Breastfeeding Not established There is not enough reliable information, so caution is advised.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Nadolol and Same? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Nadolol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Nadolol is filed under 5 classifications — including beta-blockers, antihypertensive drugs, seizure threshold lowering drugs. Same has documented interactions with 2 drug classes — the most serious being levodopa (moderate) and serotonergic drugs (moderate) — and none of Nadolol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Same Does Interact With Other Medications

Same has 189 moderate known drug interactions in our database — Nadolol isn’t one of them. If you take anything else, check it against the full list below.

Moderate 189 No known interaction 2,641 (incl. Nadolol)
Taking anything else?

Check Another of Your Medications Against Same

Covers the 2,830 medications we’ve checked against Same. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Same and Nadolol May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Low mood Worth acting on Additional detail

    Same

    “Orally, anxiety and tiredness have been reported in patients with depression. Rare adverse effects associated with SAMe include hypermania. Hypomania has occurred with a combination of intramuscular and oral SAMe. Cases of mania with suicidal ideation have also been reported in otherwise healthy patients. A crawling sensation on the skin has been reported in a clinical trial.”

    Same · Natural Medicines adverse-effect record, reported in anxiety.

    6 sources cited
    1. 5231. Friedel HA, Goa KL, Benfield P. S-adenosyl-L-methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs 1989;38:389-416. PubMed
    2. 14841. Arnold O, Saletu B, Anderer P, et al. Double-blind, placebo-controlled pharmacodynamic studies with a nutraceutical and a pharmaceutical dose of ademetionine (SAMe) in elderly subjects, utilizing EEG mapping and psychometry. Eur Neuropsychopharmacol 2005; PubMed
    3. 5196. Rosenbaum JF, Fava M, Falk WE, et al. The antidepressant potential of oral S-adenosyl-l-methionine. Acta Psychiatr Scand 1990;81:432-6. PubMed
    4. 20218. Carrieri PB, Indaco A, Gentile S, et al. S-adenosylmethionine treatment of depressioin in patients with Parkinson's disease: a double-blind, crossover study versus placebo. Curr Ther Res 1990;48(1):154-60.
    5. 5195. Kagan BL, Sultzer DL, Rosenlicht N, Gerner RH. Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry 1990;147:591-5. PubMed
    6. 12231. Goren JL, Stoll AL, Damico KE, et al. Bioavailability and lack of toxicity of S-adenosyl-L-methionine (SAMe) in humans. Pharmacotherapy 2004;24:1501-7. PubMed

    Nadolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Nadolol. Read the label on DailyMed ›

  • Bloating or gas / Dry mouth / Reduced appetite / Constipation Additional detail

    Same

    “When taken orally or given intravenously, SAMe may cause increased salivation, bloating, flatulence, nausea, vomiting, diarrhea, stomach ache, heartburn, constipation, hunger, thirst, anorexia, blood in the stool, and dry mouth.”

    Same · Natural Medicines adverse-effect record, reported in anorexia.

    Nadolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Nadolol. Read the label on DailyMed ›

  • Hair loss Additional detail

    Same

    “Orally, SAMe may cause rash and itching, transient hair loss, sweating, and night sweats.

    Intravenously, SAMe may cause rash and sweating.”

    Same · Natural Medicines adverse-effect record, reported in alopecia.

    6 sources cited
    1. 5196. Rosenbaum JF, Fava M, Falk WE, et al. The antidepressant potential of oral S-adenosyl-l-methionine. Acta Psychiatr Scand 1990;81:432-6. PubMed
    2. 5199. Domljan Z, Vrhovac B, Durrigl T, Pucar I. A double-blind trial of ademetionine vs naproxen in activated gonarthrosis. Int J Clin Pharmacol Ther Toxicol 1989;27:329-33.
    3. 5203. Konig B. A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis. Am J Med 1987;83:89-94. PubMed
    4. 20202. Kim J, Lee EY, Koh EM, et al. Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients. Clin Ther 2009; PubMed
    5. 20230. Medici V., Virata M. C., Peerson J. M., Stabler S. P., French S. W., Gregory J. F. III, Albanese A., Bowlus C. L., Devaraj S., Panacek E. A., Richards J. R., Halsted C. H. S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, ra
    6. 73035. Capretto C, Cremona C, and Canaparo L. A double-blind controlled study of S-adenosylmethionine (SAMe) v. ibuprofen in gonarthrosis, coxarthrosis and spondylarthrosis. Clin Trials J 1985;22(1):15-24.

    Nadolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Nadolol. Read the label on DailyMed ›

  • Sweating Additional detail

    Same

    Recorded for Same in the same Natural Medicines adverse-effect record shown under Bloating or gas / Dry mouth / Reduced appetite / Constipation above.

    Nadolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Nadolol. Read the label on DailyMed ›

  • Drowsiness Additional detail

    Same

    “Orally, SAMe may cause vertigo, headache, insomnia, fatigue, tremors, agitation, dizziness, vivid dreams, and anxiety.

    Intramuscularly, SAMe may cause insomnia , anxiety, hostility, dizziness and drowsiness, and headache, although these events are rare.

    Intravenously, side effects rarely associated with SAMe include insomnia, anxiety, and psychomotor agitation.”

    Same · Natural Medicines adverse-effect record, reported in anxiety.

    6 sources cited
    1. 5188. Bradley JD, Flusser D, Katz BP, et al. A randomized, double blind, placebo controlled trial of intravenous loading with S-adenosylmethionine (SAM) followed by oral SAM therapy in patients with knee osteoarthritis. J Rheumatol 1994;21:905-11.
    2. 20218. Carrieri PB, Indaco A, Gentile S, et al. S-adenosylmethionine treatment of depressioin in patients with Parkinson's disease: a double-blind, crossover study versus placebo. Curr Ther Res 1990;48(1):154-60.
    3. 73002. Muscettola G, Galzenati M, Balbi A. SAMe versus placebo: a double blind comparison in major depressive disorders. Advances in Biochemical Psychopharmacology 1982;32:151-6.
    4. 20204. Manzillo G, Piccinino F, Surrenti C, et al. Multicentre double-blind placebo-controlled study of intravenous and oral S-adenosyl-L-methionine (SAMe) in cholestatic patients with liver disease. Drug Invest 1992;4 (Suppl 4):90-100. DOI
    5. 72978. Carney, M. W., Edeh, J., Bottiglieri, T., Reynolds, E. M., and Toone, B. K. Affective illness and S-adenosyl methionine: a preliminary report. Clin Neuropharmacol. 1986;9(4):379-385. PubMed
    6. 72988. Miccoli, L., Porro, V., and Bertolino, A. Comparison between the antidepressant activity and of S- adenosylmethionine (SAMe) and that of some tricyclic drugs. Acta Neurol (Napoli) 1978;33 (3):243-255.

    Nadolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Nadolol. Read the label on DailyMed ›

  • Trouble sleeping Additional detail

    Same

    Recorded for Same in the same Natural Medicines adverse-effect record shown under Bloating or gas / Dry mouth / Reduced appetite / Constipation above.

    Nadolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Nadolol. Read the label on DailyMed ›

  • Tiredness reported in 7.0% of FDA reports for Nadolol Additional detail

    Same

    Recorded for Same in the same Natural Medicines adverse-effect record shown under Low mood above.

    Nadolol

    Listed in the ADVERSE REACTIONS section of the FDA label for Nadolol, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Showing the 10 most notable of 17 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Same but not commonly for Nadolol: bleeding in the gut, thoughts of self-harm, vivid dreams or nightmares and anxiety or restlessness.

Effects for Nadolol come from the ADVERSE REACTIONS section of its FDA label; effects for Same come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 7,530 voluntary FDA FAERS reports for Nadolol that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Same in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used intravenously short-term during the third trimester of pregnancy. In two small-scale trials, SAMe 800 mg daily was used intravenously for 14-20 days during the third trimester of pregnancy for cholestasis. No adverse effects were observed. However, use of SAMe in pregnancy should only be considered when benefits clearly outweigh the potential risks. There is insufficient reliable information available about the use of SAMe at higher doses, for extended periods of time, or during the earlier trimesters of pregnancy.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Nadolol

This page covers Same only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Nadolol page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Green Tea (major) and Indian Snakeroot (major).

By severity: 6 major · 119 moderate · 20 minor.

From our pharmacist’s overview on the Nadolol page

“If you take nadolol (Corgard) for blood pressure, angina, or heart rhythm, treat this list with real care, and green tea is the surprise at the top. In a clinical study, green tea cut nadolol blood levels by roughly 85 percent, which can quietly leave you undertreated.”

Reviewed by 2 · Jul 18, 2026

Open the Nadolol interaction page

One more smart check

Taking Same as Part of a Dietary Supplement Product? Check It for Interactions

We hold 9 real supplement products containing Same, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Same. Even though Same itself has no known interaction with Nadolol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Same and Nadolol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Same
Top half

#438 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Nadolol
Steady interest

#1,682 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Same reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Same and Nadolol records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Same

What is Same?

Same
  • Depression
  • Osteoarthritis joint pain
  • Liver conditions
  • Fibromyalgia

SAM-e is a compound your body makes naturally that is sold as a supplement, most often for depression and osteoarthritis. Some research suggests it may help with these conditions, but the quality of evidence is mixed and more study is needed. Talk with your pharmacist or doctor before trying it, especially if you take other medicines or have bipolar disorder.

Not a plant; a compound made naturally in the body (supplements are made synthetically) · Enteric-coated tablets, capsules; less commonly injectable (used in some countries under medical supervision)

An interaction check asks whether these two react with each other — it does not ask whether Same is a good idea for someone in your situation. Here is what our Same record says about it on its own.

Same: dosing

There is no single official standardized dose of SAM-e, and the amount studied has varied depending on the condition and the salt form used. SAM-e is often sold as enteric-coated tablets to help it survive stomach acid, and some people take it before meals.Do not assume more is better. Starting low and using the lowest helpful dose may reduce the chance of side effects.

From our Same monograph — the full record covers uses, side effects and every documented interaction.

Read the full Same monograph & all interactions
Medication

About Nadolol

What Is Nadolol Used For?

Brand names: Corgard, Nadolol

Nadolol tablets are used for two main conditions: high blood pressure (hypertension) and angina pectoris (ongoing chest pain caused by reduced blood flow to the heart). Lowering high blood pressure reduces the risk of stroke and heart attack.

For high blood pressure, nadolol may be prescribed on its own or combined with other blood pressure medications, especially thiazide-type diuretics (water pills). For angina, it is used for long-term management to help reduce how often chest pain occurs.

Most-Reported Side Effects for Nadolol

From FAERS, the FDA’s public side-effect reporting system (7,530 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Macular degeneration 831 reports
Nausea 673 reports
Headache 603 reports
Fatigue 526 reports
Weight decreased 464 reports
See full Nadolol drug information
Keep checking

Other Drugs & Same

Browse every other medication we’ve checked against Same — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
189Moderate
0Minor
2,640No known interaction
189 Moderate 2,640 No interaction
Moderate

189 interactions

Showing 60 of 189 moderate interactions — see all 189 on the Same page.

No interaction 2,640 drugs checked — show the list

We also checked Same against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,640 medications checked with no known interaction — see the full Same list.

See the full Same interactions page
See every supplement checked against Nadolol, ranked by severity
Evidence & sources

Same References

The 31 references that drive our Same monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Perna AF, Castaldo P, Ingrosso D, et al. Homocysteine, a new cardiovascular risk factor, is also a powerful uremic toxin. J Nephrol 1999;12:230-40.
  2. Mato JM, Camara J, Fernandez de Paz J, et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 1999;30:1081-9. PubMed
  3. Iruela LM, Minguez L, Merino J, Monedero G. Toxic interaction of S-adenosylmethionine and clomipramine. Am J Psychiatry 1993;150:522. PubMed
  4. Bradley JD, Flusser D, Katz BP, et al. A randomized, double blind, placebo controlled trial of intravenous loading with S-adenosylmethionine (SAM) followed by oral SAM therapy in patients with knee osteoarthritis. J Rheumatol 1994;21:905-11.
  5. Berlanga C, Ortega-Soto HA, Ontiveros M, Senties H. Efficacy of S-adenosyl-L-methionine in speeding the onset of action of imipramine. Psychiatry Res 1992;44:257-62. PubMed
  6. Kagan BL, Sultzer DL, Rosenlicht N, Gerner RH. Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry 1990;147:591-5. PubMed
  7. Rosenbaum JF, Fava M, Falk WE, et al. The antidepressant potential of oral S-adenosyl-l-methionine. Acta Psychiatr Scand 1990;81:432-6. PubMed
  8. Domljan Z, Vrhovac B, Durrigl T, Pucar I. A double-blind trial of ademetionine vs naproxen in activated gonarthrosis. Int J Clin Pharmacol Ther Toxicol 1989;27:329-33.
  9. Konig B. A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis. Am J Med 1987;83:89-94. PubMed
  10. Lipinski JF, Cohen BM, Frankenburg F, et al. Open trial of S-adenosylmethionine for treatment of depression. Am J Psychiatry 1984;141:448-50.
  11. Almasio P, Bortolini M, Pagliaro L, Coltorti M. Role of S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis. Drugs 1990;40:111-23. PubMed
  12. Friedel HA, Goa KL, Benfield P. S-adenosyl-L-methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs 1989;38:389-416. PubMed
  13. Bottiglieri T, Hyland K, Reynolds EH. The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders. Drugs 1994;48:137-52. PubMed
  14. Frezza M, Centini G, Cammareri G, et al. S-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy. Results of a controlled clinical trial. Hepatogastroenterology 1990;37:122-5.
  15. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Same and Nadolol Together: Common Questions

Is it safe to take Same with Nadolol?
We do not list a known interaction between Same and Nadolol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Same and Nadolol have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Same and Nadolol combination checked?
Interactions in our licensed database are recorded against drug classes. Nadolol is filed under 5 classifications, and Same has documented interactions with 2 drug classes — none of Nadolol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Same interact with any other medications?
Yes. Same has 189 documented drug interactions in our database — Nadolol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Nadolol interact with any supplements?
Yes. Nadolol has documented interactions with 145 supplements in our database — Same is not one of them. The Nadolol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Same monograph Uses, safety profile, and every drug interaction in one place Nadolol drug information The full plain-English guide to this medication Nadolol supplement interactions Every supplement checked against Nadolol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 31 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Nadolol and Same?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.