Drug & supplement interaction

Solomon's Seal + Black Widow Spider Antivenin

Black Widow Spider Antivenin brand name: Antivenin (Lactrodectus mactans).

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Solomon's Seal and Black Widow Spider Antivenin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Solomon's Seal and Black Widow Spider Antivenin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Black Widow Spider Antivenin and Solomon's Seal in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Solomon's Seal safety at a glance

Solomon's Seal overall Use caution Limited safety data exists in people, so use carefully and choose reputable products.

Pregnancy Avoid Safety has not been established, so it is best to avoid use during pregnancy.

Breastfeeding Avoid There is not enough information to consider it safe while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Black Widow Spider Antivenin and Solomon's Seal? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

Keep it in perspective

Solomon's Seal Does Interact With Other Medications

Solomon's Seal has 86 moderate known drug interactions in our database — Black Widow Spider Antivenin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Black Widow Spider Antivenin)

Taking anything else?

Check Another of Your Medications Against Solomon's Seal

Covers the 2,830 medications we’ve checked against Solomon's Seal. Pick one to open its full report.

What to actually watch for

What Solomon's Seal Itself Has Been Linked To

This is not an interaction — nothing below involves Black Widow Spider Antivenin. It is the side-effect record for Solomon's Seal on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Solomon's Seal, this list is the first place to look.

Diarrhea / Nausea Additional detail
“A thorough evaluation of safety outcomes has not been conducted. Orally, long-term use of Solomon's seal has been reported to cause gastrointestinal irritation. Use of large doses or overdoses may cause nausea, diarrhea, and other gastrointestinal complaints (18).”

Solomon's Seal · Natural Medicines adverse-effect record, reported in diarrhea.
1 source cited

18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
“Orally, Solomon's seal may cause gastrointestinal irritation when used long-term. Use of large doses or overdoses may cause nausea, diarrhea, and other gastrointestinal complaints (18).”

Solomon's Seal · Natural Medicines adverse-effect record, reported in diarrhea.
1 source cited

18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Solomon's Seal — expand a row for the licensed statement it rests on. We haven’t matched Black Widow Spider Antivenin to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Black Widow Spider Antivenin.

One more smart check

Taking Solomon's Seal as Part of a Dietary Supplement Product? Check It for Interactions

We hold 113 real supplement products containing Solomon's Seal, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Solomon's Seal. Even though Solomon's Seal itself has no known interaction with Black Widow Spider Antivenin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Solomon's Seal and Black Widow Spider Antivenin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Solomon's Seal

Top half

#497 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Black Widow Spider Antivenin

Steady interest

#1,462 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Solomon's Seal reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Solomon's Seal and Black Widow Spider Antivenin records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Solomon's Seal

What is Solomon's Seal?

Joint and muscle discomfort
Tendon and ligament injuries
Inflammation
Digestive complaints
Skin and wound care
Dry cough and throat irritation

Solomon's Seal is a traditional herb whose root has long been used for joint, tendon, and muscle complaints, but high-quality human studies are largely lacking. There is not enough reliable evidence to confirm it works for any specific condition, so use it cautiously and talk with your pharmacist or doctor first.

Polygonatum multiflorum · Asparagaceae · Rhizome (root) and sometimes the whole plant · Capsules, dried root, teas, tinctures, powders, and topical salves

An interaction check asks whether these two react with each other — it does not ask whether Solomon's Seal is a good idea for someone in your situation. Here is what our Solomon's Seal record says about it on its own.

Solomon's Seal: dosing

There is no standardized, scientifically established dose for Solomon's Seal. Products vary widely in strength and form, so amounts on labels are not based on strong clinical research.If you choose to use it, follow the directions on the product label and do not exceed the suggested amount. Because doses are not well studied, it is wise to start low.

From our Solomon's Seal monograph — the full record covers uses, side effects and every documented interaction.

Read the full Solomon's Seal monograph & all interactions

Keep checking

Other Drugs & Solomon's Seal

Browse every other medication we’ve checked against Solomon's Seal — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

86Moderate

0Minor

2,743No known interaction

86 Moderate 2,743 No interaction

Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Solomon's Seal page.

No interaction 2,743 drugs checked — show the list

We also checked Solomon's Seal against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Solomon's Seal list.

See the full Solomon's Seal interactions page

See every supplement checked against Black Widow Spider Antivenin, ranked by severity

Evidence & sources

Solomon's Seal References

The 2 references that drive our Solomon's Seal monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Solomon's Seal and Black Widow Spider Antivenin Together: Common Questions

Is it safe to take Solomon's Seal with Black Widow Spider Antivenin?

We do not list a known interaction between Solomon's Seal and Black Widow Spider Antivenin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Does Solomon's Seal interact with any other medications?

Yes. Solomon's Seal has 86 documented drug interactions in our database — Black Widow Spider Antivenin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Solomon's Seal monograph Uses, safety profile, and every drug interaction in one place Black Widow Spider Antivenin supplement interactions Every supplement checked against Black Widow Spider Antivenin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Black Widow Spider Antivenin and Solomon's Seal?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.