Drug & supplement interaction

Solomon's Seal + Sodium Phenylbutyrate

Sodium Phenylbutyrate brand names: Buphenyl, Pheburane, Olpruva.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Solomon's Seal and Sodium Phenylbutyrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sodium Phenylbutyrate states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Solomon's Seal and Sodium Phenylbutyrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sodium Phenylbutyrate and Solomon's Seal in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Solomon's Seal safety at a glance

Solomon's Seal overall Use caution Limited safety data exists in people, so use carefully and choose reputable products.
Pregnancy Avoid Safety has not been established, so it is best to avoid use during pregnancy.
Breastfeeding Avoid There is not enough information to consider it safe while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sodium Phenylbutyrate and Solomon's Seal? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sodium Phenylbutyrate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sodium Phenylbutyrate is filed under 2 classifications — sodium-containing drugs, oral drugs. Solomon's Seal has documented interactions with 3 drug classes — the most serious being antidiabetes drugs (moderate), chlorpropamide (diabinese) (moderate) and insulin (moderate) — and none of Sodium Phenylbutyrate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Solomon's Seal Does Interact With Other Medications

Solomon's Seal has 86 moderate known drug interactions in our database — Sodium Phenylbutyrate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Sodium Phenylbutyrate)
Taking anything else?

Check Another of Your Medications Against Solomon's Seal

Covers the 2,830 medications we’ve checked against Solomon's Seal. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Solomon's Seal and Sodium Phenylbutyrate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea reported in 6.6% of FDA reports for Sodium Phenylbutyrate Additional detail

    Solomon's Seal

    “A thorough evaluation of safety outcomes has not been conducted. Orally, long-term use of Solomon's seal has been reported to cause gastrointestinal irritation. Use of large doses or overdoses may cause nausea, diarrhea, and other gastrointestinal complaints (18).”

    Solomon's Seal · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    “Orally, Solomon's seal may cause gastrointestinal irritation when used long-term. Use of large doses or overdoses may cause nausea, diarrhea, and other gastrointestinal complaints (18).”

    Solomon's Seal · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Sodium Phenylbutyrate

    Listed in the ADVERSE REACTIONS section of the FDA label for Sodium Phenylbutyrate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Solomon's Seal but not commonly for Sodium Phenylbutyrate: diarrhea.

Effects for Sodium Phenylbutyrate come from the ADVERSE REACTIONS section of its FDA label; effects for Solomon's Seal come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 411 voluntary FDA FAERS reports for Sodium Phenylbutyrate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Sodium Phenylbutyrate Products Have a Food Rule — Solomon's Seal Should Not Break It

At least one FDA label for a product containing Sodium Phenylbutyrate says to take it with food. If you take Solomon's Seal on an empty stomach out of habit, keep them separate — and take Sodium Phenylbutyrate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sodium Phenylbutyrate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

The powder is to be mixed with food (solid or liquid) for immediate use; however, when dissolved in water, BUPHENYL Powder has been shown to be stable for up to one week at room temperature or refrigerated.

From the Dosage and Administration section of the FDA label we read for Sodium Phenylbutyrate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Sodium Phenylbutyrate

This page covers Solomon's Seal only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sodium Phenylbutyrate page lists 19 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 9 moderate · 9 minor.

From our pharmacist’s overview on the Sodium Phenylbutyrate page

“Sodium phenylbutyrate (Buphenyl, Pheburane, Olpruva) keeps ammonia in check in people with urea cycle disorders, so a supplement that blunts its absorption is not a small problem, it is the difference between a controlled ammonia level and a dangerous one. Seventeen of the 19 ingredients on this page, mostly fibers, gums, and mucilages…”

Reviewed by 2 · Jul 18, 2026

Open the Sodium Phenylbutyrate interaction page

One more smart check

Taking Solomon's Seal as Part of a Dietary Supplement Product? Check It for Interactions

We hold 113 real supplement products containing Solomon's Seal, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Solomon's Seal. Even though Solomon's Seal itself has no known interaction with Sodium Phenylbutyrate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Solomon's Seal and Sodium Phenylbutyrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Solomon's Seal
Top half

#497 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sodium Phenylbutyrate
Steady interest

#2,720 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Solomon's Seal reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Solomon's Seal and Sodium Phenylbutyrate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Solomon's Seal

What is Solomon's Seal?

Solomon's Seal
  • Joint and muscle discomfort
  • Tendon and ligament injuries
  • Inflammation
  • Digestive complaints
  • Skin and wound care
  • Dry cough and throat irritation

Solomon's Seal is a traditional herb whose root has long been used for joint, tendon, and muscle complaints, but high-quality human studies are largely lacking. There is not enough reliable evidence to confirm it works for any specific condition, so use it cautiously and talk with your pharmacist or doctor first.

Polygonatum multiflorum · Asparagaceae · Rhizome (root) and sometimes the whole plant · Capsules, dried root, teas, tinctures, powders, and topical salves

An interaction check asks whether these two react with each other — it does not ask whether Solomon's Seal is a good idea for someone in your situation. Here is what our Solomon's Seal record says about it on its own.

Solomon's Seal: dosing

There is no standardized, scientifically established dose for Solomon's Seal. Products vary widely in strength and form, so amounts on labels are not based on strong clinical research.If you choose to use it, follow the directions on the product label and do not exceed the suggested amount. Because doses are not well studied, it is wise to start low.

From our Solomon's Seal monograph — the full record covers uses, side effects and every documented interaction.

Read the full Solomon's Seal monograph & all interactions
Keep checking

Other Drugs & Solomon's Seal

Browse every other medication we’ve checked against Solomon's Seal — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Solomon's Seal page.

No interaction 2,743 drugs checked — show the list

We also checked Solomon's Seal against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Solomon's Seal list.

See the full Solomon's Seal interactions page
See every supplement checked against Sodium Phenylbutyrate, ranked by severity
Evidence & sources

Solomon's Seal References

The 2 references that drive our Solomon's Seal monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Solomon's Seal and Sodium Phenylbutyrate Together: Common Questions

Is it safe to take Solomon's Seal with Sodium Phenylbutyrate?
We do not list a known interaction between Solomon's Seal and Sodium Phenylbutyrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Solomon's Seal and Sodium Phenylbutyrate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Solomon's Seal and Sodium Phenylbutyrate at the same time of day?
At least one FDA label for a product containing Sodium Phenylbutyrate says to take it with food. If you take Solomon's Seal on an empty stomach out of habit, keep them separate and take Sodium Phenylbutyrate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Sodium Phenylbutyrate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Solomon's Seal and Sodium Phenylbutyrate combination checked?
Interactions in our licensed database are recorded against drug classes. Sodium Phenylbutyrate is filed under 2 classifications, and Solomon's Seal has documented interactions with 3 drug classes — none of Sodium Phenylbutyrate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Solomon's Seal interact with any other medications?
Yes. Solomon's Seal has 86 documented drug interactions in our database — Sodium Phenylbutyrate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sodium Phenylbutyrate interact with any supplements?
Yes. Sodium Phenylbutyrate has documented interactions with 19 supplements in our database — Solomon's Seal is not one of them. The Sodium Phenylbutyrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Solomon's Seal monograph Uses, safety profile, and every drug interaction in one place Sodium Phenylbutyrate supplement interactions Every supplement checked against Sodium Phenylbutyrate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sodium Phenylbutyrate and Solomon's Seal?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.