Drug & supplement interaction

Strophanthus + Prednisone

Prednisone brand names: Deltasone, Cortan, Orasone, Prednisone, Prednicen-M, and others.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Strophanthus has a moderate interaction with Prednisone. Use of corticosteroids may cause electrolyte depletion and increase the risk of strophanthus toxicity.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Strophanthus and Prednisone

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CORTICOSTEROIDS

Why this applies to Prednisone

Prednisone falls under CORTICOSTEROIDS — the group Strophanthus interacts with.

Use of corticosteroids may cause electrolyte depletion and increase the risk of strophanthus toxicity.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the connection between these two. Prednisone is a steroid, and one of its quieter effects is that it can lower your body's potassium over time, especially with longer use. Strophanthus contains potent heart compounds (cardiac glycosides much like digoxin), and these become more dangerous when potassium runs low. So the worry isn't that prednisone changes how strophanthus is broken down, it's that the steroid can set the stage for stronger, more toxic effects from strophanthus on the heart.

If potassium drops too far, strophanthus could trigger nausea, dizziness, or irregular heartbeats. This is a theoretical concern based on how the drugs work, not solid human studies, but strophanthus is risky enough that I'd urge you to talk with your doctor or pharmacist before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Strophanthus Also Interacts With Other Medications

Strophanthus has 3 major, 119 moderate known drug interactions in our database — the Prednisone one above is one of them. If you take anything else, check it against the full list below.

Major 3 Moderate 119 No known interaction 2,708 (incl. Prednisone)
Taking anything else?

Check Another of Your Medications Against Strophanthus

Covers the 2,830 medications we’ve checked against Strophanthus. Pick one to open its full report.

From our Q&A

Questions About Strophanthus or Prednisone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Strophanthus or Prednisone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Prednisone

This page covers Strophanthus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Prednisone page lists 208 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lily-of-the-valley (major), St. John's Wort (major) and Acacia Rigidula (moderate).

By severity: 4 major · 168 moderate · 36 minor.

From our pharmacist’s overview on the Prednisone page

“Prednisone (Deltasone) suppresses the immune system to control inflammation, and that mechanism shapes most of what can go wrong on this 208-ingredient list, which I read as one to approach carefully rather than casually. Four entries rate major.”

Reviewed by 2 · Jul 18, 2026

Open the Prednisone interaction page

How much people look this up

Where Strophanthus and Prednisone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Strophanthus
Steady interest

#989 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Prednisone
Top 5%

#37 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Strophanthus

What is Strophanthus?

  • Heart failure
  • Angina (chest pain)
  • Irregular heartbeat
  • Circulation support
  • Traditional African arrow poison (historical)

Strophanthus is a plant that contains powerful heart-affecting compounds called cardiac glycosides (the best known is ouabain/g-strophanthin). Because these substances can strongly affect heart rhythm and are toxic in the wrong amount, Strophanthus is not a casual supplement and should never be used without close medical supervision. Reliable modern evidence for its supplement use is limited.

Read the full Strophanthus monograph & all interactions
Medication

About Prednisone

What Is Prednisone Used For?

Brand names: Deltasone, Cortan, Orasone, Prednisone, Prednicen-M, Meticorten, Sterapred, Rayos

Prednisone treats a broad range of conditions where the body's immune system is overactive or inflammation needs to be controlled. It works across many organ systems, from the lungs and skin to the joints and blood.

Doctors prescribe it for conditions like asthma, severe allergies, Crohn's disease, multiple sclerosis flares, certain cancers, and to prevent organ rejection after transplant, among many others.

See full Prednisone drug information
Keep checking

Other Drugs & Strophanthus

Browse every other medication we’ve checked against Strophanthus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

3Major
119Moderate
0Minor
2,707No known interaction
3 Major 119 Moderate 2,707 No interaction
Major

3 interactions

Moderate

119 interactions

Showing 60 of 119 moderate interactions — see all 119 on the Strophanthus page.

No interaction 2,707 drugs checked — show the list

We also checked Strophanthus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Strophanthus list.

See the full Strophanthus interactions page
See every supplement checked against Prednisone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Strophanthus monograph › Uses, safety, and every drug interaction in one place Prednisone supplement interactions › Every supplement checked against Prednisone, ranked by severity Prednisone drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Strophanthus and Prednisone Together: Common Questions

Can you take Strophanthus with Prednisone?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Strophanthus and Prednisone interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Prednisone and Strophanthus?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.