Drug & supplement interaction

Vitamin B6 + Desmopressin Acetate

Desmopressin Acetate brand names: DDAVP, Noctiva, Nocdurna.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Vitamin B6 and Desmopressin Acetate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Vitamin B6 and Desmopressin Acetate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Desmopressin Acetate and Vitamin B6 in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Vitamin B6 safety at a glance

Vitamin B6 overall Use caution Safe at normal amounts from food and standard supplements, but high doses over time can harm nerves.
Pregnancy Likely Safe When used orally and appropriately. A special sustained-release product providing vitamin B6 (pyridoxine) 75 mg daily is FDA-approved for use in pregnancy. Vita... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in doses not exceeding the tolerable upper intake level (UL) of vitamin B6 in the form of pyridoxine 80 mg daily for those aged 14-18 years and... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Desmopressin Acetate and Vitamin B6? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Desmopressin Acetate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Desmopressin Acetate is filed under a single classification — oral drugs. Vitamin B6 has documented interactions with 5 drug classes — the most serious being amiodarone (cordarone) (moderate), antihypertensive drugs (moderate) and phenobarbital (luminal) (moderate) — and none of Desmopressin Acetate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Vitamin B6 Does Interact With Other Medications

Vitamin B6 has 205 moderate, 5 minor known drug interactions in our database — Desmopressin Acetate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 205 Minor 5 No known interaction 2,620 (incl. Desmopressin Acetate)
Taking anything else?

Check Another of Your Medications Against Vitamin B6

Covers the 2,830 medications we’ve checked against Vitamin B6. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Vitamin B6 and Desmopressin Acetate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Bleeding or bruising Worth acting on Additional detail

    Vitamin B6

    “Orally or by injection, vitamin B6 (pyridoxine) can cause decreased serum folic acid concentrations. One case of persistent bleeding of unknown origin has been reported in a clinical trial for a patient who used vitamin B6 (pyridoxine) 100 mg twice daily on days 16 to 35 of the menstrual cycle. It is unclear if this effect was due to vitamin B6 intake.”

    Vitamin B6 · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    3 sources cited
    1. 8195. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
    2. 9479. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
    3. 83103. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed

    Desmopressin Acetate

    Listed in the ADVERSE REACTIONS section of the FDA label for Desmopressin Acetate. Read the label on DailyMed ›

  • An allergic reaction Worth acting on Additional detail

    Vitamin B6

    “Orally, vitamin B6 (pyridoxine) has been linked to reports of skin and other allergic reactions and photosensitivity. High-dose vitamin B6 (80 mg daily as pyridoxine) and vitamin B12 (20 mcg daily) have been associated with cases of rosacea fulminans characterized by intense erythema with nodules, papules, and pustules.”

    Vitamin B6 · Natural Medicines adverse-effect record, reported in erythema.

    4 sources cited
    1. 8195. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
    2. 9479. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
    3. 90375. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
    4. 10998. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..

    Desmopressin Acetate

    Listed in the ADVERSE REACTIONS section of the FDA label for Desmopressin Acetate. Read the label on DailyMed ›

  • Drowsiness / Headache reported in 7.1% of FDA reports for Desmopressin Acetate Additional detail

    Vitamin B6

    “Orally or by injection, vitamin B6 (pyridoxine) can cause headache, paresthesia, and somnolence. Vitamin B6 (pyridoxine) can also cause sensory neuropathy, which is related to daily dose and duration of intake. Doses exceeding 1000 mg daily or total doses of 1000 grams or more pose the most risk, although neuropathy can occur with lower daily or total doses as well.”

    Vitamin B6 · Natural Medicines adverse-effect record, reported in cluster headache.

    6 sources cited
    1. 8195. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
    2. 9479. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
    3. 16306. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
    4. 8204. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
    5. 8196. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
    6. 10439. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI

    Desmopressin Acetate

    Listed in the ADVERSE REACTIONS section of the FDA label for Desmopressin Acetate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Stomach pain / Nausea reported in 5.4% of FDA reports for Desmopressin Acetate Additional detail

    Vitamin B6

    “Orally or by injection, vitamin B6 (pyridoxine) can cause nausea, vomiting, heartburn, abdominal pain, mild diarrhea, and loss of appetite. In a clinical trial, one patient experienced infectious gastroenteritis that was deemed possibly related to taking vitamin B6 (pyridoxine) orally up to 20 mg/kg daily.”

    Vitamin B6 · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 8195. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
    2. 9479. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
    3. 16306. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
    4. 83064. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
    5. 83103. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
    6. 107124. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed

    Desmopressin Acetate

    Listed in the ADVERSE REACTIONS section of the FDA label for Desmopressin Acetate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Vitamin B6 but not commonly for Desmopressin Acetate: reduced appetite, sun sensitivity, numbness or tingling and heartburn.

Effects for Desmopressin Acetate come from the ADVERSE REACTIONS section of its FDA label; effects for Vitamin B6 come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 3,776 voluntary FDA FAERS reports for Desmopressin Acetate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Vitamin B6 in Pregnancy & Breastfeeding

Pregnancy Likely Safe

When used orally and appropriately. A special sustained-release product providing vitamin B6 (pyridoxine) 75 mg daily is FDA-approved for use in pregnancy. Vitamin B6 (pyridoxine) is also considered a first-line treatment for nausea and vomiting in pregnancy by the American College of Obstetrics and Gynecology. However, it should not be used long-term or without medical supervision and close monitoring. The tolerable upper intake level (UL) refers to vitamin B6 in the form of pyridoxine and is 80 mg daily for those aged 14-18 years and 100 mg daily for 19 years and older.

Pregnancy Possibly Unsafe

When used orally in excessive doses. There is some concern that high-dose maternal vitamin B6 (pyridoxine) can cause neonatal seizures.

Lactation Likely Safe

When used orally in doses not exceeding the tolerable upper intake level (UL) of vitamin B6 in the form of pyridoxine 80 mg daily for those aged 14-18 years and 100 mg daily for those 19 years and older. The recommended dietary allowance (RDA) in lactating women is 2 mg daily. There is insufficient reliable information available about the safety of vitamin B6 when used in higher doses in breast-feeding women.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Desmopressin Acetate

This page covers Vitamin B6 only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Desmopressin Acetate page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Desmopressin Acetate page

“Every one of the 17 supplements flagged for desmopressin acetate (DDAVP, Nocdurna, Noctiva) works the same basic way, by changing how much of the drug is absorbed from the gut, and that deserves real attention. Desmopressin controls urine output in diabetes insipidus and nighttime urination, and only a small fraction of an oral dose re…”

Reviewed by 2 · Jul 18, 2026

Open the Desmopressin Acetate interaction page

One more smart check

Taking Vitamin B6 as Part of a Dietary Supplement Product? Check It for Interactions

We hold 24,838 real supplement products containing Vitamin B6, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Vitamin B6. Even though Vitamin B6 itself has no known interaction with Desmopressin Acetate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Vitamin B6 and Desmopressin Acetate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Vitamin B6
Top 10

#3 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Desmopressin Acetate
Top 25%

#299 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Vitamin B6 reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Vitamin B6 and Desmopressin Acetate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Vitamin B6

What is Vitamin B6?

  • Morning sickness in pregnancy
  • Premenstrual syndrome (PMS)
  • Preventing or treating B6 deficiency
  • Nerve health and metabolism support
  • Nausea

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-related nausea and may help some people with PMS, but taking very high doses for long periods can cause nerve damage. Get most of your B6 from food, and check with a pharmacist or doctor before taking high-dose supplements.

Tablets, capsules, softgels, liquid drops, part of B-complex and multivitamins

An interaction check asks whether these two react with each other — it does not ask whether Vitamin B6 is a good idea for someone in your situation. Here is what our Vitamin B6 record says about it on its own.

Vitamin B6: dosing

There is no single "best" supplement dose for everyone, and the right amount depends on your age, health, and the reason you are taking it. Health authorities set recommended daily intakes and an upper limit to help avoid nerve-related side effects from too much.The safest approach is to follow the directions on the product label and not exceed the upper limit unless a healthcare provider tells you to. Avoid taking high-dose B6 for long periods on your own.If you take a B-complex or multivitamin, check how much B6 it already contains so you do not accidentally take too much from multiple products.

From our Vitamin B6 monograph — the full record covers uses, side effects and every documented interaction.

Read the full Vitamin B6 monograph & all interactions
Medication

About Desmopressin

What Is Desmopressin Used For?

Brand names: DDAVP, Noctiva, Nocdurna

Desmopressin treats central diabetes insipidus — a condition where the body doesn't make enough antidiuretic hormone (ADH), causing the kidneys to release far too much water. It's also used for temporary excessive urination and thirst that can follow head trauma or surgery near the pituitary gland.

It's also approved for primary nocturnal enuresis (bedwetting at night) and can be used alone or alongside behavioral approaches. Note: it does not work for nephrogenic diabetes insipidus, a different type of the condition.

Most-Reported Side Effects for Desmopressin Acetate

From FAERS, the FDA’s public side-effect reporting system (3,776 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hyponatraemia 357 reports
Headache 268 reports
Nausea 204 reports
Fatigue 173 reports
Vomiting 155 reports
See full Desmopressin drug information
Keep checking

Other Drugs & Vitamin B6

Browse every other medication we’ve checked against Vitamin B6 — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
205Moderate
5Minor
2,619No known interaction
205 Moderate 5 Minor 2,619 No interaction
Moderate

205 interactions

Showing 60 of 205 moderate interactions — see all 205 on the Vitamin B6 page.

Minor

5 interactions

No interaction 2,619 drugs checked — show the list

We also checked Vitamin B6 against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,619 medications checked with no known interaction — see the full Vitamin B6 list.

See the full Vitamin B6 interactions page
See every supplement checked against Desmopressin Acetate, ranked by severity
Evidence & sources

Vitamin B6 References

The 32 references that drive our Vitamin B6 monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Vitamin B6 and Desmopressin Acetate Together: Common Questions

Is it safe to take Vitamin B6 with Desmopressin Acetate?
We do not list a known interaction between Vitamin B6 and Desmopressin Acetate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Vitamin B6 and Desmopressin Acetate have any of the same side effects?
Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Vitamin B6 and Desmopressin Acetate combination checked?
Interactions in our licensed database are recorded against drug classes. Desmopressin Acetate is filed under 1 classification, and Vitamin B6 has documented interactions with 5 drug classes — none of Desmopressin Acetate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Vitamin B6 interact with any other medications?
Yes. Vitamin B6 has 210 documented drug interactions in our database — Desmopressin Acetate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Desmopressin Acetate interact with any supplements?
Yes. Desmopressin Acetate has documented interactions with 17 supplements in our database — Vitamin B6 is not one of them. The Desmopressin Acetate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Vitamin B6 monograph Uses, safety profile, and every drug interaction in one place Desmopressin drug information The full plain-English guide to this medication Desmopressin Acetate supplement interactions Every supplement checked against Desmopressin Acetate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 32 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Desmopressin Acetate and Vitamin B6?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.