Wheat Bran + Entrectinib
Entrectinib brand name: Rozlytrek.
We found no known interaction between Wheat Bran and Entrectinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Wheat Bran and Entrectinib
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Entrectinib and Wheat Bran in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Wheat Bran at all — not against Entrectinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Wheat Bran safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Wheat Bran in Pregnancy & Breastfeeding
When used orally.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Entrectinib Is Prescribed For, and What Wheat Bran Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Entrectinib is a prescription medicine with approved uses on its FDA label. Wheat Bran is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Entrectinib is prescribed for: Rozlytrek (entrectinib) is used to treat adult patients with ROS1-positive metastatic non-small cell lung cancer (NSCLC), as confirmed by an FDA-approved test. It is also approved for adult and pediatric patients older than 1 month of age who have solid tumors — any cancer type — that carry an NTRK gene fusion detected by an FDA-approved test, provided the tumor has no known acquired resistance mutation, is metastatic or cannot be surgically removed without severe harm, and has progressed after prior treatment or has no satisfactory alternative therapy. The NTRK gene fusion approval in solid tumors was granted under accelerated approval, meaning it is based on tumor response rates. Continued approval may depend on results from confirmatory clinical trials.
Wheat Bran has been studied for:
-
Cancer studied, not established Wheat Bran has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Wheat Bran for cancer
Although there is interest in using oral wheat bran to prevent various types of cancer, there is insufficient reliable information about the clinical effects of wheat bran for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Entrectinib on your own; if you are taking Wheat Bran for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Entrectinib
This page covers Wheat Bran only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Entrectinib page lists 175 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Beer (major) and Cesium (major).
By severity: 11 major · 127 moderate · 37 minor.
From our pharmacist’s overview on the Entrectinib page
“Grapefruit tops my worry list for anyone taking entrectinib (Rozlytrek), a targeted cancer therapy cleared by the liver enzyme CYP3A4. 121 of the 175 supplement ingredients on this page can shift how that enzyme handles the drug.”
Reviewed by 2 · Jul 18, 2026
Taking Wheat Bran as Part of a Dietary Supplement Product? Check It for Interactions
We hold 8 real supplement products containing Wheat Bran, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wheat Bran. Even though Wheat Bran itself has no known interaction with Entrectinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Wheat Bran and Entrectinib Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#514 of 1,452 supplements looked up here in the last 7 days
#1,026 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wheat Bran reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Wheat Bran and Entrectinib records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Wheat Bran
What is Wheat Bran?
- Constipation relief
- Digestive regularity
- Heart health support
- Blood sugar support
- Weight management
Wheat bran is the fiber-rich outer layer of the wheat kernel and is best known as a natural bulk-forming way to relieve constipation and support regular bowel movements. It is generally safe for most people who can eat wheat, but it must be taken with plenty of water and should be avoided by anyone with a wheat allergy, celiac disease, or gluten sensitivity.
Triticum aestivum · Poaceae · Outer bran layer of the wheat grain · Loose bran, breakfast cereals, baked goods, capsules, and powders
An interaction check asks whether these two react with each other — it does not ask whether Wheat Bran is a good idea for someone in your situation. Here is what our Wheat Bran record says about it on its own.
Wheat Bran: dosing
There is no single official dose of wheat bran as a supplement. Most people use it simply as a food, adjusting the amount to keep their bowels regular.A good general rule is to start with a small amount and increase slowly over days to weeks, while drinking plenty of water.
From our Wheat Bran monograph — the full record covers uses, side effects and every documented interaction.
About Entrectinib
What Is Entrectinib Used For?
Brand name: Rozlytrek
Rozlytrek (entrectinib) is used to treat adult patients with ROS1-positive metastatic non-small cell lung cancer (NSCLC), as confirmed by an FDA-approved test. It is also approved for adult and pediatric patients older than 1 month of age who have solid tumors — any cancer type — that carry an NTRK gene fusion detected by an FDA-approved test, provided the tumor has no known acquired resistance mutation, is metastatic or cannot be surgically removed without severe harm, and has progressed after prior treatment or has no satisfactory alternative therapy.
The NTRK gene fusion approval in solid tumors was granted under accelerated approval, meaning it is based on tumor response rates. Continued approval may depend on results from confirmatory clinical trials.
Most-Reported Side Effects for Entrectinib
From FAERS, the FDA’s public side-effect reporting system (1,653 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Wheat Bran
Browse every other medication we’ve checked against Wheat Bran — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Wheat Bran against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Wheat Bran list.
Wheat Bran References
The 4 references that drive our Wheat Bran monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
- McRorie J, Kesler J, Bishop L, et al. Effects of wheat bran and Olestra on objective measures of stool and subjective reports of GI symptoms. Am J Gastroenterol 2000;95:1244-52. PubMed
- Food and Drug Administration. Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA); Public Law 108-282, Title II. Accessed on May 19, 2021. Available at: https://www.fda.gov/food/food-allergensgluten-free-guidance-documents-regulatory-infor
- Dalile B, La Torre D, Kalc P, et al. Extruded Wheat Bran Consumption Increases Serum Short-Chain Fatty Acids but Does Not Modulate Psychobiological Functions in Healthy Men: A Randomized, Placebo-Controlled Trial. Front Nutr 2022;9:896154. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Wheat Bran and Entrectinib Together: Common Questions
Is it safe to take Wheat Bran with Entrectinib?
Do Wheat Bran and Entrectinib have any of the same side effects?
Are Wheat Bran and Entrectinib used for the same thing?
Does Entrectinib interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.