Herb & supplement monograph

N-methyltyramine Drug Interactions, Uses, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated June 2026

What is this page for?

First and foremost: how N-methyltyramine interacts with medications. The heart of this page is the interaction list — every drug N-methyltyramine is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what N-methyltyramine is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Interaction report

Drugs that interact with N-methyltyramine

344 medications have a known interaction with N-methyltyramine, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against N-methyltyramine using our pharmacist-reviewed interaction data.

AI summaries are generated from our N-methyltyramine interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact N-methyltyramine combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs N-methyltyramine affects

Every type of medication (drug category) N-methyltyramine is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 2 drug categories N-methyltyramine interacts with

Antihypertensive DrugsStimulant Drugs

Antihypertensive Drugs

In animal research, N-methyltyramine increased blood pressure. This has not been shown in humans. Theoretically, concomitant use of N-methyltyramine and antihypertensive drugs might reduce the effects of antihypertensive drugs.
Some antihypertensive drugs include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.

Likelihood Possible Evidence D

Stimulant Drugs

N-methyltyramine is thought to have stimulant effects. However, this has not been shown in humans and laboratory research does not support the proposed stimulant effects of N-methyltyramine. Theoretically, taking N-methyltyramine with other stimulant drugs might increase the risk of hypertension and adverse cardiovascular effects. Until more is known, avoid taking N-methyltyramine with stimulant drugs.
Some stimulant drugs include amphetamine, caffeine, diethylpropion (Tenuate), methylphenidate, phentermine (Ionamin), pseudoephedrine (Sudafed, others), and many others.

Likelihood Possible Evidence D

Monograph

N-methyltyramine: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed June 2026 ·

The bottom line

N-methyltyramine is a natural compound related to tyramine that is found in bitter orange, barley, and other plants, and it is often added to weight-loss and pre-workout supplements. Solid human research on its safety and effectiveness is very limited, and because it may stimulate the body like other amines, people with heart problems or high blood pressure should be especially careful. Talk to a pharmacist or doctor before using any product that contains it.

Part used: Found naturally in citrus fruits (especially bitter orange), barley, and certain plants; also produced synthetically
Common forms: Capsules, tablets, and powders (usually as part of pre-workout, fat-burner, or weight-loss blends)

People commonly use it for

Weight loss and fat burning
Energy and pre-workout supplements
Sports performance
Appetite control

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallUse caution

Human safety data are limited, and as a stimulant-like amine it may raise heart rate or blood pressure.

PregnancyInsufficient reliable information

Insufficient reliable information is available; avoid using.

Read the full pregnancy detail

BreastfeedingInsufficient reliable information

Insufficient reliable information is available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

N-methyltyramine (sometimes shortened to NMT) is a naturally occurring compound that belongs to a group of substances called phenylethylamines. It is chemically related to tyramine, which is found in many foods. N-methyltyramine occurs naturally in plants such as bitter orange (Citrus aurantium), barley, and some grasses, and it can also be made in a lab.

In the supplement world, N-methyltyramine is mostly used as an added ingredient in weight-loss products, fat burners, and pre-workout or energy formulas. It is rarely sold on its own and is usually combined with caffeine, synephrine, or other stimulant-type ingredients.

Because it is a relatively new and lightly studied supplement ingredient, there is far less information available about it than about more familiar herbs.

Uses & effectiveness

People mainly take N-methyltyramine hoping it will help with weight loss, fat burning, energy, and exercise performance. These uses are based on the idea that it acts like a mild stimulant, similar to other amines found in bitter orange.

The honest answer is that good human evidence is lacking. Most of what is known comes from laboratory studies, animal research, or general knowledge about related compounds. There are no large, high-quality clinical trials showing that N-methyltyramine reliably helps people lose weight, burn fat, or improve workouts.

Because it is usually combined with other active ingredients in products, it is also hard to know what (if anything) N-methyltyramine itself contributes. At this time, its benefits should be considered unproven.

How it works

N-methyltyramine is thought to act as a mild sympathomimetic, meaning it may gently stimulate the body's "fight or flight" system. In laboratory and animal studies, related compounds can trigger the release of norepinephrine, a natural chemical that can speed up heart rate, raise blood pressure, and increase the breakdown of fat for energy.

Supporters claim this activity could boost metabolism and energy. However, these proposed mechanisms are largely based on test-tube and animal work, not on solid human studies. The actual effect in people taking supplement doses is not well understood.

Safety & precautions

The safety of N-methyltyramine in humans has not been well studied. Because it may act like a stimulant, there is a reasonable concern that it could raise blood pressure or heart rate, or cause palpitations, especially when combined with caffeine or other stimulants in the same product.

People who should be especially cautious or avoid it include those with heart disease, high blood pressure, irregular heartbeat, anxiety, an overactive thyroid, or a history of stroke. Older adults and anyone sensitive to stimulants should also be careful.

For pregnancy and breastfeeding, there is no reliable safety information, so it should be avoided. The same goes for children and teens. Because supplement products are not tightly regulated, the actual amount of N-methyltyramine in a product may differ from the label. Always check with a pharmacist or doctor before starting it.

Side effects

Because human data are limited, the full side-effect profile is unknown. Based on its stimulant-like nature, possible side effects may include increased heart rate, higher blood pressure, palpitations, jitteriness, anxiety, headache, and trouble sleeping.

More serious effects, though not well documented for this specific compound, are a theoretical concern when stimulant-type ingredients are combined—such as chest pain or dangerous changes in heart rhythm or blood pressure. If you experience chest pain, a racing or irregular heartbeat, severe headache, or shortness of breath, stop the product and seek medical care right away.

Dosing

There is no established or standardized dose for N-methyltyramine. It has not been studied enough in humans to know a safe or effective amount, and it is usually found as one ingredient in a blended product rather than sold alone.

If you choose to use a product that contains it, follow the directions on the label and do not exceed them. Avoid stacking it with other stimulants like caffeine or synephrine unless a healthcare professional says it is okay. When in doubt, ask a pharmacist to review the product with you.

Pregnancy & Breastfeeding

N-methyltyramine & Pregnancy

Insufficient reliable information

Insufficient reliable information is available; avoid using.

N-methyltyramine & Breastfeeding

Insufficient reliable information

Insufficient reliable information is available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 references that drive our N-methyltyramine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Pawar RS, Grundel E. Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs). Drug Test Anal 2017;9:500-517. PubMed
Stohs SJ, Hartman MJ. A review of the receptor binding and pharmacological effects of N-methyltyramine. Phytother Res. 2015;29(1):14-6.

Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

Brand directory

Brands that make products with N-methyltyramine

50 brands in our database make a supplement containing N-methyltyramine.

VPX 115 products Xcel Sports Nutrition 88 products

Product directory

Supplement products with N-methyltyramine

213 products in our database contain N-methyltyramine. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

N-methyltyramine: Common Questions

Does N-methyltyramine interact with prescription medications?

Yes. We list 344 medications with a known interaction with N-methyltyramine. Use the checker above to see how N-methyltyramine interacts with a specific drug.

How are N-methyltyramine interactions rated?

Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.

Is it safe to take N-methyltyramine with my medications?

It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.

Where does this N-methyltyramine interaction information come from?

Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.

What is N-methyltyramine used for?

It is mostly added to weight-loss, fat-burner, and pre-workout supplements because it is believed to act like a mild stimulant. However, there is little solid human evidence that it actually helps with these goals.

Is N-methyltyramine safe?

Its safety in humans has not been well studied. Because it may behave like a stimulant, people with heart problems, high blood pressure, or anxiety should be cautious, and everyone should check with a pharmacist or doctor first.

Can I take N-methyltyramine while pregnant or breastfeeding?

No reliable safety information exists for these situations, so it is best to avoid it during pregnancy and breastfeeding.

Is N-methyltyramine a natural compound?

Yes, it occurs naturally in plants such as bitter orange and barley, but it can also be made synthetically and added to supplements. "Natural" does not automatically mean safe or effective.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain N-methyltyramine

A rotating sample of real supplements in our database that list N-methyltyramine — open any to see its full ingredients and every drug interaction we check.

See all 213 products with N-methyltyramine →

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N-methyltyramine Drug Interactions, Uses, Safety & More

Your Choice:

Drugs that interact with N-methyltyramine

Don’t want to scroll the list? Just ask.

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Likelihood — How Well It’s Documented

Where This Data Comes From

The kinds of drugs N-methyltyramine affects

N-methyltyramine: Uses, Safety & Side Effects

Overview

Uses & effectiveness

How it works

Safety & precautions

Side effects

Dosing

N-methyltyramine & Pregnancy

N-methyltyramine & Breastfeeding

References & further reading

Brands that make products with N-methyltyramine

Supplement products with N-methyltyramine

N-methyltyramine: Common Questions

Related supplements & herbs

Products that contain N-methyltyramine

Have a question about N-methyltyramine?