Herb & supplement monograph

Senna Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Senna interacts with medications. The heart of this page is the interaction list — every drug Senna is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Senna is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Senna Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Senna drug interaction appears low for most people who use senna occasionally and as directed. None of the listed interactions are rated major, and almost all are theoretical concerns tied mainly to overusing senna rather than to typical short-term use.

Interactions deserving the most attention

The pairing we watch most closely is warfarin: in one reported case, heavy senna use for several weeks caused diarrhea and a sharply raised INR, which increases bleeding risk. Prolonged or excessive senna use can also deplete potassium, which matters for people taking digoxin or diuretics, since low potassium raises the chance of side effects with those medicines. There is also early human evidence that senna may reduce the absorption of estrogen medicines by speeding up how fast things move through the gut.

What the rest of the list means

Seeing senna paired with a long list of medications does not mean every combination is harmful. Most of these concerns are predicted from how senna works as a stimulant laxative rather than proven in people, and the real risks mostly come from overuse or long-term use, not occasional appropriate use.

Check your medications against Senna

Based on HelloPharmacist’s Senna interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Senna

140 medications have a known interaction with Senna, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual› Acetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES› AcetazolamideAk-Zol, Diamox› Amiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic› Ammonium ChlorideAmmonium Chloride› ArmodafinilNuvigil› Atenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic› Atenolol, ChlorthalidoneTenoretic› Azilsartan, ChlorthalidoneEdarbyclor› Bazedoxifene Acetate, Conjugated EstrogensDuavee› Benazepril, HydrochlorothiazideLotensin HCT› BendroflumethiazideAprinox, Naturetin, Neo-NaClex› Bendroflumethiazide, NadololCorzide› Bendroflumethiazide, PotassiumCentyl K, Neo-NaClex-K› Bendroflumethiazide, Rauwolfia SerpentinaRauzide› BenzthiazideExna› BisacodylDulcolax, Gentlax› Bisacodyl, DocusateDulcolax Laxative Tabs› Bisoprolol, HydrochlorothiazideZiac› BumetanideBurinex› Bumetanide, PotassiumBurinex K› Caffeine, Potassium Salicylate, SalicylamideTrim-Elim› Candesartan Cilexetil, HydrochlorothiazideAtacand HCT› Captopril, HydrochlorothiazideAcezide, Capozide› CasanthranolDoxidan Liquid Gels› Casanthranol, DocusateDoxidan› Casanthranol, Docusate PotassiumDialose Plus› Casanthranol, Docusate SodiumPeri-Colace› Castor Oil (otc Drug)Purge› ChlorothiazideDiuril›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Senna combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Senna affects

Every type of medication (drug category) Senna is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 5 drug categories Senna interacts with
Digoxin (lanoxin)Diuretic DrugsEstrogensStimulant LaxativesWarfarin (coumadin)
Digoxin (Lanoxin)

Theoretically, senna might increase the risk of adverse effects when taken with digoxin.
Overuse/abuse of senna increases the risk of adverse effects from cardiac glycosides, such as digoxin, due to potassium depletion.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of senna might compound diuretic-induced potassium loss and increase the risk for hypokalemia.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking senna may interfere with the absorption of exogenous estrogens.
Some preliminary clinical evidence suggests that senna reduces the absorption of estradiol and decreases serum concentrations of estrone and estrone sulfate by decreasing intestinal transit time.

Likelihood Possible Evidence B
Stimulant Laxatives

Theoretically, senna might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Senna is a stimulant laxative; concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, excessive use of senna might increase the effects of warfarin.
Senna has stimulant laxative effects and can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. In one case report, excessive use of senna for 3 weeks resulted in diarrhea, bloody stools, and an elevated INR of 11.9.

Likelihood Possible Evidence D
Monograph

Senna: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Senna is a plant-based stimulant laxative that is widely used and generally effective for short-term relief of constipation. It is best used occasionally and for only a few days at a time, since long-term use can lead to dependence and other problems. Talk with a pharmacist or doctor before using it regularly or if you have ongoing constipation.

Senna
Scientific name
Senna alexandrina
Family
Fabaceae
Part used
Leaves and pods (fruit)
Common forms
Tablets, capsules, tea, liquid extract, syrup
People commonly use it for
  • Short-term constipation relief
  • Bowel cleansing before procedures
  • Occasional irregularity
  • Traditional digestive remedy

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally safe for short-term occasional use but not for long-term daily use without medical advice.

PregnancyPossibly Safe

When used orally and appropriately, short-term. POSSIBLY UNSAFE...when used orally long-term or in high doses. Long-term, frequent use, or use of high...

Read the full pregnancy detail
BreastfeedingPossibly Safe

When used orally and appropriately, short term. Although small amounts of constituents of senna cross into breast milk, senna has been taken while bre...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Senna is a flowering plant in the legume family. It grows in warm, tropical, and subtropical parts of the world and has long been cultivated for its medicinal leaves and pods.

People have used senna for hundreds of years as a natural laxative to relieve constipation. Today it is found in many over-the-counter products and is often marketed as a "natural vegetable laxative." It comes in tablets, capsules, teas, and liquid extracts.

Senna works as a stimulant laxative, meaning it encourages the muscles of the intestines to move stool along. It is meant for short-term, occasional use rather than as a daily habit.

How it works

Senna contains active compounds called sennosides, which are found in the leaves and pods. After you swallow senna, bacteria in the colon break the sennosides down into substances that act directly on the lining of the large intestine.

These substances do two main things: they stimulate the muscles in the intestinal wall to contract, which pushes stool forward, and they increase the amount of water and salts in the bowel, which softens the stool. The combined effect usually produces a bowel movement within several hours.

This is why senna does not work instantly; it typically takes about 6 to 12 hours to have an effect, so it is often taken at bedtime.

Effectiveness

Does Senna work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 3 uses evaluated
1 Likely effective 1 Possibly effective 1 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Likely Effective Constipation
Rating & evidence shown verbatim from Natural Medicines

Taking senna orally is effective for the short-term treatment of constipation.

Possibly Effective Bowel preparation
Rating & evidence shown verbatim from Natural Medicines

Taking oral senna might be effective for bowel cleansing before colonoscopy.

Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Hyperkalemia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral senna is beneficial for reducing potassium levels.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

For most healthy adults, senna is considered reasonably safe when used occasionally and for a short time (generally no more than about one week unless a doctor advises otherwise). Using it for longer or in higher amounts can cause problems.

Long-term or frequent use can lead to a "lazy bowel," where the intestines become dependent on stimulant laxatives to move. It can also cause loss of fluids and important salts like potassium, which can affect the heart and muscles.

Do not use senna if you have unexplained stomach pain, nausea, vomiting, signs of a bowel blockage, appendicitis, or inflammatory bowel conditions unless your doctor tells you to. People with heart problems, kidney problems, or electrolyte imbalances should be especially careful.

Pregnancy: Senna is sometimes used short-term for constipation during pregnancy and is often considered an acceptable option under medical guidance, but you should only use it if your doctor recommends it. Breastfeeding: Only small amounts are thought to pass into breast milk at standard doses, and it is generally considered low risk, but check with your doctor or pharmacist first. Senna should not be given to children unless directed by a healthcare provider.

Side effects

The most common side effects are stomach cramps, bloating, and diarrhea, especially at higher doses. Senna may also cause a harmless reddish or brownish color in the urine.

With long-term use, more serious problems can occur, including dehydration, low potassium and other electrolyte imbalances, and dependence on laxatives. Long-term use may also cause a dark discoloration of the bowel lining (called melanosis coli), which is usually harmless and reversible.

Stop using senna and contact a healthcare provider if you have severe stomach pain, rectal bleeding, or no bowel movement after using a laxative, as these may signal a more serious problem.

Senna: Reported Adverse Effects

Documented safety reports on Senna from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, senna is generally well-tolerated when used short-term in appropriate doses.

Most Common Adverse Effects:

Orally: Abdominal pain and discomfort, cramps, diarrhea, flatulence, nausea, fecal urgency, and urine discoloration.

Serious Adverse Effects (Rare):

Orally: Skin eruptions.

Reports by condition
Burns Dermatologic

In adults, there are rare case reports of skin eruptions associated with senna, including erythema multiforme, fixed drug eruption, lichenoid reaction, toxic epidermal necrolysis, urticaria, photosensitivity, and contact dermatitis. Infants and young children given senna products have experienced contact reactions on the buttocks due to prolonged exposure to stool while wearing a diaper overnight. These reactions range from erythema with small blisters, to large fluid-filled blisters with skin sloughing, as occurs with second degree burns. In a case series of children treated with senna for chronic constipation, burn-like reactions occurred in 2.2%, typically with higher doses (mean 60 mg/day, range 35.2 to 150 mg/day). These reactions can be avoided by giving senna early in the day, so that bowel movements occur at a time when diapers can be changed quickly.

  1. Vilanova-Sanchez A, Gasior AC, Toocheck N, et al. Are Senna based laxatives safe when used as long term treatment for constipation in children? J Pediatr Surg 2018;53(4):722-7.
  2. Cogley K, Echevarria A, Correa C, De la Torre-Mondragón L. Contact Burn with Blister Formation in Children Treated with Sennosides. Pediatr Dermatol 2017;34(2):e85-e88.
Cachexia Musculoskeletal

Hypertrophic osteoarthropathy, finger clubbing, cachexia, and tetany have been reported from excessive oral senna use in humans.

  1. Prior J, White I. Tetany and clubbing in patient who ingested large quantities of senna. Lancet 1978;2:947.
  2. Lim, A. K., Hooke, D. H., and Kerr, P. G. Anorexia nervosa and senna misuse: nephrocalcinosis, digital clubbing and hypertrophic osteoarthropathy. Med J Aust. 1-21-2008;188(2):121-122.
  3. McLaughlin, A. F. Anorexia nervosa and senna misuse: nephrocalcinosis, digital clubbing and hypertrophic osteoarthropathy. Med J Aust. 9-15-2008;189(6):348.
  4. Levine, D., Goode, A. W., and Wingate, D. L. Purgative abuse associated with reversible cachexia, hypogammaglobulinaemia, and finger clubbing. Lancet 4-25-1981;1(8226):919-920.
  5. Malmquist, J., Ericsson, B., Hulten-Nosslin, M. B., Jeppsson, J. O., and Ljungberg, O. Finger clubbing and aspartylglucosamine excretion in a laxative-abusing patient. Postgrad.Med J 1980;56(662):862-864.
Colorectal adenoma Gastrointestinal

Orally, senna can cause abdominal pain and discomfort, cramps, bloating, flatulence, nausea, fecal urgency, and diarrhea. Chronic use has also been associated with "cathartic colon," radiographically diagnosed anatomical changes to the colon such as benign narrowing, colonic dilation, and loss of colonic folds. The clinical relevance of these findings is unclear. Chronic use can also cause pseudomelanosis coli (pigment spots in intestinal mucosa) which is harmless, usually reverses with discontinuation, and is not associated with an increased risk of developing colorectal adenoma or carcinoma. The cathartic properties of senna leaf are greater than the fruit. Thus, the American Herbal Products Association only warns against long-term use of senna leaf.

  1. Langmead L, Rampton DS. Review article: herbal treatment in gastrointestinal and liver disease--benefits and dangers. Aliment Pharmacol Ther 2001;15:1239-52.
  2. Sondheimer JM, Gervaise EP. Lubricant versus laxative in the treatment of chronic functional constipation of children: a comparative study. J Pediatr Gastroenterol Nutr 1982;1:223-6.
  3. Perkin JM. Constipation in childhood: a controlled comparison between lactulose and standardized senna. Curr Med Res Opin 1977;4:540-3.
  4. Shelton MG. Standardized senna in the management of constipation in the puerperium: A clinical trial. S Afr Med J 1980;57:78-80.
  5. Passmore AP, Davies KW, Flanagan PG, et al. A comparison of Agiolax and lactulose in elderly patients with chronic constipation. Pharmacology 1993;47:249-52.
  6. Passmore AP, Wilson-Davies K, Stoker C, Scott ME. Chronic constipation in long stay elderly patients: a comparison of lactulose and a senna-fibre combination. BMJ 1993;307:769-71.
  7. MacLennan WJ, Pooler AFWM. A comparison of sodium picosulphate ("Laxoberal") with standardised senna ("Senokot") in geriatric patients. Curr Med Res Opin. 1974;2:641-7.
  8. Coskun Y, Yuksel I. Polyethylene glycol versus split high-dose senna for bowel preparation: A comparative prospective randomized study. J Gastroenterol Hepatol 2020;35(11):1923-1929.
  9. Joo JS, Ehrenpreis ED, Gonzalez L, et al. Alterations in colonic anatomy induced by chronic stimulant laxatives: the cathartic colon revisited. J Clin Gastroenterol 1998;26:283-6.
  10. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5.
  11. van Os FH. Anthraquinone derivatives in vegetable laxatives. Pharmacology 1976;14:7-17.
  12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Hepatitis Hepatic

Chronic liver damage, portal vein thrombosis, and hepatitis have been reported following oral use of senna alkaloids, such as in tea made from senna leaves . There is a case report of hepatitis in a female who consumed moderate amounts of senna tea. The patient was a poor metabolizer of cytochrome P450 2D6 (CYP2D6). It's thought that moderate doses of senna in this patient led to toxic hepatitis due to the patient's reduced ability to metabolize and eliminate the rhein anthrone metabolites of senna, which are thought to cause systemic toxicity. There is also a case of liver failure, encephalopathy, and renal insufficiency in a female who consumed 1 liter/day of senna tea, prepared from 70 grams of dried senna fruit, over 3 years. In another case report, a 3-year-old female presented with hepatitis that led to pancytopenia after drinking tea made from 2-3 grams dry senna leaves three times or more weekly for over one year.

  1. Seybold U, Landauer N, Hillebrand S, Goebel FD. Senna-induced hepatitis in a poor metabolizer. Ann Intern Med 2004;141:650-1.
  2. Vanderperren B, Rizzo M, Angenot L, et al. Acute liver failure with renal impairment related to the abuse of senna anthraquinone glycosides. Ann Pharmacother 2005;39:1353-7.
  3. Stickel, F. and Schuppan, D. Herbal medicine in the treatment of liver diseases. Dig.Liver Dis. 2007;39(4):293-304.
  4. Sonmez, A., Yilmaz, M. I., Mas, R., Ozcan, A., Celasun, B., Dogru, T., Taslipinar, A., and Kocar, I. H. Subacute cholestatic hepatitis likely related to the use of senna for chronic constipation. Acta Gastroenterol.Belg. 2005;68(3):385-387.
  5. Beuers, U., Spengler, U., and Pape, G. R. Hepatitis after chronic abuse of senna. Lancet 2-9-1991;337(8737):372-373.
  6. Soyuncu, S., Cete, Y., and Nokay, A. E. Portal vein thrombosis related to Cassia angustifolia. Clin.Toxicol.(Phila) 2008;46(8):774-777.
  7. Haoudar A, Chekhlabi N, El Kettani C, Dini N. Acute Hepatitis and Pancytopenia in a Child With Chronic Abuse of Senna. Cureus 2021;13(1):e12436.
Pregnancy-related edema Immunologic

In one case report, a 19-year-old male developed anaphylaxis with dyspnea, facial edema, and hives. This reaction was determined to be caused by the senna content in a specific combination product (Delgaxan Plus, Pompadour Ibérica) that the patient ingested.

  1. Irazábal B, Sánchez de Vicente J, Galán C, et al. Anaphylaxis Due to Senna (Cassia angustifolia). J Investig Allergol Clin Immunol 2021;31(1):71-73.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no single "best" dose of senna for everyone, and the right amount depends on the specific product and the form used. The safest approach is to follow the directions on the product label or the advice of your pharmacist or doctor.

Senna is usually taken at bedtime so a bowel movement occurs the next morning. Use the lowest amount that works, and avoid using it for more than about a week unless a healthcare provider advises otherwise. Drinking plenty of water can help reduce side effects.

If you find you need a laxative regularly, talk with your pharmacist or doctor instead of increasing the dose on your own.

Pregnancy & Breastfeeding
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 42 references that drive our Senna monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 2001;108:776-89. PubMed
  4. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
  5. Seybold U, Landauer N, Hillebrand S, Goebel FD. Senna-induced hepatitis in a poor metabolizer. Ann Intern Med 2004;141:650-1. PubMed
  6. Vanderperren B, Rizzo M, Angenot L, et al. Acute liver failure with renal impairment related to the abuse of senna anthraquinone glycosides. Ann Pharmacother 2005;39:1353-7. PubMed
  7. Xing JH, Soffer EE. Adverse effects of laxatives. Dis Colon Rectum 2001;44:1201-9. PubMed
  8. Prior J, White I. Tetany and clubbing in patient who ingested large quantities of senna. Lancet 1978;2:947. PubMed
  9. Langmead L, Rampton DS. Review article: herbal treatment in gastrointestinal and liver disease--benefits and dangers. Aliment Pharmacol Ther 2001;15:1239-52. PubMed
  10. Joo JS, Ehrenpreis ED, Gonzalez L, et al. Alterations in colonic anatomy induced by chronic stimulant laxatives: the cathartic colon revisited. J Clin Gastroenterol 1998;26:283-6. PubMed
  11. Godding EW. Laxatives and the special role of senna. Pharmacology 1988;36:230-6. PubMed
  12. van Os FH. Anthraquinone derivatives in vegetable laxatives. Pharmacology 1976;14:7-17. PubMed
  13. Sondheimer JM, Gervaise EP. Lubricant versus laxative in the treatment of chronic functional constipation of children: a comparative study. J Pediatr Gastroenterol Nutr 1982;1:223-6. DOI
  14. Perkin JM. Constipation in childhood: a controlled comparison between lactulose and standardized senna. Curr Med Res Opin 1977;4:540-3. PubMed
  15. Shelton MG. Standardized senna in the management of constipation in the puerperium: A clinical trial. S Afr Med J 1980;57:78-80.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Senna

257 brands in our database make a supplement containing Senna.

Product directory

Supplement products with Senna

764 products in our database contain Senna. Open any to see its full ingredient list and every drug interaction we check.

Aramhills Powder by Herbal Hills Powder 100 Gram(s) View ingredients & interactions Arsohills by Herbal Hills Tablet Or Pill 900 Tablet(s) View ingredients & interactions Arsohills by Herbal Hills Tablet Or Pill 900 Tablet(s) View ingredients & interactions Arsohills by Herbal Hills Tablet Or Pill 120 Tablet(s) View ingredients & interactions Artemisia Complex by MBi Nutraceuticals Capsule 90 Capsule(s) View ingredients & interactions Artemisiacom by Energique Liquid 2 Fluid Ounce(s) · 59 mL View ingredients & interactions AtraFen Pro-3 by NutraTech Capsule 60 Capsule(s) View ingredients & interactions Bio-Lax by MBi Nutraceuticals Capsule 90 Capsule(s) View ingredients & interactions Blood Pressure Vitality by U.S. Doctors' Clinical Capsule 60 Capsule(s) View ingredients & interactions Bowel Cleansing Formula by TerraVita Premium Collection Powder 4 Oz(s) View ingredients & interactions Bowel Cleansing Formula by TerraVita Premium Collection Powder 1 Oz(s) View ingredients & interactions Bowel Cleansing Formula by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Bowel Cleansing Formula by TerraVita Premium Collection Capsule 100 Capsule(s) View ingredients & interactions Bowel Cleansing Formula Chocolate Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Bowel Cleansing Formula Mint Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Bowel Cleansing Formula Strawberry Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Bowel Cleansing Formula Vanilla Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Cape Aloe Lax by Vitabase Capsule 90 Capsule(s) View ingredients & interactions Carmelite Water Blend by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Carmelite Water Blend Chocolate Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Carmelite Water Blend Mint Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Carmelite Water Blend Strawberry Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Carmelite Water Blend Vanilla Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions CCE-W by Pure Herbs Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions
Pharmacist Counseling Corner

Senna: Common Questions

What is Senna used for, and does it work?
People use Senna for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Senna for Constipation and Bowel preparation. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Senna interact with prescription medications?
Yes. We list 140 medications with a known interaction with Senna. Use the checker above to see how Senna interacts with a specific drug.
How are Senna interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Senna with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Senna interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Senna used for?
Senna is mainly used as a short-term laxative to relieve occasional constipation. It is also sometimes used to clear the bowel before medical procedures like a colonoscopy.
How long does Senna take to work?
Senna usually produces a bowel movement within about 6 to 12 hours, which is why it is often taken at bedtime to work overnight.
Is it safe to take Senna every day?
Senna is meant for short-term, occasional use. Taking it daily for long periods can lead to dependence, dehydration, and loss of important salts, so check with your doctor if you need a laxative regularly.
Can Senna help with weight loss?
No. There is no good evidence that Senna helps with weight loss, and using laxatives this way can be dangerous and lead to dehydration and electrolyte problems.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Senna

A rotating sample of real supplements in our database that list Senna — open any to see its full ingredients and every drug interaction we check.

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