Medication interaction hub

What Supplements Interact with Baricitinib?

Baricitinib brand name: Olumiant. Every interaction below applies to the brands too.

59 Interactions 4 Major 46 Moderate 9 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Baricitinib? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Baricitinib against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Liver strain dominates this page. Baricitinib (Olumiant), a JAK inhibitor for rheumatoid arthritis and alopecia areata, can raise liver enzymes on its own, so I'd approach these combinations warily, since nearly two thirds of the listed supplements carry their own record of liver injury, and ordinary beer and wine sit among the highest-rated risks for the same reason. Siberian cocklebur, an herb tied to outright liver failure, heads the list.

A smaller cluster works at the gut instead. Activated charcoal can soak up baricitinib and cut how much reaches your blood, and bulky fibers may blunt absorption too, so space them well apart from your dose. Four ingredients may also slow the drug's exit through the kidneys, nudging its levels up. All told there are 59 entries, 46 moderate and nine minor, but the four rated major, charcoal, cocklebur, and alcohol in both forms, carry the real weight here.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 46 Minor 9 No known interaction 1,393

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Baricitinib: Top Interactions at a Glance

The most significant Baricitinib supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 59 interacting ingredients — plus 1,393 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Baricitinib + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Baricitinibi

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Probable Activated Charcoal + Baricitinibi

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Beer + Baricitinibi

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable Wine + Baricitinibi

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Baricitinib

All 1,452 ingredients in our database, ranked by severity — 59 with a Baricitinib interaction on file and 1,393 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Baricitinib?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Kudzu with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Kudzu + Baricitinib answer

Can you take Ligandrol with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Ligandrol + Baricitinib answer

Can you take Manchurian Thorn with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that high doses of Manchurian thorn can induce liver damage.

Full Manchurian Thorn + Baricitinib answer

Can you take Niacin with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Full Niacin + Baricitinib answer

Can you take Noni with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.

Full Noni + Baricitinib answer

Can you take Ostarine with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.

Full Ostarine + Baricitinib answer

Can you take Padang Cassia with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that ingesting large amounts of Padang cassia might cause hepatotoxicity in some people.

Full Padang Cassia + Baricitinib answer

Can you take Quercetin with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the effects and adverse effects of OAT3 substrates.

Full Quercetin + Baricitinib answer

Can you take Red Yeast Rice with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of liver damage.

Full Red Yeast Rice + Baricitinib answer

Can you take Rhubarb with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.

Full Rhubarb + Baricitinib answer

Can you take Saigon Cinnamon with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Saigon Cinnamon + Baricitinib answer

Can you take Slippery Elm with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Baricitinib answer

Can you take Spearmint with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Spearmint + Baricitinib answer

Can you take Sweet Annie with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Sweet Annie + Baricitinib answer

Can you take Sweet Clover with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.

Full Sweet Clover + Baricitinib answer

Can you take Syrian Rue with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of Syrian rue might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Syrian Rue + Baricitinib answer

Can you take Testolone with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Testolone + Baricitinib answer

Can you take Tragacanth with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Baricitinib answer

Can you take Turmeric with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Turmeric + Baricitinib answer

Can you take Vitamin A with Baricitinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disea...

Full Vitamin A + Baricitinib answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Baricitinib is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Baricitinib, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Baricitinib sits in 3 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Baricitinib through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Baricitinib through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Baricitinib through this category.

About Baricitinib

Baricitinib is a JAK inhibitor used to treat moderately to severely active rheumatoid arthritis, severe alopecia areata, and hospitalized adults with COVID-19 requiring breathing support.

Generic name: Baricitinib  ·  Brand name: Olumiant.

See the full Baricitinib drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Baricitinib

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Baricitinib.

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Products that contain Baricitinib-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Baricitinib.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Baricitinib & Supplements: Common Questions

What supplements interact with Baricitinib?
In our interaction database, 59 supplement and herbal ingredients have an interaction with Baricitinib on file — 4 rated major, 46 moderate, and 9 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Baricitinib supplement interactions are the most serious?
The 4 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Beer and Wine — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Baricitinib?
That depends entirely on which supplement. The honest answer for Baricitinib is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Olumiant have the same supplement interactions as Baricitinib?
Yes — Olumiant all contain Baricitinib, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Baricitinib and my other medications?
This page covers Baricitinib against supplements and herbal ingredients. Checking Baricitinib against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Baricitinib drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.