Medication interaction hub

What Supplements Interact with Butalbital, Phenobarbital, Secobarbital?

Butalbital, Phenobarbital, Secobarbital brand name: Tribarb. Every interaction below applies to the brands too.

151 Interactions 8 Major 124 Moderate 19 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Butalbital, Phenobarbital, Secobarbital? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Butalbital, Phenobarbital, Secobarbital against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Barbiturates leave little margin for error, and the butalbital, phenobarbital, and secobarbital combination sold as Tribarb is no exception, so its 151 supplement and herbal interactions deserve genuine care. Seventy-eight of those ingredients deepen the drug's sedation, which at the worst end means dangerously slowed breathing. Alcohol, even a casual beer or glass of wine, sits among the eight major-rated entries for exactly that reason, alongside several sedating herbs.

St. John's wort pulls the opposite direction, speeding phenobarbital's breakdown until blood levels can drop enough to matter, and nineteen other ingredients nudge the same liver enzymes more mildly. The remaining 124 moderate and 19 minor entries are mostly gentler versions of the sedation theme. Folic acid is a quieter concern, since it can undercut phenobarbital's seizure control in some people, and charcoal or thick fiber products can blunt absorption, so space those well apart from your dose.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 124 Minor 19 No known interaction 1,301

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Butalbital, Phenobarbital, Secobarbital: Top Interactions at a Glance

The Butalbital, Phenobarbital, Secobarbital supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 151 interacting ingredients — plus 1,301 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Butalbital, Phenobarbital, Secobarbital Combinations Today

The Butalbital, Phenobarbital, Secobarbital + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Glutamine + Butalbital, Phenobarbital, Secobarbitali

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.

Read the full interaction Moderate Likelihood Possible Boneset + Butalbital, Phenobarbital, Secobarbitali

Boneset belongs to the genus Eupatorium, and many species of this genus contain hepatotoxic pyrrolizidine alkaloids (PAs).

Read the full interaction Moderate Likelihood Possible Sassafras + Butalbital, Phenobarbital, Secobarbitali

Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.

Read the full interaction Moderate Likelihood Possible Gravel Root + Butalbital, Phenobarbital, Secobarbitali

Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4).

Read the full interaction Moderate Likelihood Possible Oregon Grape + Butalbital, Phenobarbital, Secobarbitali

Theoretically, Oregon grape might increase the sedative effects of CNS depressants.

Read the full interaction Major Likelihood Likely Beer + Butalbital, Phenobarbital, Secobarbitali

Concomitant use may increase sedative and other adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Butalbital, Phenobarbital, Secobarbital

All 1,452 ingredients in our database, ranked by severity — 151 with a Butalbital, Phenobarbital, Secobarbital interaction on file and 1,301 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Butalbital, Phenobarbital, Secobarbital?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Glutamine with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glutamine might antagonize the effects of anticonvulsant medications.

Full Glutamine + Butalbital, Phenobarbital, Secobarbital answer

Can you take Boneset with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Boneset belongs to the genus Eupatorium, and many species of this genus contain hepatotoxic pyrrolizidine alkaloids (PAs).

Full Boneset + Butalbital, Phenobarbital, Secobarbital answer

Can you take Sassafras with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.

Full Sassafras + Butalbital, Phenobarbital, Secobarbital answer

Can you take Gravel Root with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4).

Full Gravel Root + Butalbital, Phenobarbital, Secobarbital answer

Can you take Oregon Grape with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the sedative effects of CNS depressants.

Full Oregon Grape + Butalbital, Phenobarbital, Secobarbital answer

Can you take Adrue with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold comp...

Full Adrue + Butalbital, Phenobarbital, Secobarbital answer

Can you take African Wild Potato with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that African wild potato extract inhibits cytochrome P450 2B6 (CYP2B6).

Full African Wild Potato + Butalbital, Phenobarbital, Secobarbital answer

Can you take Albizia Julibrissin with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that certain constituents from Albizia julibrissin flowers can potentiate pentobarbital-induced sleeping time in mi...

Full Albizia Julibrissin + Butalbital, Phenobarbital, Secobarbital answer

Can you take Alkanna with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hepatotoxic pyrrolizidine alkaloids (PAs) are substrates of cytochrome P450 3A4 (CYP3A4).

Full Alkanna + Butalbital, Phenobarbital, Secobarbital answer

Can you take Alpine Ragwort with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in alpine ragwor...

Full Alpine Ragwort + Butalbital, Phenobarbital, Secobarbital answer

Can you take Artichoke with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.

Full Artichoke + Butalbital, Phenobarbital, Secobarbital answer

Can you take Ashwagandha with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Full Ashwagandha + Butalbital, Phenobarbital, Secobarbital answer

Can you take Astaxanthin with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.

Full Astaxanthin + Butalbital, Phenobarbital, Secobarbital answer

Can you take Bay Leaf with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking bay leaf in large amounts may enhance the therapeutic and adverse effects of sedatives.

Full Bay Leaf + Butalbital, Phenobarbital, Secobarbital answer

Can you take Berberine with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase the sedative effects of CNS depressants.

Full Berberine + Butalbital, Phenobarbital, Secobarbital answer

Can you take Bitter Almond with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter almond oil may have additive effects with other CNS depressants.

Full Bitter Almond + Butalbital, Phenobarbital, Secobarbital answer

Can you take Black Seed with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full Black Seed + Butalbital, Phenobarbital, Secobarbital answer

Can you take Black Tea with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black tea might reduce the effects of phenobarbital and increase the risk for convulsions.

Full Black Tea + Butalbital, Phenobarbital, Secobarbital answer

Can you take Borage with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.

Full Borage + Butalbital, Phenobarbital, Secobarbital answer

Can you take Butterbur with Butalbital, Phenobarbital, Secobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.

Full Butterbur + Butalbital, Phenobarbital, Secobarbital answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Butalbital, Phenobarbital, Secobarbital is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Butalbital, Phenobarbital, Secobarbital, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Butalbital, Phenobarbital, Secobarbital sits in 10 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Butalbital, Phenobarbital, Secobarbital through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Butalbital, Phenobarbital, Secobarbital through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Butalbital, Phenobarbital, Secobarbital through this category.

Phenobarbital (Luminal) 16 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

16 of the supplement ingredients on this page reach Butalbital, Phenobarbital, Secobarbital through this category.

Anticonvulsants 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Butalbital, Phenobarbital, Secobarbital through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Butalbital, Phenobarbital, Secobarbital through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Butalbital, Phenobarbital, Secobarbital through this category.

Cytochrome P450 2C9 (Cyp2C9) Inducers 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Butalbital, Phenobarbital, Secobarbital through this category.

Cytochrome P450 2C19 (Cyp2C19) Inducers 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Butalbital, Phenobarbital, Secobarbital through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Butalbital, Phenobarbital, Secobarbital through this category.

Related: does Butalbital, Phenobarbital, Secobarbital deplete any nutrients?

Butalbital, Phenobarbital, Secobarbital has 8 reported nutrient associations in the research literature — see the Butalbital, Phenobarbital, Secobarbital nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Butalbital, Phenobarbital, Secobarbital

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Butalbital, Phenobarbital, Secobarbital.

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Type a product name, brand, or UPC — smart search across our full catalog.

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Products that contain Butalbital, Phenobarbital, Secobarbital-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Butalbital, Phenobarbital, Secobarbital.

Standardized St. John's Wort 600 mg by Nature's Truth contains St. John's Wort St. John's Wort-IMT by SP Standard Process contains St. John's Wort St John's Wort Extract by SuperSmart contains St. John's Wort St John's Wort 400 mg by Signature Supplements contains St. John's Wort
Pharmacist Counseling Corner

Butalbital, Phenobarbital, Secobarbital & Supplements: Common Questions

What supplements interact with Butalbital, Phenobarbital, Secobarbital?
Our database currently documents 151 ingredients with a known Butalbital, Phenobarbital, Secobarbital interaction (8 major, 124 moderate, 19 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 151. The highest-ranked right now: Beer, St. John's Wort, Wine.
Which Butalbital, Phenobarbital, Secobarbital supplement interactions are the most serious?
The 8 major-rated combinations — led by Beer, St. John's Wort, Wine, 1,4-butanediol and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Butalbital, Phenobarbital, Secobarbital?
Plenty of supplements coexist fine with Butalbital, Phenobarbital, Secobarbital; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Tribarb have the same supplement interactions as Butalbital, Phenobarbital, Secobarbital?
Yes — Tribarb all contain Butalbital, Phenobarbital, Secobarbital, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Butalbital, Phenobarbital, Secobarbital deplete any vitamins or nutrients?
It might — Butalbital, Phenobarbital, Secobarbital has 8 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Butalbital, Phenobarbital, Secobarbital nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Butalbital, Phenobarbital, Secobarbital and my other medications?
This page covers Butalbital, Phenobarbital, Secobarbital against supplements and herbal ingredients. Checking Butalbital, Phenobarbital, Secobarbital against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.