Drug & supplement interaction

Grape + Butalbital, Phenobarbital, Secobarbital

Butalbital, Phenobarbital, Secobarbital brand name: Tribarb.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Grape and Butalbital, Phenobarbital, Secobarbital in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Grape and Butalbital, Phenobarbital, Secobarbital

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Butalbital, Phenobarbital, Secobarbital and Grape in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Grape safety at a glance

Grape overall Generally safe Grapes as food are safe for most people, and grape seed extract appears generally well tolerated in studies.
Pregnancy Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of medicinal amounts during pregnancy... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of medicinal amounts during pregnancy... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Butalbital, Phenobarbital, Secobarbital and Grape? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Butalbital, Phenobarbital, Secobarbital

Interactions in our licensed database are recorded against drug classes, not just single drug names. Butalbital, Phenobarbital, Secobarbital is filed under 10 classifications — including cytochrome p450 2b6 (cyp2b6) substrates, cytochrome p450 2c9 (cyp2c9) inducers, barbiturates. Grape has documented interactions with 9 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), cyclosporine (neoral, sandimmune) (moderate) and cytochrome p450 1a2 (cyp1a2) substrates (moderate) — and none of Butalbital, Phenobarbital, Secobarbital’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Grape Does Interact With Other Medications

Grape has 868 moderate, 42 minor known drug interactions in our database — Butalbital, Phenobarbital, Secobarbital isn’t one of them. If you take anything else, check it against the full list below.

Moderate 868 Minor 42 No known interaction 1,920 (incl. Butalbital, Phenobarbital, Secobarbital)
Taking anything else?

Check Another of Your Medications Against Grape

Covers the 2,830 medications we’ve checked against Grape. Pick one to open its full report.

What to actually watch for

What Grape Itself Has Been Linked To

This is not an interaction — nothing below involves Butalbital, Phenobarbital, Secobarbital. It is the side-effect record for Grape on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Grape, this list is the first place to look. 5 entries are worth acting on rather than waiting out — marked below.

  • A bowel blockage Worth acting on Additional detail

    “Orally, abdominal pain and nausea have been reported with use of grape seed extract, but these effects typically occur at rates similar to placebo. In a case report of a 57-year-old man, intermittent nausea, vomiting, and diarrhea occurred over a 10-day period and improved once grape seed extract was stopped.”

    Grape · Natural Medicines adverse-effect record, reported in constipation.

    6 sources cited
    1. 9182. Bernstein DI, Bernstein CK, Deng C, et al. Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 2002;88:272-8.. PubMed
    2. 13162. Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. PubMed
    3. 96764. Berry AC, Nakshabendi R, Abidali H, et al. Adverse effects of grape seed extract supplement: A clinical case and long-term follow-up. J Diet Suppl. 2016;13(2):232-5. PubMed
    4. 100954. Moon SW, Shin YU, Cho H, Bae SH, Kim HK; and for the Mogen Study Group. Effect of grape seed proanthocyanidin extract on hard exudates in patients with non-proliferative diabetic retinopathy. Medicine (Baltimore) 2019;98(21):e15515. PubMed
    5. 2538. Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
    6. 52985. Schaefer, E., Peil, H., Ambrosetti, L., and Petrini, O. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency. A 6-week observational clinical trial. Arzneimittelforschun PubMed
  • Wheezing Worth acting on Additional detail

    “Orally, nasopharyngitis and oropharyngeal pain have been reported with use of a specific grape leaf extract AS195 (Antistax, Boehringer Ingelheim Pharma GmbH & Co. KG). Sore throat, cough, allergic rhinitis, and nasopharyngitis have been reported with use of grape seed extract, but these effects occur at rates similar to placebo.”

    Grape · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    6 sources cited
    1. 53206. Rabe, E., Stucker, M., Esperester, A., Schafer, E., and Ottillinger, B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur.J Vasc.Endovasc. PubMed
    2. 9182. Bernstein DI, Bernstein CK, Deng C, et al. Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 2002;88:272-8.. PubMed
    3. 91541. Ras RT, Zock PL, Zebregs YE, et al. Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension. Br J Nutr 2013;110(12):2234-41. PubMed
    4. 53301. Brito, FF., Martinez, A., Palacios, R., Mur, P., Gomez, E., Galindo, P. A., Borja, J., and Martinez, J. Rhinoconjunctivitis and asthma caused by vine pollen: a case report. J Allergy Clin Immunol 1999;103(2 Pt 1):262-266. PubMed
    5. 53080. Samet, J. M. and Coultas, D. B. Reduced forced vital capacity in California grape workers. What does it mean? Am Rev.Respir.Dis 1992;145(2 Pt 1):255-256. PubMed
    6. 53081. Gamsky, T. E., McCurdy, S. A., Samuels, S. J., and Schenker, M. B. Reduced FVC among California grape workers. Am Rev.Respir.Dis 1992;145(2 Pt 1):257-262. PubMed
  • A severe allergic reaction Worth acting on Additional detail

    “Orally, there is one report of an anaphylactic reaction to oral grape skin extract, which included urticaria and angioedema.”

    Grape · Natural Medicines adverse-effect record, reported in urticaria.

    1 source cited
    1. 4073. Vaswani SK, Hamilton RG, Carey RN, et al. Anaphylaxis recurrent urticaria and angioedema from grape hypersensitivity. J Allergy Clin Immunol 1998;101:S31.
  • Hives Worth acting on Additional detail

    “Orally, mild hair thinning has been reported in a patient taking a specific grape leaf extract AS195 (Antistax, Boehringer Ingelheim Pharma GmbH & Co. KG). Urticaria (hives) has also been reported with this same extract. Cases of contact dermatitis have been reported in grape workers, including those working in California vineyards.”

    Grape · Natural Medicines adverse-effect record, reported in dermatitis.

    5 sources cited
    1. 2538. Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
    2. 53206. Rabe, E., Stucker, M., Esperester, A., Schafer, E., and Ottillinger, B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur.J Vasc.Endovasc. PubMed
    3. 53270. McCurdy, S. A., Wiggins, P., Schenker, M. B., Munn, S., Shaieb, A. M., Weinbaum, Z., Goldsmith, D., McGillis, S. T., Berman, B., and Samuels, S. Assessing dermatitis in epidemiologic studies: occupational skin disease among California grape and tomato ha
    4. 53272. Winter, C. K. and Kurtz, P. H. Factors influencing grape worker susceptibility to skin rashes. Bull.Environ.Contam Toxicol. 1985;35(3):418-426. PubMed
    5. 53275. Yamasaki, R., Dekio, S., and Jidoi, J. Contact dermatitis from grape bud. Contact Dermatitis 1985;12(4):226-227. PubMed
  • Bleeding or bruising Worth acting on Additional detail

    “Orally, one case of leg hematoma following a minor trauma was reported in a person using grape leaf extract. Also, one case of bruising was reported in a person drinking Concord grape juice daily for 2 weeks.”

    Grape · Natural Medicines adverse-effect record, reported in critical illness (trauma).

    2 sources cited
    1. 2538. Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
    2. 52972. O'Byrne, D. J., Devaraj, S., Grundy, S. M., and Jialal, I. Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin.Nutr. 2002;76(6):1367-1374.
  • Bloating or gas Additional detail

    Recorded for Grape in the same Natural Medicines adverse-effect record shown under A bowel blockage above.

  • Hair loss Additional detail

    Recorded for Grape in the same Natural Medicines adverse-effect record shown under Hives above.

  • A stuffy or runny nose / Sore throat Additional detail

    Recorded for Grape in the same Natural Medicines adverse-effect record shown under Wheezing above.

  • Dry mouth Additional detail

    Recorded for Grape in the same Natural Medicines adverse-effect record shown under A severe allergic reaction above.

Showing the 10 most notable of 23 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Grape — expand a row for the licensed statement it rests on. We haven’t matched Butalbital, Phenobarbital, Secobarbital to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Butalbital, Phenobarbital, Secobarbital.

Special populations

Grape in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of medicinal amounts during pregnancy and breast-feeding; avoid using in amounts greater than what is commonly found in foods.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Grape or Butalbital, Phenobarbital, Secobarbital

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Grape or Butalbital, Phenobarbital, Secobarbital, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Butalbital, Phenobarbital, Secobarbital

This page covers Grape only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Butalbital, Phenobarbital, Secobarbital page lists 151 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 8 major · 124 moderate · 19 minor.

From our pharmacist’s overview on the Butalbital, Phenobarbital, Secobarbital page

“Barbiturates leave little margin for error, and the butalbital, phenobarbital, and secobarbital combination sold as Tribarb is no exception, so its 151 supplement and herbal interactions deserve genuine care. Seventy-eight of those ingredients deepen the drug's sedation, which at the worst end means dangerously slowed breathing.”

Reviewed by 2 · Jul 18, 2026

Open the Butalbital, Phenobarbital, Secobarbital interaction page

One more smart check

Taking Grape as Part of a Dietary Supplement Product? Check It for Interactions

We hold 8,053 real supplement products containing Grape, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Grape. Even though Grape itself has no known interaction with Butalbital, Phenobarbital, Secobarbital, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Grape and Butalbital, Phenobarbital, Secobarbital Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Grape
Top 5%

#33 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Butalbital, Phenobarbital, Secobarbital
Steady interest

#2,279 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Grape reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Grape and Butalbital, Phenobarbital, Secobarbital records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Grape

What is Grape?

Grape
  • Antioxidant support
  • Heart and circulation health
  • Vein problems (such as varicose veins)
  • Eye health
  • General anti-inflammatory support

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and blood vessel health. While the food is healthy and generally safe, the supplement evidence for treating specific conditions is mostly limited or preliminary. Talk with your pharmacist or doctor before starting a grape supplement.

Vitis vinifera · Vitaceae · Fruit, skin, seed, and leaves · Fresh fruit, juice, wine, capsules, tablets, grape seed extract, and standardized extracts

An interaction check asks whether these two react with each other — it does not ask whether Grape is a good idea for someone in your situation. Here is what our Grape record says about it on its own.

Grape: dosing

There is no single official or proven dose for grape supplements. The right amount can depend on the specific product, the form (such as grape seed extract), and how it is standardized.Because products vary widely in strength, the best approach is to follow the directions on the product label and not exceed the recommended amount. They can help you decide whether a grape supplement is appropriate for you.

From our Grape monograph — the full record covers uses, side effects and every documented interaction.

Read the full Grape monograph & all interactions
Keep checking

Other Drugs & Grape

Browse every other medication we’ve checked against Grape — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
868Moderate
42Minor
1,919No known interaction
868 Moderate 42 Minor 1,919 No interaction
Moderate

868 interactions

Showing 60 of 868 moderate interactions — see all 868 on the Grape page.

Minor

42 interactions

No interaction 1,919 drugs checked — show the list

We also checked Grape against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,919 medications checked with no known interaction — see the full Grape list.

See the full Grape interactions page
See every supplement checked against Butalbital, Phenobarbital, Secobarbital, ranked by severity
Evidence & sources

Grape References

The 34 references that drive our Grape monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
  2. Xiao Dong S, Zhi Ping Z, Zhong Xiao W, et al. Possible enhancement of the first-pass metabolism of phenacetin by ingestion of grape juice in Chinese subjects. Br J Clin Pharmacol 1999;48:638-40. PubMed
  3. Vaswani SK, Hamilton RG, Carey RN, et al. Anaphylaxis recurrent urticaria and angioedema from grape hypersensitivity. J Allergy Clin Immunol 1998;101:S31.
  4. Chevallier A. The Encyclopedia of Medicinal Plants. London, UK: Dorling Kindersley, Ltd., 1996.
  5. Bernstein DI, Bernstein CK, Deng C, et al. Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 2002;88:272-8.. PubMed
  6. Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
  7. Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. PubMed
  8. Ray, S. D., Parikh, H., Hickey, E., Bagchi, M., and Bagchi, D. Differential effects of IH636 grape seed proanthocyanidin extract and a DNA repair modulator 4-aminobenzamide on liver microsomal cytochrome 4502E1-dependent aniline hydroxylation. Mol Cell B PubMed
  9. O'Byrne, D. J., Devaraj, S., Grundy, S. M., and Jialal, I. Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin.Nutr. 2002;76(6):1367-1374.
  10. Schaefer, E., Peil, H., Ambrosetti, L., and Petrini, O. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency. A 6-week observational clinical trial. Arzneimittelforschun PubMed
  11. Nishikawa, M., Ariyoshi, N., Kotani, A., Ishii, I., Nakamura, H., Nakasa, H., Ida, M., Nakamura, H., Kimura, N., Kimura, M., Hasegawa, A., Kusu, F., Ohmori, S., Nakazawa, K., and Kitada, M. Effects of continuous ingestion of green tea or grape seed extra
  12. de Lange, D. W., Scholman, W. L., Kraaijenhagen, R. J., Akkerman, J. W., and van de Wiel, A. Alcohol and polyphenolic grape extract inhibit platelet adhesion in flowing blood. Eur.J Clin.Invest 2004;34(12):818-824. PubMed
  13. Samet, J. M. and Coultas, D. B. Reduced forced vital capacity in California grape workers. What does it mean? Am Rev.Respir.Dis 1992;145(2 Pt 1):255-256. PubMed
  14. Gamsky, T. E., McCurdy, S. A., Samuels, S. J., and Schenker, M. B. Reduced FVC among California grape workers. Am Rev.Respir.Dis 1992;145(2 Pt 1):257-262. PubMed
  15. de Lange, D. W., Verhoef, S., Gorter, G., Kraaijenhagen, R. J., van de Wiel, A., and Akkerman, J. W. Polyphenolic grape extract inhibits platelet activation through PECAM-1: an explanation for the French paradox. Alcohol Clin.Exp.Res 2007;31(8):1308-1314 PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Grape and Butalbital, Phenobarbital, Secobarbital Together: Common Questions

Is it safe to take Grape with Butalbital, Phenobarbital, Secobarbital?
We do not list a known interaction between Grape and Butalbital, Phenobarbital, Secobarbital. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Grape and Butalbital, Phenobarbital, Secobarbital combination checked?
Interactions in our licensed database are recorded against drug classes. Butalbital, Phenobarbital, Secobarbital is filed under 10 classifications, and Grape has documented interactions with 9 drug classes — none of Butalbital, Phenobarbital, Secobarbital's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Grape interact with any other medications?
Yes. Grape has 910 documented drug interactions in our database — Butalbital, Phenobarbital, Secobarbital is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Butalbital, Phenobarbital, Secobarbital interact with any supplements?
Yes. Butalbital, Phenobarbital, Secobarbital has documented interactions with 151 supplements in our database — Grape is not one of them. The Butalbital, Phenobarbital, Secobarbital interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Grape monograph Uses, safety profile, and every drug interaction in one place Butalbital, Phenobarbital, Secobarbital supplement interactions Every supplement checked against Butalbital, Phenobarbital, Secobarbital, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 34 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Butalbital, Phenobarbital, Secobarbital and Grape?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.