Medication interaction hub

What Supplements Interact with hydrocortisone, pyrilamine, chlorpheniramine?

hydrocortisone, pyrilamine, chlorpheniramine brand name: HC Derma-Pax Liquid. Every interaction below applies to the brands too.

24 Interactions 1 Major 20 Moderate 3 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with hydrocortisone, pyrilamine, chlorpheniramine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check hydrocortisone, pyrilamine, chlorpheniramine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

HC Derma-Pax Liquid (hydrocortisone with pyrilamine and chlorpheniramine) looks like a simple anti-itch product, yet 21 of its 24 supplement interactions exist because its antihistamine ingredients also act on serotonin. Herbs and amino acids that raise serotonin, St. John's wort among them, can stack with that effect and edge toward serotonin syndrome, so this is a list to treat with genuine respect. The single major-rated entry is lithium, backed by a case report, and it deserves your attention before anything else.

The other three entries act on the skin itself. DMSO is the notable one, since it can carry more of the medication through the skin than the label intends. With 20 of the 24 rated moderate and three minor, lithium stands alone at the severe end, but the warning signs of too much serotonin (agitation, fast heartbeat, fever, twitching muscles) are worth learning before adding any serotonin-boosting supplement while using this product.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 20 Minor 3 No known interaction 1,428

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

hydrocortisone, pyrilamine, chlorpheniramine: Top Interactions at a Glance

The most significant hydrocortisone, pyrilamine, chlorpheniramine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 24 interacting ingredients — plus 1,428 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant hydrocortisone, pyrilamine, chlorpheniramine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Lithium + hydrocortisone, pyrilamine, chlorpheniraminei

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full interaction
The complete list

Every Supplement Checked Against hydrocortisone, pyrilamine, chlorpheniramine

All 1,452 ingredients in our database, ranked by severity — 24 with a hydrocortisone, pyrilamine, chlorpheniramine interaction on file and 1,428 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With hydrocortisone, pyrilamine, chlorpheniramine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Lithium with hydrocortisone, pyrilamine, chlorpheniramine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Full Lithium + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take 5-htp with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.

Full 5-htp + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take Acetyl-l-carnitine with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstr...

Full Acetyl-l-carnitine + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take Ayahuasca with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase levels of serotonin, which may have additive effects with serotonergic drugs.

Full Ayahuasca + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take Black Cohosh with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with black cohosh might cause additive serotonergic effects.

Full Black Cohosh + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take Black Seed with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndro...

Full Black Seed + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take Dimethylsulfoxide (dmso) with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Topical DMSO might increase the effects and adverse effects of topical drugs.

Full Dimethylsulfoxide (dmso) + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take Ergot with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Certain ergot alkaloids, such as dihydroergotamine, act as serotonin agonists.

Full Ergot + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take Fermented Wheat Germ Extract with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of fermented wheat germ extract with serotonergic medications may increase the risk of serotonergic adverse e...

Full Fermented Wheat Germ Extract + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take Garcinia with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin sy...

Full Garcinia + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take Hawaiian Baby Woodrose with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may increase the risk for serotonergic adverse effects.

Full Hawaiian Baby Woodrose + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take Iboga with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking iboga with serotonergic drugs might increase levels of serotonin, resulting in additive effects with serotonergic drug...

Full Iboga + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take Kratom with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking kratom in combination with serotonergic drugs may increase levels of serotonin, increasing the risk of serotonin syndr...

Full Kratom + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take L-tryptophan with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.

Full L-tryptophan + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take Methylene Blue with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with methylene blue can cause additive serotonergic effects, including serotonin syndrome.

Full Methylene Blue + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take Phenethylamine (pea) with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of serotonergic adverse effects.

Full Phenethylamine (pea) + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take Psilocybin with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining psilocybin with serotonergic drugs might cause additive serotonergic effects.

Full Psilocybin + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take Same with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.

Full Same + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take St. John's Wort with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, St.

Full St. John's Wort + hydrocortisone, pyrilamine, chlorpheniramine answer

Can you take Syrian Rue with hydrocortisone, pyrilamine, chlorpheniramine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might increase the risk of serotonergic adverse effects, including serotonin syndrome, when taken with serotonergi...

Full Syrian Rue + hydrocortisone, pyrilamine, chlorpheniramine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) hydrocortisone, pyrilamine, chlorpheniramine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by hydrocortisone, pyrilamine, chlorpheniramine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

hydrocortisone, pyrilamine, chlorpheniramine sits in 3 interaction categories. Open any one to see what the group means:

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach hydrocortisone, pyrilamine, chlorpheniramine through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach hydrocortisone, pyrilamine, chlorpheniramine through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches hydrocortisone, pyrilamine, chlorpheniramine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against hydrocortisone, pyrilamine, chlorpheniramine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against hydrocortisone, pyrilamine, chlorpheniramine.

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Products that contain hydrocortisone, pyrilamine, chlorpheniramine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with hydrocortisone, pyrilamine, chlorpheniramine.

SHRED Tropic Heat by Core Nutritionals contains Acetyl-l-carnitine Strong Bones by Herbal Terra contains Black Cohosh Natural Changes by Nature's Sunshine contains Black Cohosh Menopause Support for Women by Stonehenge Health contains Black Cohosh David Winston's Women's Transition Compound by Herbalist & Alchemist contains Black Cohosh
Pharmacist Counseling Corner

hydrocortisone, pyrilamine, chlorpheniramine & Supplements: Common Questions

What supplements interact with hydrocortisone, pyrilamine, chlorpheniramine?
Our database currently documents 24 ingredients with a known hydrocortisone, pyrilamine, chlorpheniramine interaction (1 major, 20 moderate, 3 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 24. The highest-ranked right now: Lithium, 5-htp, Acetyl-l-carnitine.
Which hydrocortisone, pyrilamine, chlorpheniramine supplement interactions are the most serious?
Focus on the major group: Lithium. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on hydrocortisone, pyrilamine, chlorpheniramine?
Plenty of supplements coexist fine with hydrocortisone, pyrilamine, chlorpheniramine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like HC Derma-Pax Liquid have the same supplement interactions as hydrocortisone, pyrilamine, chlorpheniramine?
Yes — HC Derma-Pax Liquid all contain hydrocortisone, pyrilamine, chlorpheniramine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about hydrocortisone, pyrilamine, chlorpheniramine and my other medications?
This page covers hydrocortisone, pyrilamine, chlorpheniramine against supplements and herbal ingredients. Checking hydrocortisone, pyrilamine, chlorpheniramine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.