Drug & supplement interaction

Andiroba + hydrocortisone, pyrilamine, chlorpheniramine

hydrocortisone, pyrilamine, chlorpheniramine brand name: HC Derma-Pax Liquid.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated June 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Andiroba and hydrocortisone, pyrilamine, chlorpheniramine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share

Facebook Post Reddit Email

On this page

Interaction report

Andiroba and hydrocortisone, pyrilamine, chlorpheniramine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between hydrocortisone, pyrilamine, chlorpheniramine and Andiroba in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Andiroba safety at a glance

Andiroba overall Use caution Generally used on the skin; safety of taking it internally is not well studied.

Pregnancy Avoid Not enough safety data; best to avoid during pregnancy.

Breastfeeding Avoid Not enough safety data; best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining hydrocortisone, pyrilamine, chlorpheniramine and Andiroba? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for hydrocortisone, pyrilamine, chlorpheniramine

Interactions in our licensed database are recorded against drug classes, not just single drug names. hydrocortisone, pyrilamine, chlorpheniramine is filed under 3 classifications — serotonergic drugs, serotonergic drugs, topical drugs. Andiroba has documented interactions with 1 drug class — the most serious being anticonvulsants (minor) — and none of hydrocortisone, pyrilamine, chlorpheniramine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Andiroba Does Interact With Other Medications

Andiroba has 50 minor known drug interactions in our database — hydrocortisone, pyrilamine, chlorpheniramine isn’t one of them. If you take anything else, check it against the full list below.

Minor 50 No known interaction 2,780 (incl. hydrocortisone, pyrilamine, chlorpheniramine)

Taking anything else?

Check Another of Your Medications Against Andiroba

Covers the 2,830 medications we’ve checked against Andiroba. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With hydrocortisone, pyrilamine, chlorpheniramine

This page covers Andiroba only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the hydrocortisone, pyrilamine, chlorpheniramine page lists 24 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Lithium (major), 5-htp (moderate), Acetyl-l-carnitine (moderate), Ayahuasca (moderate) and Black Cohosh (moderate).

By severity: 1 major · 20 moderate · 3 minor.

From our pharmacist’s overview on the hydrocortisone, pyrilamine, chlorpheniramine page

“HC Derma-Pax Liquid (hydrocortisone with pyrilamine and chlorpheniramine) looks like a simple anti-itch product, yet 21 of its 24 supplement interactions exist because its antihistamine ingredients also act on serotonin. Herbs and amino acids that raise serotonin, St.”

Reviewed by 2 · Jul 18, 2026

Open the hydrocortisone, pyrilamine, chlorpheniramine interaction page

How much people look this up

Where Andiroba and hydrocortisone, pyrilamine, chlorpheniramine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Andiroba

Steady interest

#1,156 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication hydrocortisone, pyrilamine, chlorpheniramine

Steady interest

#2,289 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Andiroba is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Andiroba reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Andiroba and hydrocortisone, pyrilamine, chlorpheniramine records this page draws on were last updated June 22, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Andiroba

What is Andiroba?

Skin care and wound healing
Insect repellent
Muscle and joint aches
Anti-inflammatory skin conditions
Hair and scalp care

Andiroba is an oil pressed from the seeds of an Amazonian tree, used mainly on the skin for inflammation, minor wounds, aches, and as an insect repellent. Most evidence comes from laboratory and animal studies, so its benefits in people are not well proven. It is most often used topically; avoid internal use and use during pregnancy or breastfeeding because safety has not been established.

Carapa guianensis · Meliaceae · Seed oil (mainly), bark, and leaves · Topical oil, skin and hair products, soaps, balms, candles (insect repellent)

An interaction check asks whether these two react with each other — it does not ask whether Andiroba is a good idea for someone in your situation. Here is what our Andiroba record says about it on its own.

Andiroba: dosing

There is no established standard dose for andiroba. Doses have not been confirmed in reliable human studies.For topical products, follow the directions on the label.

From our Andiroba monograph — the full record covers uses, side effects and every documented interaction.

Read the full Andiroba monograph & all interactions

Keep checking

Other Drugs & Andiroba

Browse every other medication we’ve checked against Andiroba — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

0Moderate

50Minor

2,779No known interaction

50 Minor 2,779 No interaction

Minor

50 interactions

No interaction 2,779 drugs checked — show the list

We also checked Andiroba against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,779 medications checked with no known interaction — see the full Andiroba list.

See the full Andiroba interactions page

See every supplement checked against hydrocortisone, pyrilamine, chlorpheniramine, ranked by severity

Evidence & sources

Andiroba References

The 3 sources that drive our Andiroba monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Andiroba is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

Carapa guianensis (Andiroba) — U.S. National Library of Medicine (PubChem / NCBI) Source
Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
Using Dietary Supplements Safely — MedlinePlus (U.S. National Library of Medicine) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Andiroba and hydrocortisone, pyrilamine, chlorpheniramine Together: Common Questions

Is it safe to take Andiroba with hydrocortisone, pyrilamine, chlorpheniramine?

We do not list a known interaction between Andiroba and hydrocortisone, pyrilamine, chlorpheniramine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Andiroba and hydrocortisone, pyrilamine, chlorpheniramine combination checked?

Interactions in our licensed database are recorded against drug classes. hydrocortisone, pyrilamine, chlorpheniramine is filed under 3 classifications, and Andiroba has documented interactions with 1 drug class — none of hydrocortisone, pyrilamine, chlorpheniramine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Andiroba interact with any other medications?

Yes. Andiroba has 50 documented drug interactions in our database — hydrocortisone, pyrilamine, chlorpheniramine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does hydrocortisone, pyrilamine, chlorpheniramine interact with any supplements?

Yes. hydrocortisone, pyrilamine, chlorpheniramine has documented interactions with 24 supplements in our database — Andiroba is not one of them. The hydrocortisone, pyrilamine, chlorpheniramine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Andiroba monograph Uses, safety profile, and every drug interaction in one place hydrocortisone, pyrilamine, chlorpheniramine supplement interactions Every supplement checked against hydrocortisone, pyrilamine, chlorpheniramine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About hydrocortisone, pyrilamine, chlorpheniramine and Andiroba?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.