Drug & supplement interaction

Andiroba + Isotretinoin

Isotretinoin brand names: Accutane, Amnesteem, Claravis, Sotret, Absorica, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Andiroba and Isotretinoin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Andiroba and Isotretinoin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Isotretinoin and Andiroba in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Andiroba safety at a glance

Andiroba overall Use caution Generally used on the skin; safety of taking it internally is not well studied.
Pregnancy Avoid Not enough safety data; best to avoid during pregnancy.
Breastfeeding Avoid Not enough safety data; best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Isotretinoin and Andiroba? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Isotretinoin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Isotretinoin is filed under 4 classifications — including retinoids, cytochrome p450 2c8 (cyp2c8) substrates, photosensitizing drugs. Andiroba has documented interactions with 1 drug class — the most serious being anticonvulsants (minor) — and none of Isotretinoin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Andiroba Does Interact With Other Medications

Andiroba has 50 minor known drug interactions in our database — Isotretinoin isn’t one of them. If you take anything else, check it against the full list below.

Minor 50 No known interaction 2,780 (incl. Isotretinoin)
Taking anything else?

Check Another of Your Medications Against Andiroba

Covers the 2,830 medications we’ve checked against Andiroba. Pick one to open its full report.

What to actually watch for

What Isotretinoin’s Own FDA Label Lists

This is not an interaction — none of it involves Andiroba. These are the most notable effects listed in the ADVERSE REACTIONS section of Isotretinoin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Thoughts of self-harm Worth acting on mentioned in 4.5% of FDA reports for Isotretinoin
  • Low mood Worth acting on mentioned in 12.1% of FDA reports for Isotretinoin
  • Bone thinning Worth acting on
  • Severe muscle breakdown Worth acting on
  • Hallucinations Worth acting on
  • Pancreatitis Worth acting on
  • Fainting Worth acting on
  • Wheezing Worth acting on
  • A severe skin reaction Worth acting on
  • Seizures Worth acting on

Showing the 10 most notable of 56 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Isotretinoin. Read the label on DailyMed › Where a percentage is shown, it is the share of 46,523 voluntary FDA FAERS reports for Isotretinoin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Andiroba’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Andiroba side to compare — that is a limit of the record, not a statement that Andiroba has no side effects.

From our Q&A

Questions About Andiroba or Isotretinoin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Andiroba or Isotretinoin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Isotretinoin

This page covers Andiroba only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Isotretinoin page lists 49 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Vitamin A (major), African Wild Potato (moderate), Alfalfa (moderate) and Angelica Archangelica (moderate).

By severity: 2 major · 35 moderate · 12 minor.

From our pharmacist’s overview on the Isotretinoin page

“Vitamin A is the first thing anyone on isotretinoin (Accutane, Absorica, Claravis) should check their supplements for, because isotretinoin is itself a vitamin A derivative and stacking more on top can push levels into toxic range. It is one of two major-rated entries among the 49 supplements and herbs known to interact with this acne…”

Reviewed by 2 · Jul 18, 2026

Open the Isotretinoin interaction page

How much people look this up

Where Andiroba and Isotretinoin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Andiroba
Steady interest

#1,447 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Isotretinoin
Top 5%

#43 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Andiroba is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Andiroba reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Andiroba and Isotretinoin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Andiroba

What is Andiroba?

Andiroba
  • Skin care and wound healing
  • Insect repellent
  • Muscle and joint aches
  • Anti-inflammatory skin conditions
  • Hair and scalp care

Andiroba is an oil pressed from the seeds of an Amazonian tree, used mainly on the skin for inflammation, minor wounds, aches, and as an insect repellent. Most evidence comes from laboratory and animal studies, so its benefits in people are not well proven. It is most often used topically; avoid internal use and use during pregnancy or breastfeeding because safety has not been established.

Carapa guianensis · Meliaceae · Seed oil (mainly), bark, and leaves · Topical oil, skin and hair products, soaps, balms, candles (insect repellent)

An interaction check asks whether these two react with each other — it does not ask whether Andiroba is a good idea for someone in your situation. Here is what our Andiroba record says about it on its own.

Andiroba: dosing

There is no established standard dose for andiroba. Doses have not been confirmed in reliable human studies.For topical products, follow the directions on the label.

From our Andiroba monograph — the full record covers uses, side effects and every documented interaction.

Read the full Andiroba monograph & all interactions
Medication

About Isotretinoin

What Is Isotretinoin Used For?

Brand names: Accutane, Amnesteem, Claravis, Sotret, Absorica, Roaccutane

Isotretinoin is used to treat severe recalcitrant nodular acne — large, deep, inflamed breakouts (nodules 5 mm or bigger) that haven't cleared with conventional treatments like antibiotics. It is approved for non-pregnant patients 12 years of age and older. Brands include Absorica, Absorica LD, Accutane, Amnesteem, Claravis, and generic isotretinoin capsules.

Because of its serious potential side effects, isotretinoin is reserved for patients whose acne is truly severe and has not responded to other standard treatments. A typical course lasts 15 to 20 weeks, and many patients experience prolonged remission — sometimes permanent clearing — after a single course.

Most-Reported Side Effects for Isotretinoin

From FAERS, the FDA’s public side-effect reporting system (46,523 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Depression 5,609 reports
Inflammatory bowel disease 5,250 reports
Colitis ulcerative 3,800 reports
Dry skin 2,326 reports
Pregnancy 2,080 reports
See full Isotretinoin drug information
Keep checking

Other Drugs & Andiroba

Browse every other medication we’ve checked against Andiroba — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
50Minor
2,779No known interaction
50 Minor 2,779 No interaction
Minor

50 interactions

No interaction 2,779 drugs checked — show the list

We also checked Andiroba against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,779 medications checked with no known interaction — see the full Andiroba list.

See the full Andiroba interactions page
See every supplement checked against Isotretinoin, ranked by severity
Evidence & sources

Andiroba References

The 3 sources that drive our Andiroba monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Andiroba is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Carapa guianensis (Andiroba) — U.S. National Library of Medicine (PubChem / NCBI) Source
  2. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  3. Using Dietary Supplements Safely — MedlinePlus (U.S. National Library of Medicine) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Andiroba and Isotretinoin Together: Common Questions

Is it safe to take Andiroba with Isotretinoin?
We do not list a known interaction between Andiroba and Isotretinoin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Andiroba and Isotretinoin combination checked?
Interactions in our licensed database are recorded against drug classes. Isotretinoin is filed under 4 classifications, and Andiroba has documented interactions with 1 drug class — none of Isotretinoin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Andiroba interact with any other medications?
Yes. Andiroba has 50 documented drug interactions in our database — Isotretinoin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Isotretinoin interact with any supplements?
Yes. Isotretinoin has documented interactions with 49 supplements in our database — Andiroba is not one of them. The Isotretinoin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Andiroba monograph Uses, safety profile, and every drug interaction in one place Isotretinoin drug information The full plain-English guide to this medication Isotretinoin supplement interactions Every supplement checked against Isotretinoin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Isotretinoin and Andiroba?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.