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Dietary supplement

Advanced Heartburn Rescue Ingredients & Drug Interactions

by Terry Naturally

Advanced Heartburn Rescue label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Advanced Heartburn Rescue against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Advanced Heartburn Rescue is a dietary supplement by Terry Naturally with 2 active ingredients. Its ingredients are commonly taken for heartburn and acid reflux, digestive upset, stress and mood support.Based on those ingredients, 472 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sea Buckthorn (Hippophae rhamnoides) Berry Pulp and Seed Oil, D-Limonene. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Advanced Heartburn Rescue by Terry Naturally

Ask about any prescription or over-the-counter medication and we check it for interactions with Advanced Heartburn Rescue by Terry Naturally — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Advanced Heartburn Rescue by Terry Naturally

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Complex” is a proprietary blend — the label gives one combined amount (600 mg) without saying how much of each component you get.

Advanced Heartburn Rescue contains 2 active ingredients. D-limonene is a natural compound found in citrus peels — it's included here for its potential digestive benefits.

Sea buckthorn berry pulp and seed oil comes from a plant rich in vitamins and fatty acids, traditionally used to support skin and digestive health. The product also contains several inactive ingredients — gelatin, glycerin, purified water, sunflower oil, and rosemary oil — that make up the softgel capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: relief for occasional heartburn and acid indigestion.
  • We looked for evidence on: Dyspepsia, Peptic ulcers, Gastroesophageal reflux disease (GERD), Acid reflux.
  • The closest evidence on file: Sea Buckthorn is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).
  • Also on file: Sea Buckthorn is rated "Insufficient Reliable Evidence To Rate" for Peptic ulcers.

The evidence for this product's effectiveness is limited. For D-limonene, we don't have reliable data on whether it works for cancer or irritable bowel syndrome (IBS).

Sea buckthorn shows possibly effective evidence for burns, but the data on skin aging, cholesterol levels (dyslipidemia), and eczema is either insufficient or suggests it may not work. If you're buying this specifically to treat heartburn or one of these conditions, the science behind these ingredients isn't yet solid enough to promise results.

The evidence, ingredient by ingredient Limonene Sea Buckthorn

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

D-limonene is generally well tolerated at food levels, but high-dose supplement safety data in humans is sparse. It can cause nausea, vomiting, and diarrhea.

When inhaled (from fragrances or cleaning products), limonene has been linked to wheezing and asthma, especially in children. Sea buckthorn is also well tolerated as a food, though supplement doses aren't fully studied.

High doses may stain your skin yellow — one case involved someone eating 100 grams daily for 6 months. Both ingredients lack solid safety data for supplement use while breastfeeding; D-limonene is rated likely safe while lactating, but sea buckthorn safety during breastfeeding isn't well established, so caution is advised.

Side effects, ingredient by ingredient Limonene Sea Buckthorn

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Sea Buckthorn, Limonene.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 472 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or aspirin) — sea buckthorn may increase bleeding risk. Blood pressure medications also need attention, as sea buckthorn may lower pressure further.

D-limonene interacts preliminarily with liver-enzyme inhibitors and inducers (including some psychiatric drugs and seizure medications), though these haven't been confirmed in humans yet. Use the medication checker on this page to verify your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines two ingredients with theoretical interactions mainly affecting liver enzyme systems and blood clotting. The effectiveness evidence is thin — we don't have solid proof either ingredient tackles heartburn or the other conditions listed.

If you take blood thinners, blood pressure meds, or drugs metabolized through liver pathways, check your specific medications with our tool before starting. Talk to your pharmacist about whether this fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 28, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Advanced Heartburn Rescue, straight from the product label.

Brand Terry Naturally
Barcode (UPC) 367703202736
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD May 28, 2019
DSLD ID 202297
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Advanced Heartburn Rescue by Terry Naturally, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
UPC/BARCODE
367703202736
IngredientAmount% DV
Proprietary Complex600 mg--
D-Limonene0 NP--
Sea Buckthorn (Hippophae rhamnoides) Berry Pulp and Seed Oil0 NP--

Other ingredients: Gelatin, Glycerin, purified Water, Sunflower Oil, Rosemary Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Money-Back Guarantee

Make the decision to stop heartburn now!

Lasting relief from occasional heartburn

Complete, long-lasting heartburn relief Supports digestive function For your good health Terry

Brand IP Statement(s)

Advanced Heartburn Rescue provides relief for occasional heartburn, acid indigestion, and upset stomach.

Terry Naturally EuroPharma

Formula

The synergistic blend of D-Limonene and Sea Buckthorn oil provides support for healthy digestive function and mucous membrane health, while soothing the gastrointestinal tract.

Suggested/Recommended/Usage/Directions

Recommendations: 1 softgel daily, may increase to 1 softgel twice daily if desired.

Precautions

If pregnant or nursing, consult a healthcare practitioner before using.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

JC 34 91 + 3(5,6)EP L20273.07

FDA Statement of Identity

Dietary Supplement

Formulation

No sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring, or artificial preservatives. Non-GMO

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Advanced Heartburn Rescue by Terry Naturally label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Advanced Heartburn Rescue label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Advanced Heartburn Rescue by Terry Naturally

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Complex

600 mg per serving

Other (inactive) ingredients: Gelatin, Glycerin, Purified Water, Sunflower Oil, Rosemary Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Advanced Heartburn Rescue by Terry Naturally Drug Interactions

Want to check YOUR meds against Advanced Heartburn Rescue?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
472Drugs
472 Moderate

Ingredients driving the most interactions

Sea Buckthorn (Hippophae rhamnoides) Berry Pulp and Seed Oil 289
D-Limonene 229

Individual Drug Interactions

The ingredients in Advanced Heartburn Rescue interact with 472 drugs. Click any drug to see the details.

2 of the 2 ingredients in Advanced Heartburn Rescue interact with drugs. Each result below shows which ingredient is responsible. Sea Buckthorn (Hippophae rhamnoides) Berry Pulp and Seed Oil D-Limonene

Each ingredient & the kinds of drugs it affects

For each ingredient in Advanced Heartburn Rescue with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sea Buckthorn (Hippophae rhamnoides) Berry Pulp and Seed Oil2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research suggests that sea buckthorn fruit extracts can inhibit platelet aggregation and adhesion to collagen and fibrinogen.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.
Taking sea buckthorn appears to reduce blood pressure in some patients.

Likelihood Possible Evidence D
Sea Buckthorn (Hippophae rhamnoides) Berry Pulp and Seed Oil full monograph & interactions

D-Limonene5 drug types · 229 drugs

Cytochrome P450 2C19 (Cyp2C19) Inducers

There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C19 (CYP2C19). CYP2C19 inducers might decrease the effects of limonene. So far, this interaction has not been reported in humans. Inducers of CYP2C19 include carbamazepine (Tegretol), prednisone (Deltasone), and rifampin (Rifadin, Rimactane).

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Inhibitors

There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C19 (CYP2C19). So far, this interaction has not been reported in humans. However, watch for an increase in the limonene levels when it is taken with drugs that inhibit CYP2C19. Some drugs that inhibit CYP2C19 include cimetidine (Tagamet), fluvoxamine (Luvox), omeprazole (Prilosec); ticlopidine (Ticlid), topiramate (Topamax), and others.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Inducers

There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C9 (CYP2C9). Inducers of CYP2C9 might decrease limonene levels. Inducers of CYP2C9 include rifampin (Rifadin, Rimactane) and secobarbital (Seconal).

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Inhibitors

There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C9 (CYP2C9). So far, this interaction has not been reported in humans. However, watch for side effects in patients taking limonene and CYP2C9 inhibitors. Some CYP2C9 inhibitors include amiodarone (Cordarone), fluconazole (Diflucan), lovastatin (Mevacor), paroxetine (Paxil), zafirlukast (Accolate), and many others.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C9 (CYP2C9), as well causing its induction. So far, this interaction has not been reported in humans. However, watch for a decrease in the levels of drugs metabolized by CYP2C9 in patients taking limonene. Some drugs metabolized by CYP2C9 include nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), and piroxicam (Feldene); celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); and others.

Likelihood Possible Evidence D
D-Limonene full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Advanced Heartburn Rescue, from the product label.

Terry Naturally

See all Terry Naturally products
Name
EuroPharma, Inc.
City
Green Bay
State
WI
ZipCode
54311
Phone Number
(866) 807-2731
Web Address
EuroPharmaUSA.com
Pharmacist Counseling Corner

Advanced Heartburn Rescue by Terry Naturally: Common Questions

Does Advanced Heartburn Rescue by Terry Naturally interact with any medications?
Yes. Based on its ingredients, Advanced Heartburn Rescue has a known interaction with 472 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Advanced Heartburn Rescue contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is D-limonene the same as lemon extract or lemon juice?
Not quite. D-limonene is a single compound isolated from citrus peels and other plants. Lemon juice or lemon extract contains D-limonene plus many other ingredients, so they're not the same thing. This product uses the isolated form.
Will this turn my skin yellow?
It's possible but rare. High doses of sea buckthorn can cause temporary yellow staining of the skin. One documented case involved someone eating 100 grams of sea buckthorn daily for 6 months. At normal supplement doses, this is unlikely, but it's something to watch for.
Can I take this while breastfeeding?
D-limonene is rated likely safe, but sea buckthorn safety data during breastfeeding is limited. There isn't enough information to say either way. Talk with your doctor or pharmacist about what's right for your situation.
What should I do if I get nausea or diarrhea?
Nausea, vomiting, and diarrhea are documented side effects of D-limonene, though they're not common. If they happen, stop taking the product and let your pharmacist know. They can help you figure out if the supplement is the cause.
Does sea buckthorn really work for heartburn?
We don't have reliable evidence that sea buckthorn works for heartburn specifically. The ingredient is listed as possibly effective for burns and has insufficient evidence for other digestive or stomach issues. You're taking it partly on the hope it may help, not on proven results.
Is this product safe to use long-term?
Safety data for long-term supplement use isn't solid. Both D-limonene and sea buckthorn are generally well tolerated as foods, but high-dose supplement safety over months or years hasn't been fully studied. Check in with your pharmacist if you plan to use it regularly.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Advanced Heartburn Rescue label
Go deeper

The Full Monographs Behind Advanced Heartburn Rescue’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Limonene

Interacts with 229 drugs

Limonene is a natural compound found in the peel of citrus fruits like oranges and lemons, and it is used as a flavoring agent and dietary supplement. People take it for heartburn, digestion...

Read the full Limonene monograph → Herb & supplement monograph

Sea Buckthorn

Interacts with 289 drugs

Sea buckthorn is a berry-bearing shrub rich in vitamins, carotenoids, and fatty acids that people use for skin, eye, digestive, and heart health. Early research is promising for a few uses l...

Read the full Sea Buckthorn monograph →
Sources

Sources & How We Checked

Advanced Heartburn Rescue's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Limonene 10 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Vigushin DM, Poon GK, Boddy A, et al. Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee. Cancer Chemother Pharmacol 1998;42:111-7. PubMed
  3. Crowell PL. Prevention and therapy of cancer by dietary monoterpenes. J Nutr 1999;129:775S-778S. PubMed
  4. Matura M, Goossens A, Bordalo O, et al. Oxidized citrus oil (R-limonene): a frequent skin sensitizer in Europe. J Am Acad Dermatol 2002;47:709-14. PubMed
  5. Topham EJ, Wakelin SH. D-Limonene contact dermatitis from hand cleansers. Contact Dermatitis 2003;49:108-9.
  6. Miyazawa M, Shindo M, Shimada T. Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes. Drug Metab Dispos 2002;30:602-7. PubMed
  7. Dales RE, Cakmak S. Is residential ambient air limonene associated with asthma? Findings from the Canadian Health Measures Survey. Environ Pollut 2019;244:966-70. PubMed
  8. Dittmar D, Schuttelaar MLA. Contact sensitization to hydroperoxides of limonene and linalool: results of consecutive patch testing and clinical relevance. Contact Dermatitis 2019;80(2):101-9. PubMed
  9. Gatica-Ortega ME, Pastor-Nieto MA, Schoendorff-Ortega C, Mollejo-Villanueva M, Giménez-Arnau A. Lymphomatoid contact dermatitis caused by limonene hydroperoxides confirmed by an exposure provocation test with the involved personal hygiene products. Contac PubMed
  10. Nath NS, Liu B, Green C, Atwater AR. Contact allergy to hydroperoxides of linalool and D-limonene in a US population. Dermatitis 2017;28(5):313-6. PubMed

See these in context on the Limonene monograph →

Sea Buckthorn 7 references
  1. Johansson AK, Korte H, Yang B, et al. Sea buckthorn berry oil inhibits platelet aggregation. J Nutr Biochem 2000;11:491-5.. PubMed
  2. Grad, S. C., Muresan, I., and Dumitrascu, D. L. Generalized yellow skin caused by high intake of sea buckthorn. Forsch.Komplementmed. 2012;19(3):153-156. PubMed
  3. Vlasov, V. V. [Hippophae oil in the treatment of superficial skin burns]. Vestn.Dermatol Venerol. 1970;44(6):69-72.
  4. Chang BB, Wang F Xu TY Zhang QQ He J Zhang XJ Li J. Total flavones of Hippophae rhamnoides L. for essential hypertension: a systematic review of randomized controlled trials. Chinese Journal of Evidence-Based Medicine. 2009;9(11):1207-1213. DOI
  5. Olas B, Kontek B, Szczesna M, et al. Inhibition of blood platelet adhesion by phenolics rich fraction of Hippophae rhamnoides L. fruits. J Physiol Pharmacol. 2017;68(2):223-9.
  6. Larmo P, Järvinen R, Laihia J, et al. Effects of a sea buckthorn oil spray emulsion on dry eye. Cont Lens Anterior Eye. 2019;42(4):428-433. PubMed
  7. De Seta F, Caruso S, Di Lorenzo G, Romano F, Mirandola M, Nappi RE. Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled study. Ma PubMed

See these in context on the Sea Buckthorn monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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