Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Advanced Probiotic Gummies Ingredients & Drug Interactions

by CVS Health

Advanced Probiotic Gummies label
See full label image
Gummy Or Jelly Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Advanced Probiotic Gummies against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Advanced Probiotic Gummies is a dietary supplement by CVS Health with 3 active ingredients. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus coagulans. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Advanced Probiotic Gummies by CVS Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Advanced Probiotic Gummies by CVS Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Advanced Probiotic Gummies by CVS Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.

This product contains 2 active ingredients, both Bacillus coagulans — a live probiotic organism. The other ingredients are inactive: corn syrup, gelatin, sodium citrate, citric acid, lactic acid, natural flavors, food colors, and corn starch (which give the gummy its texture, taste, and shelf life).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Bacillus Coagulans's overall clinical evidence instead.

Moderate

Some clinical evidence supports Bacillus Coagulans for:

Why this rating?
  • The label markets general wellness (“digestive health support”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Constipation — rated "Possibly Effective" (Natural Medicines).
  • On file: Irritable bowel syndrome (IBS) — rated "Possibly Effective" (Natural Medicines).

Bacillus coagulans is possibly effective for constipation and irritable bowel syndrome (IBS), meaning some evidence supports its use, though more research would help confirm that. For antibiotic-associated diarrhea, athletic performance, cancer, and fatty liver disease, we don't have enough reliable evidence to rate whether it works.

The evidence, ingredient by ingredient Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacillus coagulans is generally well tolerated in healthy adults, but the evidence and quality of probiotic products vary widely, so it's worth talking to your doctor before you start. Since this product contains live organisms, there's a theoretical concern it could cause infection in people who are severely ill, immunocompromised, or have central lines (tubes placed into veins).

Cases of serious infection have been reported in those at-risk groups, though healthy people with intact immune systems haven't shown similar problems in the data we hold. We don't have enough safety information about pregnancy and breastfeeding — talk to your doctor or pharmacist for personalized advice if that applies to you.

Side effects, ingredient by ingredient Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotics, don't take this probiotic at the same time — space them out several hours apart so the antibiotic doesn't kill the live organisms. Run your full medication list through the checker on this page, since one ingredient interacts with 182 medications overall.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you have constipation or IBS and no serious immune issues or central lines, this probiotic may be worth trying — but check with your pharmacist first, especially if you take antibiotics. Quality varies, so know the brand matters.

If you're severely ill or immunocompromised, ask your doctor before using any probiotic product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Advanced Probiotic Gummies, straight from the product label.

Brand CVS Health
Barcode (UPC) 050428359686
Net contents 30 Assorted Gummy(ies)
Market status On market
Date entered into DSLD Nov 21, 2020
DSLD ID 239545
Product type Non-nutrient/non-botanical
Supplement form Gummy Or Jelly
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Gluten Free, Dairy Free, Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Advanced Probiotic Gummies by CVS Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gummy(ies)
Maximum serving Sizes:
2 Gummy(ies)
Servings per container
15
UPC/BARCODE
050428359686
IngredientAmount% DV
Calories15 Calorie(s), 10 Calorie(s)--
Total Carbohydrates4 Gram(s), 2 Gram(s)1%
Sugar3 Gram(s), 1 Gram(s)--
Bacillus coagulans0 NP--
Bacillus coagulans0 NP--

Other ingredients: Corn Syrup, Gelatin, Sodium Citrate, Citric Acid, Lactic Acid, Natural Flavors, Colors Added, Corn Starch

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Compare to Digestive Advantage Probiotic Gummies

Daily probiotic

Serving Size: 1 gummy (for children 2 to under 4 years); 2 gummies (4 years old and above) Servings Per Container: 30; 15

For export only. CVS Quality Money back guarantee Please recycle Questions or comments? 1-866-942-2429

FDA Statement of Identity

Dietary Supplement

Formula

Bacillus coagluans

Made with natural fruit flavors with other natural flavors

500 million viable cells per adult serving of 2 gummies

Natural fruit flavors with other natural flavors Colors from natural sources

Formulation

Helps support digestive health

Easy-to-take gummies

Gluten free

Made in Canada with domestic and imported ingredients.

No preservatives Free from wheat (gluten), milk, eggs, tree nuts, peanuts

Gummy colors may change over time due to natural colors. This does not alter the potency of the product. Any clouding of clear bottle is normal.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: Adults and children 4 years and older: chew two gummies daily. Children 2-3 years old: chew one gummy daily. Gummy should be chewed before swallowing.

Do not exceed recommended dosage.

Precautions

Sealed for your protection.

Consult a physician if you are taking any prescription medications.

Keep out of reach of children

Storage

Store: tightly closed; in the dark: dry and cool (between 45 degrees Fahrenheit-75 degrees Fahrenheit)

Brand IP Statement(s)

This product is not manufactured or distributed by Reckitt Benckiser, distributor of Digestive Advantage Probiotic Gummies

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Advanced Probiotic Gummies by CVS Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Advanced Probiotic Gummies label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Advanced Probiotic Gummies by CVS Health

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Gummy(ies) Dosage formGummy Or Jelly Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

3 Gram(s) per serving

Bacillus coagulans

Interacts with
182 drugs
0 NP per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

Bacillus coagulans monograph & interactions

Bacillus coagulans

Interacts with
182 drugs
0 NP per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

Bacillus coagulans monograph & interactions

Other (inactive) ingredients: Corn Syrup, Gelatin, Sodium Citrate, Citric Acid, Lactic Acid, Natural Flavors, Colors Added, Corn Starch. These complete the product’s ingredient list but are not active constituents.

Interaction report

Advanced Probiotic Gummies by CVS Health Drug Interactions

Want to check YOUR meds against Advanced Probiotic Gummies?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bacillus coagulans 182

Individual Drug Interactions

The ingredients in Advanced Probiotic Gummies interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in Advanced Probiotic Gummies interact with drugs. Each result below shows which ingredient is responsible. Bacillus coagulans

Each ingredient & the kinds of drugs it affects

For each ingredient in Advanced Probiotic Gummies with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacillus coagulans1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Bacillus coagulans full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Advanced Probiotic Gummies, from the product label.

CVS Health

See all CVS Health products
Name
CVS Pharmacy, Inc.
Street Address
One CVS Drive
City
Woonsocket
State
RI
ZipCode
02895
Phone Number
1-800-746 7287
Web Address
CVS.com
Pharmacist Counseling Corner

Advanced Probiotic Gummies by CVS Health: Common Questions

Does Advanced Probiotic Gummies by CVS Health interact with any medications?
Yes. Based on its ingredients, Advanced Probiotic Gummies has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Advanced Probiotic Gummies contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic work if I'm taking an antibiotic?
Not if you take them together. The antibiotic will kill the live bacteria in the supplement, making it ineffective. Separate them by a few hours, and ask your pharmacist which order and timing makes sense for your specific drugs.
Is it safe if I have a weak immune system or a central line?
The data shows live probiotic organisms can cause serious infection in severely immunocompromised people or those with central catheters. Talk to your doctor before starting this product if that's your situation.
Does this actually help with IBS or constipation?
Bacillus coagulans is possibly effective for both — meaning some evidence supports it, but we'd like to see more research. Results vary by person, so it's worth a trial if your doctor thinks it's right for you.
Is it safe during pregnancy or breastfeeding?
We don't have enough safety data to know. Talk to your doctor or pharmacist — they can give you personalized advice based on your situation.
What's actually in these gummies besides the probiotic?
Corn syrup, gelatin, sodium citrate, citric acid, lactic acid, natural flavors, food colors, and corn starch. Those are the inactive ingredients that make it taste and work like a gummy.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Advanced Probiotic Gummies is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Advanced Probiotic Gummies label
Go deeper

The Full Monographs Behind Advanced Probiotic Gummies’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Advanced Probiotic Gummies's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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