Ageless Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Ageless against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Ageless is a dietary supplement by OL Olympian Labs with 5 active ingredients. Its ingredients are commonly taken for high triglycerides, heart health, joint pain and inflammation.Based on those ingredients, 1,056 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Grape seed extract, Resveratrol, Fish Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Ageless by OL Olympian Labs
Ask about any prescription or over-the-counter medication and we check it for interactions with Ageless by OL Olympian Labs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Ageless by OL Olympian Labs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Ageless contains five active ingredients. The product is built around fish oil, supplied as Eicosapentaenoic Acid and Docosahexaenoic Acid — two omega-3 fatty acids that support heart and brain health.
It also contains Coenzyme Q10, a compound your cells use to make energy and defend against oxidative stress; Resveratrol, a plant compound found in grapes and red wine; and Grape seed extract, which delivers polyphenols (protective plant compounds). The softgel also holds inactive ingredients — gelatin capsule, glycerin, water, caramel color, beeswax, and lecithin — that help bind and deliver the actives.
Does it work?
Moderate evidence
Coenzyme Q10 is likely effective for CoQ10 deficiency and possibly effective for fibromyalgia, migraines, congestive heart failure, and diabetic nerve pain. Resveratrol is possibly effective for obesity and allergic rhinitis (hay fever), but possibly ineffective for cardiovascular disease and high cholesterol.
Grape seed extract is possibly effective for chronic venous insufficiency (poor circulation in the legs) but possibly ineffective for chemotherapy-related nausea, hay fever, and obesity. We hold no effectiveness data for the omega-3 fatty acids in this product.
How safe is it?
Well-documented data
Coenzyme Q10 is generally well tolerated; the most common side effects are digestive — appetite loss, diarrhea, heartburn, nausea, and vomiting in less than 1% of people. Headache, dizziness, and insomnia have been reported, and a very small number of people have experienced skin itching or rash.
Resveratrol causes digestive upset (diarrhea and loose stools) at higher doses; headache, fatigue, and memory loss were reported in patients on dialysis but causality wasn't established. Grape seed extract is generally well tolerated; the most common side effects are digestive (abdominal pain, diarrhea, dry mouth, nausea), and rare cases of anaphylaxis to grape skin have been reported.
For pregnancy, concentrated resveratrol supplements should be avoided — safety data is insufficient. Breastfeeding safety for resveratrol also has not been studied enough; avoid supplement use.
Coenzyme Q10 safety in breastfeeding hasn't been well studied — check with your doctor. Grape seed extract as a whole fruit is fine during pregnancy and breastfeeding, but concentrated supplements during breastfeeding lack sufficient safety information.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your pharmacist if you're on any of these: chemotherapy drugs that work by generating free radicals (like alkylating agents such as cyclophosphamide) — CoQ10 may reduce their effectiveness. Blood thinners (anticoagulants) like warfarin — CoQ10 may weaken its effect, and both Resveratrol and Grape seed extract may increase bleeding risk.
Blood pressure medications — CoQ10 may lower pressure further. Medications broken down by your liver's CYP pathways (CYP2C19, CYP1A2, CYP3A4, CYP2E1) — Resveratrol and Grape seed extract may raise their blood levels.
Cyclosporine (an immunosuppressant) — Grape seed extract may reduce its absorption. Midazolam (a sedative) — long-term Grape seed extract use may decrease its effect.
Use the medication checker below to see if you're affected.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Ageless is a multi-ingredient anti-aging blend best suited for adults looking to support energy, circulation, and cell protection. If you take chemotherapy, warfarin, blood pressure medications, blood thinners, or cyclosporine, check your specific drugs with the tool below before starting — the interactions are real and need attention.
Anyone pregnant or breastfeeding should talk to their pharmacist or doctor first, especially regarding resveratrol. For most other adults, it's generally well tolerated, though some digestive upset is possible.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Ageless, straight from the product label.
| Brand | OL Olympian Labs |
|---|---|
| Barcode (UPC) | 710013100603 |
| Net contents | 90 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Apr 25, 2018 |
| DSLD ID | 175962 |
| Product type | Other Combinations |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Ageless by OL Olympian Labs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 27 Calorie(s) | -- |
| Calories from Fat | 18 Calorie(s) | -- |
| Eicosapentaenoic Acid | 840 mg | -- |
| Docosahexaenoic Acid | 420 mg | -- |
| Protein | 1 Gram(s) | 1% |
| Total Fat | 2 Gram(s) | 3% |
| Fish Oil | 2100 mg | -- |
| Coenzyme Q10 | 150 mg | -- |
| Resveratrol | 275 mg | -- |
| Trans Resveratrol | 55 mg | -- |
| Grape seed extract | 275 mg | -- |
Other ingredients: Gelatin, Glycerin, Water, Caramel, Beeswax, Lecithin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Olympian Labs, Inc. products are made with the highest quality ingredients and manufactured according to current Good Manufacturing Practices (cGMP).
Supports skin hydration & elasticity Aids in reducing inflammation Supports heart health
Made in USA
Precautions
Caution: If you are pregnant or nursing, have a medical condition, or are taking medication, consult your healthcare professional before using this or any other nutritional supplement.
Discontinue use if allergic reaction occurs.
Keep out of reach of children.
Allergen Information: Product contains fish (walleye pollack and/or Pacific whiting) and soy.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General
REV 02-24-17
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take three (3) softgels daily, or as directed by a healthcare professional.
Formula
Allergen Information: Product contains fish (walleye pollack and/or Pacific whiting) and soy.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Ageless by OL Olympian Labs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Ageless by OL Olympian Labs
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Protein
Fish Oil
Interacts with327 drugs
Fish oil provides omega-3 fatty acids (EPA and DHA) that are best known for lowering high triglyceride levels. The evidence for other heart and health...
Fish Oil monograph & interactions- › Eicosapentaenoic Acid
- › Docosahexaenoic Acid
Coenzyme Q10
Interacts with198 drugs
CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...
Coenzyme Q10 monograph & interactionsResveratrol
Interacts with822 drugs
Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While...
Resveratrol monograph & interactionsGrape seed extract
Interacts with910 drugs
Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and b...
Grape seed extract monograph & interactionsOther (inactive) ingredients: Gelatin, Glycerin, Water, Caramel, Beeswax, Lecithin. These complete the product’s ingredient list but are not active constituents.
Ageless by OL Olympian Labs Drug Interactions
HelloPharmacist Interaction Report
Ageless by OL Olympian Labs contains five ingredients, three of which we have interaction data for.
The most serious interactions come from Coenzyme Q10, which can theoretically reduce the effectiveness of chemotherapy drugs (alkylating agents like cyclophosphamide) by interfering with how they generate damaging free radicals — a Moderate severity concern.
Read the full breakdown — every affected drug type, severity by severity
Coenzyme Q10 also has a Moderate interaction with warfarin (a blood thinner used to prevent clots), potentially decreasing its anticoagulant effect; four cases of reduced warfarin efficacy linked to CoQ10 have been reported. It may also lower blood pressure slightly if you're already taking blood pressure medications (Minor severity).
Trans Resveratrol and Grape seed extract both interact with several drug categories at Moderate severity: they can theoretically raise blood levels of medications processed through multiple liver pathways (CYP2C19, CYP1A2, CYP3A4, and CYP2E1 substrates), and both may increase bleeding risk with blood thinners or antiplatelet drugs. Grape seed extract also specifically interacts with cyclosporine (an immunosuppressant) and midazolam (a sedative).
We could not check Eicosapentaenoic Acid or Docosahexaenoic Acid — these omega-3 components have no interaction data on file. Altogether, these interactions span 1,041 individual medications.
Use the medication checker on this page to see if any of your prescriptions are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Ageless?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Ageless interact with 1,056 drugs. Click any drug to see the details.
4 of the 5 ingredients in Ageless interact with drugs. Each result below shows which ingredient is responsible. Grape seed extract Resveratrol Fish Oil Coenzyme Q10
Acetaminophen, OrphenadrineOrfenagesic
How Acetaminophen, Orphenadrine interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Grape Seed ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
Read the full Grape Seed Extract + Acetaminophen, Orphenadrine interactionTrans ResveratrolCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Trans Resveratrol + Acetaminophen, Orphenadrine interactionAcetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
How Acetaminophen, Oxycodone interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Trans Resveratrol + Acetaminophen, Oxycodone interactionGrape Seed ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
Read the full Grape Seed Extract + Acetaminophen, Oxycodone interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Grape Seed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
Read the full Grape Seed Extract + Acetaminophen, Pamabrom, Pyrilamine interactionTrans ResveratrolCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Trans Resveratrol + Acetaminophen, Pamabrom, Pyrilamine interactionAcetaminophen, PentazocineTalacen
How Acetaminophen, Pentazocine interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Trans Resveratrol + Acetaminophen, Pentazocine interactionGrape Seed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
Read the full Grape Seed Extract + Acetaminophen, Pentazocine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Grape Seed ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
Read the full Grape Seed Extract + Acetaminophen, Phenylephrine, Chlorpheniramine interactionTrans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetaminophen, PhenylpropanolamineTetra Caps
How Acetaminophen, Phenylpropanolamine interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Trans Resveratrol + Acetaminophen, Phenylpropanolamine interactionGrape Seed ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
Read the full Grape Seed Extract + Acetaminophen, Phenylpropanolamine interactionAcetaminophen, Phenylpropanolamine, PhenyltoloxamineSinubid
How Acetaminophen, Phenylpropanolamine, Phenyltoloxamine interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Grape Seed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
Read the full Grape Seed Extract + Acetaminophen, Phenylpropanolamine, Phenyltoloxamine interactionTrans ResveratrolCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Trans Resveratrol + Acetaminophen, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, PhenyltoloxaminePercogesic, Relagesic
How Acetaminophen, Phenyltoloxamine interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Grape Seed ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
Read the full Grape Seed Extract + Acetaminophen, Phenyltoloxamine interactionTrans ResveratrolCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Trans Resveratrol + Acetaminophen, Phenyltoloxamine interactionAcetaminophen, Phenyltoloxamine, SalicylamideLobac
How Acetaminophen, Phenyltoloxamine, Salicylamide interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Trans Resveratrol + Acetaminophen, Phenyltoloxamine, Salicylamide interactionGrape Seed ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
Read the full Grape Seed Extract + Acetaminophen, Phenyltoloxamine, Salicylamide interactionAcetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
How Acetaminophen, Propoxyphene interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Grape Seed ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
Read the full Grape Seed Extract + Acetaminophen, Propoxyphene interactionTrans ResveratrolCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Trans Resveratrol + Acetaminophen, Propoxyphene interactionAcetaminophen, PseudoephedrineChildren's Tylenol Sinus, Dristan N.D., Non-Aspirin Sinus, Ornex, Ornex-Max, Sinutab +5 more
How Acetaminophen, Pseudoephedrine interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Grape Seed ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
Read the full Grape Seed Extract + Acetaminophen, Pseudoephedrine interactionTrans ResveratrolCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Resveratrol might increase levels of drugs metabolized by CYP2E1.
Read the full Trans Resveratrol + Acetaminophen, Pseudoephedrine interactionAcetaminophen, Pseudoephedrine, TriprolidineActifed Plus ES
How Acetaminophen, Pseudoephedrine, Triprolidine interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Trans Resveratrol + Acetaminophen, Pseudoephedrine, Triprolidine interactionGrape Seed ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
Read the full Grape Seed Extract + Acetaminophen, Pseudoephedrine, Triprolidine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Fish OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Fish Oil + Acetazolamide interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Acetazolamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Ageless — through 3 ingredients. Tap an ingredient for the detail:
Grape Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Grape Seed Extract + Acetylsalicylic Acid interactionTrans ResveratrolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Trans Resveratrol + Acetylsalicylic Acid interactionFish OilAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Fish Oil + Acetylsalicylic Acid interactionAdagrasibKrazati
How Adagrasib interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Adagrasib interactionGrape Seed ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Seed Extract + Adagrasib interactionAerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri
How Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
Read the full Trans Resveratrol + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interactionGrape Seed ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Grape Seed Extract + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interactionAgomelatineValdoxan
How Agomelatine interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Grape Seed ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
Read the full Grape Seed Extract + Agomelatine interactionTrans ResveratrolCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
Read the full Trans Resveratrol + Agomelatine interactionAlfentanilAlfenta
How Alfentanil interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Grape Seed ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Seed Extract + Alfentanil interactionTrans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Alfentanil interactionAlfuzosinUroxatral
How Alfuzosin interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Alfuzosin interactionGrape Seed ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Seed Extract + Alfuzosin interactionAliskirenTekturna
How Aliskiren interacts with Ageless — through 4 ingredients. Tap an ingredient for the detail:
Grape Seed ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Seed Extract + Aliskiren interactionTrans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Aliskiren interactionFish OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Fish Oil + Aliskiren interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Aliskiren interactionAlmotriptanAlmogran, Axert
How Almotriptan interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Grape Seed ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Seed Extract + Almotriptan interactionTrans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Almotriptan interactionAlogliptinNesina
How Alogliptin interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Alogliptin interactionGrape Seed ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Seed Extract + Alogliptin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Grape Seed ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Seed Extract + Alogliptin, Pioglitazone interactionTrans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Alogliptin, Pioglitazone interactionAlpelisibPiqray
How Alpelisib interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Grape Seed ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Seed Extract + Alpelisib interactionTrans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Alpelisib interactionAlprazolamNiravam, Xanax
How Alprazolam interacts with Ageless — through 2 ingredients. Tap an ingredient for the detail:
Trans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Alprazolam interactionGrape Seed ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Seed Extract + Alprazolam interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Ageless — through 3 ingredients. Tap an ingredient for the detail:
Trans ResveratrolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Trans Resveratrol + Alteplase, Tpa interactionGrape Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Grape Seed Extract + Alteplase, Tpa interactionFish OilAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Fish Oil + Alteplase, Tpa interactionAltretamineHexalen
How Altretamine interacts with Ageless — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Altretamine interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Ageless — through 3 ingredients. Tap an ingredient for the detail:
Trans ResveratrolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Trans Resveratrol + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionGrape Seed ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
Read the full Grape Seed Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionFish OilAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Fish Oil + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Ageless — through 3 ingredients. Tap an ingredient for the detail:
Grape Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Grape Seed Extract + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionTrans ResveratrolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Trans Resveratrol + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionFish OilAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Fish Oil + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Ageless — through 4 ingredients. Tap an ingredient for the detail:
Fish OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Fish Oil + Ambrisentan interactionGrape Seed ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
Read the full Grape Seed Extract + Ambrisentan interactionTrans ResveratrolCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
Read the full Trans Resveratrol + Ambrisentan interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Ambrisentan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Ageless with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Grape seed extract
Anticoagulant/Antiplatelet Drugs
Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.
Cyclosporine (Neoral, Sandimmune)
Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.
Midazolam (Versed)
Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.
Phenacetin
Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).
Cytochrome P450 2C9 (Cyp2C9) Substrates
It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.
Resveratrol
Anticoagulant/Antiplatelet Drugs
Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Resveratrol seems to have antiplatelet effects.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that resveratrol can inhibit CYP2C19 enzymes. However, this interaction has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Resveratrol might increase levels of drugs metabolized by CYP2E1.
In vitro research suggests that resveratrol inhibits CYP2E1 isoenzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.
Fish Oil
Antihypertensive Drugs
Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.
Clinical evidence indicates that fish oils can modestly lower blood pressure and might have additive effects in patients treated with antihypertensives.
Contraceptive Drugs
Theoretically, taking fish oil with contraceptive drugs might decrease the triglyceride-lowering effects of fish oil.
There is some evidence that contraceptive drugs might interfere with the triglyceride lowering effects of fish oils.
Cyclosporine (Neoral, Sandimmune)
Taking fish oil with cyclosporine might increase levels and adverse effects of cyclosporine.
In kidney transplant recipients on a general immunosuppressive regimen, taking omega-3 fatty acids daily seems to increase peak blood levels of cyclosporine when compared with placebo. This increase was as much as 20% after one month. However, the area under the curve was not significantly affected.
Orlistat (Xenical, Alli)
Theoretically, taking fish oil with orlistat might decrease the absorption of fish oil fatty acids.
Orlistat binds lipase in the gastrointestinal tract and reduces fat absorption. Theoretically, taking fish oil with orlistat might decrease absorption of fish oil fatty acids. To avoid this potential interaction, recommend separating administration of orlistat and fish oil by at least 2 hours.
Sirolimus (Rapamune)
Taking fish oil with sirolimus might increase levels and adverse effects of sirolimus.
Pharmacokinetic research shows that omega-3 fatty acids increase exposure to sirolimus in kidney transplant patients on a calcineurin inhibitor-free immunosuppressive regimen. A 25% dose reduction in sirolimus was required to keep patients within the expected trough-concentration window. Researchers hypothesize that this may be due to inhibition of cytochrome P450 3A4 (CYP3A4) by fish oil, although this has not been confirmed in clinical research.
Tacrolimus (Prograf)
Taking fish oil with tacrolimus might increase levels and adverse effects of tacrolimus.
In a small group of patients, taking fish oil 2.6 grams (Omacor) daily for 4 weeks increased the 8-hour area under the curve of tacrolimus by 25% when compared with baseline. Peak levels were increased by approximately 22%. Researchers hypothesize that this may be due either to an increase in bioavailability or to inhibition of cytochrome P450 3A4 (CYP3A4) by fish oil, although this has not been confirmed in clinical research.
Anticoagulant/Antiplatelet Drugs
Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, evidence is conflicting.
While fish oil may not be a potent inhibitor of platelet function, high doses of fish oil might have antiplatelet effects. Theoretically, concomitant use of fish oil with anticoagulant or antiplatelet drugs may increase the risk of bleeding. However, the most rigorous research shows that short-term doses of fish oil 10 grams daily or long-term doses of 1.5 grams daily for up to 52 weeks does not increase the risk of bleeding or affect coagulation parameters in chronically ill and vulnerable patients. Other controlled research shows that fish oil does not affect platelet function or increase the risk of bleeding. Some research even suggests that perioperative fish oil use decreases bleeding risk. Some research suggests fish oil does not have additive antiplatelet effects when combined with aspirin, but other clinical evidence suggests that adding fish oil to low-dose aspirin treatment increases antiplatelet effects in patients who are aspirin-resistant. Also, some clinical research seems to show that fish oil has additive antiplatelet effects when used with aspirin and clopidogrel compared to aspirin and clopidogrel alone.
Platinum Agents
Theoretically, taking fish oil with platinum agents can cause resistance to platinum agents, potentially decreasing their effectiveness.
Platinum-induced fatty acids (PIFAs) are fatty acids secreted from human and mouse stem cells when exposed to platinum-based chemotherapy. Animal research suggests that PIFAs cause resistance to chemotherapy by stimulating lysophospholipid production in the spleen, which interferes with the DNA damage caused by certain chemotherapy drugs. One PIFA, known as 16:4(n-3), has been found in both raw fish and some commercially available fish oil products. Mackerel and herring have high PIFA concentrations, while salmon and tuna have low PIFA concentrations. Levels of PIFA in commercial fish oil products ranged from 0.2- 5.7 microMol. Animal research shows that PIFA-containing fish oil products cause resistance to cisplatin, fluorouracil, irinotecan, and oxaliplatin. It is unclear if all commercially available fish oil products contain PIFAs. Additionally, it is argued that levels of PIFA found in some fish oil products are too low to be of clinical concern. Furthermore, a lack of chemotherapy resistance in countries with high fish intake, such as Greenland, Japan, and Norway, suggest that this interaction may not be clinically significant.
Warfarin (Coumadin)
Fish oil may have antiplatelet effects and might increase the risk of bleeding if used with warfarin.
Fish oil has antiplatelet effects at high doses. Case reports show elevated INR in patients taking warfarin and fish oil 1-2 grams daily. However, some clinical research shows that taking fish oil 3-6 grams daily does not significantly increase INR in patients taking warfarin.
Coenzyme Q10
Alkylating Agents
Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.
Warfarin (Coumadin)
Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.
Antihypertensive Drugs
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.
Brand information
Manufacturer and brand details for Ageless, from the product label.
OL Olympian Labs
See all OL Olympian Labs products- Name
- Olympian Labs, Inc.
- City
- Phoenix
- State
- AZ
- ZipCode
- 85027
- Phone Number
- 1.800.473.5883
- Web Address
- www.olympianlabs.com
Ageless by OL Olympian Labs: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Ageless’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Fish Oil
Interacts with 327 drugsFish oil provides omega-3 fatty acids (EPA and DHA) that are best known for lowering high triglyceride levels. The evidence for other heart and health benefits is mixed, and it is generally...
Read the full Fish Oil monograph → Herb & supplement monographCoenzyme Q10
Interacts with 198 drugsCoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...
Read the full Coenzyme Q10 monograph → Herb & supplement monographResveratrol
Interacts with 822 drugsResveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While lab and animal studies are promising, s...
Read the full Resveratrol monograph → Herb & supplement monographGrape
Interacts with 910 drugsGrapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and blood vessel health. While the food is he...
Read the full Grape monograph →Sources & How We Checked
Ageless's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 255 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Fish Oil 157 references
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- Allard JP, Kurian R, Aghdassi E, Muggli R, et al. Lipid peroxidation during n-3 fatty acid and vitamin E supplementation in humans. Lipids 1997;32:535-41.. PubMed
- Toft I, Bonaa KH, Ingebretsen OC, et al. Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension. A randomized, controlled trial. Ann Intern Med 1995;123:911-8.
- Onwude JL, Lilford RJ, Hjartardottir H, et al. A randomised double blind placebo controlled trial of fish oil in high risk pregnancy. Br J Obstet Gynaecol 1995;102:95-100. PubMed
- Bulstra-Ramakers MT, Huisjes HJ, Visser GH. The effects of 3g eicosapentaenoic acid daily on recurrence of intrauterine growth retardation and pregnancy induced hypertension. Br J Obstet Gynaecol 1995;102:123-6. PubMed
- Sacks FM, Hebert P, Appel LJ, et al. Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the trials of hypertension prevention. J Hypertens 1994;12:209-13.
- Vandongen R, Mori TA, Burke V, et al. Effects on blood pressure of omega 3 fats in subjects at increased risk of cardiovascular disease. Hypertension 1993;22:371-9. PubMed
- Hawthorne AB, Daneshmend TK, Hawkey CJ, et al. Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial. Gut 1992;33:922-8. PubMed
- D'Almeida A, Carter JP, Anatol A, Prost C. Effects of a combination of evening primrose oil (gamma linolenic acid) and fish oil (eicosapentaenoic + docahexaenoic acid) versus magnesium, and versus placebo in preventing pre-eclampsia. Women Health 1992;19 PubMed
- FDA. Center for Food Safety and Applied Nutrition. Letter regarding dietary supplement health claim for omega-3 fatty acids and coronary heart disease. Available at: http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-Rpt0272-38-Appendix-D-Reference
- Montori VM, Farmer A, Wollan PC, Dinneen SF. Fish oil supplementation in type 2 diabetes: a quantitative systemic review (abstract). Diabetes Care 2000;23:1407-15.
- Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
- Adler A, Holub BJ. Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men. Am J Clin Nutr 1997;65:445-50. PubMed
- Higdon JV, Liu J, Du S, et al. Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as asses
- Kastrup EK. Drug Facts and Comparisons. 1998 ed. St. Louis, MO: Facts and Comparisons, 1998.
- Belluzzi A, Brignola C, Campieri M, et al. Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease. N Engl J Med 1996;334:1557-60. PubMed
- Belluzzi A, Brignola C, Campieri M, et al. Effects of new fish oil derivative on fatty acid phospholipid-membrane pattern in a group of Crohn's disease patients. Dig Dis Sci 1994;39:2589-94. PubMed
- Mahan LK, Escott-Stump S. Krause's Food, Nutrition, and Diet Therapy. 9th edition. W.B. Saunders Co., Philadelphia, PA, 1996.
- Yetiv JZ. Clinical applications of fish oils. JAMA 1988;260:665-70. DOI
- de Deckere EAM, Korver O, Verschuren PM, Katan MB. Health aspects of fish and n-3 polyunsaturated fatty acids from plant and marine origin. Eur J Clin Nutr 1998;52:749-53. PubMed
- Sorensen NS, Marckmann P, Hoy CE, et al. Effect of fish-oil-enriched margarine on plasma lipids, low-density-lipoprotein particle composition, size, and susceptibility to oxidation. Am J Clin Nutr 1998;68:235-41. PubMed
- Kelley DS, Rudolph IL. Effect of individual fatty acids of omega-6 and omega-3 type on human immune status and role of eicosanoids. Nutrition 2000;16:143-5.
- Meydani SN, Dinarello CA. Influence of dietary fatty acids on cytokine production and its clinical implications. Nutr Clin Pract 1993;8:65-72. PubMed
- Caicoya M. Fish consumption and stroke: a community case-control study in Asturias, Spain. Neuroepidemiology 2002;21:107-14. PubMed
- Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
- Dewailly E, Blanchet C, Lemieux S, et al. n-3 Fatty acids and cardiovascular disease risk factors among the Inuit of Nunavik. Am J Clin Nutr 2001;74:464-73. PubMed
- Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
- Maresta A, Balduccelli M, Varani E, et al. Prevention of postcoronary angioplasty restenosis by omega-3 fatty acids: main results of the Esapent for Prevention of Restenosis Italian Study (ESPRIT). Am Heart J 143:E5. PubMed
- Deutch B, Jorgensen EB, Hansen JC. n-3 PUFA from fish or seal oil reduce atherogenic risk indicators in Danish women. Nutr Res 2000;20:1065-77. DOI
- Higgins S, McCarthy SN, Corridan BM, et al. Measurement of free cholesterol, cholesteryl esters and cholesteryl linoleate hydroperoxide in copper-oxidised low density lipoprotein in healthy volunteers supplemented with a low dose of n-3 polyunsaturated f
- Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
- Lacaille B, Julien P, Deshaies Y, et al. Responses of plasma lipoproteins and sex hormones to the consumption of lean fish incorporated in a prudent-type diet in normolipidemic men. J Am Coll Nutr 2000;19:745-53. PubMed
- Pedersen HS, Mulvad G, Seidelin KN, et al. N-3 fatty acids as a risk factor for haemorrhagic stroke. Lancet 1999;353:812-3. PubMed
- Higdon JV, Du SH, Lee YS, et al. Supplementation of postmenopausal women with fish oil does not increase overall oxidation of LDL ex vivo compared to dietary oils rich in oleate and linoleate. J Lipid Res 2001;42:407-18. DOI
- Olsen SF, Sorensen JD, Secher NJ, et al. Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration. Lancet 1992;339:1003-7. PubMed
- Ito Y, Suzuki K, Imai H, et al. Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. Cancer Lett 2001;163:171-8. PubMed
- Bender NK, Kraynak MA, Chiquette E, et al. Effects of marine fish oils on the anticoagulation status of patients receiving chronic warfarin therapy. J Thromb Thrombolysis 1998;5:257-61.. PubMed
- Suzukawa M, Abbey M, Howe PR, Nestel PJ. Effects of fish oil fatty acids on low density lipoprotein size, oxidizability, and uptake by macrophages. J Lipid Res 1995;36:473-84.. DOI
- Su KP, Huang SY, Chiu CC, Shen WW. Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial. Eur Neuropsychopharmacol 2003;13:267-71..
- Wang C, Chung M, Lichtenstein A, et al. Effects of omega-3 fatty acids on cardiovascular disease. Evid Rep Technol Assess (Summ) 2004 Mar;(94):1-8.
- US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Seafood. Mercury levels in seafood species. Available at: http://www.cfsan.fda.gov/~frf/sea-mehg.html.
- US Environmental Protection Agency. Fish Advisories web page. Available at: http://www.epa.gov/waterscience/fish.
- Dunstan JA, Roper J, Mitoulas L, et al. The effect of supplementation with fish oil during pregnancy on breast milk immunoglobulin A, soluble CD14, cytokine levels and fatty acid composition. Clin Exp Allergy 2004;34:1237-42. PubMed
- Lauritzen L, Jorgensen MH, Mikkelsen TB, et al. Maternal fish oil supplementation in lactation: effect on visual acuity and n-3 fatty acid content of infant erythrocytes. Lipids 2004;39:195-206. PubMed
- Dunstan JA, Mori TA, Barden A et al. Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial. J Allergy Clin Immunol 2003;112:1178-84 PubMed
- Olsen SF, Secher NJ, Tabor A, et al. Randomised clinical trials of fish oil supplementation in high risk pregnancies. Fish Oil Trials In Pregnancy (FOTIP) Team. BJOG 2000;107:382-95. PubMed
- Stern AH. A review of the studies of the cardiovascular health effects of methylmercury with consideration of their suitability for risk assessment. Environ Res 2005;98:133-42. PubMed
- Harris WS. Fish oil supplementation: evidence for health benefits. Cleve Clin J Med 2004;71:208-10, 212, 215-8 passim. PubMed
- Raitt MH, Connor WE, Morris C, et al. Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators: a randomized controlled trial. JAMA 2005;293:2884-91. DOI
- Svaneborg N, Kristensen SD, Hansen LM, et al. The acute and short-time effect of supplementation with the combination of n-3 fatty acids and acetylsalicylic acid on platelet function and plasma lipids. Thromb Res 2002;105:311-6. PubMed
- Lauritzen L, Hoppe C, Straarup EM, Michaelsen KF. Maternal fish oil supplementation in lactation and growth during the first 2.5 years of life. Pediatr Res 2005;58:235-42. PubMed
- Dunstan JA, Mori TA, Barden A, et al. Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition. Eur J Clin Nutr 2004;58:429-37. PubMed
- Dunstan JA, Simmer K, Dixon G, Prescott SL. Cognitive assessment at 2 1/2 years following fish oil supplementation in pregnancy: a randomized controlled trial. Arch Dis Child Fetal Neonatal Ed 2008;93(1):F45-50.
- McKenney JM, Sica D. Prescription omega-3 fatty acids for the treatment of hypertriglyceridemia. Am J Health-Syst Pharm 2007;64:595-605. PubMed
- Malinowski JM, Metka K. Elevation of low-density lipoprotein cholesterol concentration with over-the-counter fish oil supplementation. Ann Pharmacother 2007;41:1296-300. PubMed
- Gissi-HF Investigators; Tavazzi L, Maggioni AP, Marchioli R, et al. Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet 2008;372:1223-30. PubMed
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