Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Andrographis with AP-Bio 1000 mg Ingredients & Drug Interactions

by Double Wood Supplements

Capsule Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Andrographis with AP-Bio 1000 mg is a dietary supplement by Double Wood Supplements with 3 active ingredients. Its ingredients are commonly taken for common cold and flu symptoms, upper respiratory infections, sore throat.Based on those ingredients, 413 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Andrographis paniculata extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Andrographis with AP-Bio 1000 mg by Double Wood Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 3 active ingredients, all of which are andrographis paniculata extract — the same herb listed three times. Andrographis is a traditional plant used in herbal medicine, and the extract is where the active compounds concentrate.

The capsule also contains two inactive ingredients: hypromellose and rice flour, which are there to hold the supplement together and make it easier to take.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: immune system health support.
  • We looked for evidence on: Acute bronchitis, Coronavirus disease 2019 (COVID-19), Influenza, Rhinosinusitis, Tonsillopharyngitis, Upper respiratory tract infection (URTI) — and 3 related terms.
  • The strongest evidence on file: Andrographis is rated "Possibly Effective" for Tonsillopharyngitis (Natural Medicines).
  • Also on file: Andrographis is rated "Insufficient Reliable Evidence To Rate" for Acute bronchitis, Upper respiratory tract infection (URTI), Influenza, Rhinosinusitis, and more.

Andrographis is possibly effective for three uses: ulcerative colitis (inflammatory bowel condition), tonsillopharyngitis (sore throat and tonsil inflammation), and osteoarthritis (joint wear and tear). For familial Mediterranean fever (a rare inherited inflammatory condition), there isn't enough reliable evidence to know whether it works.

The data we hold doesn't establish effectiveness for other purposes.

The evidence, ingredient by ingredient Andrographis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Andrographis is generally well tolerated in the short term, but we don't have solid long-term safety data or reliable information about product quality across brands. The most common side effects are abdominal discomfort, altered taste, diarrhea, dizziness, fatigue, headache, nausea, vomiting, itching, and rash.

Headache and fatigue happen more often at high doses and beyond 14 days of use. Rarely, severe allergic reactions including anaphylaxis have been reported.

Skin reactions — including rash, itching, hives, and in rare cases Stevens-Johnson syndrome (a serious blistering condition) — have also been reported. Don't use this during pregnancy; the safety data advises against it because of theoretical and animal-study concerns about reproductive effects.

There isn't enough information about safety while breastfeeding, so avoid it then too.

Side effects, ingredient by ingredient Andrographis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Andrographis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs.
  • For scale: 413 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, check with your pharmacist if you're on blood pressure–lowering drugs, blood thinners or antiplatelet drugs, or immunosuppressants. Also double-check if you take etoricoxib, celecoxib, or glipizide.

These are the drug types most likely to interact with andrographis.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Andrographis may be worth considering if you have a sore throat, inflammatory bowel symptoms, or joint pain and you aren't on blood pressure drugs, blood thinners, or immune-suppressing medications. If you take any of those drugs or have a history of allergic reactions, talk to your pharmacist or doctor first.

Pregnant or breastfeeding? Skip this one.

Short-term use seems safer than long-term — stick to the label duration.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Andrographis with AP-Bio 1000 mg, straight from the product label.

Brand Double Wood Supplements
Barcode (UPC) 859793007754
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2021
DSLD ID 241710
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Andrographis with AP-Bio 1000 mg by Double Wood Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
859793007754
IngredientAmount% DV
Andrographis paniculata extract600 mg--
Andrographis paniculata extract300 mg--
Andrographis paniculata extract100 mg--

Other ingredients: Hypromellose, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Directions: Andrographis paniculata,commonly known as "king of bitters,' is an herb used in Ayurveda and Traditional Chinese Medicine for immune system health. The active ingredient can be traced back to a single diterpene molecule called andrographolide. This product contains two generic forms of Andrographis and patented AP-Bio Andrographis which is standardized to a minimum 30% Andrographolides.

With AP-Bio 1000 mg per serving

Formulation

Ap-Bio has been clilnically studied to support immune system health.

Supports immune system health Clinically studied for immune health

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement for immune system support, take 2 capsules per day with meals. It is not recommended to exceed a 4 capsule dosage per day.

Storage

Storage: Store in a cool, dark place. Do not freeze or expose to moisture or heat above room temperature.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

AP-Bio is a registered trademark of Natural Remedies.

Precautions

Warning: Consult your physician before use.

Do not use Andrographis if you are pregnant, nursing or are under 18 years of age.

Do not use Andrographis if you are pregnant, nursing or are under 18 years of age.

Do not take Andrographis and operate heavy machinery until you know how it affects you.

Keep out of reach of children.

Do not exceed 4 capsules per day.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Andrographis with AP-Bio 1000 mg by Double Wood Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Andrographis with AP-Bio 1000 mg by Double Wood Supplements

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Andrographis paniculata extract

Interacts with
413 drugs
600 mg per serving

Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten...

Andrographis paniculata extract monograph & interactions

Andrographis paniculata extract

Interacts with
413 drugs
300 mg per serving Form: Andrographolides

Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten...

Andrographis paniculata extract monograph & interactions

Andrographis paniculata extract

Interacts with
413 drugs
100 mg per serving Form: Andrographolides

Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten...

Andrographis paniculata extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Andrographis with AP-Bio 1000 mg by Double Wood Supplements Drug Interactions

Want to check YOUR meds against Andrographis with AP-Bio 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
413Drugs
408 Moderate 5 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Andrographis with AP-Bio 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Andrographis paniculata extract6 drug types · 413 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal and laboratory studies suggest that andrographis has antiplatelet effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Animal research suggests that andrographis has hypotensive effects.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Laboratory research suggests that andrographolide has immunostimulant activity.

Likelihood Possible Evidence D
Celecoxib (Celebrex)

Theoretically, andrographis extract might increase the maximum concentration and time to peak concentration of celecoxib. The clinical significance of these changes is unclear.
Animal research suggests that andrographis extract taken orally increases the maximum concentration and time to peak concentration of celecoxib but does not appear to impact the area under the curve.

Likelihood Possible Evidence D
Etoricoxib (Arcoxia)

Theoretically, andrographis might decrease the absorption of etoricoxib, although the clinical significance is unclear.
Animal research shows that andrographis extract, or the constituent andrographolide, taken orally with etoricoxib decreases the bioavailability of etoricoxib. However, this reduced bioavailability is not correlated with a reduction in the anti-inflammatory effects of etoricoxib in arthritic mice models. The clinical significance of this interaction is unclear.

Likelihood Possible Evidence D
Glipizide (Glucotrol)

Theoretically, andrographis extract might increase the maximum concentration and area under the curve of glipizide; however, opposite effects are seen with the constituent, andrographolide. The clinical significance of this interaction is unclear.
Animal research suggests that andrographis extract taken orally with glipizide in diabetes-induced rats increases the maximum concentration and area under the curve of glipizide. However, the opposite effect is seen with the constituent, andrographolide, in which the maximum concentration and area under the curve are decreased when taken with glipizide.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Andrographis with AP-Bio 1000 mg, from the product label.

Double Wood Supplements

See all Double Wood Supplements products
Name
Double Wood LLC
Street Address
3510 Scotts Ln Ste 219
City
Philadelphia
State
PA
ZipCode
19129-1573
Web Address
www.doublewoodsupplements.com
Pharmacist Counseling Corner

Andrographis with AP-Bio 1000 mg by Double Wood Supplements: Common Questions

Does Andrographis with AP-Bio 1000 mg by Double Wood Supplements interact with any medications?
Yes. Based on its ingredients, Andrographis with AP-Bio 1000 mg has a known interaction with 413 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Andrographis with AP-Bio 1000 mg contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is in this product?
It's andrographis paniculata extract — a plant herb used traditionally. The extract concentrates the active compounds. The capsule also has hypromellose and rice flour to hold it together. That's it.
Can I take this while I'm pregnant or breastfeeding?
No. The safety data advises against it during pregnancy because of concerns about reproductive effects shown in animal studies. There's not enough information about safety while breastfeeding either, so you should avoid it then too. Talk with your doctor if you're wondering about safety in either situation.
How long can I safely take andrographis?
Short-term is safer than long-term — adverse effects are more likely when doses are high or when you take it for more than 14 days. Quality and long-term safety data aren't well established, so follow the label directions and don't assume longer is better.
What side effects might I notice?
Common ones are upset stomach, taste changes, diarrhea, dizziness, tiredness, headache, nausea, vomiting, itching, and rash. Headache and fatigue are more likely at higher doses. Rarely, severe allergic reactions or serious skin conditions like Stevens-Johnson syndrome have occurred.
Does andrographis actually work for sore throat or joint pain?
It's possibly effective for sore throat and joint pain (osteoarthritis), and also for ulcerative colitis. That means there's some evidence, but it's not yet definitive. For familial Mediterranean fever, there isn't enough reliable evidence to say one way or the other.
What should I know before I start taking it?
Check with your pharmacist if you take blood pressure drugs, blood thinners, antiplatelet drugs, or immune-suppressing medications — andrographis interacts with these. Also mention pain relievers or diabetes drugs you're on. Keep to short-term use and watch for any rash, itching, or allergic signs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Andrographis with AP-Bio 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Andrographis with AP-Bio 1000 mg label
Go deeper

The Full Monographs Behind Andrographis with AP-Bio 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Andrographis with AP-Bio 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Andrographis 26 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Thamlikitkul V, Dechatiwongse T, Theerapong S, et al. Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults. J Med Assoc Thai 1991;74:437-42.
  3. Zhang CY, Tan BK. Mechanisms of cardiovascular activity of Andrographis paniculata in the anaesthetized rat. J Ethnopharmacol 1997;56:97-101. PubMed
  4. Zhao HY, Fang WY. Antithrombotic effects of Andrographis paniculata nees in preventing myocardial infarction. Chin Med J (Engl) 1991;104:770-5.
  5. Amroyan E, Gabrielian E, Panossian A, et al. Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation. Phytomedicine 1999;6:27-31. PubMed
  6. Zhang C, Kuroyangi M, Tan BK. Cardiovascular activity of 14-deoxy-11,12-didehydroandrographolide in the anaesthetised rat and isolated right atria. Pharmacol Res 1998;38:413-7. PubMed
  7. Puri A, Saxena R, Saxena RP, et al. Immunostimulant agents from Andrographis paniculata. J Nat Prod 1993;56:995-9. PubMed
  8. Melchoir J, Spasov AA, Ostrovskij OV, et al. Double-blind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (Kan Jang) in the treatment of uncomplicated upper-respirator
  9. Calabrese C, Berman SH, Babish JG, et al. A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytother Res 2000;14:333-8. PubMed
  10. Gabrielian ES, Shukarian AK, Goukasova GI, et al. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine 2002;9:589-97 PubMed
  11. Poolsup N, Suthisisang C, Prathanturarug S, et al. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. J Clin Pharm Ther 2004;29:37-45. PubMed
  12. Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med 2004;70:293-8.
  13. Kligler, B., Ulbricht, C., Basch, E., Kirkwood, C. D., Abrams, T. R., Miranda, M., Singh Khalsa, K. P., Giles, M., Boon, H., and Woods, J. Andrographis paniculata for the treatment of upper respiratory infection: a systematic review by the natural standa
  14. Burgos, R. A., Hancke, J. L., Bertoglio, J. C., Aguirre, V., Arriagada, S., Calvo, M., and Caceres, D. D. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled tria
  15. Saxena, R. C., Singh, R., Kumar, P., Yadav, S. C., Negi, M. P., Saxena, V. S., Joshua, A. J., Vijayabalaji, V., Goudar, K. S., Venkateshwarlu, K., and Amit, A. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis pa
  16. Tang, T., Targan, S. R., Li, Z. S., Xu, C., Byers, V. S., and Sandborn, W. J. Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine. Aliment.Pharmacol Ther 2011;33(2) PubMed
  17. Sandborn, W. J., Targan, S. R., Byers, V. S., Rutty, D. A., Mu, H., Zhang, X., and Tang, T. Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. Am J Gastroenterol. 2013;108(1):90-98. PubMed
  18. Melchior, J., Palm, S., and Wikman, G. Controlled clinical study of standardized Andrographis paniculata extract in common cold - a pilot trial. Phytomedicine. 1997;3(4):315-318. PubMed
  19. Balap A, Atre B, Lohidasan S, et al. Pharmacokinetic and pharmacodynamic herb-drug interaction of Andrographis paniculata (Nees) extract and andrographolide with etoricoxib after oral administration in rats. J Ethnopharmacol. 2016 May 13;183:9-17. PubMed
  20. Bertoglio JC, Baumgartner M, Palma R, et al. Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis: a 12-month double-blind placebo-controlled pilot study. BMC Neurol. 2016; 16(1):77. PubMed
  21. Suwankesawong W, Saokaew S, Permsuwan U, et al. Characterization of hypersensitivity reactions reported among Andrographis paniculata users in Thailand using Health Product Vigilance Center (HPVC) database. BMC Complement Altern Med. 2014; 14:515. PubMed
  22. Ciampi E, Uribe-San-Martin R, Cárcamo C, et al. Efficacy of andrographolide in not active progressive multiple sclerosis: a prospective exploratory double-blind, parallel-group, randomized, placebo-controlled trial. BMC Neurol 2020;20(1):173. PubMed
  23. Worakunphanich W, Thavorncharoensap M, Youngkong S, Thadanipon K, Thakkinstian A. Safety of Andrographis paniculata: A systematic review and meta-analysis. Pharmacoepidemiol Drug Saf 2021;30(6):727-739.
  24. More SJ, Tandulwadkar SS, Balap AR, Lohidasan S, Sinnathambi A, Mahadik KR. Effect of Andrographis paniculata extract and Andrographolide on the pharmacokinetics of Aceclofenac and Celecoxib in rats. Futur J Pharm Sci. 2023;9(1):1. PubMed
  25. Sundhani E, Nugroho AE, Nurrochmad A, Puspitasari I, Amalia Prihati D, Lukitaningsih E. Pharmacokinetic Herb-Drug Interactions of Glipizide with Andrographis paniculata (Burm. f.) and Andrographolide in Normal and Diabetic Rats by Validated HPLC Method. M PubMed
  26. Shang YX, Shen C, Stub T, et al. Adverse Effects of Andrographolide Derivative Medications Compared to the Safe use of Herbal Preparations of Andrographis paniculata: Results of a Systematic Review and Meta-Analysis of Clinical Studies. Front Pharmacol 20 PubMed

See these in context on the Andrographis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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