Andrographis with AP-Bio 1000 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Andrographis with AP-Bio 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Andrographis with AP-Bio 1000 mg is a dietary supplement by Double Wood Supplements with 3 active ingredients. Its ingredients are commonly taken for common cold and flu symptoms, upper respiratory infections, sore throat.Based on those ingredients, 413 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Andrographis paniculata extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Andrographis with AP-Bio 1000 mg by Double Wood Supplements
Ask about any prescription or over-the-counter medication and we check it for interactions with Andrographis with AP-Bio 1000 mg by Double Wood Supplements — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Andrographis with AP-Bio 1000 mg by Double Wood Supplements
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 3 active ingredients, all of which are andrographis paniculata extract — the same herb listed three times. Andrographis is a traditional plant used in herbal medicine, and the extract is where the active compounds concentrate.
The capsule also contains two inactive ingredients: hypromellose and rice flour, which are there to hold the supplement together and make it easier to take.
Does it work?
Moderate evidence
Andrographis is possibly effective for three uses: ulcerative colitis (inflammatory bowel condition), tonsillopharyngitis (sore throat and tonsil inflammation), and osteoarthritis (joint wear and tear). For familial Mediterranean fever (a rare inherited inflammatory condition), there isn't enough reliable evidence to know whether it works.
The data we hold doesn't establish effectiveness for other purposes.
How safe is it?
Well-documented data
Andrographis is generally well tolerated in the short term, but we don't have solid long-term safety data or reliable information about product quality across brands. The most common side effects are abdominal discomfort, altered taste, diarrhea, dizziness, fatigue, headache, nausea, vomiting, itching, and rash.
Headache and fatigue happen more often at high doses and beyond 14 days of use. Rarely, severe allergic reactions including anaphylaxis have been reported.
Skin reactions — including rash, itching, hives, and in rare cases Stevens-Johnson syndrome (a serious blistering condition) — have also been reported. Don't use this during pregnancy; the safety data advises against it because of theoretical and animal-study concerns about reproductive effects.
There isn't enough information about safety while breastfeeding, so avoid it then too.
Meds to double-check
Moderate interaction found
Before you take this, check with your pharmacist if you're on blood pressure–lowering drugs, blood thinners or antiplatelet drugs, or immunosuppressants. Also double-check if you take etoricoxib, celecoxib, or glipizide.
These are the drug types most likely to interact with andrographis.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Andrographis may be worth considering if you have a sore throat, inflammatory bowel symptoms, or joint pain and you aren't on blood pressure drugs, blood thinners, or immune-suppressing medications. If you take any of those drugs or have a history of allergic reactions, talk to your pharmacist or doctor first.
Pregnant or breastfeeding? Skip this one.
Short-term use seems safer than long-term — stick to the label duration.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Andrographis with AP-Bio 1000 mg, straight from the product label.
| Brand | Double Wood Supplements |
|---|---|
| Barcode (UPC) | 859793007754 |
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 22, 2021 |
| DSLD ID | 241710 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Andrographis with AP-Bio 1000 mg by Double Wood Supplements, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Andrographis paniculata extract | 600 mg | -- |
| Andrographis paniculata extract | 300 mg | -- |
| Andrographis paniculata extract | 100 mg | -- |
Other ingredients: Hypromellose, Rice Flour
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Directions: Andrographis paniculata,commonly known as "king of bitters,' is an herb used in Ayurveda and Traditional Chinese Medicine for immune system health. The active ingredient can be traced back to a single diterpene molecule called andrographolide. This product contains two generic forms of Andrographis and patented AP-Bio Andrographis which is standardized to a minimum 30% Andrographolides.
With AP-Bio 1000 mg per serving
Formulation
Ap-Bio has been clilnically studied to support immune system health.
Supports immune system health Clinically studied for immune health
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement for immune system support, take 2 capsules per day with meals. It is not recommended to exceed a 4 capsule dosage per day.
Storage
Storage: Store in a cool, dark place. Do not freeze or expose to moisture or heat above room temperature.
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
AP-Bio is a registered trademark of Natural Remedies.
Precautions
Warning: Consult your physician before use.
Do not use Andrographis if you are pregnant, nursing or are under 18 years of age.
Do not use Andrographis if you are pregnant, nursing or are under 18 years of age.
Do not take Andrographis and operate heavy machinery until you know how it affects you.
Keep out of reach of children.
Do not exceed 4 capsules per day.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Andrographis with AP-Bio 1000 mg by Double Wood Supplements label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Andrographis with AP-Bio 1000 mg by Double Wood Supplements
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Andrographis paniculata extract
Interacts with413 drugs
Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten...
Andrographis paniculata extract monograph & interactionsAndrographis paniculata extract
Interacts with413 drugs
Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten...
Andrographis paniculata extract monograph & interactionsAndrographis paniculata extract
Interacts with413 drugs
Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten...
Andrographis paniculata extract monograph & interactionsOther (inactive) ingredients: Hypromellose, Rice Flour. These complete the product’s ingredient list but are not active constituents.
Andrographis with AP-Bio 1000 mg by Double Wood Supplements Drug Interactions
HelloPharmacist Interaction Report
Andrographis with AP-Bio 1000 mg from Double Wood Supplements does interact with medications.
The most serious concern is with blood pressure–lowering drugs (antihypertensive drugs): andrographis may increase the risk of low blood pressure when combined with these medications. Animal research shows andrographis has blood pressure–lowering effects.
Read the full breakdown — every affected drug type, severity by severity
Andrographis also carries Moderate risk with blood thinners and antiplatelet drugs like warfarin or aspirin — it may increase your bleeding risk. The supplement appears to have antiplatelet effects based on animal and lab studies.
Additionally, it may interfere with immunosuppressants (drugs that tamp down your immune system), since andrographis seems to stimulate immune activity.
Minor interactions are documented with the pain reliever etoricoxib (which andrographis may reduce the absorption of), celecoxib, and the diabetes medication glipizide, though the clinical significance of these changes isn't yet clear. Altogether, these interactions span 407 individual medications.
Check your exact medications with the search tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Andrographis with AP-Bio 1000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Andrographis with AP-Bio 1000 mg interact with 413 drugs. Click any drug to see the details.
1 of the 3 ingredients in Andrographis with AP-Bio 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Andrographis paniculata extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Paniculata Extract + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata Extract + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata Extract + Abrocitinib interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata Extract + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata Extract + Acetaminophen, Ibuprofen interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata Extract + Acetazolamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata Extract + Acetylsalicylic Acid interactionAdalimumabHumira
How Adalimumab interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Paniculata Extract + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Paniculata Extract + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Paniculata Extract + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Paniculata Extract + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Paniculata Extract + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Paniculata Extract + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Paniculata Extract + Adalimumab-fkjp interactionAlefaceptAmevive
How Alefacept interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Paniculata Extract + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Read the full Andrographis Paniculata Extract + Alemtuzumab interactionAliskirenTekturna
How Aliskiren interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata Extract + Aliskiren interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata Extract + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Andrographis Paniculata Extract + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata Extract + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata Extract + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata Extract + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata Extract + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata Extract + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata Extract + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Andrographis with AP-Bio 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
Andrographis Paniculata ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis Paniculata Extract + Amlodipine Besylate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Andrographis with AP-Bio 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Andrographis paniculata extract
Anticoagulant/Antiplatelet Drugs
Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal and laboratory studies suggest that andrographis has antiplatelet effects.
Antihypertensive Drugs
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Animal research suggests that andrographis has hypotensive effects.
Immunosuppressants
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Laboratory research suggests that andrographolide has immunostimulant activity.
Celecoxib (Celebrex)
Theoretically, andrographis extract might increase the maximum concentration and time to peak concentration of celecoxib. The clinical significance of these changes is unclear.
Animal research suggests that andrographis extract taken orally increases the maximum concentration and time to peak concentration of celecoxib but does not appear to impact the area under the curve.
Etoricoxib (Arcoxia)
Theoretically, andrographis might decrease the absorption of etoricoxib, although the clinical significance is unclear.
Animal research shows that andrographis extract, or the constituent andrographolide, taken orally with etoricoxib decreases the bioavailability of etoricoxib. However, this reduced bioavailability is not correlated with a reduction in the anti-inflammatory effects of etoricoxib in arthritic mice models. The clinical significance of this interaction is unclear.
Glipizide (Glucotrol)
Theoretically, andrographis extract might increase the maximum concentration and area under the curve of glipizide; however, opposite effects are seen with the constituent, andrographolide. The clinical significance of this interaction is unclear.
Animal research suggests that andrographis extract taken orally with glipizide in diabetes-induced rats increases the maximum concentration and area under the curve of glipizide. However, the opposite effect is seen with the constituent, andrographolide, in which the maximum concentration and area under the curve are decreased when taken with glipizide.
Brand information
Manufacturer and brand details for Andrographis with AP-Bio 1000 mg, from the product label.
Double Wood Supplements
See all Double Wood Supplements products- Name
- Double Wood LLC
- Street Address
- 3510 Scotts Ln Ste 219
- City
- Philadelphia
- State
- PA
- ZipCode
- 19129-1573
- Web Address
- www.doublewoodsupplements.com
Andrographis with AP-Bio 1000 mg by Double Wood Supplements: Common Questions
Does Andrographis with AP-Bio 1000 mg by Double Wood Supplements interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What exactly is in this product?
Can I take this while I'm pregnant or breastfeeding?
How long can I safely take andrographis?
What side effects might I notice?
Does andrographis actually work for sore throat or joint pain?
What should I know before I start taking it?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Andrographis with AP-Bio 1000 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Andrographis with AP-Bio 1000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Andrographis with AP-Bio 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Andrographis 26 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Thamlikitkul V, Dechatiwongse T, Theerapong S, et al. Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults. J Med Assoc Thai 1991;74:437-42.
- Zhang CY, Tan BK. Mechanisms of cardiovascular activity of Andrographis paniculata in the anaesthetized rat. J Ethnopharmacol 1997;56:97-101. PubMed
- Zhao HY, Fang WY. Antithrombotic effects of Andrographis paniculata nees in preventing myocardial infarction. Chin Med J (Engl) 1991;104:770-5.
- Amroyan E, Gabrielian E, Panossian A, et al. Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation. Phytomedicine 1999;6:27-31. PubMed
- Zhang C, Kuroyangi M, Tan BK. Cardiovascular activity of 14-deoxy-11,12-didehydroandrographolide in the anaesthetised rat and isolated right atria. Pharmacol Res 1998;38:413-7. PubMed
- Puri A, Saxena R, Saxena RP, et al. Immunostimulant agents from Andrographis paniculata. J Nat Prod 1993;56:995-9. PubMed
- Melchoir J, Spasov AA, Ostrovskij OV, et al. Double-blind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (Kan Jang) in the treatment of uncomplicated upper-respirator
- Calabrese C, Berman SH, Babish JG, et al. A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytother Res 2000;14:333-8. PubMed
- Gabrielian ES, Shukarian AK, Goukasova GI, et al. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine 2002;9:589-97 PubMed
- Poolsup N, Suthisisang C, Prathanturarug S, et al. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. J Clin Pharm Ther 2004;29:37-45. PubMed
- Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med 2004;70:293-8.
- Kligler, B., Ulbricht, C., Basch, E., Kirkwood, C. D., Abrams, T. R., Miranda, M., Singh Khalsa, K. P., Giles, M., Boon, H., and Woods, J. Andrographis paniculata for the treatment of upper respiratory infection: a systematic review by the natural standa
- Burgos, R. A., Hancke, J. L., Bertoglio, J. C., Aguirre, V., Arriagada, S., Calvo, M., and Caceres, D. D. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled tria
- Saxena, R. C., Singh, R., Kumar, P., Yadav, S. C., Negi, M. P., Saxena, V. S., Joshua, A. J., Vijayabalaji, V., Goudar, K. S., Venkateshwarlu, K., and Amit, A. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis pa
- Tang, T., Targan, S. R., Li, Z. S., Xu, C., Byers, V. S., and Sandborn, W. J. Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine. Aliment.Pharmacol Ther 2011;33(2) PubMed
- Sandborn, W. J., Targan, S. R., Byers, V. S., Rutty, D. A., Mu, H., Zhang, X., and Tang, T. Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. Am J Gastroenterol. 2013;108(1):90-98. PubMed
- Melchior, J., Palm, S., and Wikman, G. Controlled clinical study of standardized Andrographis paniculata extract in common cold - a pilot trial. Phytomedicine. 1997;3(4):315-318. PubMed
- Balap A, Atre B, Lohidasan S, et al. Pharmacokinetic and pharmacodynamic herb-drug interaction of Andrographis paniculata (Nees) extract and andrographolide with etoricoxib after oral administration in rats. J Ethnopharmacol. 2016 May 13;183:9-17. PubMed
- Bertoglio JC, Baumgartner M, Palma R, et al. Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis: a 12-month double-blind placebo-controlled pilot study. BMC Neurol. 2016; 16(1):77. PubMed
- Suwankesawong W, Saokaew S, Permsuwan U, et al. Characterization of hypersensitivity reactions reported among Andrographis paniculata users in Thailand using Health Product Vigilance Center (HPVC) database. BMC Complement Altern Med. 2014; 14:515. PubMed
- Ciampi E, Uribe-San-Martin R, Cárcamo C, et al. Efficacy of andrographolide in not active progressive multiple sclerosis: a prospective exploratory double-blind, parallel-group, randomized, placebo-controlled trial. BMC Neurol 2020;20(1):173. PubMed
- Worakunphanich W, Thavorncharoensap M, Youngkong S, Thadanipon K, Thakkinstian A. Safety of Andrographis paniculata: A systematic review and meta-analysis. Pharmacoepidemiol Drug Saf 2021;30(6):727-739.
- More SJ, Tandulwadkar SS, Balap AR, Lohidasan S, Sinnathambi A, Mahadik KR. Effect of Andrographis paniculata extract and Andrographolide on the pharmacokinetics of Aceclofenac and Celecoxib in rats. Futur J Pharm Sci. 2023;9(1):1. PubMed
- Sundhani E, Nugroho AE, Nurrochmad A, Puspitasari I, Amalia Prihati D, Lukitaningsih E. Pharmacokinetic Herb-Drug Interactions of Glipizide with Andrographis paniculata (Burm. f.) and Andrographolide in Normal and Diabetic Rats by Validated HPLC Method. M PubMed
- Shang YX, Shen C, Stub T, et al. Adverse Effects of Andrographolide Derivative Medications Compared to the Safe use of Herbal Preparations of Andrographis paniculata: Results of a Systematic Review and Meta-Analysis of Clinical Studies. Front Pharmacol 20 PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC