Ashwagandha Extract Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Ashwagandha Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Ashwagandha Extract is a dietary supplement by Eclectic Herb with 1 active ingredient. Its ingredients are commonly taken for stress and anxiety, sleep problems, fatigue and low energy.Based on those ingredients, 1,372 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ashwagandha Root Extract, Dried. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Ashwagandha Extract by Eclectic Herb
Ask about any prescription or over-the-counter medication and we check it for interactions with Ashwagandha Extract by Eclectic Herb — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Ashwagandha Extract by Eclectic Herb
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains one active ingredient: Ashwagandha Root Extract, Dried — a concentrated form of ashwagandha, a plant used traditionally to support relaxation and stress response. The liquid also contains alcohol and filtered water as inactive ingredients.
Does it work?
Moderate evidence
The evidence supports ashwagandha for insomnia and anxiety — both are rated Possibly Effective based on clinical research. It's also rated Possibly Effective for general stress and generalized anxiety disorder (GAD).
For bipolar disorder, we don't have enough reliable evidence yet to rate it.
How safe is it?
Well-documented data
Ashwagandha is generally well tolerated in short-term use by healthy adults, though long-term safety data are limited. The most common side effects when they do occur are digestive — diarrhea, stomach upset, nausea, or vomiting — but these are uncommon with typical doses.
Rare serious effects include liver damage (acute hepatitis and liver failure have been reported in case reports) and, in isolated cases, drowsiness, headache, or changes in vision. During pregnancy, safety data advise against use — ashwagandha is traditionally thought to carry miscarriage risk.
There isn't enough safety information for breastfeeding, so talk with your pharmacist or doctor about whether to use it while nursing.
Meds to double-check
Moderate interaction found
Before taking this ashwagandha extract, check with your pharmacist if you use immune-suppressing drugs, CNS depressants or benzodiazepines, blood pressure medications, diabetes drugs, thyroid hormones, drugs that stress the liver, or certain medications processed through CYP1A2. All of these have Moderate or Minor interactions documented.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Ashwagandha Extract may help with insomnia, anxiety, and stress if you're otherwise healthy and not on medications that interact with it. If you take any blood pressure pills, diabetes medications, thyroid drugs, immunosuppressants, or sedatives — or anything else — run it through the checker on this page first.
Talk to your pharmacist before starting, especially if you're pregnant or breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Ashwagandha Extract, straight from the product label.
| Brand | Eclectic Herb |
|---|---|
| Barcode (UPC) | 023363287970 |
| Net contents | 1 Fluid Ounce(s); 30 Milliliter(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2024 |
| DSLD ID | 316717 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Kosher, Organic |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Ashwagandha Extract by Eclectic Herb, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Ashwagandha Root Extract, Dried | 0 NP | -- |
Other ingredients: Alcohol, Water, Filtered
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Certified Organic by Oregon Tilth
Stress Support
USDA Organic
Seals/Symbols
USDA Organic
FDA Statement of Identity
Dietary Supplement
Formula
Herbal Extract
100% Kosher
Suggested/Recommended/Usage/Directions
Suggested Use: Shake well; Mix 1 full dropper in water; take 3 times daily.
Storage
Store upright.
Precautions
Keep out of reach of children.
Discontinue use if unusual symptoms occur.
Consult your health care advisor regarding the use of herbs during pregnancy, with infants or prescription drugs.
Consult your health care advisor regarding the use of herbs during pregnancy, with infants or prescription drugs.
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent diseases.
General Statements
@electicherb
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Ashwagandha Extract by Eclectic Herb label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Ashwagandha Extract by Eclectic Herb
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Dropper(s) Dosage formLiquid Amounts shown are per serving.
Ashwagandha Root Extract, Dried
Interacts with1,372 drugs
Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...
Ashwagandha Root Extract, Dried monograph & interactionsOther (inactive) ingredients: Alcohol, Water, Filtered. These complete the product’s ingredient list but are not active constituents.
Ashwagandha Extract by Eclectic Herb Drug Interactions
HelloPharmacist Interaction Report
Ashwagandha Extract by Eclectic Herb has documented interactions with a number of medication types.
The most serious concern is with drugs that suppress the immune system (immunosuppressants) — ashwagandha appears to boost immune activity, which could reduce how well these medications work. This is a Moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Other Moderate-severity interactions to watch for: CNS depressants (sedatives, including benzodiazepines like Valium and Klonopin), which may cause extra drowsiness; blood pressure medications (antihypertensives), which might lower your blood pressure too much; diabetes medications, which could increase the risk of low blood sugar (hypoglycemia); thyroid hormone medications, which ashwagandha might strengthen — potentially causing too much thyroid hormone effect; and drugs that stress the liver (hepatotoxic drugs), since ashwagandha has been linked to rare cases of liver damage. There's also a Minor interaction with certain drugs processed through a specific liver enzyme (CYP1A2 substrates), where ashwagandha may reduce their effectiveness.
Although many medications are affected, we have no data on interactions with several others. Altogether, these interactions span 1,351 individual medications.
Use the medication checker on this page to look up your exact prescriptions before starting this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Ashwagandha Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Ashwagandha Extract interact with 1,372 drugs. Click any drug to see the details.
1 of the 1 ingredient in Ashwagandha Extract interact with drugs. Each result below shows which ingredient is responsible. Ashwagandha Root Extract, Dried
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Ado-trastuzumab Emtansine interactionAbemaciclibVerzenio
How Abemaciclib interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Abemaciclib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Acalabrutinib interactionAgomelatineValdoxan
How Agomelatine interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root Extract, Dried + Agomelatine interactionAlfuzosinUroxatral
How Alfuzosin interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Alfuzosin interactionAlmotriptanAlmogran, Axert
How Almotriptan interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedSerotonergic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Ashwagandha Root Extract, Dried + Almotriptan interactionAlosetronLotronex
How Alosetron interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedSerotonergic Drugs Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Ashwagandha Root Extract, Dried + Alosetron interactionAlpelisibPiqray
How Alpelisib interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Alpelisib interactionAmoxapineAsendin
How Amoxapine interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedSerotonergic Drugs Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Ashwagandha Root Extract, Dried + Amoxapine interactionAmphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine SulfateAdderall, Adderall XR
How Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedSerotonergic Drugs Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Ashwagandha Root Extract, Dried + Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interactionAmprenavirAgenerase
How Amprenavir interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Amprenavir interactionAnagrelideAgrylin
How Anagrelide interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root Extract, Dried + Anagrelide interactionApalutamideErleada
How Apalutamide interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Apalutamide interactionApixabanEliquis
How Apixaban interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Apixaban interactionApremilastOtezla
How Apremilast interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Apremilast interactionAprepitantCinvanti, Emend
How Aprepitant interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Aprepitant interactionArmodafinilNuvigil
How Armodafinil interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Armodafinil interactionAsenapineSaphris, Secuado
How Asenapine interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root Extract, Dried + Asenapine interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root Extract, Dried + Aspirin, Caffeine interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Ashwagandha Root Extract, Dried + Aspirin, Caffeine, Orphenadrine interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedSerotonergic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Ashwagandha Root Extract, Dried + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Aspirin, Omeprazole interactionAtazanavirReyataz
How Atazanavir interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Atazanavir interactionAtazanavir, CobicistatEvotaz
How Atazanavir, Cobicistat interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Atazanavir, Cobicistat interactionAtogepantQulipta
How Atogepant interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Ashwagandha Root Extract, Dried + Atogepant interactionAtropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, PhenylAtrosept
How Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl interacts with Ashwagandha Extract — through 1 ingredient. Tap an ingredient for the detail:
Ashwagandha Root Extract, DriedSerotonergic Drugs Minor
Interaction Summary
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors.
Read the full Ashwagandha Root Extract, Dried + Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Ashwagandha Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Ashwagandha Root Extract, Dried
Antidiabetes Drugs
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.
Antihypertensive Drugs
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Benzodiazepines
Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.
Cns Depressants
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.
Hepatotoxic Drugs
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.
Immunosuppressants
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.
Thyroid Hormone
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.
Serotonergic Drugs
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]
Brand information
Manufacturer and brand details for Ashwagandha Extract, from the product label.
Eclectic Herb
See all Eclectic Herb products- Name
- Eclectic Herb
- Street Address
- 755 NE 6th St.
- City
- Gresham
- State
- OR
- ZipCode
- 97030
- Phone Number
- 503-668-4120
- Web Address
- eclecticherb.com
Ashwagandha Extract by Eclectic Herb: Common Questions
Does Ashwagandha Extract by Eclectic Herb interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will ashwagandha make me drowsy?
Can I take ashwagandha if I'm on thyroid medication?
Is ashwagandha safe to take long-term?
Can I take ashwagandha while pregnant or breastfeeding?
Does ashwagandha actually work for anxiety?
What's in this liquid besides ashwagandha?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Ashwagandha Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Ashwagandha Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Ashwagandha Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ashwagandha 32 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
- Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
- Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
- Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
- Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
- Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5. PubMed
- Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.
- Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67:233-39. PubMed
- Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol 1998;50:1065-68. PubMed
- Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Skinmed. 2012;10(1):48-49.
- Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. 2013;45(4):417-8. PubMed
- Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther. 2013;12(4):312-22.
- Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248. PubMed
- Durg S, Bavage S, Shivaram SB. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Phytother Res. 2020;34(5):1041-1059.
- Björnsson HK, Björnsson ES, Avula B, et al. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Liver Int. 2020;40(4):825-829. PubMed
- Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. J Clin Med 2021;1 PubMed
- Ireland PJ, Hardy T, Burt AD, Donnelly MC. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. J R Coll Physicians Edinb. 2021;51(4):363-365. PubMed
- Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. Cureus. 2022 Mar 25;14(3):e23494. PubMed
- Suryawanshi G, Abdallah M, Thomson M, Desai N, Chauhan A, Lim N. Ashwagandha-Associated Acute Liver Failure Requiring Liver Transplantation. Am J Ther 2023;30(1):e80-e83. PubMed
- Pusec CM, Wolsky R, Llerena C, Sura P. A Case of Supplement-Induced Hepatitis. Cureus 2022;14(10):e30433. PubMed
- Ajgaonkar A, Jain M, Debnath K. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. Cureus 2022;14(10):e30787. PubMed
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Lubarska M, Halasinski P, Hryhorowicz S, et al. Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury. Int J Environ Res Public Health 2023;20(5):3921. PubMed
- Tóth M, Benedek AE, Longerich T, Seitz HK. Ashwagandha-induced acute liver injury: A case report. Clin Case Rep 2023;11(3):e7078.
- Bokan G, Glamocanin T, Mavija Z, et al. Herb-Induced Liver Injury by Ayurvedic Ashwagandha as Assessed for Causality by the Updated RUCAM: An Emerging Cause. Pharmaceuticals (Basel) 2023;16(8):1129. PubMed
- Patel PA, Sanborn E, Then R, Williams DM. Recurrent Reversible Cerebral Vasoconstriction Syndrome: A Report of Two Cases. Cureus 2023;15(8):e42992. PubMed
- Majeed M, Nagabhushanam K, Murali A, Vishwanathan DT, Mamidala RV, Mundkur L. A Standardized Withania somniferra (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomize
- Philips CA, Valsan A, Theruvath AH, et al. Ashwagandha-induced liver injury-A case series from India and literature review. Hepatol Commun 2023;7(10):e0270. PubMed
- Hayashi M, Hamada H, Azuma SI, Hayashi K. Painless Thyroiditis by Withania somnifera (Ashwagandha). Cureus 2024;16(3):e55352. PubMed
- Vazirani S, Kothari A, Fujimoto J, Gomez M. Supplements Are Not a Synonym for Safe: Suspected Liver Injury From Ashwagandha. Fed Pract 2023;40(9):315-319. PubMed
- Patel M, Newell R, Hillier M, Ramalingam R. Herbal remedies as a potential cause of hypoadrenalism. Br J Hosp Med (Lond) 2024;85(6):1-4. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC