Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Bitters tonic Vanilla Orange Ingredients & Drug Interactions

by Vitanica Tasty Tonics

Bitters tonic Vanilla Orange label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bitters tonic Vanilla Orange against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Bitters tonic Vanilla Orange is a dietary supplement by Vitanica Tasty Tonics with 5 active ingredients. Its ingredients are commonly taken for water retention (diuretic), digestive upset, liver and gallbladder support.Based on those ingredients, 1,138 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Fennel, Dandelion, Stevia Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Bitters tonic Vanilla Orange by Vitanica Tasty Tonics

Ask about any prescription or over-the-counter medication and we check it for interactions with Bitters tonic Vanilla Orange by Vitanica Tasty Tonics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Bitters tonic Vanilla Orange by Vitanica Tasty Tonics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This liquid tonic contains five active ingredients. Dandelion and gentian are traditional digestive bitters—herbs that stimulate stomach acid and digestive juices.

Fennel seed has long been used to ease stomach discomfort and reduce bloating. Stevia leaf extract serves as a sweetener and contributes its own digestive properties.

Sweet orange rounds out the formula, providing flavor and vitamin C, along with the other ingredients' traditional support for digestion and general wellness. The product also contains inactive ingredients—glycerin, deionized water, natural orange and vanilla flavors, and orange essential oil—which add sweetness, texture, and taste.

The tonic form (liquid) allows you to use small amounts and control how much you take. This matters because, as you'll see, some of these ingredients have stronger effects at higher doses.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: promote normal digestive enzyme function.
  • We looked for evidence on: Dyspepsia, Flatulence, Gastritis, Nausea and vomiting, Constipation, Diarrhea — and 4 related terms.
  • The closest evidence on file: Fennel is rated "Insufficient Reliable Evidence To Rate" for Constipation (Natural Medicines).
  • Also on file: Fennel is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia, Flatulence, Irritable bowel syndrome (IBS), Nausea and vomiting.
  • Also on file: Dandelion is rated "Insufficient Reliable Evidence To Rate" for Constipation, Dyspepsia.

The evidence on file does not yet establish how well this combination works for any specific condition. Dandelion, stevia, orange, and gentian all lack reliable evidence in our data for their marketed uses—whether that's digestive support, blood sugar, or wound healing.

Fennel is the one exception: it's rated possibly effective for period pain (dysmenorrhea). For the other conditions these herbs are traditionally used for, the science hasn't yet caught up.

That doesn't mean they don't work; it means rigorous clinical trials haven't been done or published in the databases we track.

The evidence, ingredient by ingredient Dandelion Stevia Sweet Orange Gentian Fennel

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Dandelion and fennel are generally well tolerated as foods, but supplement-strength doses are less studied. The most common side effects from dandelion are diarrhea, heartburn, and stomach upset; fennel may cause gastrointestinal discomfort, photosensitivity (increased sun sensitivity), or allergic reactions.

Both can rarely trigger serious allergic reactions in sensitive people—dandelion pollen can cause anaphylaxis, and fennel has been linked to bronchial asthma. If you're allergic to ragweed, chrysanthemums, daisies, or other plants in the daisy family, dandelion poses a risk.

Stevia is generally well tolerated; common mild effects include bloating, dizziness, headache, muscle aches, nausea, and numbness, most of which fade within a week. Sweet orange fruit is safe in normal amounts.

Gentian, in the amounts used here, is generally tolerated but can cause nausea, vomiting, diarrhea, or bloating—especially in people with sensitive stomachs. None of the ingredients carry reliable safety data for pregnancy or breastfeeding; talk with your doctor or pharmacist before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Dandelion Stevia Sweet Orange Gentian Fennel

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Fennel, Stevia, Dandelion, Gentian, Sweet Orange.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,139 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this tonic, double-check any of the following with your pharmacist: oral absorption-blocking drugs (like fexofenadine for allergies), pravastatin or other statins, ivermectin, celiprolol or other heart medicines, blood thinners (anticoagulants or antiplatelets), diabetes medications, potassium-sparing water pills, birth control pills, hormone replacement therapy, lithium, fluoroquinolone or other antibiotics (including ciprofloxacin), blood pressure drugs, and tamoxifen. The severity ranges from major (orange's effect on several drug types) to moderate (dandelion, fennel, stevia, and gentian).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This is a traditional digestive bitter blend with no proven effectiveness in clinical trials, but fennel is possibly effective for period pain if that's relevant to you. Because it contains orange and several potent herbs, it interacts with a wide range of medications—especially blood thinners, diabetes drugs, heart drugs, birth control, and blood pressure medications.

If you take any prescription drug, check it here first. Talk to your pharmacist before starting if you're pregnant, breastfeeding, or have a sensitive stomach or known allergies to ragweed or the daisy family.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bitters tonic Vanilla Orange, straight from the product label.

Brand Vitanica Tasty Tonics
Barcode (UPC) 708118023224
Net contents 4 Ounce(s); 118 Milliliter(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 302781
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), No Allergies, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bitters tonic Vanilla Orange by Vitanica Tasty Tonics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2.46 mL
Maximum serving Sizes:
4.92 mL
Servings per container
24
UPC/BARCODE
708118023224
IngredientAmount% DV
Dandelion125 mg--
Stevia Leaf Extract6.5 mg--
Orange125 mg--
Gentian125 mg--
Fennel125 mg--

Other ingredients: Glycerin, Water, Deionized, Orange Flavor, Natural, Vanilla Flavor, Natural, Orange essential Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Formulated by Dr. Tori Hudson, a naturopathic physician specializing in women's health.

Formulated by Dr. Tori Hudson

Formulation

Bitters Tonic is a tasty vanilla orange herbal blend promoting the body's normal digestive enzymes to process carbohydrates, fats and proteins.

Herbal residue inside bottle is normal.

This product contains no common allergens.

Healthy digestion

Bitters Tonic is suitable for vegetarians and vegans.

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. Adults: One half (1/2) (approx. 2 droppers) to one (1) teaspoon (approx. 4 droppers) before meals. Dilute in 2-3 ounces of water, or to taste. May also be taken undiluted or diluted in hot water for a nice herbal tea. Also suitable for men.

Precautions

Avoid during pregnancy and lactation. Use with caution or check with your healthcare practitioner if using blood pressure medication, blood sugar medication and blood thinners.

Tamper resistant: Please do not use if outer safety seal is broken or missing.

Keep in a cool, dry place out of reach of children.

Storage

Keep in a cool, dry place out of reach of children.

Formula

Vanilla orange

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bitters tonic Vanilla Orange by Vitanica Tasty Tonics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bitters tonic Vanilla Orange label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bitters tonic Vanilla Orange by Vitanica Tasty Tonics

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2.46 mL Dosage formLiquid Servings per container24 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dandelion

Interacts with
457 drugs
125 mg per serving

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for thes...

Dandelion monograph & interactions

Stevia Leaf Extract

Interacts with
259 drugs
6.5 mg per serving Form: Stevia rebaudiana leaf extract

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regu...

Stevia Leaf Extract monograph & interactions

Orange

Interacts with
246 drugs
125 mg per serving

Sweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and es...

Orange monograph & interactions

Gentian

Interacts with
172 drugs
125 mg per serving

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. Th...

Gentian monograph & interactions

Fennel

Interacts with
740 drugs
125 mg per serving

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some sm...

Fennel monograph & interactions

Other (inactive) ingredients: Glycerin, Water, Deionized, Orange Flavor, Natural, Vanilla Flavor, Natural, Orange essential Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bitters tonic Vanilla Orange by Vitanica Tasty Tonics Drug Interactions

Want to check YOUR meds against Bitters tonic Vanilla Orange?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,138Drugs
48 Major 1,090 Moderate

Ingredients driving the most interactions

Fennel 740
Dandelion 457
Stevia Leaf Extract 259
Orange 246
Gentian 172

Individual Drug Interactions

The ingredients in Bitters tonic Vanilla Orange interact with 1,138 drugs. Click any drug to see the details.

5 of the 5 ingredients in Bitters tonic Vanilla Orange interact with drugs. Each result below shows which ingredient is responsible. Fennel Dandelion Stevia Leaf Extract Orange Gentian

Each ingredient & the kinds of drugs it affects

For each ingredient in Bitters tonic Vanilla Orange with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Fennel6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
Fennel full monograph & interactions

Dandelion7 drug types · 457 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro research suggests that dandelion root inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Laboratory research suggests that dandelion extract may have moderate alpha-glucosidase inhibitor activity and might also increase insulin secretion. Also, in a case report, a 58-year-old woman with type 2 diabetes who was being treated with insulin developed hypoglycemia 2 weeks after beginning to eat salads containing dandelion.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
There is some preliminary evidence that dandelion might induce UDP-glucuronosyltransferase, a phase II enzyme.

Likelihood Possible Evidence D
Lithium

Theoretically, through diuretic effects, dandelion might reduce excretion and increase levels of lithium.
Animal research suggests that dandelion has diuretic properties. As diuretics can increase serum lithium levels, the dose of lithium might need to be decreased when taken with dandelion.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dandelion contains significant amounts of potassium.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, dandelion might lower fluoroquinolone levels.
Animal research shows that dandelion reduces absorption of ciprofloxacin and can lower levels by 73%. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Dandelion full monograph & interactions

Stevia Leaf Extract3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D
Stevia Leaf Extract full monograph & interactions

Orange7 drug types · 246 drugs

Celiprolol (Celicard)

Consuming sweet orange with celiprolol can decrease oral absorption of celiprolol.
A pharmacokinetic study in healthy volunteers shows that celiprolol levels, after a single dose of 100 mg, are decreased by up to 90% in people who drink sweet orange juice 200 mL three times daily. It's not known if lower consumption of sweet orange juice will have the same effect. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.

Likelihood Likely Evidence B
Ivermectin (Stromectol, Others)

Consuming sweet orange juice with ivermectin can decrease the oral absorption of ivermectin.
A pharmacokinetic study in healthy volunteers shows that taking ivermectin orally with sweet orange juice 750 mL over 4 hours reduces the bioavailability of ivermectin. This effect does not seem to be related to effects on P-glycoprotein. The effect on ivermectin is more pronounced in males compared to females.

Likelihood Likely Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Consuming sweet orange juice can decrease oral absorption of OATP substrates. Separate administration by at least 4 hours.
Clinical research shows that consuming sweet orange juice inhibits OATP, which reduces bioavailability of oral drugs that are substrates of OATP. For example, sweet orange juice decreases bioavailability of fexofenadine, a substrate of OATP, by about 72% and of celiprolol, another OATP substrate, by up to 90%. Since sweet orange juice seems to affect OATP for a short time, recommend separating drug administration and consumption of sweet orange juice by at least 4 hours.

Likelihood Likely Evidence B
Pravastatin (Pravachol)

Consuming sweet orange juice with pravastatin can increase the absorption of pravastatin.
A small pharmacokinetic study in healthy volunteers shows that consuming sweet orange juice 800 mL over 3 hours, including before, during, and after taking pravastatin 10 mg, increases pravastatin levels by about 149%, without affecting pravastatin elimination. Theoretically this effect might be due to modulation of organic anion transporting polypeptides (OATPs) by sweet orange juice. Sweet orange juice does not seem to affect simvastatin levels, but it is not known if sweet orange affects any of the other statins.

Likelihood Likely Evidence B
Fexofenadine (Allegra)

Consuming sweet orange juice with fexofenadine can decrease oral absorption of fexofenadine.
Clinical research shows that coadministration of sweet orange juice 1200 mL decreases bioavailability of fexofenadine by about 72%. In an animal model, sweet orange juice decreased bioavailability of fexofenadine by 31%. Fexofenadine manufacturer data indicates that concomitant administration of sweet orange juice and fexofenadine results in larger wheal and flare sizes in research models. This suggests that sweet orange reduces the clinical response to fexofenadine. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.

Likelihood Likely Evidence B
P-Glycoprotein Substrates

Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Animal and in vitro research suggest that orange juice extract inhibits drug efflux by P-gp, increasing absorption and levels of P-gp substrates. In contrast, pharmacokinetic research in humans shows that drinking large amounts of sweet orange juice decreases absorption and levels of the P-gp substrate celiprolol. This suggests that orange juice actually induces drug efflux by P-gp or affects drug levels by another mechanism such as inhibiting the gut drug transporter called organic anion transporting polypeptide (OATP). Until more is known, sweet orange juice should be used cautiously in people taking P-gp substrates.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium-fortified sweet orange juice might reduce quinolone absorption.
Calcium binds to quinolones in the gut. Theoretically, the calcium in certain fortified orange juices can also bind to quinolone antibiotics and reduce their absorption and levels.

Likelihood Possible Evidence D
Orange full monograph & interactions

Gentian1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.

Likelihood Possible Evidence D
Gentian full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bitters tonic Vanilla Orange, from the product label.

Vitanica Tasty Tonics

See all Vitanica Tasty Tonics products
Name
Vitanica
Street Address
12401 SW Leveton Dr.
City
Tualatin
State
OR
ZipCode
97062
Web Address
www.vitanica.com
Pharmacist Counseling Corner

Bitters tonic Vanilla Orange by Vitanica Tasty Tonics: Common Questions

Does Bitters tonic Vanilla Orange by Vitanica Tasty Tonics interact with any medications?
Yes. Based on its ingredients, Bitters tonic Vanilla Orange has a known interaction with 1,138 medications, including 48 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bitters tonic Vanilla Orange contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
There isn't enough data on file to say either way for most ingredients. Orange is likely safe in food amounts during pregnancy, but dandelion, stevia, fennel, and gentian all lack reliable safety information. Fennel in particular is marked as possibly unsafe during pregnancy and lactation due to its hormone-like effects. Talk with your doctor or pharmacist for personalized advice before use.
What's dandelion supposed to do?
Dandelion is a traditional digestive bitter—it stimulates your stomach to produce more acid and digestive juices. However, our data shows insufficient evidence that it actually works for any condition in clinical trials.
Is fennel safe for kids?
Fennel is generally well tolerated as a food, but this is a supplement-strength tonic. The only side effect we have on file for children is a case report of a severe allergic reaction. If your child has known food or plant allergies, check with your pediatrician first.
Will this upset my stomach?
Gastrointestinal discomfort—nausea, vomiting, diarrhea, bloating, or heartburn—is the most common adverse effect across these ingredients, especially in people with sensitive stomachs. Gentian in particular can cause stomach upset. Start with a small amount to see how you tolerate it.
Can I take this with my diabetes medication?
Both dandelion and stevia may lower blood sugar levels and theoretically increase the risk of low blood sugar when combined with diabetes drugs. Talk with your pharmacist or doctor before adding this tonic to your routine.
Is this safe if I take a blood thinner?
No. Dandelion and fennel both carry moderate interactions with blood thinners and may increase bleeding risk. Do not start this tonic without checking with your pharmacist or doctor first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bitters tonic Vanilla Orange label
Go deeper

The Full Monographs Behind Bitters tonic Vanilla Orange’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Dandelion

Interacts with 457 drugs

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits...

Read the full Dandelion monograph → Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph → Herb & supplement monograph

Sweet Orange

Interacts with 246 drugs

Sweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and essential oil are used in aromatherapy and...

Read the full Sweet Orange monograph → Herb & supplement monograph

Gentian

Interacts with 172 drugs

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...

Read the full Gentian monograph → Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph →
Sources

Sources & How We Checked

Bitters tonic Vanilla Orange's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 76 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Dandelion 27 references
  1. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
  2. Williams CA, Goldstone F, Greenham J. Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale. Phytochemistry 1996;42:121-7. PubMed
  3. Hussain Z, Waheed A, Qureshi RA, et al. The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS-1 cells. Phytother Res 2004;18:73-7. PubMed
  4. Racz-Kotilla E, Racz G, Solomon A. The action of Taraxacum officinale extracts on the body weight and diuresis of laboratory animals. Planta Med 1974;26:212-7. PubMed
  5. Zhu M, Wong PY, Li RC. Effects of taraxacum mongolicum on the bioavailability and disposition of ciprofloxacin in rats. J Pharm Sci 1999;88:632-4. PubMed
  6. Jovanovic M, Mimica-Dukic N, Poljacki M, Boza P. Erythema multiforme due to contact with weeds: a recurrence after patch testing. Contact Dermatitis 2003;48:17-25. PubMed
  7. Chivato T, Juan F, Montoro A, Laguna R. Anaphylaxis induced by ingestion of a pollen compound. J Investig Allergol Clin Immunol 1996;6:208-9.
  8. Cohen SH, Yunginger JW, Rosenberg N, Fink JN. Acute allergic reaction after composite pollen ingestion. J Allergy Clin Immunol 1979;64:270-4. PubMed
  9. Lovell CR, Rowan M. Dandelion dermatitis. Contact Dermatitis 1991;25:185-8. PubMed
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Sweet Orange 17 references
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Gentian 5 references
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Fennel 17 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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