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Dietary supplement

Black Elderberry Sugar Free Formula Ingredients & Drug Interactions

by Sambucol

Black Elderberry Sugar Free Formula label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Black Elderberry Sugar Free Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Black Elderberry Sugar Free Formula is a dietary supplement by Sambucol with 2 active ingredients. Its ingredients are commonly taken for colds, flu (influenza), other respiratory infections.Based on those ingredients, 121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are European Elder (Sambucus nigra) berry juice extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Black Elderberry Sugar Free Formula by Sambucol

Ask about any prescription or over-the-counter medication and we check it for interactions with Black Elderberry Sugar Free Formula by Sambucol — and tell you which ingredient is responsible.

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Computed from our clinical databases

HelloPharmacist Scorecard of Black Elderberry Sugar Free Formula by Sambucol

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

None of the active ingredients could be matched to our evidence database, so intended use can't be graded.

Why this rating?
  • None of the active ingredients could be matched to a HelloPharmacist monograph, so intended use can't be graded against our evidence data.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “European Elder (Sambucus nigra) berry juice extract” is listed as a grouped ingredient — the label gives one combined amount (126.76 mg) without saying how much of each component you get.
Known Interaction Concern
Not assessable

None of the active ingredients could be matched to our interaction database.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was nothing to check interactions against.
Safety Information
Unable to assess

None of the active ingredients could be matched to our safety data.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was no safety data to measure.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Medication interactions could not be assessed, and safety information could not be assessed.

Assessment coverage: 0 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Black Elderberry Sugar Free Formula, straight from the product label.

Brand Sambucol
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 245367
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Black Elderberry Sugar Free Formula by Sambucol, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 mL
Maximum serving Sizes:
10 mL
IngredientAmount% DV
Calories11 Calorie(s)--
Total Carbohydrates3 Gram(s)1%
Sugar0 Gram(s)--
European Elder (Sambucus nigra) berry juice extract126.76 mg--
fresh European Elderberry3.8 Gram(s)--

Other ingredients: purified Water, Glycerin, Elderberry natural flavor, Citric Acid, Maltodextrin, Xanthan Gum, Natural flavor, Potassium Sorbate, Silica Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Sambucol, the original Black Elderberry extract, provides strong immune system support to help you and your family stay healthy throughout the year. Sambucol Black Elderberry extract conveniently arms you with some of the best protection nature has to offer. Developed by a world renowned virologist, Sambucol has been trusted by millions worldwide.

Made in the USA with domestic and imported ingredients.

Supports immune system Virologist developed Scientifically tested Great tasting syrup Natural sweetener

Not a low calorie food

Scientifically tested Supports immunity Natural sweetener Syrup

Free from wheat, artificial color and flavor

Suggested/Recommended/Usage/Directions

Sambucol can be taken every day for continuous immune support.

Use daily for maximum benefit Directions for use: For daily maintenance: Adults and children over 4 years: take 2 teaspoons (10ml) daily. For intensive use: Adults and children over 4 years: Take 2 teaspoons (10ml) four times daily. If desired, mix syrup in water, fruit juice, smoothies, yogurt, or most anything!

General Statements

Satisfaction Guaranteed. If for any reason you are not satisfied, please visit our website for details on our refund policy.

See the full line of Sambucol products at our website.

Brand IP Statement(s)

Sambucol is a registered trademark of PharmaCare Laboratories Pty Ltd.

Precautions

Sealed for your protection. Do not use if seal is broken or missing.

Keep out of reach of children.

Storage

To preserve quality and freshness, keep tightly sealed and keep in cool, dry place.

FDA Statement of Identity

Dietary Supplement

Formula

adds a trivial amount of sugar.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Dug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Black Elderberry Sugar Free Formula by Sambucol label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Black Elderberry Sugar Free Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Black Elderberry Sugar Free Formula by Sambucol

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size10 mL Dosage formLiquid Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

0 Gram(s) per serving

European Elder (Sambucus nigra) berry juice extract

Interacts with
121 drugs
126.76 mg per serving

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...

European Elder (Sambucus nigra) berry juice extract monograph & interactions
  • › Fresh European Elderberry

Other (inactive) ingredients: Purified Water, Glycerin, Elderberry natural flavor, Citric Acid, Maltodextrin, Xanthan Gum, Natural flavor, Potassium Sorbate, Silica Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Black Elderberry Sugar Free Formula by Sambucol Drug Interactions

Black Elderberry Sugar Free Formula contains 2 ingredients, and 1 of them has known drug interactions. Altogether it interacts with 121 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against Black Elderberry Sugar Free Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
121Drugs
121 Moderate

Ingredients driving the most interactions

European Elder (Sambucus nigra) berry juice extract 121

Individual Drug Interactions

The ingredients in Black Elderberry Sugar Free Formula interact with 121 drugs. Click any drug to see the details.

1 of the 2 ingredients in Black Elderberry Sugar Free Formula interact with drugs. Each result below shows which ingredient is responsible. European Elder (Sambucus nigra) berry juice extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Black Elderberry Sugar Free Formula with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

European Elder (Sambucus nigra) berry juice extract2 drug types · 121 drugs

Immunosuppressants

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.

Likelihood Possible Evidence B
Pazopanib (Votrient)

Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 4 weeks for soft-tissue sarcoma developed severe nausea, loose stools, and elevated alanine transaminase and aspartate transaminase levels and was diagnosed with grade 3 liver injury. The patient reported taking elderberry supplements for 2 years, dose unspecified, and was also taking a multivitamin and a calcium supplement. The patient's symptoms and liver enzyme levels improved upon discontinuation of pazopanib and all supplements. Pazopanib treatment was re-initiated, at a lower dose, with no further evidence of liver injury. It was unclear in this case report if the elderberry supplements were derived from the berry, the flower, or the combination.

Likelihood Possible Evidence D
European Elder (Sambucus nigra) berry juice extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Black Elderberry Sugar Free Formula, from the product label.

Sambucol

See all Sambucol products
Name
PharmaCare US, Inc.
City
San Diego
State
CA
ZipCode
92108
Phone Number
1-888-871-9098
Web Address
www.SambucolUSA.com
Pharmacist Counseling Corner

Black Elderberry Sugar Free Formula by Sambucol: Common Questions

Does Black Elderberry Sugar Free Formula by Sambucol interact with any medications?
Yes. Based on its ingredients, Black Elderberry Sugar Free Formula has a known interaction with 121 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Black Elderberry Sugar Free Formula contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Black Elderberry Sugar Free Formula is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Black Elderberry Sugar Free Formula label
Go deeper

The Full Monographs Behind Black Elderberry Sugar Free Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Elderberry

Interacts with 121 drugs

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu symptoms, but the evidence is limited and n...

Read the full Elderberry monograph →
Sources

Sources & How We Checked

Black Elderberry Sugar Free Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Elderberry 6 references
  1. Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 2001;12:290-6..
  2. Elderberry (Sambucus species). The Poison Plant Patch, Novia Scotia Museum, 2007. Available at: http://museum.gov.ns.ca/poison/?section=species&id=117 (Accessed 16 October 2009).
  3. European elder. Canadian Poisonous Plants Information System. Available at: http://www.cbif.gc.ca/pls/pp/ppack.jump?p_null=all&p_psn=121&p_type=all&p_sci=comm&p_x=px (Accessed 16 October 2009).
  4. Raus K, Pleschka S, Klein P, Schoop R, Fisher P. Effect of an echinacea-based hot drink versus oseltamivir in Influenza treatment: a randomized, double-blind, double-dummy, multicenter, noninferiority clinical trial. . Curr Ther Res Clin Exp. 2015;20;77:6 PubMed
  5. Ramachandran A, Antala D, Pudasainee P, Panginikkod S, Gupta H. A Plausible Association Between the Use of Elderberry and Autoimmune Hepatitis. Cureus 2022;14(4):e24250. PubMed
  6. Agarwal N, Mangla A. Elderberry interaction with pazopanib in a patient with soft-tissue sarcoma: A case report and literature review. Mol Clin Oncol 2024;20(5):36. PubMed

See these in context on the Elderberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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