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Dietary supplement

Blazei Extract Ingredients & Drug Interactions

by Host Defense Mushrooms

Blazei Extract label
See full label image
Liquid Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Blazei Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Blazei Extract is a dietary supplement by Host Defense Mushrooms with 1 active ingredient. Its ingredients are commonly taken for immune support, general wellness and antioxidant, adjunct interest during cancer care.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are fresh Royal Sun Blazei (Agaricus brasiliensis f. blazei) mycelium extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Blazei Extract by Host Defense Mushrooms

Ask about any prescription or over-the-counter medication and we check it for interactions with Blazei Extract by Host Defense Mushrooms — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Blazei Extract by Host Defense Mushrooms

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: fresh Royal Sun Blazei mushroom mycelium extract (Agaricus brasiliensis f. blazei). The liquid formulation also includes water, alcohol, and myceliated brown rice as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Agaricus Mushroom product and its label doesn't state a use — see Agaricus Mushroom's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold for Blazei Extract is insufficient to rate how well it works for allergic rhinitis (hay fever), osteoporosis, cancer, cardiovascular disease, chemotherapy-induced side effects, or Crohn disease. That doesn't mean it doesn't work — it means the studies so far haven't been robust enough to draw firm conclusions.

The evidence, ingredient by ingredient Agaricus Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, Royal Sun Blazei mushroom is generally well tolerated. The most common side effects reported are abdominal discomfort, diarrhea, and nausea.

Rare but serious adverse effects include allergic reactions, liver damage (hepatotoxicity), and interstitial lung disease — a serious lung condition. Three cases of severe liver damage have been reported in women with ovarian or breast cancer who took agaricus mushroom supplements while undergoing chemotherapy; two progressed to fatal liver failure.

Because long-term supplement safety isn't well established, it's best to avoid this product during pregnancy and while breastfeeding.

Side effects, ingredient by ingredient Agaricus Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agaricus Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check any antidiabetes medications you're taking (insulin, metformin, sulfonylureas, or others) before using this product — there's a documented moderate risk of low blood sugar when combined.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take diabetes medication, talk to your pharmacist before starting this supplement — there's a documented risk of low blood sugar. If you have a history of liver disease, lung problems, or cancer, or you're pregnant or breastfeeding, discuss it with your doctor first.

The evidence for what this mushroom actually treats is still too limited to know.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Blazei Extract, straight from the product label.

Brand Host Defense Mushrooms
Net contents 2 fl. Oz.; 60 mL
Market status On market
Date entered into DSLD Feb 25, 2019
DSLD ID 200102
Product type Non-nutrient/non-botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Blazei Extract by Host Defense Mushrooms, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
60
IngredientAmount% DV
fresh Royal Sun Blazei (Agaricus brasiliensis f. blazei) mycelium extract1 mL--

Other ingredients: Water, Alcohol, myceliated Brown Rice

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Made with U.S. grown, double extracted organic mushroom mycelium

Suggested/Recommended/Usage/Directions

Directions for Use: As a dietary supplement, take 1 mL twice per day. Can be taken with food or without, on an empty stomach or as recommended by your healthcare advisor. Shake well before using, refrigerate after opening.

Storage

Shake well before using, refrigerate after opening.

Precautions

Consult your healthcare advisor regarding the use of this product during pregnancy.

Keep out of reach of children.

General

NXAB2 REV A4

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

USDA Organic

Producer Certified Organic Washington State Dept. of Agriculture

General Statements

Immune support

Formulation

Gluten free

Certified Organic by the Washington State Department of Agriculture.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Blazei Extract by Host Defense Mushrooms label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Blazei Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Blazei Extract by Host Defense Mushrooms

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Fresh Royal Sun Blazei (Agaricus brasiliensis f. blazei) mycelium extract

Interacts with
86 drugs
1 mL per serving

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects...

Fresh Royal Sun Blazei (Agaricus brasiliensis f. blazei) mycelium extract monograph & interactions

Other (inactive) ingredients: Water, Alcohol, Myceliated Brown Rice. These complete the product’s ingredient list but are not active constituents.

Interaction report

Blazei Extract by Host Defense Mushrooms Drug Interactions

Want to check YOUR meds against Blazei Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

fresh Royal Sun Blazei (Agaricus brasiliensis f. blazei) mycelium extract 86

Individual Drug Interactions

The ingredients in Blazei Extract interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Blazei Extract interact with drugs. Each result below shows which ingredient is responsible. fresh Royal Sun Blazei (Agaricus brasiliensis f. blazei) mycelium extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Blazei Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

fresh Royal Sun Blazei (Agaricus brasiliensis f. blazei) mycelium extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.

Likelihood Possible Evidence D
fresh Royal Sun Blazei (Agaricus brasiliensis f. blazei) mycelium extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Blazei Extract, from the product label.

Host Defense Mushrooms

See all Host Defense Mushrooms products
Name
Fungi Perfecti, LLC
Street Address
PO Box 7634
City
Olympia
State
WA
ZipCode
98507
Phone Number
877-504-6926
Web Address
Hostdefense.com
Pharmacist Counseling Corner

Blazei Extract by Host Defense Mushrooms: Common Questions

Does Blazei Extract by Host Defense Mushrooms interact with any medications?
Yes. Based on its ingredients, Blazei Extract has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Blazei Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the most common side effects?
The most common ones are abdominal discomfort, diarrhea, and nausea. Most people who take it orally tolerate it well, but these digestive issues do show up in some users.
Is this safe to take while pregnant?
There isn't enough safety data, so the facts advise against it during pregnancy. Talk with your doctor or pharmacist about whether it's right for your situation.
Can I take this while breastfeeding?
There isn't enough safety data for breastfeeding either, so it's best to avoid it. Check with your pharmacist or doctor if you're considering it.
Does this product actually work for any health condition?
The evidence we have is insufficient to rate how well it works for allergic rhinitis, osteoporosis, cancer, heart disease, chemotherapy side effects, or Crohn disease. More research is needed.
Are there any serious side effects I should know about?
Serious adverse effects are rare, but they include allergic reactions, liver damage, and a lung condition called interstitial lung disease. Liver damage has been reported in cancer patients taking agaricus mushroom during chemotherapy — talk to your oncologist if that applies to you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Blazei Extract is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Blazei Extract label
Go deeper

The Full Monographs Behind Blazei Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agaricus Mushroom

Interacts with 86 drugs

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...

Read the full Agaricus Mushroom monograph →
Sources

Sources & How We Checked

Blazei Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agaricus Mushroom 5 references
  1. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2
  2. Mukai H, Watanabe T, Ando M, Katsumata N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 2006;36:808-10. PubMed
  3. Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.
  4. Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4.
  5. Iwai N, Okuda T, Sawada R, et al. Interstitial lung disease associated with Agaricus blazei Murill in a patient with pancreatic ductal adenocarcinoma receiving gemcitabine-based therapy. Case Rep Gastroenterol 2022;16(1):229-234.

See these in context on the Agaricus Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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