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Dietary supplement

Boswellia serrata Extract 125 mg Ingredients & Drug Interactions

by Swanson

Boswellia serrata Extract 125 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Boswellia serrata Extract 125 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Boswellia serrata Extract 125 mg is a dietary supplement by Swanson with 1 active ingredient. Its ingredients are commonly taken for osteoarthritis joint pain, rheumatoid arthritis, inflammation.Based on those ingredients, 952 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 5-LOXIN. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Boswellia serrata Extract 125 mg by Swanson

Ask about any prescription or over-the-counter medication and we check it for interactions with Boswellia serrata Extract 125 mg by Swanson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Boswellia serrata Extract 125 mg by Swanson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: 5-LOXIN, a standardized Boswellia serrata extract at 125 mg per capsule. Boswellia serrata is a tree resin traditionally used in herbal medicine; 5-LOXIN is a branded extract designed to provide consistent potency.

The capsule also contains inactive ingredients—brown rice flour, hypromellose (a plant-based capsule material), and magnesium stearate (a flow agent)—but these are fillers and binders, not active components.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports joint integrity, movement and flexibility.
  • We looked for evidence on: Osteoarthritis, Rheumatoid arthritis (RA), Knee pain, Exercise-induced muscle soreness, Joint mobility, Cartilage support.
  • The strongest evidence on file: Boswellia Serrata is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Boswellia Serrata is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Rheumatoid arthritis (RA), Knee pain.

Boswellia serrata extract is possibly effective for osteoarthritis, meaning some clinical evidence supports its use, though more research would strengthen confidence. For allergic rhinitis (hay fever), asthma, Alzheimer disease, and cluster headache, the evidence we hold is insufficient to establish whether it works.

If you're considering this supplement for one of those other uses, talk with your doctor about what the current research actually shows.

The evidence, ingredient by ingredient Boswellia Serrata

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boswellia serrata extract taken by mouth is generally well tolerated in the short term. The most common side effects are mild: abdominal pain, diarrhea, headache, heartburn, itching, and nausea.

Some trial participants also reported dizziness and vertigo. A rare but serious concern is bezoar formation (an intestinal blockage from undigested plant material) with very large doses; this was reported in one case of someone chewing and swallowing large quantities of boswellia gum resin.

During pregnancy, there isn't enough safety data, so it's best avoided. While breastfeeding, safety is unknown, so you should skip it.

Talk with your doctor or pharmacist before taking this if you're pregnant, planning pregnancy, or nursing.

Side effects, ingredient by ingredient Boswellia Serrata

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Boswellia Serrata.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 953 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this, check with your pharmacist or doctor if you take any medications processed by the liver, especially those broken down by CYP2D6, CYP2C19, CYP1A2, CYP2C9, or CYP3A4 enzymes—these include many heart drugs, antidepressants, and pain relievers. If you take immunosuppressive medications (such as after a transplant or for severe autoimmune disease), discuss this supplement with your doctor first, as it may alter their effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Boswellia serrata is worth a conversation if you have osteoarthritis and want to explore herbal options alongside your current plan. Because it can affect how your liver breaks down many medications, you'll need to check your exact drug list with your pharmacist or doctor first—especially if you take heart medications, antidepressants, or immunosuppressive drugs.

It's not recommended during pregnancy or while breastfeeding. Make the call with your own healthcare provider on whether it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Boswellia serrata Extract 125 mg, straight from the product label.

Brand Swanson
Barcode (UPC) 087614027708
Net contents 60 Veggie Cap(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 308483
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Boswellia serrata Extract 125 mg by Swanson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
60
UPC/BARCODE
087614027708
IngredientAmount% DV
5-LOXIN125 mg--

Other ingredients: Brown Rice Flour, Hypromellose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Swanson.com or call 1-800-437-4148

Formulation

Supports joint integrity, movement and flexibility

Joint Health and Mobility

Formula

Delivers 30% AKBA for superior, reliable results

Boswellia Serrata Extract 125mg per capsule 5-LOXIN with 30% AKBA

Brand IP Statement(s)

Swanson Science-Backed Quality Since 1969

5-LOXIN is a registered trademark of P.L. Thomas- Laila Nutra LLC and is used under license. International patents pending.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one veggie capsule two times per day with food and water.

Precautions

Warning: For adults only. Keep out of reach of children.

Consult your physician before using this or any product if you are pregnant or nursing, taking medication or have a medical condition.

Do not use if seal is broken.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Boswellia serrata Extract 125 mg by Swanson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Boswellia serrata Extract 125 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Boswellia serrata Extract 125 mg by Swanson

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

5-LOXIN

Interacts with
952 drugs
125 mg per serving Form: Boswellia serrata Gum Resin Extract

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoart...

5-LOXIN monograph & interactions

Other (inactive) ingredients: Brown Rice Flour, Hypromellose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Boswellia serrata Extract 125 mg by Swanson Drug Interactions

Want to check YOUR meds against Boswellia serrata Extract 125 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
952Drugs
952 Moderate

Ingredients driving the most interactions

5-LOXIN 952

Individual Drug Interactions

The ingredients in Boswellia serrata Extract 125 mg interact with 952 drugs. Click any drug to see the details.

1 of the 1 ingredient in Boswellia serrata Extract 125 mg interact with drugs. Each result below shows which ingredient is responsible. 5-LOXIN

Each ingredient & the kinds of drugs it affects

For each ingredient in Boswellia serrata Extract 125 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

5-LOXIN6 drug types · 952 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.

Likelihood Possible Evidence D
5-LOXIN full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Boswellia serrata Extract 125 mg, from the product label.

Swanson

See all Swanson products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
swanson.com
Pharmacist Counseling Corner

Boswellia serrata Extract 125 mg by Swanson: Common Questions

Does Boswellia serrata Extract 125 mg by Swanson interact with any medications?
Yes. Based on its ingredients, Boswellia serrata Extract 125 mg has a known interaction with 952 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Boswellia serrata Extract 125 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is 5-LOXIN?
5-LOXIN is a standardized extract of Boswellia serrata, a tree resin. This branded form is designed to provide consistent levels of the extract in each dose.
Can I take this if I'm pregnant?
No. There isn't enough safety data on Boswellia serrata in pregnancy, so it's best avoided. Talk with your doctor about alternatives if you're pregnant or planning pregnancy.
What are the most common side effects?
The most common are mild gastrointestinal complaints: abdominal pain, diarrhea, nausea, and heartburn. Headache, heartburn, itching, and dizziness have also been reported. Most people tolerate it well over the short term.
Does this actually work for arthritis?
Boswellia serrata is possibly effective for osteoarthritis—meaning there's some clinical evidence it may help—but the evidence could be stronger. For other conditions like asthma or hay fever, we don't have enough reliable evidence yet to say whether it works.
Why do I need to check my medications with a pharmacist?
Boswellia serrata inhibits several liver enzymes that break down many common drugs, from heart medications to antidepressants. If it slows how your body clears these drugs, their levels could rise and cause side effects. Your pharmacist can check your specific meds to see if there's a concern.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Boswellia serrata Extract 125 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Boswellia serrata Extract 125 mg label
Go deeper

The Full Monographs Behind Boswellia serrata Extract 125 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boswellia Serrata

Interacts with 952 drugs

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...

Read the full Boswellia Serrata monograph →
Sources

Sources & How We Checked

Boswellia serrata Extract 125 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boswellia Serrata 16 references
  1. Gupta I, Gupta V, Parihar A, et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res 1998;3:511-4.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine 2003;10:3-7. PubMed
  4. Liu JJ, Nilsson A, Oredsson S, et al. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 2002;23:2087-93. PubMed
  5. Wildfeuer A, Neu IS, Safayhi H, et al. Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. Arzneimittelforschung 1998;48:668-74.
  6. Gupta I, Parihar A, Malhotra P, et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med 2001;67:391-5. PubMed
  7. Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin. Arthritis Res Ther 2008;10:R85.
  8. Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci 2010;7:366-77.
  9. Ernst E. Frankincense: systematic review. BMJ 2008;337:a2813. PubMed
  10. Kirste S, Treier M, Wehrle SJ, et al. Boswellia serratea extract acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. Cancer 2011;117:3788-95.
  11. Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
  12. Altmann A, Poeckel D, Fischer L, et al. Coupling of boswellic acid-incuded Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Br J Pharmacol 2004;141:223-32.
  13. El Fortia, M., Badi, H., Elalem, Kh, Kadiki, O., and Topov, Y. Olibanum bezoar: complication of a traditional popular medicine. East Mediterr.Health J 2006;12(6):927-929.
  14. Meshkat S, Mahmoodi Baram S, Rajaei S, et al. Boswellia serrata extract shows cognitive benefits in a double-blind, randomized, placebo-controlled pilot clinical trial in individuals who suffered traumatic brain injury. Brain Inj 2022;36(4):553-559. PubMed
  15. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  16. Valente IVB, Garcia D, Abbott A, et al. The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer. Breast Cancer Res Treat 2024;204(3):521-530. PubMed

See these in context on the Boswellia Serrata monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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