Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Brain Power with Sage Extract Ingredients & Drug Interactions

by Mason Natural

Brain Power with Sage Extract label
See full label image
Tablet Or Pill Category: Botanical With Nutrients
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Brain Power with Sage Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Brain Power with Sage Extract is a dietary supplement by Mason Natural with 3 active ingredients. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 1,356 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sage extract, Phosphatidylserine, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Brain Power with Sage Extract by Mason Natural

Ask about any prescription or over-the-counter medication and we check it for interactions with Brain Power with Sage Extract by Mason Natural — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Brain Power with Sage Extract by Mason Natural

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Brain Power with Sage Extract contains three active ingredients. Phosphatidylserine is a natural compound found in cell membranes that may support cognitive health.

Calcium is a mineral essential for bone strength and many other body functions. Sage extract comes from the leaves of the sage plant and has been used traditionally to support mental clarity and menopausal comfort.

The product also contains several inactive ingredients—microcrystalline cellulose, stearic acid, vegetable magnesium stearate, silicon dioxide, croscarmellose sodium, pharmaceutical glaze, magnesium silicate, and maltodextrin—which serve as fillers, binders, and tablet structuring agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: mental focus, memory and positive mood.
  • We looked for evidence on: Age-related cognitive decline, Cognitive function, Attention deficit-hyperactivity disorder (ADHD), Depression, Dementia, Concentration — and 2 related terms.
  • The strongest evidence on file: Sage is rated "Possibly Effective" for Cognitive function (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline.
  • Also on file: Sage is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline.

The evidence for this product's ingredients is mixed. Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease, but evidence is insufficient to rate its use for ADHD, general cognitive function, dementia, or athletic performance.

Sage extract is possibly effective for menopausal symptoms, high cholesterol (hyperlipidemia), and cognitive function, though it appears possibly ineffective for postoperative pain relief. Calcium is well-established for preventing kidney failure, treating low blood calcium (hypocalcemia), managing high potassium levels (hyperkalemia), and treating indigestion; it's also likely effective for osteoporosis prevention.

The evidence, ingredient by ingredient Phosphatidylserine Calcium Sage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated, though long-term safety isn't fully established. The most common side effects are flatulence, stomach upset, headache, insomnia (especially at higher doses around 600 mg), and nausea.

Calcium is well tolerated at recommended doses, but very high intakes raise theoretical concerns about kidney stones and, in some research, prostate cancer risk and cardiovascular issues—though these findings remain debated. Common side effects include belching, constipation, diarrhea, and stomach upset.

Sage extract is generally safe as food and short-term tea, but concentrated extracts should be used cautiously; side effects may include abdominal pain, agitation, diarrhea, dizziness, nausea, and vomiting. Rare serious effects include seizures from constituents like thujone.

Phosphatidylserine is not recommended in pregnancy or while breastfeeding due to insufficient safety data. Calcium is likely safe in pregnancy at recommended amounts and safe while breastfeeding.

Sage should be avoided in medicinal amounts during pregnancy because of thujone content (food amounts are likely fine) and avoided in medicinal doses while breastfeeding, as it may reduce milk supply.

Side effects, ingredient by ingredient Phosphatidylserine Calcium Sage

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Sage, Calcium, Phosphatidylserine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: seizure medications; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,357 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take any HIV integrase inhibitors (dolutegravir, elvitegravir, raltegravir), intravenous ceftriaxone antibiotics, levothyroxine (thyroid medication), sotalol or diltiazem (heart/blood pressure drugs), calcipotriene (psoriasis treatment), sedatives or sleep aids, blood pressure medications, or any medications metabolized by your liver's CYP2D6, CYP2C19, CYP2C9, or CYP3A4 systems. Calcium especially needs timing separation from several of these drugs.

Additionally, if you take estrogen-based hormone therapy, check before starting sage extract.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Brain Power with Sage Extract may help support memory and cognitive function, particularly if you're dealing with age-related decline or menopausal symptoms. However, if you take any prescription medications—especially HIV drugs, thyroid medication, blood pressure drugs, or heart medications—you must check your specific medicines with the interaction tool below before starting this product.

Talk to your pharmacist or doctor to make sure it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Brain Power with Sage Extract, straight from the product label.

Brand Mason Natural
Barcode (UPC) 311845181459
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 244964
Product type Botanical With Nutrients
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Brain Power with Sage Extract by Mason Natural, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
UPC/BARCODE
311845181459
IngredientAmount% DV
Phosphatidylserine50 mg--
Calcium65 mg6%
Sage extract400 mg--

Other ingredients: Microcrystalline Cellulose, Stearic Acid, Vegetable Magnesium Stearate, Silicon Dioxide, Croscarmellose Sodium, Pharmaceutical Glaze, Magnesium Silicate, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Mason guarantee Laboratory Tested cGMP Certified Good Manufacturing Practice

General Statements

Certified N Mason natural Est. 1967

Please recycle

Formulation

May Support mental focus, memory & positive mood

Guaranteed no added: Sugar, yeast, soy wheat, dairy, fish, tree nuts, peanuts, egg, fragrance, artificial colors or flavors, preservatives, animal products, crustacean shellfish. Sodium free.

Soy free

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: Adults - Take one tablet daily, preferably with food, as a dietary supplement.

Precautions

Caution: If you are pregnant, nursing, taking any medications or have any medical condition, consult your physician before use.

Discontinue use and consult your physician if any adverse reactions occur.

Keep out of reach of children.

Tamper-Evident Seal: Do not use product if seal appears tampered.

Storage

Store in a dry place under controlled room temperature: 20 degrees - 25 degrees C (68 degrees - 77 degrees F).

Brand IP Statement(s)

Mason Natural is a registered trademark and does not refer to any product or ingredient claim.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Brain Power with Sage Extract by Mason Natural label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Brain Power with Sage Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Brain Power with Sage Extract by Mason Natural

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Phosphatidylserine

Interacts with
219 drugs
50 mg per serving

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Calcium

Interacts with
168 drugs
65 mg per serving Form: Dicalcium Phosphate, Tricalcium Phosphate

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Sage extract

Interacts with
1,296 drugs
400 mg per serving

Sage is a common kitchen herb that is generally safe in food amounts and is traditionally used for sore throats, digestion, sweating, and memory. Some...

Sage extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Stearic Acid, Vegetable Magnesium Stearate, Silicon Dioxide, Croscarmellose Sodium, Pharmaceutical Glaze, Magnesium Silicate, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Brain Power with Sage Extract by Mason Natural Drug Interactions

Want to check YOUR meds against Brain Power with Sage Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,356Drugs
7 Major 1,349 Moderate

Ingredients driving the most interactions

Sage extract 1,296
Phosphatidylserine 219
Calcium 168

Individual Drug Interactions

The ingredients in Brain Power with Sage Extract interact with 1,356 drugs. Click any drug to see the details.

3 of the 3 ingredients in Brain Power with Sage Extract interact with drugs. Each result below shows which ingredient is responsible. Sage extract Phosphatidylserine Calcium

Each ingredient & the kinds of drugs it affects

For each ingredient in Brain Power with Sage Extract with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sage extract14 drug types · 1,296 drugs

Anticholinergic Drugs

Theoretically, sage might decrease the clinical effects of anticholinergic drugs.
In vitro evidence suggests that common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia) can inhibit acetylcholinesterase and might increase acetylcholine levels.

Likelihood Possible Evidence D
Anticonvulsants

Theoretically, sage might interfere with the clinical effects of anticonvulsant drugs.
Some species of sage can cause convulsions when consumed in large quantities.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking sage with antidiabetes drugs might increase the risk of hypoglycemia.
In patients with polycystic ovary syndrome (PCOS) or inadequately controlled type 2 diabetes, common sage (Salvia officinalis) has demonstrated hypoglycemic activity. However, other clinical research in patients with inadequately controlled type 2 diabetes shows that common sage extract does not lower fasting blood glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, sage might increase or decrease the effects of antihypertensive drugs.
Animal research suggests that common sage (Salvia officinalis) can cause prolonged blood pressure reduction. However, clinical research suggests that Spanish sage (Salvia lavandulaefolia) can increase blood pressure in some people with hypertension. Until more is known, use with caution.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking sage might increase the sedative and adverse effects of benzodiazepines.
In vitro evidence suggests that certain components of common sage (Salvia officinalis) can bind to benzodiazepine receptors. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, sage might have additive effects when used with cholinergic drugs.
In vitro evidence suggests that common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia) can inhibit acetylcholinesterase and might increase acetylcholine levels.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Some constituents of sage have CNS depressant activity.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C19.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C9.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2D6. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Animal research suggests that drinking common sage (Salvia officinalis) tea increases the expression of CYP2E1. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP3A4. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, sage might interfere with hormone therapy.
In vitro evidence suggests that geraniol, a constituent of Spanish sage (Salvia lavandulaefolia), exerts estrogenic activity. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, sage might increase levels of drugs transported by P-glycoprotein.
In vitro research suggests that common sage (Salvia officinalis) can inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Sage extract full monograph & interactions

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Brain Power with Sage Extract, from the product label.

Mason Natural

See all Mason Natural products
Name
Mason Vitamins, Inc.
City
Miami Lakes
State
FL
ZipCode
33014
Phone Number
1-888-860-5376
Web Address
www.MasonVitamins.com
Pharmacist Counseling Corner

Brain Power with Sage Extract by Mason Natural: Common Questions

Does Brain Power with Sage Extract by Mason Natural interact with any medications?
Yes. Based on its ingredients, Brain Power with Sage Extract has a known interaction with 1,356 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Brain Power with Sage Extract contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does phosphatidylserine actually do?
Phosphatidylserine is a compound that's naturally part of your cell membranes. Research suggests it may help with age-related memory loss and Alzheimer disease, though the evidence is still developing for other uses like general brain fog or ADHD.
Can I take this if I'm pregnant or breastfeeding?
Phosphatidylserine is not recommended in pregnancy or while breastfeeding because we don't have enough safety data. Sage should be avoided in medicinal amounts during pregnancy due to thujone content, though food-form sage is likely fine. Calcium is safe at recommended amounts in both pregnancy and breastfeeding. Talk to your doctor or pharmacist about your specific situation.
What are the most common side effects I should watch for?
The main ones are stomach-related: flatulence, gas, upset stomach, nausea, diarrhea, or constipation. You might also notice headache, insomnia (especially if you take a large dose), dizziness, or agitation. These are generally mild, but if they're bothersome, stop and talk to your pharmacist.
Does this product help with memory?
Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease. Sage extract is possibly effective for cognitive function. So there's some evidence these ingredients may help, but results vary from person to person and more research is ongoing.
How does sage extract in this product relate to sage tea or cooking with sage?
Sage extract is a concentrated form, much stronger than the amount you'd use in cooking or a casual cup of tea. The safety data warns to use concentrated extracts cautiously, which is why it's important to follow the dosing on the label and talk to your pharmacist if you're also regularly consuming large amounts of sage in other forms.
Will this interact with my thyroid medication or blood pressure pills?
The calcium in this product can reduce how well levothyroxine (thyroid medication) and several blood pressure or heart drugs are absorbed, which could make them less effective. You'd need to space doses several hours apart. Use the medication checker below with your specific drug names, or ask your pharmacist to review your medications against this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Brain Power with Sage Extract label
Go deeper

The Full Monographs Behind Brain Power with Sage Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Sage

Interacts with 1,296 drugs

Sage is a common kitchen herb that is generally safe in food amounts and is traditionally used for sore throats, digestion, sweating, and memory. Some early research is encouraging for sore...

Read the full Sage monograph →
Sources

Sources & How We Checked

Brain Power with Sage Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 98 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
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See these in context on the Calcium monograph →

Sage 27 references
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