Broad Spectrum Hemp Softgels 300 mg Ingredients & Drug Interactions
by Rx Select
What is this page for?
First and foremost: checking Broad Spectrum Hemp Softgels 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Broad Spectrum Hemp Softgels 300 mg is a dietary supplement by Rx Select with 3 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,100 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Broad Spectrum Hemp Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Broad Spectrum Hemp Softgels 300 mg by Rx Select
Ask about any prescription or over-the-counter medication and we check it for interactions with Broad Spectrum Hemp Softgels 300 mg by Rx Select — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Broad Spectrum Hemp Softgels 300 mg by Rx Select
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
This product contains one active ingredient: Broad Spectrum Hemp Oil, a 300 mg dose per softgel. The inactive ingredients are various emulsifiers, oils, gelling agents, glycerin, sorbitol, water, and colorants (Red 40, Red 3, Yellow 5, Yellow 6, Blue 1, Blue 2).
Does it work?
Strong evidence
The evidence we hold doesn't establish that hemp is effective for constipation, eczema (atopic dermatitis), or familial hypercholesterolemia. For all these uses, the data shows insufficient reliable evidence to rate it one way or the other.
How safe is it?
Well-documented data
Hemp seed foods in normal amounts are generally well tolerated. However, concentrated extracts and supplements—like this one—are less well studied, so caution is advised.
Serious adverse effects are rare but have been reported: case reports include allergic reactions ranging from hives and facial swelling to anaphylaxis and worsening asthma. There are also rare reports of serious heart rhythm problems (long QT syndrome, torsades de pointes, syncope).
In one case, a young child given high-dose hemp extract developed elevated liver enzymes and hepatitis; however, that dose was much higher than typical supplement use. We don't hold safety data on use during pregnancy or breastfeeding, so talk with your doctor or pharmacist before using this product if you're pregnant, planning to become pregnant, or breastfeeding.
Meds to double-check
Moderate interaction found
Before taking this product, check your exact medications if you take estrogens or hormone therapy (Moderate risk), blood pressure medications or ACE inhibitors, blood thinners, or any drugs your liver breaks down. No interactions are documented for the only active ingredient we could check; however, the theoretical interactions above are grounded in how the herb works in your body.
The bottom line
Scorecard at a glancePartially disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
If you take hormone therapy, blood pressure medications, blood thinners, or any drugs metabolized by your liver, check with your pharmacist before adding this product—the potential for interaction is real. Even though serious side effects are uncommon, allergic reactions to hemp have been reported.
A conversation with your pharmacist is your best first step.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Broad Spectrum Hemp Softgels 300 mg, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Broad Spectrum Hemp Softgels 300 mg by Rx Select, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 1 Calorie(s) | -- |
| Total Carbohydrates | 0 Gram(s) | -- |
| Calories from Fat | 1 Calorie(s) | -- |
| Dietary Fiber | 0 Gram(s) | -- |
| Total Sugars | 0 Gram(s) | -- |
| Protein | 0 Gram(s) | -- |
| Broad Spectrum Hemp Oil | 10 mg | -- |
Other ingredients: Polysorbate emulsifiers, Medium Chain Triglyceride Oil, Beta-Caryophyllene, Bovine Gelatin, Glycerine, Sorbitol, Water, Red 40, Red 3, Yellow 5, Yellow 6, Blue 1, Blue 2
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
100% American hemp
300 mg total cannabinoids
Brand IP Statement(s)
Copyright Windmill Health Products All rights reserved.
Formulation
0% THC
Made in U.S.A. from globally sourced ingredients
FDA Disclaimer Statement
This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Take 1 or 2 softgels daily.
Precautions
Contains: Tree nuts (coconut)
Keep out of reach of children
Do not purchase if seal is broken
Storage
Protect from heat, light, and moisture Store in a cool, dry place
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Broad Spectrum Hemp Softgels 300 mg by Rx Select label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Broad Spectrum Hemp Softgels 300 mg by Rx Select
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Dietary Fiber
Interacts with2,025 drugs
Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...
Dietary Fiber monograph & interactionsProtein
Broad Spectrum Hemp Oil
Interacts with938 drugs
Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for...
Broad Spectrum Hemp Oil monograph & interactionsOther (inactive) ingredients: Polysorbate emulsifiers, Medium Chain Triglyceride Oil, Beta-Caryophyllene, Bovine Gelatin, Glycerine, Sorbitol, Water, Red 40, Red 3, Yellow 5, Yellow 6, Blue 1, Blue 2. These complete the product’s ingredient list but are not active constituents.
Broad Spectrum Hemp Softgels 300 mg by Rx Select Drug Interactions
HelloPharmacist Interaction Report
Rx Select's Broad Spectrum Hemp Softgels may interact with several medication types.
The most serious documented concern is with estrogens (hormone therapy): hemp has shown estrogenic effects in animal studies and theoretically could interfere with how your hormones work.
Read the full breakdown — every affected drug type, severity by severity
Minor interactions are documented with blood pressure medications (antihypertensives and ACE inhibitors), where hemp seed protein may have additive effects and increase the risk of low blood pressure. There's also a theoretical Minor concern with blood thinners (anticoagulant and antiplatelet drugs)—animal studies suggest hemp seed might increase bleeding risk, though human research with hemp seed oil at typical doses hasn't shown this effect.
Additionally, hemp may induce two liver enzymes (CYP1A2 and CYP3A4) that break down many medications, potentially lowering their levels and effectiveness.
Although the product contains only one active ingredient, these interactions span 939 individual medications. Use the medication checker below to look up your exact drugs before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Broad Spectrum Hemp Softgels 300 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Broad Spectrum Hemp Softgels 300 mg interact with 2,100 drugs. Click any drug to see the details.
2 of the 3 ingredients in Broad Spectrum Hemp Softgels 300 mg interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Broad Spectrum Hemp Oil
Alogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Broad Spectrum Hemp Softgels 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Alogliptin, Metformin interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Broad Spectrum Hemp Oil + Bazedoxifene Acetate, Conjugated Estrogens interactionDietary FiberEthinyl Estradiol, Oral Drugs Minor
Interaction Summary
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Read the full Dietary Fiber + Bazedoxifene Acetate, Conjugated Estrogens interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Broad Spectrum Hemp Softgels 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Broad Spectrum Hemp Softgels 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Canagliflozin, Metformin Hydrochloride interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Carbamazepine (tegretol) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Carbamazepine interactionBroad Spectrum Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Broad Spectrum Hemp Oil + Carbamazepine interactionConjugated EstrogensCenestin, Enjuvia, Premarin, Premarin Vaginal Cream
How Conjugated Estrogens interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Broad Spectrum Hemp Oil + Conjugated Estrogens interactionDietary FiberOral Drugs, Ethinyl Estradiol Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Conjugated Estrogens interactionConjugated Estrogens, Medroxyprogesterone AcetatePremplus, Prempro
How Conjugated Estrogens, Medroxyprogesterone Acetate interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Broad Spectrum Hemp Oil + Conjugated Estrogens, Medroxyprogesterone Acetate interactionDietary FiberOral Drugs, Ethinyl Estradiol Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Conjugated Estrogens, Medroxyprogesterone Acetate interactionConjugated Estrogens, MeprobamatePMB 200, PMB 400
How Conjugated Estrogens, Meprobamate interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Broad Spectrum Hemp Oil + Conjugated Estrogens, Meprobamate interactionDietary FiberEthinyl Estradiol, Oral Drugs Minor
Interaction Summary
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Read the full Dietary Fiber + Conjugated Estrogens, Meprobamate interactionConjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone
How Conjugated Estrogens, Methyltestosterone interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Broad Spectrum Hemp Oil + Conjugated Estrogens, Methyltestosterone interactionDietary FiberOral Drugs, Ethinyl Estradiol Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Conjugated Estrogens, Methyltestosterone interactionCyproterone Acetate, Ethinyl EstradiolDiane-35, Dianette
How Cyproterone Acetate, Ethinyl Estradiol interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Broad Spectrum Hemp Oil + Cyproterone Acetate, Ethinyl Estradiol interactionDietary FiberOral Drugs, Ethinyl Estradiol Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Cyproterone Acetate, Ethinyl Estradiol interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Broad Spectrum Hemp Softgels 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Dapagliflozin Propanediol, Metformin interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionBroad Spectrum Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Broad Spectrum Hemp Oil + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDesogestrel, Ethinyl EstradiolDesogen, Marvelon, Marvelon 21, Marvelon 28, Mircette, Ortho-Cept +2 more
How Desogestrel, Ethinyl Estradiol interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Broad Spectrum Hemp Oil + Desogestrel, Ethinyl Estradiol interactionDietary FiberEthinyl Estradiol, Oral Drugs Minor
Interaction Summary
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Read the full Dietary Fiber + Desogestrel, Ethinyl Estradiol interactionDrospirenone, EstetrolNextstellis
How Drospirenone, Estetrol interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Broad Spectrum Hemp Oil + Drospirenone, Estetrol interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Drospirenone, Estetrol interactionDrospirenone, Ethinyl EstradiolAngeliq, Gianvi, Yasmin
How Drospirenone, Ethinyl Estradiol interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Broad Spectrum Hemp Oil + Drospirenone, Ethinyl Estradiol interactionDietary FiberEthinyl Estradiol, Oral Drugs Minor
Interaction Summary
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Read the full Dietary Fiber + Drospirenone, Ethinyl Estradiol interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Broad Spectrum Hemp Softgels 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Broad Spectrum Hemp Softgels 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Dietary Fiber + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Broad Spectrum Hemp Softgels 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Empagliflozin, Metformin Hydrochloride interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Broad Spectrum Hemp Softgels 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ertugliflozin, Metformin Hydrochloride interactionEsterified EstrogensEstratab, Menest
How Esterified Estrogens interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Broad Spectrum Hemp Oil + Esterified Estrogens interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Esterified Estrogens interactionEsterified Estrogens, MethyltestosteroneEstratest
How Esterified Estrogens, Methyltestosterone interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Broad Spectrum Hemp Oil + Esterified Estrogens, Methyltestosterone interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Esterified Estrogens, Methyltestosterone interactionEstradiolDivigel, Elestrin, Estrace, Estraderm, Estring, Evamist +6 more
How Estradiol interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Broad Spectrum Hemp Oil + Estradiol interactionDietary FiberOral Drugs, Ethinyl Estradiol Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Estradiol interactionEstradiol, MedroxyprogesteroneDivitren
How Estradiol, Medroxyprogesterone interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Broad Spectrum Hemp Oil + Estradiol, Medroxyprogesterone interactionDietary FiberOral Drugs, Ethinyl Estradiol Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Estradiol, Medroxyprogesterone interactionEstradiol, Norethindrone AcetateActivella
How Estradiol, Norethindrone Acetate interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Broad Spectrum Hemp Oil + Estradiol, Norethindrone Acetate interactionDietary FiberEthinyl Estradiol, Oral Drugs Minor
Interaction Summary
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Read the full Dietary Fiber + Estradiol, Norethindrone Acetate interactionEstradiol, NorgestimateOrtho-Prefest
How Estradiol, Norgestimate interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Broad Spectrum Hemp Oil + Estradiol, Norgestimate interactionDietary FiberOral Drugs, Ethinyl Estradiol Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Estradiol, Norgestimate interactionEstradiol, ProgesteroneBijuvanda
How Estradiol, Progesterone interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Broad Spectrum Hemp Oil + Estradiol, Progesterone interactionDietary FiberEthinyl Estradiol, Oral Drugs Minor
Interaction Summary
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Read the full Dietary Fiber + Estradiol, Progesterone interactionEstrogenEstrogen
How Estrogen interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Broad Spectrum Hemp Oil + Estrogen interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Estrogen interactionEstroneOrtho-Est
How Estrone interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilEstrogens Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Broad Spectrum Hemp Oil + Estrone interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Estrone interactionEstropipateOgen, Ortho EST
How Estropipate interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilEstrogens Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Broad Spectrum Hemp Oil + Estropipate interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Estropipate interactionEthiny Estradiol, LevonorgestrelLogynon, Microgynon 30 ED
How Ethiny Estradiol, Levonorgestrel interacts with Broad Spectrum Hemp Softgels 300 mg — through 2 ingredients. Tap an ingredient for the detail:
Broad Spectrum Hemp OilEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Broad Spectrum Hemp Oil + Ethiny Estradiol, Levonorgestrel interactionDietary FiberOral Drugs, Ethinyl Estradiol Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ethiny Estradiol, Levonorgestrel interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Broad Spectrum Hemp Softgels 300 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Dietary Fiber
Carbamazepine (Tegretol)
Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.
Lithium
Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.
Metformin (Glucophage)
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
Broad Spectrum Hemp Oil
Estrogens
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.
Ace Inhibitors (Aceis)
Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.
Anticoagulant/Antiplatelet Drugs
Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.
Antihypertensive Drugs
Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.
Brand information
Manufacturer and brand details for Broad Spectrum Hemp Softgels 300 mg, from the product label.
Rx Select
See all Rx Select products- Name
- Windmill Health Products
- Street Address
- 10 Henderson Drive
- City
- West Caldwell
- State
- NJ
- ZipCode
- 07006
- Web Address
- RXSelectHemp.com
Broad Spectrum Hemp Softgels 300 mg by Rx Select: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Broad Spectrum Hemp Softgels 300 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Black Psyllium
Interacts with 2,025 drugsBlack psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...
Read the full Black Psyllium monograph → Herb & supplement monographHemp
Interacts with 938 drugsHemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...
Read the full Hemp monograph →Sources & How We Checked
Broad Spectrum Hemp Softgels 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Psyllium 18 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
- Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
- Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
- Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
- Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
- Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
- Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
- Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
- Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
- Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
- Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
- Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed
Hemp 12 references
- Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
- Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
- Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
- Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
- Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
- Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
- Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
- Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed
- Déléaval M, Burri H, Bakelants E. Harmless herbs? A case report of acquired long QT syndrome and torsades de pointes in a patient taking herbal supplements. HeartRhythm Case Rep 2022;8(5):309-12. PubMed
- Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed
- Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC