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Dietary supplement

Butterbur Extract Ingredients & Drug Interactions

by SuperSmart

Butterbur Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Butterbur Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Butterbur Extract is a dietary supplement by SuperSmart with 1 active ingredient. Its ingredients are commonly taken for migraine prevention, hay fever (allergic rhinitis), asthma symptoms.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Petasites hybridus Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Butterbur Extract by SuperSmart

Ask about any prescription or over-the-counter medication and we check it for interactions with Butterbur Extract by SuperSmart — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Butterbur Extract by SuperSmart

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product has one active ingredient: petasites hybridus extract, commonly known as butterbur. It also contains two inactive ingredients — acacia gum and white rice flour — which are fillers and binders.

Butterbur extract is traditionally used for migraine prevention and allergy relief. The critical point here is that only PA-free (pyrrolizidine alkaloid-free) standardized products should be used, because raw butterbur can damage the liver.

Make sure the label confirms this product is PA-free before using it.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Butterbur's overall clinical evidence instead.

Moderate

Some clinical evidence supports Butterbur for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Allergic rhinitis (hay fever) — rated "Possibly Effective" (Natural Medicines).
  • On file: Migraine headache — rated "Possibly Effective" (Natural Medicines).

According to the data we hold, butterbur extract is possibly effective for migraine headache prevention and for allergic rhinitis (hay fever). That means there's some evidence it may help, but the research isn't conclusive.

If you're considering it for either of these conditions, talk with your pharmacist or doctor about whether it's a fit for you alongside your other options.

The evidence, ingredient by ingredient Butterbur

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Butterbur is generally well tolerated when taken by mouth, but common side effects do occur — belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, itching, rash, and stomach upset are the most frequently reported. Serious liver damage (hepatotoxicity) from pyrrolizidine alkaloids is rare, though there are even rare reports of liver injury linked to products labeled as PA-free.

Do not use this product during pregnancy — the safety data advises against it. Breastfeeding safety is unknown, so it's best to avoid it while nursing.

Always confirm the label states PA-free before purchasing.

Side effects, ingredient by ingredient Butterbur

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Butterbur.
  • The most serious interaction on file is rated Moderate.
  • For scale: 88 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, have your pharmacist check whether you take any CYP3A4 inducers (drugs that speed up liver processing of certain substances). These medications carry a Moderate interaction risk with butterbur.

If you're unsure whether your medications are in this group, use the interaction checker on this page with your exact medication names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Butterbur extract may be worth considering if you're looking for migraine or allergy support and have no interacting medications. Anyone taking CYP3A4-inducing drugs should check their specific medication list with a pharmacist first.

Pregnant or breastfeeding women should avoid it. Always buy PA-free products only.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Butterbur Extract, straight from the product label.

Brand SuperSmart
Barcode (UPC) 5453003827214
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 332638
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Butterbur Extract by SuperSmart, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
5453003827214
IngredientAmount% DV
Petasites hybridus Extract100 mg--

Other ingredients: Acacia Gum, White Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults. Take two vegetarian capsules a day.

Formula

Each capsule contains 50 mg of Petasites hybridus extract.

Precautions

Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not replace a varied, balanced diet.

Keep out of childrens' reach.

As with any nutritional supplement, you should consult a health professional before taking this product if you are pregnant, breastfeeding or have a health problem.

Storage

Store away from direct light, heat and humidity.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Butterbur Extract by SuperSmart label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Butterbur Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Butterbur Extract by SuperSmart

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Petasites hybridus Extract

Interacts with
87 drugs
100 mg per serving Form: Sesquiterpene Lactones

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However...

Petasites hybridus Extract monograph & interactions

Other (inactive) ingredients: Acacia Gum, White Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Butterbur Extract by SuperSmart Drug Interactions

Want to check YOUR meds against Butterbur Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Petasites hybridus Extract 87

Individual Drug Interactions

The ingredients in Butterbur Extract interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Butterbur Extract interact with drugs. Each result below shows which ingredient is responsible. Petasites hybridus Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Butterbur Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Petasites hybridus Extract1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.
The pyrrolizidine alkaloid (PA) constituents found in some butterbur products are substrates of CYP3A4. Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites.

Likelihood Possible Evidence D
Petasites hybridus Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Butterbur Extract, from the product label.

SuperSmart

See all SuperSmart products
Name
SN Worldwide Unipessoal, Lda
Street Address
Avenida Do Infante 66, Edificio Quinta Avenida 1 C
City
Funchal
ZipCode
9000-015
Pharmacist Counseling Corner

Butterbur Extract by SuperSmart: Common Questions

Does Butterbur Extract by SuperSmart interact with any medications?
Yes. Based on its ingredients, Butterbur Extract has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Butterbur Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this butterbur product safe to use?
Only if it's PA-free — the label must confirm that. Raw butterbur can damage your liver. This product is generally well tolerated, but common side effects like belching, diarrhea, drowsiness, and stomach upset do happen, and rare liver injury has been reported even with PA-free products.
Can I take butterbur while pregnant or breastfeeding?
No — the safety data advises against it during pregnancy because of possible liver and other risks. While breastfeeding, safety is unknown, so it's best to avoid it. Talk with your doctor or pharmacist if you're in either situation and looking for alternatives.
What is butterbur supposed to help with?
The evidence shows butterbur extract is possibly effective for migraine headache prevention and for allergic rhinitis (hay fever). The research isn't conclusive, but it may be worth discussing with your doctor if you're interested in these uses.
What are the most common side effects?
Belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, itching, rash, and stomach upset are the side effects reported most often. Most people tolerate it well, but these are not rare.
Why do I need to check my medications before taking this?
Butterbur contains compounds that interact with drugs called CYP3A4 inducers. If you take one of these medications, the butterbur may be processed differently in your body and could increase your risk of liver damage. Your pharmacist can tell you if any of your drugs are in this group.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Butterbur Extract label
Go deeper

The Full Monographs Behind Butterbur Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Butterbur

Interacts with 87 drugs

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However, raw or unprocessed butterbur contains...

Read the full Butterbur monograph →
Sources

Sources & How We Checked

Butterbur Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Butterbur 7 references
  1. Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003;43:76-8.. PubMed
  2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  4. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  5. Pothmann R, Danesch U. Migraine Prevention in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 2005;45:196-203.. PubMed
  6. Oelkers-Ax R, Leins A, Parzer P, et al. Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study. Eur J Pain 2008;12:301-13. PubMed
  7. Schapowal A. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol.Head Neck Surg. 2004;130:1381-86. PubMed

See these in context on the Butterbur monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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