Carb Intercept with Phase 2 Carb Controller Ingredients & Drug Interactions
by Natrol
What is this page for?
First and foremost: checking Carb Intercept with Phase 2 Carb Controller against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Carb Intercept with Phase 2 Carb Controller is a dietary supplement by Natrol with 5 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 339 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Chromium, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Carb Intercept with Phase 2 Carb Controller by Natrol
Ask about any prescription or over-the-counter medication and we check it for interactions with Carb Intercept with Phase 2 Carb Controller by Natrol — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Carb Intercept with Phase 2 Carb Controller by Natrol
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Carb Intercept contains five active ingredients. The product is built primarily on two forms of calcium—Calcium and Dibasic Calcium Phosphate—which work to support bone health and help regulate mineral balance.
It also includes two chromium sources: Chromium and Foodbound Chromium, which are minerals involved in blood sugar control. White Kidney Bean extract is included to support carbohydrate management, though we have no interaction data on file for that ingredient.
The remaining ingredients are inert substances (hypromellose, gum arabic, magnesium stearate, silicon dioxide, and maltodextrin) that form the capsule and help blend the actives.
Does it work?
Moderate evidence
Calcium in this product is rated Likely Effective for osteoporosis and Effective for a range of conditions including low blood calcium (hypocalcemia) and dyspepsia (acid reflux discomfort). Chromium is rated Possibly Effective for type 2 diabetes but Possibly Ineffective for prediabetes, high blood pressure, and schizophrenia.
The evidence for chromium deficiency is Likely Effective. White Kidney Bean extract effectiveness is not established in the data we hold.
How safe is it?
Well-documented data
Calcium is generally well tolerated at recommended doses, though high doses can cause problems. Common side effects from oral calcium include belching, constipation, diarrhea, bloating, and stomach upset.
Rare serious concerns include kidney stones and a serious condition called calciphylaxis. Some research suggests that very high calcium intake (over 2,000 mg daily from food or supplements) may be weakly linked to increased prostate cancer risk and possibly higher cardiovascular risk, though these findings are debated.
Chromium is also generally well tolerated at typical supplement doses, but high or long-term use may pose risks. Common side effects include gastrointestinal irritation, headaches, insomnia, mood changes, and rarely skin rashes.
Very rare cases of kidney or liver damage and blood disorders have been reported with high-dose chromium picolinate.
Meds to double-check
Major interaction found
Before taking this product, ask your pharmacist about: HIV integrase inhibitors (dolutegravir, elvitegravir), ceftriaxone (especially if given intravenously), thyroid medication (levothyroxine), heart rhythm or blood pressure drugs (diltiazem, sotalol), diabetes or insulin medications, NSAIDs (ibuprofen, naproxen) and aspirin, and calcipotriene (a psoriasis cream). Separate doses by at least 2–6 hours depending on the medication.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This product is worth considering if you're looking to support bone health and steady blood sugar without taking multiple pills. However, if you take HIV medications (especially integrase inhibitors), thyroid medication, heart drugs, NSAIDs, or diabetes or insulin therapy, you need to run this past your pharmacist first—timing and spacing will likely matter.
Pregnant or nursing women should check with their doctor before adding extra calcium or chromium beyond what's in prenatal vitamins or food.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Carb Intercept with Phase 2 Carb Controller, straight from the product label.
| Brand | Natrol |
|---|---|
| Barcode (UPC) | 047469042912 |
| Net contents | 120 Veggie Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 23, 2020 |
| DSLD ID | 230435 |
| Product type | Botanical With Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Carb Intercept with Phase 2 Carb Controller by Natrol, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calcium | 190 mg | 15% |
| Dibasic Calcium Phosphate | 0 NP | -- |
| White Kidney Bean extract | 0 NP | -- |
| Chromium | 40 mcg | 115% |
| Foodbound Chromium | 0 NP | -- |
| Phase 2 Carb Controller Complex | 1000 mg | -- |
Other ingredients: Hypromellose, Gum Arabic, Magnesium Stearate, Silicon Dioxide, Maltodextrin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Natrol Carb Intercept contains Phase 2, a patented and clinically tested non-stimulant all-natural white kidney bean extract shown to help control carbs by reducing the enzymatic digestion of dietary starches and delaying the digestion of carbs, which reduces the caloric impact of starchy foods.
White Kidney Bean Extract
General Statements
For detailed clinical studies, visit: www.phase2info.com A healthy calorie reduction diet and exercise regimen is essential for weight loss. The amount of weight loss varies by individual and is related to your diet, exercise, daily activities, age and body frame.
Precautions
Warning: Consult your healthcare professional prior to use if you have or suspect a medical condition, or are taking prescription drugs, or are pregnant or lactating.
Do not exceed 4 capsules per day.
Contains: Milk and Soy
Keep out of reach of children.
Brand IP Statement(s)
The trademarks Phase 2 Carb Controller and Foodbound are being used under license.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
Weight Management Helps Control Carbs Helps Metabolize Fats
Vegetarian
No: Egg, Fish, Crustacean Shellfish, Tree Nuts, Peanuts, Wheat, Artificial Colors or Flavors, Added Sugar or Preservatives
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: For optimal effect, take 2 capsules, immediately before starch-heavy meals. Do not exceed 4 capsules per day.
Storage
Store in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Carb Intercept with Phase 2 Carb Controller by Natrol label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Carb Intercept with Phase 2 Carb Controller by Natrol
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Calcium
Interacts with168 drugs
Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...
Calcium monograph & interactionsChromium
Interacts with178 drugs
Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...
Chromium monograph & interactionsPhase 2 Carb Controller Complex
- › Dibasic Calcium Phosphate
- › White Kidney Bean extract
- › Foodbound Chromium
Other (inactive) ingredients: Hypromellose, Gum Arabic, Magnesium Stearate, Silicon Dioxide, Maltodextrin. These complete the product’s ingredient list but are not active constituents.
Carb Intercept with Phase 2 Carb Controller by Natrol Drug Interactions
HelloPharmacist Interaction Report
Carb Intercept with Phase 2 Carb Controller by Natrol contains calcium and chromium—both have documented interactions with medications.
The most serious concern is calcium's effect on HIV integrase inhibitors (dolutegravir and elvitegravir), which can reduce their blood levels by up to 40%, potentially compromising viral control. Calcium also poses a Major-severity risk with ceftriaxone (an antibiotic), where combining them intravenously can cause dangerous precipitation in the lungs and kidneys.
Read the full breakdown — every affected drug type, severity by severity
Moderate interactions include calcium reducing the absorption of thyroid medication (levothyroxine), the heart drug diltiazem, and the beta-blocker sotalol—all requiring timed separation of doses. Calcium may also increase the risk of elevated blood calcium (hypercalcemia) if you're using calcipotriene (a vitamin D–like psoriasis cream).
Additionally, chromium may lower blood sugar and increase insulin's effect, raising the risk of low blood sugar (hypoglycemia) if you take diabetes medications or insulin. Chromium can also decrease levothyroxine absorption by about 17% and may cause a Minor interaction with NSAIDs and aspirin by increasing chromium levels in the body.
We could not check White Kidney Bean extract against medication databases; no interaction data is on file for it. Altogether, these interactions span 339 individual medications.
Before starting this product, use the interaction checker below with your exact prescriptions.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Carb Intercept with Phase 2 Carb Controller?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Carb Intercept with Phase 2 Carb Controller interact with 339 drugs. Click any drug to see the details.
2 of the 5 ingredients in Carb Intercept with Phase 2 Carb Controller interact with drugs. Each result below shows which ingredient is responsible. Chromium Calcium
Cryptenamine, MethyclothiazideDiutensen
How Cryptenamine, Methyclothiazide interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateThiazide Diuretics Moderate
Interaction Summary
Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Read the full Dibasic Calcium Phosphate + Cryptenamine, Methyclothiazide interactionCyclothiazideAnhydron, Fluidil
How Cyclothiazide interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateThiazide Diuretics Moderate
Interaction Summary
Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Read the full Dibasic Calcium Phosphate + Cyclothiazide interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Foodbound ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Foodbound Chromium + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Foodbound ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Foodbound Chromium + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Foodbound ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Foodbound Chromium + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Foodbound ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Foodbound Chromium + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDarunavir, Cobicistat, Emtricitabine, Tenofovir AlafenamideSymtuza
How Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateBictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Read the full Dibasic Calcium Phosphate + Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide interactionDasiglucagon HydrochlorideZegalogue
How Dasiglucagon Hydrochloride interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Foodbound ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Foodbound Chromium + Dasiglucagon Hydrochloride interactionDemeclocyclineDeclomycin
How Demeclocycline interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateTetracycline Antibiotics Moderate
Interaction Summary
Calcium seems to reduce the absorption of tetracycline antibiotics.
Read the full Dibasic Calcium Phosphate + Demeclocycline interactionDeserpidine, HydrochlorothiazideOreticyl, Oreticyl Forte
How Deserpidine, Hydrochlorothiazide interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateThiazide Diuretics Moderate
Interaction Summary
Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Read the full Dibasic Calcium Phosphate + Deserpidine, Hydrochlorothiazide interactionDeserpidine, MethyclothiazideEnduronyl, Enduronyl Forte
How Deserpidine, Methyclothiazide interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateThiazide Diuretics Moderate
Interaction Summary
Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Read the full Dibasic Calcium Phosphate + Deserpidine, Methyclothiazide interactionDigoxinDigitek, Lanoxicaps, Lanoxin
How Digoxin interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateDigoxin (lanoxin) Moderate
Interaction Summary
Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Read the full Dibasic Calcium Phosphate + Digoxin interactionDihydroxyaluminum Sodium CarbonateRolaids
How Dihydroxyaluminum Sodium Carbonate interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateAluminum Moderate
Interaction Summary
Calcium citrate might increase aluminum absorption and toxicity.
Read the full Dibasic Calcium Phosphate + Dihydroxyaluminum Sodium Carbonate interactionDiltiazemAdizem-SR, Adizem-XL, Angitil SR, Angitil XL, Calcicard CR, Cardizem +23 more
How Diltiazem interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateCalcium Channel Blockers, Diltiazem (cardizem, Others) Moderate
Interaction Summary
Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Read the full Dibasic Calcium Phosphate + Diltiazem interactionDiltiazem, EnalaprilTeczem
How Diltiazem, Enalapril interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateCalcium Channel Blockers, Diltiazem (cardizem, Others) Moderate
Interaction Summary
Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Read the full Dibasic Calcium Phosphate + Diltiazem, Enalapril interactionDoripenemDoribax
How Doripenem interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateQuinolone Antibiotics, Tetracycline Antibiotics Moderate
Interaction Summary
Calcium seems to reduce the absorption of quinolone antibiotics.
Read the full Dibasic Calcium Phosphate + Doripenem interactionDoxycyclineDoryx, Doxy, Doxy-D, Doxycin, Doxycycline Injection, Doxylin +6 more
How Doxycycline interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateTetracycline Antibiotics Moderate
Interaction Summary
Calcium seems to reduce the absorption of tetracycline antibiotics.
Read the full Dibasic Calcium Phosphate + Doxycycline interactionDoxycycline HyclateActiclate, Acticlate Cap, Lymepak
How Doxycycline Hyclate interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateTetracycline Antibiotics Moderate
Interaction Summary
Calcium seems to reduce the absorption of tetracycline antibiotics.
Read the full Dibasic Calcium Phosphate + Doxycycline Hyclate interactionDoxycycline MonohydrateErfacea
How Doxycycline Monohydrate interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateTetracycline Antibiotics Moderate
Interaction Summary
Calcium seems to reduce the absorption of tetracycline antibiotics.
Read the full Dibasic Calcium Phosphate + Doxycycline Monohydrate interactionDoxycylineDoxychel
How Doxycyline interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateTetracycline Antibiotics Moderate
Interaction Summary
Calcium seems to reduce the absorption of tetracycline antibiotics.
Read the full Dibasic Calcium Phosphate + Doxycyline interactionDulaglutideTrulicity
How Dulaglutide interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Foodbound ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Foodbound Chromium + Dulaglutide interactionEmpagliflozinJardiance
How Empagliflozin interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Foodbound ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Foodbound Chromium + Empagliflozin interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Foodbound ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Foodbound Chromium + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Foodbound ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Foodbound Chromium + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Foodbound ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Foodbound Chromium + Empagliflozin, Metformin Hydrochloride interactionEmtricitabineEmtriva
How Emtricitabine interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateBictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Read the full Dibasic Calcium Phosphate + Emtricitabine interactionEmtricitabine, Rilpivirine, TenofovirComplera
How Emtricitabine, Rilpivirine, Tenofovir interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateBictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Read the full Dibasic Calcium Phosphate + Emtricitabine, Rilpivirine, Tenofovir interactionEmtricitabine, Rilpivirine, Tenofovir AlafenamideOdefsey
How Emtricitabine, Rilpivirine, Tenofovir Alafenamide interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateBictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Read the full Dibasic Calcium Phosphate + Emtricitabine, Rilpivirine, Tenofovir Alafenamide interactionEmtricitabine, Tenofovir Alafenamide FumarateDescovy
How Emtricitabine, Tenofovir Alafenamide Fumarate interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateBictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Read the full Dibasic Calcium Phosphate + Emtricitabine, Tenofovir Alafenamide Fumarate interactionEnalapril Maleate, HydrochlorothiazideVaseretic
How Enalapril Maleate, Hydrochlorothiazide interacts with Carb Intercept with Phase 2 Carb Controller — through 1 ingredient. Tap an ingredient for the detail:
Dibasic Calcium PhosphateThiazide Diuretics Moderate
Interaction Summary
Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Read the full Dibasic Calcium Phosphate + Enalapril Maleate, Hydrochlorothiazide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Carb Intercept with Phase 2 Carb Controller with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Chromium
Antidiabetes Drugs
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.
Insulin
Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,
Levothyroxine (Synthroid, Others)
Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.
Aspirin
Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)
NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.
Calcium
Ceftriaxone (Rocephin)
Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.
Dolutegravir (Tivicay)
Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.
Elvitegravir (Vitekta)
Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.
Aluminum
Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.
Bisphosphonates
Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.
Calcipotriene (Dovonex)
Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.
Digoxin (Lanoxin)
Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.
Diltiazem (Cardizem, Others)
Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.
Levothyroxine (Synthroid, Others)
Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.
Lithium
Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.
Quinolone Antibiotics
Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.
Raltegravir (Isentress)
Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.
Sotalol (Betapace)
Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.
Tetracycline Antibiotics
Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.
Thiazide Diuretics
Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.
Verapamil (Calan, Others)
Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.
Calcium Channel Blockers
Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.
Brand information
Manufacturer and brand details for Carb Intercept with Phase 2 Carb Controller, from the product label.
Natrol
See all Natrol products- Name
- Natrol LLC
- City
- Chatsworth
- State
- CA
- ZipCode
- 91311
- Phone Number
- 1-800-262-8765
- Web Address
- www.natrol.com
Carb Intercept with Phase 2 Carb Controller by Natrol: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Carb Intercept with Phase 2 Carb Controller’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Calcium
Interacts with 168 drugsCalcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...
Read the full Calcium monograph → Herb & supplement monographChromium
Interacts with 178 drugsChromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...
Read the full Chromium monograph →Sources & How We Checked
Carb Intercept with Phase 2 Carb Controller's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 115 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Calcium 62 references
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- Koo WK, Walters JC, Esterlitz J, et al. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 1999;94:577-82. DOI
- Raman L, Rajalakshmi K, Krishnamachari KAVR, et al. Effect of calcium supplementation to undernourished mothers during pregnancy on the bone density of the neonates. Am J Clin Nutr 1978; 31:466-9. DOI
- Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
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- Decktor DL, Robinson M, Maton PN, et al. Effects of aluminum/magnesium hydroxide and calcium carbonate on esophageal and gastric pH in subjects with heartburn. Am J Ther 1995;2:546-52. PubMed
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- Gueguen L, Pointillart A. The bioavailability of dietary calcium. J Am Coll Nutr 2000;19:119s-136s. PubMed
- Vella A, Gerber TC, Hayes DL, Reeder GS. Digoxin, hypercalcaemia, and cardiac conduction. Postgrad Med J 1999;75:554-6. PubMed
- Bania TC, Blaufeux B, Hughes S, et al. Calcium and digoxin vs. calcium alone for severe verapamil toxicity. Acad Emerg Med 2000;7:1089-96. PubMed
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- Rocephin (ceftriaxone) and calcium interaction. Pharmacist's Letter / Prescriber's Letter 2007;23(10):231005.
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- Bolland MJ, Avenell A, Baron JA, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 2010;341:c3691. PubMed
- Calcium supplementation and vascular events. Pharmacist's Letter / Prescriber's Letter 2008;24(3):240306.
- Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
- Coburn JW, Mischel MG, Goodman WG, et al. Calcium citrate markedly enhances aluminum absorption from aluminum hydroxide. Am J Kidney Dis. 1991;17(6):708-11. PubMed
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- Kays MB, Overholser BR, Mueller BA, et al. Effects of sevelamer hydrochloride and calcium acetate on the oral bioavailability of ciprofloxacin. Am J Kidney Dis. 2003;42(6):1253-9. PubMed
- Neuhofel, A. L., Wilton, J. H., Victory, J. M., Hejmanowsk, L. G., and Amsden, G. W. Lack of bioequivalence of ciprofloxacin when administered with calcium-fortified orange juice: a new twist on an old interaction. J Clin Pharmacol. 2002;42(4):461-466. DOI
- Dickinson, H. O., Nicolson, D. J., Cook, J. V., Campbell, F., Beyer, F. R., Ford, G. A., and Mason, J. Calcium supplementation for the management of primary hypertension in adults. Cochrane.Database.Syst.Rev. 2006;(2):CD004639. PubMed
- Jones, B. J. and Twomey, P. J. Requesting patterns for serum calcium concentration in patients on long-term lithium therapy. Int J Clin Pract. 2009;63(1):170-172. PubMed
- Levine, M., Nikkanen, H., and Pallin, D. J. The effects of intravenous calcium in patients with digoxin toxicity. J Emerg.Med. 2011;40(1):41-46. PubMed
- Castelo-Branco, C., Ciria-Recasens, M., Cancelo-Hidalgo, M. J., Palacios, S., Haya-Palazuelos, J., Carbonell-Abello, J., Blanch-Rubio, J., Martinez-Zapata, M. J., Manasanch, J., and Perez-Edo, L. Efficacy of ossein-hydroxyapatite complex compared with ca
- Li K, Kaaks R, Linseisen J, Rohrmann S. Associations of dietary calcium intake and calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective Investigation i
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- Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15. PubMed
- Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
- Grove ML, Cook D. Calcium and heart attacks. Doesn't apply to most calcium prescriptions. BMJ. 2010;341:c5003. PubMed
- Insentress [package insert]. Whitehouse Station, NJ: Merck Sharp & Dohme Corp.; 2014.
- Roberts JL, Kiser JJ, Hindman JT, Meditz AL. Virologic failure with a raltegravir-containing antiretroviral regimen and concomitant calcium administration. Pharmacotherapy 2011;31(10):298e-302e. DOI
- Vitekta [package insert]. Foster City, CA: Gilead Sciences, Inc.; 2014.
- Storan ER, O'Gorman SM, Murphy A, Laing M. Case Report of Calciphylaxis Secondary to Calcium and Vitamin D<sub>3</sub> Supplementation. J Cutan Med Surg. 2017;21(2):162-163. DOI
- Jenkins DJA, Spence JD, Giovannucci EL, et al. Supplemental vitamins and minerals for CVD prevention and treatment. J Am Coll Cardiol 2018;71(22):2570-84. PubMed
- Borkenhagen JF, Connor EL, Stafstrom CE. Neonatal hypocalcemic seizures due to excessive maternal calcium ingestion. Pediatr Neurol 2013;48(6):469-71. PubMed
- WHO recommendations on antenatal care for a positive pregnancy experience. Geneva: World Health Organization; 2016 (http://www.who.int/reproductivehealth/publications/maternal_perinatal_health/ anc-positive-pregnancy-experience/en/).
- Aune D, Navarro Rosenblatt DA, Chan DS, et al. Dairy products, calcium, and prostate cancer risk: a systematic review and meta-analysis of cohort studies. Am J Clin Nutr. 2015;101(1):87-117. PubMed
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- Zhang Y, Li Y, Liu J, et al. Association of Vitamin D or Calcium Supplementation with Cardiovascular Outcomes and Mortality: A Meta-Analysis with Trial Sequential Analysis. J Nutr Health Aging 2021;25(2):263-270. PubMed
- Myung SK, Kim HB, Lee YJ, Choi YJ, Oh SW. Calcium Supplements and Risk of Cardiovascular Disease: A Meta-Analysis of Clinical Trials. Nutrients 2021;13(2):368. PubMed
- Hetaimish B. Neonatal Calcinosis Cutis After Treatment of Hypocalcemia with Calcium Gluconate: A Report of 2 Cases. Am J Case Rep 2024;25:e943397. PubMed
- US Food and Drug Administration (FDA). Biktarvy Prescribing Information. October 2024. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/210251Orig1s020lbl.pdf. Accessed July 16, 2025.
Chromium 53 references
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- Urberg M, Zemel MB. Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans. Metabolism 1987;36:896-9. PubMed
- Mohamedshah FY, Moser-Veillon PB, Yamini S, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr 1998;67:1250-5. PubMed
- Wasser WG, Feldman NS, D'Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate. [letter]. Ann Intern Med 1997;126:410. PubMed
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- Fowler JF Jr. Systemic contact dermatitis caused by oral chromium picolinate. Cutis 2000;65:116. DOI
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- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Rabinovitz H, Friedensohn A, Leibovitz A, et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res 2004;74:178-82. PubMed
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- Young P, Turiansky G, Bonner M, and et al. Acute generalized exanthematous pustulosis induced by chromium picolinate. J.Am Acad.Dermatol. 1999;41(5 Pt 2):820-823. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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