Interactions on record — worth a quick check against your medications. Based on 6 of 7 ingredients. Check your meds →
Dietary supplement

CardioDefence Ingredients & Drug Interactions

by Swiss BioEnergetics

CardioDefence label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CardioDefence against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

CardioDefence is a dietary supplement by Swiss BioEnergetics with 7 active ingredients. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 526 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Acetyl L-Carnitine, Coenzyme Q-10. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against CardioDefence by Swiss BioEnergetics

Ask about any prescription or over-the-counter medication and we check it for interactions with CardioDefence by Swiss BioEnergetics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of CardioDefence by Swiss BioEnergetics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

CardioDefence has 7 active ingredients. D-Ribose is a simple sugar your body uses for muscle and heart energy.

Thiamine (vitamin B1) and Vitamin B6 both support nerve function and energy metabolism. Vitamin B12 helps maintain red blood cells and nerve health.

Coenzyme Q10 is an antioxidant that supports heart cell energy production. Acetyl L-Carnitine helps your cells burn fat for fuel and may support brain function.

Medium Chain Triglyceride is a type of fat. The capsule also contains inactive ingredients: hydroxypropylmethylcellulose, more medium chain triglyceride oil, and gum arabic.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Supporting normal heart function.
  • We looked for evidence on: Angina, Angioplasty, Anthracycline cardiotoxicity, Atherosclerosis, Cardiac arrest, Cardiovascular disease (CVD) — and 4 related terms.
  • The strongest evidence on file: Coenzyme Q10 is rated "Possibly Effective" for Congestive heart failure (CHF) (Natural Medicines).
  • Also on file: Thiamine is rated "Possibly Ineffective" for Heart failure, Coronary artery bypass graft (CABG) surgery.
  • Also on file: Ribose is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Congestive heart failure (CHF), Coronary artery bypass graft (CABG) surgery.

The evidence behind CardioDefence's ingredients is mixed. Thiamine is effective for thiamine deficiency and Wernicke-Korsakoff syndrome.

Vitamin B12 is effective for B12 deficiency. Vitamin B6 is effective for sideroblastic anemia and pyridoxine-dependent epilepsy, and likely effective for high homocysteine levels.

Coenzyme Q10 is likely effective for CoQ10 deficiency and possibly effective for congestive heart failure, migraines, and diabetic nerve pain. Acetyl L-Carnitine is possibly effective for Alzheimer's disease, cognitive decline, and depression.

D-Ribose, however, is possibly ineffective for athletic performance and McArdle disease, and there isn't enough evidence to rate it for heart failure or muscle soreness. The evidence for this product's overall cardiac benefit isn't established in our data.

The evidence, ingredient by ingredient Ribose Thiamine Vitamin B12 Vitamin B6 Coenzyme Q10 Acetyl-l-carnitine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are generally well tolerated at standard doses. Thiamine, Vitamin B12, and Coenzyme Q10 are considered safe for healthy adults.

Vitamin B6 is safe at normal amounts, but high doses over time can damage nerves — stick to recommended levels. D-Ribose is generally well tolerated short-term but can lower blood sugar and has limited long-term safety data; common side effects include diarrhea, nausea, headache, and gastrointestinal discomfort.

Acetyl L-Carnitine is generally well tolerated short-term, though long-term safety isn't fully established; side effects may include agitation, dry mouth, headache, and insomnia. For pregnancy: D-Ribose and Coenzyme Q10 should be avoided — not enough safety data exists.

Thiamine and B12 are needed in pregnancy and considered safe at recommended amounts. Vitamin B6 is likely safe but possibly unsafe in pregnancy, so follow your provider's guidance.

For breastfeeding: D-Ribose should be avoided. Thiamine and B12 are safe at recommended amounts.

Coenzyme Q10 and Acetyl L-Carnitine lack sufficient breastfeeding safety data — check with your doctor.

Side effects, ingredient by ingredient Ribose Thiamine Vitamin B12 Vitamin B6 Coenzyme Q10 Acetyl-l-carnitine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Ribose, Acetyl-l-carnitine, Vitamin B12, Vitamin B6, Coenzyme Q10, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; Parkinson's medications.
  • For scale: 526 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking CardioDefence, check with your pharmacist if you use insulin or antidiabetes drugs (D-Ribose raises hypoglycemia risk), blood thinners like warfarin or acenocoumarol (Coenzyme Q10 and Acetyl L-Carnitine may reduce their effect), blood pressure medications (Vitamin B6 and Coenzyme Q10 may add to their effect), seizure drugs like phenobarbital or phenytoin (Vitamin B6 at high doses may lower their levels), antidepressants or serotonergic drugs (Acetyl L-Carnitine may boost serotonin effects), thyroid hormone replacement (Acetyl L-Carnitine may reduce effectiveness), or amiodarone for heart rhythm (Vitamin B6 may worsen sun sensitivity). Metformin users should know that Vitamin B12 can be depleted over time by this drug.

No interactions are documented for Medium Chain Triglyceride, which we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

CardioDefence may appeal to people looking for heart and energy support, but it's a multi-ingredient product with significant medication interactions. If you take insulin, diabetes drugs, blood thinners, seizure medications, blood pressure drugs, antidepressants, thyroid hormone, or the heart rhythm drug amiodarone, talk with your pharmacist or doctor before starting.

Pregnancy and breastfeeding require a case-by-case conversation with your provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CardioDefence, straight from the product label.

Brand Swiss BioEnergetics
Barcode (UPC) X002LGP6BF
Net contents 90 Veggie Cap(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 271186
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CardioDefence by Swiss BioEnergetics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Veggie Cap(s)
Maximum serving Sizes:
3 Veggie Cap(s)
Servings per container
30
UPC/BARCODE
X002LGP6BF
IngredientAmount% DV
D-Ribose500 mg--
Thiamine1.1 mg100%
Vitamin B122.5 mcg100%
Medium Chain Triglyceride150 mg--
Vitamin B61.4 mg100%
Coenzyme Q-10200 mg--
Acetyl L-Carnitine300 mg--

Other ingredients: Hydroxypropylmethylcellulose, Medium Chain Triglyceride Oil, Gum Arabic

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supporting normal heart function

GMP Made in the USA Consistent Quality

Suitable for vegetarians & vegans

Seals/Symbols

GMP Made in the USA Consistent Quality

Made in USA

General Statements

30 Day Supply

Suggested/Recommended/Usage/Directions

Directions: Adults take 3 capsules daily with food. Do not exceed recommended daily dose.

Precautions

Do not exceed recommended daily dose.

Cautions: Always consult your health practitioner before taking nutritional supplements, especially if you are taking medication or are under medical supervision. Not recommended for use by pregnant or breastfeeding women.

You should not take supplements as a substitute for a varied balanced diet or healthy lifestyle.

Store in a cool dry place, out of reach of children.

Storage

Store in a cool dry place, out of reach of children.

FDA Disclaimer Statement

These statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CardioDefence by Swiss BioEnergetics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CardioDefence label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CardioDefence by Swiss BioEnergetics

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Veggie Cap(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

D-Ribose

Interacts with
86 drugs
500 mg per serving

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

D-Ribose monograph & interactions

Thiamine

Interacts with
3 drugs
1.1 mg per serving Form: Thiamine Hydrochloride, Vitamin B1

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get eno...

Thiamine monograph & interactions

Vitamin B12

Interacts with
20 drugs
2.5 mcg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Medium Chain Triglyceride

150 mg per serving

Vitamin B6

Interacts with
210 drugs
1.4 mg per serving Form: Pyridoxal 5-Phosphate

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Coenzyme Q-10

Interacts with
198 drugs
200 mg per serving

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

Coenzyme Q-10 monograph & interactions

Acetyl L-Carnitine

Interacts with
203 drugs
300 mg per serving

Acetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells. It is most studied for nerve pain and mem...

Acetyl L-Carnitine monograph & interactions

Other (inactive) ingredients: Hydroxypropylmethylcellulose, Medium Chain Triglyceride Oil, Gum Arabic. These complete the product’s ingredient list but are not active constituents.

Interaction report

CardioDefence by Swiss BioEnergetics Drug Interactions

Want to check YOUR meds against CardioDefence?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
526Drugs
518 Moderate 8 Minor

Ingredients driving the most interactions

Vitamin B6 210
Acetyl L-Carnitine 203
Coenzyme Q-10 198
D-Ribose 86
Vitamin B12 20

Individual Drug Interactions

The ingredients in CardioDefence interact with 526 drugs. Click any drug to see the details.

6 of the 7 ingredients in CardioDefence interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Acetyl L-Carnitine Coenzyme Q-10 D-Ribose Vitamin B12 Thiamine

Each ingredient & the kinds of drugs it affects

For each ingredient in CardioDefence with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Acetyl L-Carnitine4 drug types · 203 drugs

Acenocoumarol (Sintrom)

Theoretically, acetyl-L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine, the parent compound of acetyl-L-carnitine, might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant that is similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation when L-carnitine was taken with acenocoumarol. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product. It is unclear if such an interaction would also occur with acetyl-L-carnitine.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, acetyl-L-carnitine might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders, when taken with serotonergic drugs.
Animal research shows that acetyl-L-carnitine can increase levels of serotonin in the brain.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, acetyl-L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism. It is unclear if such an interaction would occur with acetyl-L-carnitine.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, acetyl-L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine, the parent compound of acetyl-L-carnitine, might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with acetyl-L-carnitine and warfarin.

Likelihood Possible Evidence D
Acetyl L-Carnitine full monograph & interactions

Coenzyme Q-103 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B
Coenzyme Q-10 full monograph & interactions

D-Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
D-Ribose full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions

Thiamine1 drug type · 3 drugs

Trimethoprim (Proloprim)

Trimethoprim might increase blood levels of thiamine.
In vitro, animal, and clinical research suggest that trimethoprim inhibits intestinal thiamine transporter ThTR-2, hepatic transporter OCT1, and renal transporters OCT2, MATE1, and MATE2, resulting in paradoxically increased thiamine plasma concentrations.

Likelihood Probable Evidence B
Thiamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CardioDefence, from the product label.

Swiss BioEnergetics

See all Swiss BioEnergetics products
Name
Swiss BioEnergetics
Street Address
310 Harrow Road
State
London
ZipCode
HA9 6LL
Web Address
www.swissbioenergetics.com
Pharmacist Counseling Corner

CardioDefence by Swiss BioEnergetics: Common Questions

Does CardioDefence by Swiss BioEnergetics interact with any medications?
Yes. Based on its ingredients, CardioDefence has a known interaction with 526 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CardioDefence contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take CardioDefence if I'm pregnant?
Two of its ingredients — D-Ribose and Coenzyme Q10 — lack enough safety data and should be avoided in pregnancy. Thiamine and Vitamin B12 are needed during pregnancy and are safe at recommended amounts, but you should talk with your doctor about whether this product is right for you. Your doctor can give you personalized advice.
Is D-Ribose safe if I have diabetes or take insulin?
D-Ribose can lower blood sugar and may increase the risk of low blood sugar (hypoglycemia) when combined with insulin or diabetes medications. If you're on either, check with your pharmacist or doctor before starting — they may need to monitor your blood sugar or adjust your dose.
What are the most common side effects I might notice?
D-Ribose can cause diarrhea, nausea, headache, and gastrointestinal discomfort, and these can be dose-dependent. Acetyl L-Carnitine may cause agitation, dry mouth, headache, or insomnia. Coenzyme Q10 typically causes only mild gastrointestinal symptoms in less than 1% of people. Most B vitamins are well tolerated at recommended doses.
Does CardioDefence actually help with heart health?
The evidence behind this product for heart health isn't established in our data. Coenzyme Q10 is possibly effective for congestive heart failure, but D-Ribose hasn't shown reliable benefit for heart failure or bypass surgery recovery. Talk with your doctor about whether this product fits your specific heart health goals.
Can I take this if I'm on warfarin or another blood thinner?
No, not without checking first. Coenzyme Q10 and Acetyl L-Carnitine may reduce how well warfarin and acenocoumarol (another blood thinner) work. Your doctor may need to monitor your blood clotting or adjust your dose. Always tell your pharmacist about blood thinners before starting any supplement.
Is it safe to take CardioDefence long-term?
Long-term safety data is limited for D-Ribose and Acetyl L-Carnitine. Vitamin B6 can damage nerves if taken at high doses over time — this product should keep you within safe daily limits. Discuss long-term use with your pharmacist or doctor, especially if you're taking other medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CardioDefence label
Go deeper

The Full Monographs Behind CardioDefence’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph → Herb & supplement monograph

Thiamine

Interacts with 3 drugs

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clear...

Read the full Thiamine monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph → Herb & supplement monograph

Acetyl-l-carnitine

Interacts with 203 drugs

Acetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells. It is most studied for nerve pain and memory-related conditions, though the evide...

Read the full Acetyl-l-carnitine monograph →
Sources

Sources & How We Checked

CardioDefence's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 139 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Thiamine 7 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  4. Rogovik, A. L., Vohra, S., and Goldman, R. D. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann.Pharmacother. 2010;44(2):311-324. PubMed
  5. Arruti N, Bernedo N, Audicana MT, Villarreal O, Uriel O, Muñoz D. Systemic allergic dermatitis caused by thiamine after iontophoresis. Contact Dermatitis. 2013 Dec;69(6):375-6. PubMed
  6. Thiamine hydrochloride injection package insert. Lake Zurich, IL: Fresenius Kabi, LLC; September 2019.
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Vitamin B12 30 references
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Vitamin B6 32 references
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Coenzyme Q10 40 references
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Acetyl-l-carnitine 22 references
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