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Dietary supplement

Chanca Piedra 1000 mg Ingredients & Drug Interactions

by GM Germa

Chanca Piedra 1000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Chanca Piedra 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Chanca Piedra 1000 mg is a dietary supplement by GM Germa with 1 active ingredient. Its ingredients are commonly taken for kidney stones, gallstones, liver support.Based on those ingredients, 1,022 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phyllanthus niruri. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Chanca Piedra 1000 mg by GM Germa

Ask about any prescription or over-the-counter medication and we check it for interactions with Chanca Piedra 1000 mg by GM Germa — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Chanca Piedra 1000 mg by GM Germa

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 8, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This capsule contains one active ingredient, Phyllanthus niruri, known as chanca piedra, which is the source of its linked monograph and interaction data. Its listed role is the herbal ingredient the product is built around.

The inactive ingredients listed are magnesium stearate, rice flour, and gelatin. These are inactive excipients (non-active ingredients used for binding, filling, or making the capsule), and they are not part of the active dose.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Chanca Piedra's overall clinical evidence instead.

Moderate

Some clinical evidence supports Chanca Piedra for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Kidney stones (nephrolithiasis) — rated "Possibly Effective" (Natural Medicines).

For kidney stones (nephrolithiasis), chanca piedra is rated Possibly Effective. That is a promising rating, but it is not a firm proof of benefit.

For hepatitis B, the data rates chanca piedra Likely Ineffective. For anemia of chronic disease and benign prostatic hyperplasia (BPH, an enlarged prostate), there is insufficient reliable evidence to rate it at all.

The evidence, ingredient by ingredient Chanca Piedra

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chanca piedra is generally well tolerated in the short term, according to the data we hold, but high-quality safety data are limited. Orally, the most common adverse effects are abdominal pain, nausea, and vomiting.

Fatigue was reported in one clinical trial. Our pregnancy data rates chanca piedra as Possibly Unsafe, and the safety data advises against using it during pregnancy.

We have no lactation rating on file, but our safety notes advise avoiding it while breastfeeding. If you are pregnant or breastfeeding, talk with your own doctor or pharmacist before making any decision.

Side effects, ingredient by ingredient Chanca Piedra

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Chanca Piedra.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,023 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check with your own doctor or pharmacist before taking this if you use anticoagulant or antiplatelet drugs (blood thinners), which carry a Moderate interaction rating. Diuretics, lithium, norepinephrine, and drugs processed through CYP1A2 or CYP3A4 are also rated Moderate.

Antihypertensive drugs and antidiabetes drugs are rated Minor but still deserve a conversation with your prescriber.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be of interest to adults looking at chanca piedra for kidney stones, where the evidence is rated Possibly Effective. If you take blood thinners, diuretics, lithium, blood pressure medicines, or diabetes medicines, or you are pregnant or breastfeeding, be careful and talk it over with your own doctor or pharmacist first.

Since the data on safety is limited, your own healthcare provider should weigh the decision for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chanca Piedra 1000 mg, straight from the product label.

Brand GM Germa
Barcode (UPC) 790933901139
Net contents 100 Cap(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 303181
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chanca Piedra 1000 mg by GM Germa, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
790933901139
IngredientAmount% DV
Phyllanthus niruri500 mg--

Other ingredients: Magnesium Stearate, Rice Flour, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Natural Product, Free of sugar, sodium, starch and artificial flavors.

Promotes Urinary Tract Health

No sugar No starch No artificial color No artificial flavor No preservatives

Suggested/Recommended/Usage/Directions

Suggested Use: Adults, take two capsules daily as a dietary supplement, preferably with meal, with a full glass of water.

Precautions

Warning: Do not use if pregnant or nursing, ask a physician before use Do not use if taking any medication or have any medical condition

Do not use if allergic to any of the ingredients

Do not use if any adverse reactions occur.

Not intended for use by person under the age of 18. Keep out of the reach of children

In case of accidental overdose, get medical help or contact a Poison Control Center immediately. Do not use if either seal is torn, broken or missing

Storage

Store at controlled room temperature between 15 degrees and 30 degrees C (59 degrees-86 degrees F).

General Statements

Please Recycle

Questions or comments: 1-305-278-0033, M-F, 9-5 Eastern

FDA Disclaimer Statement

These statement have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Phyllanthus Niruri 1000 mg per serving

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Chanca Piedra 1000 mg by GM Germa label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Chanca Piedra 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Chanca Piedra 1000 mg by GM Germa

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Phyllanthus niruri

Interacts with
1,022 drugs
500 mg per serving

Chanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health. Human evidence f...

Phyllanthus niruri monograph & interactions

Other (inactive) ingredients: Magnesium Stearate, Rice Flour, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Chanca Piedra 1000 mg by GM Germa Drug Interactions

Want to check YOUR meds against Chanca Piedra 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,022Drugs
873 Moderate 149 Minor

Ingredients driving the most interactions

Phyllanthus niruri 1,022

Individual Drug Interactions

The ingredients in Chanca Piedra 1000 mg interact with 1,022 drugs. Click any drug to see the details.

1 of the 1 ingredient in Chanca Piedra 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Phyllanthus niruri

Each ingredient & the kinds of drugs it affects

For each ingredient in Chanca Piedra 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phyllanthus niruri8 drug types · 1,022 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In vitro research suggests that methyl brevifolincarboxylate, a constituent isolated from chanca piedra, can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that chanca piedra extract increases CYP1A2 activity. Theoretically, chanca piedra might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that chanca piedra extract inhibits CYP3A4. Theoretically, chanca piedra might increase the levels of CYP3A4 substrates. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of chanca piedra with diuretics might increase diuresis.
Some preliminary clinical research in adults with hypertension shows that chanca piedra has diuretic properties. However, higher quality research in adults with kidney stones shows taking chanca piedra does not increase urine volume when compared with placebo. Until more is known, use cautiously in patients taking diuretic drugs.

Likelihood Possible Evidence D
Lithium

Theoretically, chanca piedra might reduce excretion and increase levels of lithium.
Some preliminary clinical research in adults with hypertension shows that chanca piedra has diuretic properties. However, higher quality research in adults with kidney stones shows that taking chanca piedra does not increase urine volume when compared with placebo. Until more is known, use cautiously in patients taking lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Norepinephrine (Levophed)

Theoretically, chanca piedra may reduce the effects of norepinephrine.
Animal research suggests that methyl brevifolincarboxylate, a constituent isolated from chanca piedra, can reverse blood vessel contraction caused by norepinephrine.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.
Animal research suggests that chanca piedra can have hypoglycemic effects. However, a small clinical study in adults with diabetes shows that chanca piedra extract 25 grams orally daily for 1 week does not lower fasting or postprandial blood glucose levels.

Likelihood Unlikely Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of chanca piedra with antihypertensive drugs might have additive blood pressure lowering effects.
Animal research suggests that chanca piedra can decrease blood pressure. However, this effect was not observed in most hypertensive patients treated with chanca piedra for 10 days.

Likelihood Unlikely Evidence D
Phyllanthus niruri full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Chanca Piedra 1000 mg, from the product label.

GM Germa

See all GM Germa products
Name
Germa Products LLC
Street Address
12300 SW 132 Court
City
Miami
State
FL
ZipCode
33186
Phone Number
1-305-278-0033
Web Address
www.germa.net
Pharmacist Counseling Corner

Chanca Piedra 1000 mg by GM Germa: Common Questions

Does Chanca Piedra 1000 mg by GM Germa interact with any medications?
Yes. Based on its ingredients, Chanca Piedra 1000 mg has a known interaction with 1,022 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chanca Piedra 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is chanca piedra safe during pregnancy?
Our pregnancy data rates chanca piedra as Possibly Unsafe, and the safety data advises against using it during pregnancy. If you are pregnant or thinking about it, talk with your own doctor or pharmacist before making any decision.
What are the common side effects of chanca piedra?
Orally, the most common adverse effects are abdominal pain, nausea, and vomiting. Fatigue was reported in one clinical trial. Chanca piedra seems generally well tolerated, but a thorough evaluation of safety has not been conducted.
Does chanca piedra work for kidney stones?
Kidney stones are rated Possibly Effective in our data, which is a promising rating but not firm proof of benefit. Talk with your own doctor about whether it fits your situation.
What is chanca piedra used for?
Chanca piedra is the herbal active ingredient in this capsule, and the evidence we hold most directly relates to kidney stones. For hepatitis B it is rated Likely Ineffective, and for anemia of chronic disease and BPH there is insufficient reliable evidence to rate it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chanca Piedra 1000 mg label
Go deeper

The Full Monographs Behind Chanca Piedra 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chanca Piedra

Interacts with 1,022 drugs

Chanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health. Human evidence for these uses is limited and mostly smal...

Read the full Chanca Piedra monograph →
Sources

Sources & How We Checked

Chanca Piedra 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chanca Piedra 18 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Srividya N, Periwal S. Diuretic, hypotensive and hypoglycaemic effect of Phyllanthus amarus. Indian J Exp Biol 1995; 33:861-4.
  3. Rao, M. V. and Alice, K. M. Contraceptive effects of Phyllanthus amarus in female mice. Phytother.Res 2001;15(3):265-267.
  4. Moshi, M. J., Lutale, J. J., Rimoy, G. H., Abbas, Z. G., Josiah, R. M., and Swai, A. B. The effect of Phyllanthus amarus aqueous extract on blood glucose in non-insulin dependent diabetic patients. Phytother.Res 2001;15(7):577-580.
  5. Nishiura, J. L., Campos, A. H., Boim, M. A., Heilberg, I. P., and Schor, N. Phyllanthus niruri normalizes elevated urinary calcium levels in calcium stone forming (CSF) patients. Urol.Res 2004;32(5):362-366. PubMed
  6. Iizuka, T., Moriyama, H., and Nagai, M. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biol.Pharm.Bull. 2006;29(1):177-179. PubMed
  7. Adeneye, A. A., Amole, O. O., and Adeneye, A. K. Hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of Phyllanthus amarus in mice. Fitoterapia 2006;77(7-8):511-514. PubMed
  8. Iizuka, T., Nagai, M., Taniguchi, A., Moriyama, H., and Hoshi, K. Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation. Biol.Pharm.Bull. 2007;30(2):382-384. PubMed
  9. Amaechina, F. C. and Omogbai, E. K. Hypotensive effect of aqueous extract of the leaves of Phyllanthus amarus Schum and Thonn (Euphorbiaceae). Acta Pol.Pharm. 2007;64(6):547-552.
  10. Okoli, C. O., Obidike, I. C., Ezike, A. C., Akah, P. A., and Salawu, O. A. Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri. Pharm.Biol. 2011;49(3):248-255.
  11. Moshi MJ, Uiso FC Mahunnah RL et al. A study of the effect of Phyllanthus amarus extracts on blood glucose in rabbits. International Journal of Pharmacognosy 1997;35(3):167-173. DOI
  12. Kumar NG, Nair AN Raghunandanan VR et al. Hypoglycaemic effect of Phyllanthus niruri leaves in rabbits. Kerala Journal of Veterinary Science 1989;20(1):77-80.
  13. Navarro M, Coussio J Hnatyszyn O et al. Hypoglycemic Effect of an Aqueous Extract of Phyllanthus sellowianus ("sarandi blanco") in C57BL/Ks mice. Acta Farmaceutica Bonaerense 2004;23:520-523.
  14. Etta HE, Udoh PB Asuquo BO et al. Effect of Phyllanthus amarus on breeding efficiency of female albino rats. Global Journal of Agricultural Sciences 2007;215-217. DOI
  15. Etta H. Effects of Phyllanthus amarus on litter traits in albino rats. Scientific Research and Essays 2008;370-372.
  16. Pucci ND, Marchini GS, Mazzucchi E, et al. Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention. Int Braz J Urol 2018;44(4):758-64. PubMed
  17. Sowjanya K, Girish C, Bammigatti C, Prasanna Lakshmi NC. Efficacy of Phyllanthus niruri on improving liver functions in patients with alcoholic hepatitis: A double-blind randomized controlled trial. Indian J Pharmacol 2021;53(6):448-456. PubMed
  18. Husain I, Abdulrahman B, Dale OR, et al. Interaction of Phyllanthus amarus extract and its lignans with human xenobiotic receptors, drug metabolizing enzymes and drug transporters. J Ethnopharmacol 2025;339:119142. PubMed

See these in context on the Chanca Piedra monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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