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Dietary supplement

Cissus Quadrangularis Extract Ingredients & Drug Interactions

by Herbadiet

Cissus Quadrangularis Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cissus Quadrangularis Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cissus Quadrangularis Extract is a dietary supplement by Herbadiet with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cissus quadrangularis stem extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cissus Quadrangularis Extract by Herbadiet

Ask about any prescription or over-the-counter medication and we check it for interactions with Cissus Quadrangularis Extract by Herbadiet — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Cissus Quadrangularis Extract by Herbadiet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Cissus quadrangularis stem extract. It's derived from a plant used traditionally for various health purposes, and the extract is delivered in capsule form with no other inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Cissus Quadrangularis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: bone and joint health, muscle strength.
  • We looked for evidence on: Fractures, Joint pain, Muscle strength, Osteopenia, Osteoporosis, Ligament health — and 1 related terms.
  • The closest evidence on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Osteopenia (Natural Medicines).
  • Also on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Fractures, Muscle strength, Osteoporosis, Joint pain.

Cissus quadrangularis has possibly effective evidence for obesity — small studies suggest it may help with weight management in people who are overweight or obese. For high cholesterol (hyperlipidemia), bone density loss (osteopenia), cancer, and epilepsy, the evidence we hold is insufficient to rate how well it works.

The evidence, ingredient by ingredient Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The extract is generally well tolerated in short-term use, but we don't have good data on safety over longer periods. Headache and insomnia have been reported, as have flatulence, diarrhea, stomach inflammation (gastritis), and dry mouth — though in clinical trials these occurred at rates similar to or lower than placebo.

There isn't enough safety data to use this supplement during pregnancy or while breastfeeding; talk with your doctor or pharmacist about whether it's right for you in either situation.

Side effects, ingredient by ingredient Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any diabetes medication — insulin, metformin, sulfonylureas, or others — double-check it with your pharmacist or doctor before starting this product. The extract may lower your blood sugar further, raising the risk of hypoglycemia.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Cissus quadrangularis may help with weight management if the evidence applies to you, but it's mainly a consideration if you take diabetes medication — you'll want to check your specific drugs first. Pregnancy and breastfeeding are situations to discuss with your doctor or pharmacist before using it.

And because long-term safety isn't well studied, this is something to review with your healthcare provider, especially if you're thinking of using it regularly.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cissus Quadrangularis Extract, straight from the product label.

Brand Herbadiet
Barcode (UPC) 5113339163999
Net contents 60 V Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 244608
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cissus Quadrangularis Extract by Herbadiet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
5113339163999
IngredientAmount% DV
Cissus quadrangularis stem extract500 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Cissus quadrangularis is a traditional medicine for joint and bone health. It is also an effective aid in promoting bone growth rate. This high quality ingredient provides a holistic approach for enhancing lean muscle mass.

Formulation

Builds healthy muscle mass Strengthens bones, ligaments, and tendons Supports optimum weight management Enhances recovery from bone fracture

100% Natural Supports joint & cartilage health Ayurvedic proprietary medicine

Vegan

Free of fillers, binders, artificial ingredients, dairy, soy, wheat, gluten, yeast

Suitable for vegetarians and vegans

Contains nothing other than listed ingredients

FDA Disclaimer Statement

These statements have not been evaluated by FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Keep out of reach of children.

Do not use if seal under the cap is broken or missing.

Caution: If you are pregnant, breast feeding, or taking medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Storage

Store in a dry place.

General Statements

Batch No: ARK-C19

Suggested/Recommended/Usage/Directions

Directions for use: Take one capsule twice a day or as directed by your physician.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cissus Quadrangularis Extract by Herbadiet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cissus Quadrangularis Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cissus Quadrangularis Extract by Herbadiet

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Cissus quadrangularis stem extract

Interacts with
86 drugs
500 mg per serving Form: Ketosteroids

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Cissus quadrangularis stem extract monograph & interactions
Interaction report

Cissus Quadrangularis Extract by Herbadiet Drug Interactions

Want to check YOUR meds against Cissus Quadrangularis Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Cissus quadrangularis stem extract 86

Individual Drug Interactions

The ingredients in Cissus Quadrangularis Extract interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cissus Quadrangularis Extract interact with drugs. Each result below shows which ingredient is responsible. Cissus quadrangularis stem extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Cissus Quadrangularis Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cissus quadrangularis stem extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Cissus quadrangularis stem extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cissus Quadrangularis Extract, from the product label.

Herbadiet

See all Herbadiet products
Name
Arkure Health Care
Street Address
11, Sector - 14
City
Rohtak
State
Haryana
ZipCode
124001
Web Address
www.herbadiet.in
Pharmacist Counseling Corner

Cissus Quadrangularis Extract by Herbadiet: Common Questions

Does Cissus Quadrangularis Extract by Herbadiet interact with any medications?
Yes. Based on its ingredients, Cissus Quadrangularis Extract has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cissus Quadrangularis Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Cissus quadrangularis and what is it used for?
Cissus quadrangularis is a plant extract traditionally used for health purposes. In this product, it's been studied mainly for weight management — small clinical trials suggest it may help lower fasting blood sugar and support weight loss in people who are overweight or obese.
Can I take this if I'm pregnant or breastfeeding?
The safety data isn't there yet — there isn't enough information to know whether it's safe during pregnancy or while breastfeeding. Talk with your doctor or pharmacist for personalized advice before using it.
Are there any side effects I should know about?
Headache and insomnia have been reported, along with flatulence, diarrhea, stomach inflammation, and dry mouth. In clinical trials, these occurred at similar rates or lower than placebo, so they're relatively uncommon. Long-term safety hasn't been well studied, though.
Is this product safe to use long-term?
It's generally well tolerated in short-term use, but we don't have solid safety data for long-term use. If you're thinking of taking it regularly, check in with your pharmacist or doctor first.
Does this really help with weight loss?
The evidence shows it's possibly effective for obesity — small studies in people who are overweight suggest it may help. It's not a cure-all, and results vary from person to person.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cissus Quadrangularis Extract is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cissus Quadrangularis Extract label
Go deeper

The Full Monographs Behind Cissus Quadrangularis Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Cissus Quadrangularis Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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