Co Q-10 400 mg Ingredients & Drug Interactions
by 21st Century
What is this page for?
First and foremost: checking Co Q-10 400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Co Q-10 400 mg is a dietary supplement by 21st Century with 1 active ingredient. Its ingredients are commonly taken for heart health, statin-related muscle aches, migraine prevention.Based on those ingredients, 198 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Coenzyme Q-10. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Co Q-10 400 mg by 21st Century
Ask about any prescription or over-the-counter medication and we check it for interactions with Co Q-10 400 mg by 21st Century — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Co Q-10 400 mg by 21st Century
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Coenzyme Q-10 at 400 mg per capsule. CoQ-10 is a compound your body makes naturally and stores in cells, where it helps generate energy and acts as an antioxidant.
The capsule also contains inactive ingredients — vegetable cellulose and tricalcium phosphate — which are fillers and binders.
Does it work?
Strong evidence
CoQ-10 is likely effective for treating CoQ-10 deficiency. For other uses, the evidence is more limited: it's possibly effective for fibromyalgia, migraine headache, congestive heart failure, and diabetic nerve pain (diabetic neuropathy).
The research on these conditions exists but isn't conclusive enough to call it proven.
How safe is it?
Well-documented data
CoQ-10 is generally well tolerated by most adults when taken as directed. The most common side effects are gastrointestinal — appetite loss, diarrhea, stomach discomfort, heartburn, nausea, and vomiting — though these occur in less than 1% of people.
Splitting doses above 100 mg throughout the day can help reduce these effects. Headache, dizziness, and insomnia have also been reported in studies.
There isn't enough reliable safety data during pregnancy, so it's best to avoid it unless your doctor advises otherwise. Safety while breastfeeding hasn't been well studied either — talk with your doctor or pharmacist before using it if you're nursing.
Meds to double-check
Moderate interaction found
Before you start, check your medications against these drug types: chemotherapy drugs called alkylating agents, warfarin (a blood thinner), and blood pressure medications. These are the ones we have documented interaction data for with CoQ-10.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
CoQ-10 may be worth considering if you have a CoQ-10 deficiency or are dealing with fibromyalgia, migraines, heart failure, or diabetic nerve pain — though the evidence for those last four is still being sorted out. If you take warfarin, chemotherapy, or blood pressure medication, check with your pharmacist first.
Pregnant women should avoid it unless their doctor says otherwise.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Co Q-10 400 mg, straight from the product label.
| Brand | 21st Century |
|---|---|
| Barcode (UPC) | 740985228227 |
| Net contents | 30 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Nov 21, 2019 |
| DSLD ID | 206557 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Co Q-10 400 mg by 21st Century, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Coenzyme Q-10 | 400 mg | -- |
Other ingredients: Vegetable Cellulose, Tricalcium Phosphate, Contains <2% of
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, adults take one (1) capsule, three (3) times daily, preferably with a small amount of fatty food for better assimilation or as directed by a healthcare provider. Do not exceed three (3) capsules daily.
Precautions
Do not exceed three (3) capsules daily.
Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.
Stop use and contact a physician if adverse reactions occur.
Keep out of reach of children.
Do not use if product appears to be tampered with or seal is broken.
General Statements
Individual results may vary.
Heart Health Support
Storage
Store at room temperature.
Formulation
No added Sugar, Salt, Yeast, Preservatives, Artificial Flavors or Colors.
Gluten free
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
Gluten free
Guaranteed quality Laboratory tested
Formula
CoEnzyme Q-10 (Co Q-10) is an antioxidant that is necessary for cells to function properly.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Co Q-10 400 mg by 21st Century label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Co Q-10 400 mg by 21st Century
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.
Coenzyme Q-10
Interacts with198 drugs
CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...
Coenzyme Q-10 monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose, Tricalcium Phosphate, Contains <2% of. These complete the product’s ingredient list but are not active constituents.
Co Q-10 400 mg by 21st Century Drug Interactions
HelloPharmacist Interaction Report
CoQ-10 by 21st Century can interact with several important medication types.
The most serious concern is with chemotherapy drugs called alkylating agents (like cyclophosphamide). CoQ-10 has antioxidant properties that theoretically may reduce how well these cancer drugs work, since many of them rely on generating reactive molecules to kill tumor cells.
Read the full breakdown — every affected drug type, severity by severity
You'll want to be careful with warfarin (Coumadin), a blood thinner. CoQ-10 is chemically similar to vitamin K, which promotes clotting.
A small number of case reports describe people whose warfarin stopped working as well after they started CoQ-10. Blood pressure medications are a minor concern — CoQ-10 might add to their effect and lower your pressure further, though study results have been mixed.
Altogether, these interactions span 198 individual medications. Use the medication checker on this page to look up your exact drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Co Q-10 400 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Co Q-10 400 mg interact with 198 drugs. Click any drug to see the details.
1 of the 1 ingredient in Co Q-10 400 mg interact with drugs. Each result below shows which ingredient is responsible. Coenzyme Q-10
AltretamineHexalen
How Altretamine interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Altretamine interactionBendamustineBelrapzo, Treanda, Vivimusta
How Bendamustine interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Bendamustine interactionBendamustine HydrochlorideBendeka
How Bendamustine Hydrochloride interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Bendamustine Hydrochloride interactionBusulfanBusulfex, Myleran
How Busulfan interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Busulfan interactionCarboplatinParaplatin
How Carboplatin interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Carboplatin interactionCarmustineBiCNU, Gliadel, Gliadel Wafer
How Carmustine interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Carmustine interactionChlorambucilLeukeran
How Chlorambucil interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Chlorambucil interactionCisplatinPlatinol-AQ
How Cisplatin interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Cisplatin interactionCyclophosphamideCytoxan, Neosar
How Cyclophosphamide interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Cyclophosphamide interactionDacarbazineDTIC-Dome
How Dacarbazine interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Dacarbazine interactionEstramustine Phosphate SodiumEmcyt
How Estramustine Phosphate Sodium interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Estramustine Phosphate Sodium interactionIfosfamideIfex
How Ifosfamide interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Ifosfamide interactionLomustineCeenu
How Lomustine interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Lomustine interactionLurbinectedinZepzelca
How Lurbinectedin interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Lurbinectedin interactionMechlorethamine HydrochlorideValchlor
How Mechlorethamine Hydrochloride interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Mechlorethamine Hydrochloride interactionMelphalanAlkeran, Hepzato
How Melphalan interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Melphalan interactionMelphalan FlufenamidePepaxto
How Melphalan Flufenamide interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Melphalan Flufenamide interactionMelphalan HydrochlorideEvomela
How Melphalan Hydrochloride interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Melphalan Hydrochloride interactionOxaliplatinEloxatin
How Oxaliplatin interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Oxaliplatin interactionProcarbazineMatulane
How Procarbazine interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Procarbazine interactionStreptozocinZanosar
How Streptozocin interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Streptozocin interactionTemozolomideTemodar
How Temozolomide interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Temozolomide interactionThiotepaTepadina, Thioplex
How Thiotepa interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Thiotepa interactionTrabectedinYondelis
How Trabectedin interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q-10 + Trabectedin interactionWarfarinWarfarin
How Warfarin interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Warfarin (coumadin) Moderate
Interaction Summary
Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Read the full Coenzyme Q-10 + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Warfarin (coumadin) Moderate
Interaction Summary
Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Read the full Coenzyme Q-10 + Warfarin Sodium interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q-10 + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q-10 + Acetazolamide interactionAliskirenTekturna
How Aliskiren interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q-10 + Aliskiren interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Co Q-10 400 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q-10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q-10 + Ambrisentan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Co Q-10 400 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Coenzyme Q-10
Alkylating Agents
Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.
Warfarin (Coumadin)
Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.
Antihypertensive Drugs
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.
Brand information
Manufacturer and brand details for Co Q-10 400 mg, from the product label.
21st Century
See all 21st Century products- Name
- 21st Century HealthCare, Inc.
- Street Address
- 2119 S. Wilson St.
- City
- Tempe
- State
- AZ
- ZipCode
- 85282
- Web Address
- www.21stcenturyvitamins.com
Co Q-10 400 mg by 21st Century: Common Questions
Does Co Q-10 400 mg by 21st Century interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is CoQ-10 and what does it do in my body?
Will this help my heart condition?
What side effects might I experience?
Can I take this while I'm breastfeeding?
Will this interact with my blood pressure medication?
Can I take this if I'm on warfarin?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Co Q-10 400 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Co Q-10 400 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Co Q-10 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 40 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Coenzyme Q10 40 references
- Kamikawa T, Kobayashi A, Yamashita T, et al. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. Am J Cardiol 1985;56:247-51. PubMed
- Langsjoen P, Willis R, Folkers K. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med 1994;S265-72. PubMed
- Spigset O. Reduced effect of warfarin caused by ubidecarenone. Lancet 1994;334:1372-3. PubMed
- Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 1999;13:203-8. PubMed
- Portakal O, Ozkaya O, Erden Inal M, et al. Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem 2000;33:279-84. PubMed
- Lund EL, Quistorff B, Spang-Thomsen M, Kristjansen PE. Effect of radiation therapy on small-cell lung cancer is reduced by ubiquinone intake. Folia Microbiol (Praha) 1998;43:505-6. PubMed
- Langsjoen PH, Langsjoen PH, Folkers K. Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. Am J Cardiol 1990;65:521-3. PubMed
- Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
- Landbo C, Almdal TP. [Interaction between warfarin and coenzyme Q10]. Ugeskr Laeger 1998;160:3226-7.
- Baggio E, Gandini R, Plauncher AC, et al. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators. Mol Aspects Med 1994;15 Suppl:S287-94. PubMed
- Burke BE, Neuenschwander R, Olson RD. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. South Med J 2001;94:1112-7. PubMed
- The Huntington Study Group. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology 2001;57:397-404.
- Hodgson JM, Watts GF, Playford DA, et al. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr 2002;56:1137-42. PubMed
- Singh RB, Neki NS, Kartikey K, et al. Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction. Mol Cell Biochem 2003;246:75-82. DOI
- Porterfield LM. Why did the response to warfarin change? RN 2000;63:107.
- Sandor PS, Di Clemente L, Coppola G, et al. Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial. Neurology 2005;64:713-5. PubMed
- Engelsen J, Nielsen JD, Winther K. Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial. Thromb Haemost 2002;87:1075-6. DOI
- Berman M, Erman A, Ben-Gal T, et al. Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study. Clin Cardiol 2004;27:295–9. PubMed
- Storch A, Jost WH, Vieregge P, et al. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q10 in Parkinson disease. Arch Neurol 2007;64:938-44. DOI
- Digiesi V, Cantini F, Oradei A, et al. Coenzyme Q10 in essential hypertension. Mol Aspects Med 1994;15 Suppl:s257-63. PubMed
- Yamagami T, Takagi M, Akagami H, et al. Effect of coenzyme Q10 on essential hypertension, a double blind controlled study. In: Folkers KA, Yamamura Y, eds. Biomedical and Clinical Aspects of Coenzyme Q, Vol. 5. Amsterdam: Elsevier Science Publications, 19
- Ho MJ, Bellusci A, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension (review). Cochrane Database Syst Rev 2009;(4):CD007435. PubMed
- Rosenfeldt, F. L., Haas, S. J., Krum, H., Hadj, A., Ng, K., Leong, J. Y., and Watts, G. F. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum.Hypertens. 2007;21(4):297-306. PubMed
- Stamelou, M., Reuss, A., Pilatus, U., Magerkurth, J., Niklowitz, P., Eggert, K. M., Krisp, A., Menke, T., Schade-Brittinger, C., Oertel, W. H., and Hoglinger, G. U. Short-term effects of coenzyme Q10 in progressive supranuclear palsy: a randomized, place DOI
- Keogh A, Fenton S, Leslie C, et al. Randomised double-blind, placebo-controlled trial of coenzyme Q, therapy in class II and III systolic heart failure. Heart Lung Circ. 2003;12:135-41.
- Gane, E. J., Weilert, F., Orr, D. W., Keogh, G. F., Gibson, M., Lockhart, M. M., Frampton, C. M., Taylor, K. M., Smith, R. A., and Murphy, M. P. The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C
- Lynch, D. R., Perlman, S. L., and Meier, T. A phase 3, double-blind, placebo-controlled trial of idebenone in friedreich ataxia. Arch Neurol. 2010;67(8):941-947. PubMed
- Young, J. M., Florkowski, C. M., Molyneux, S. L., McEwan, R. G., Frampton, C. M., Nicholls, M. G., Scott, R. S., and George, P. M. A randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the me
- Ishiyama, T., Morita, Y., Toyama, S., Yamagami, T., and Tsukamoto, N. A clinical study of the effect of coenzyme Q on congestive heart failure. Jpn.Heart J 1976;17(1):32-42. PubMed
- Matthews, P. M., Ford, B., Dandurand, R. J., Eidelman, D. H., O'Connor, D., Sherwin, A., Karpati, G., Andermann, F., and Arnold, D. L. Coenzyme Q10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease. Neurology 1993;43(5
- Malm, C., Svensson, M., Sjoberg, B., Ekblom, B., and Sjodin, B. Supplementation with ubiquinone-10 causes cellular damage during intense exercise. Acta Physiol Scand. 1996;157(4):511-512. PubMed
- Singh, R. B., Wander, G. S., Rastogi, A., Shukla, P. K., Mittal, A., Sharma, J. P., Mehrotra, S. K., Kapoor, R., and Chopra, R. K. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc. PubMed
- Digiesi V, Cantini F, and Brodbeck B. Effect of coenzyme Q10 on essential arterial hypertension. Current Therapeutic Research 1990;47(5):841-845.
- Parkinson Study Group QE3 Investigators, Beal MF, Oakes D, et al. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. JAMA Neurol. 2014;71(5):543-52.
- Alehagen U, Johansson P, Bjornstedt M, et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citi
- Ho MJ, Li EC, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. Cochrane Database Syst Rev. 2016 Mar 3;3:CD007435. doi: 10.1002/14651858.CD007435.pub3. PubMed
- Tabrizi R, Akbari M, Sharifi N, Lankarani KB, Moosazadeh M, Kolahdooz F, et al. The effects of coenzyme Q10 supplementation on blood pressures among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. PubMed
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