Coenzyme Q10 100 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Coenzyme Q10 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Coenzyme Q10 100 mg is a dietary supplement by Natural Factors with 1 active ingredient. Its ingredients are commonly taken for heart health, statin-related muscle aches, migraine prevention.Based on those ingredients, 198 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Coenzyme Q10. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Coenzyme Q10 100 mg by Natural Factors
Ask about any prescription or over-the-counter medication and we check it for interactions with Coenzyme Q10 100 mg by Natural Factors — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Coenzyme Q10 100 mg by Natural Factors
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This softgel contains one active ingredient: Coenzyme Q10 (CoQ10) at 100 mg per capsule. CoQ10 is a compound your cells use to produce energy and to fight oxidative damage.
The softgel also contains rice bran oil, vitamin E, and the softgel capsule material itself as inactive ingredients.
Does it work?
Strong evidence
The evidence for CoQ10 is strongest if you have a CoQ10 deficiency — it's rated likely effective for that. For other conditions, the data is more mixed.
It's rated possibly effective for fibromyalgia, migraines, congestive heart failure, and diabetic nerve pain, meaning there's some clinical support but it's not definitive. The evidence isn't yet solid enough to claim it will work for everyone.
How safe is it?
Well-documented data
CoQ10 is generally well tolerated by most adults at the recommended dose. Gastrointestinal side effects like nausea, diarrhea, heartburn, and appetite suppression can occur, but they're uncommon (less than 1% of people in studies).
A few people have reported headache, dizziness, or insomnia. Skin itching and rash have been reported rarely.
There isn't enough reliable safety data to recommend it during pregnancy, so talk with your doctor if you're pregnant. Breastfeeding safety hasn't been well studied either — check with your doctor before use.
Meds to double-check
Moderate interaction found
Check before you start if you're on warfarin or other blood thinners (Moderate interaction) — CoQ10 may reduce their effectiveness. Also double-check if you're on chemotherapy, especially alkylating agents (Moderate), or any blood pressure medication (Minor).
Run your exact drugs through the tool on this page.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
CoQ10 may help if you have a documented deficiency or are exploring options for heart health, migraines, or nerve pain — but the evidence varies. If you take warfarin, chemotherapy, or blood pressure medication, run this by your pharmacist first.
It's generally easy on the stomach at 100 mg, but higher doses may need to be split to reduce GI upset.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Coenzyme Q10 100 mg, straight from the product label.
| Brand | Natural Factors |
|---|---|
| Barcode (UPC) | 068958020822 |
| Net contents | 240 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Jun 23, 2017 |
| DSLD ID | 75384 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Coenzyme Q10 100 mg by Natural Factors, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Coenzyme Q10 | 100 mg | -- |
Other ingredients: Rice Bran Oil, Softgel, Vitamin E
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols
isura Non-GMO - Mass spec Documentation - Lab tested
Purity & potency guaranteed
Suggested/Recommended/Usage/Directions
Suggested Usage: 1 softgel 1-2 times per day or as directed by a health professional.
Precautions
Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding or trying to conceive, or if you are taking medication, have a medical condition or anticipate a surgery.
Keep out of the reach of children.
Sealed for your protection. Do not use if seal is broken.
Formula
This highest grade of coenzyme Q10 is blended in a base of rice bran oil for enhanced absorption.
General Statements
Coenzyme Q10, also called CoQ10 or ubiquinone, is a natural substance essential to cellular energy production. It is also an antioxidant that scavenges free radicals throughout the body and is involved in maintaining normal heart function. CoQ10 works well with vitamin E and other antioxidants. Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.
Product of Canada
Recyclable container and label.
All-natural form Enhanced absorption
Formulation
Contains no artificial colors, preservatives or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, corn, egg, fish, shellfish, salt, tree nuts, or GMOs.
Storage
For freshness, store in a cool, dry place.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
General
R1
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Coenzyme Q10 100 mg by Natural Factors label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Coenzyme Q10 100 mg by Natural Factors
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.
Coenzyme Q10
Interacts with198 drugs
CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...
Coenzyme Q10 monograph & interactionsOther (inactive) ingredients: Rice Bran Oil, Softgel, Vitamin E. These complete the product’s ingredient list but are not active constituents.
Coenzyme Q10 100 mg by Natural Factors Drug Interactions
HelloPharmacist Interaction Report
Coenzyme Q10 by Natural Factors can interact with a few important medication types.
The main concern is warfarin (a blood thinner), where CoQ10's vitamin K-like properties may reduce how well warfarin works — we have case reports of decreased warfarin effectiveness. If you're on warfarin, this is a Moderate-severity interaction and worth a conversation with your pharmacist or doctor before starting.
Read the full breakdown — every affected drug type, severity by severity
CoQ10 may also theoretically blunt the effectiveness of certain chemotherapy drugs, specifically alkylating agents (like cyclophosphamide), because of its antioxidant effects — that's also Moderate severity. Additionally, it might add to the blood-pressure-lowering effects of antihypertensive medications (a Minor interaction), so if you're on blood pressure medication, your levels may drop further.
Altogether, these interactions span 198 individual medications. To be sure about your specific prescriptions, run them through the checker on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Coenzyme Q10 100 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Coenzyme Q10 100 mg interact with 198 drugs. Click any drug to see the details.
1 of the 1 ingredient in Coenzyme Q10 100 mg interact with drugs. Each result below shows which ingredient is responsible. Coenzyme Q10
AltretamineHexalen
How Altretamine interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Altretamine interactionBendamustineBelrapzo, Treanda, Vivimusta
How Bendamustine interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Bendamustine interactionBendamustine HydrochlorideBendeka
How Bendamustine Hydrochloride interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Bendamustine Hydrochloride interactionBusulfanBusulfex, Myleran
How Busulfan interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Busulfan interactionCarboplatinParaplatin
How Carboplatin interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Carboplatin interactionCarmustineBiCNU, Gliadel, Gliadel Wafer
How Carmustine interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Carmustine interactionChlorambucilLeukeran
How Chlorambucil interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Chlorambucil interactionCisplatinPlatinol-AQ
How Cisplatin interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Cisplatin interactionCyclophosphamideCytoxan, Neosar
How Cyclophosphamide interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Cyclophosphamide interactionDacarbazineDTIC-Dome
How Dacarbazine interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Dacarbazine interactionEstramustine Phosphate SodiumEmcyt
How Estramustine Phosphate Sodium interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Estramustine Phosphate Sodium interactionIfosfamideIfex
How Ifosfamide interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Ifosfamide interactionLomustineCeenu
How Lomustine interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Lomustine interactionLurbinectedinZepzelca
How Lurbinectedin interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Lurbinectedin interactionMechlorethamine HydrochlorideValchlor
How Mechlorethamine Hydrochloride interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Mechlorethamine Hydrochloride interactionMelphalanAlkeran, Hepzato
How Melphalan interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Melphalan interactionMelphalan FlufenamidePepaxto
How Melphalan Flufenamide interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Melphalan Flufenamide interactionMelphalan HydrochlorideEvomela
How Melphalan Hydrochloride interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Melphalan Hydrochloride interactionOxaliplatinEloxatin
How Oxaliplatin interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Oxaliplatin interactionProcarbazineMatulane
How Procarbazine interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Procarbazine interactionStreptozocinZanosar
How Streptozocin interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Streptozocin interactionTemozolomideTemodar
How Temozolomide interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Temozolomide interactionThiotepaTepadina, Thioplex
How Thiotepa interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Thiotepa interactionTrabectedinYondelis
How Trabectedin interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Trabectedin interactionWarfarinWarfarin
How Warfarin interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Warfarin (coumadin) Moderate
Interaction Summary
Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Read the full Coenzyme Q10 + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Warfarin (coumadin) Moderate
Interaction Summary
Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Read the full Coenzyme Q10 + Warfarin Sodium interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Acetazolamide interactionAliskirenTekturna
How Aliskiren interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Aliskiren interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Coenzyme Q10 100 mg — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Ambrisentan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Coenzyme Q10 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Coenzyme Q10
Alkylating Agents
Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.
Warfarin (Coumadin)
Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.
Antihypertensive Drugs
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.
Brand information
Manufacturer and brand details for Coenzyme Q10 100 mg, from the product label.
Coenzyme Q10 100 mg by Natural Factors: Common Questions
Does Coenzyme Q10 100 mg by Natural Factors interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will CoQ10 help my heart or cholesterol?
Can I take this if I'm pregnant?
What are the most common side effects?
Is this safe to take long-term?
Do I need to split this dose?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Coenzyme Q10 100 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Coenzyme Q10 100 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Coenzyme Q10 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 40 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Coenzyme Q10 40 references
- Kamikawa T, Kobayashi A, Yamashita T, et al. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. Am J Cardiol 1985;56:247-51. PubMed
- Langsjoen P, Willis R, Folkers K. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med 1994;S265-72. PubMed
- Spigset O. Reduced effect of warfarin caused by ubidecarenone. Lancet 1994;334:1372-3. PubMed
- Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 1999;13:203-8. PubMed
- Portakal O, Ozkaya O, Erden Inal M, et al. Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem 2000;33:279-84. PubMed
- Lund EL, Quistorff B, Spang-Thomsen M, Kristjansen PE. Effect of radiation therapy on small-cell lung cancer is reduced by ubiquinone intake. Folia Microbiol (Praha) 1998;43:505-6. PubMed
- Langsjoen PH, Langsjoen PH, Folkers K. Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. Am J Cardiol 1990;65:521-3. PubMed
- Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
- Landbo C, Almdal TP. [Interaction between warfarin and coenzyme Q10]. Ugeskr Laeger 1998;160:3226-7.
- Baggio E, Gandini R, Plauncher AC, et al. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators. Mol Aspects Med 1994;15 Suppl:S287-94. PubMed
- Burke BE, Neuenschwander R, Olson RD. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. South Med J 2001;94:1112-7. PubMed
- The Huntington Study Group. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology 2001;57:397-404.
- Hodgson JM, Watts GF, Playford DA, et al. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr 2002;56:1137-42. PubMed
- Singh RB, Neki NS, Kartikey K, et al. Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction. Mol Cell Biochem 2003;246:75-82. DOI
- Porterfield LM. Why did the response to warfarin change? RN 2000;63:107.
- Sandor PS, Di Clemente L, Coppola G, et al. Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial. Neurology 2005;64:713-5. PubMed
- Engelsen J, Nielsen JD, Winther K. Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial. Thromb Haemost 2002;87:1075-6. DOI
- Berman M, Erman A, Ben-Gal T, et al. Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study. Clin Cardiol 2004;27:295–9. PubMed
- Storch A, Jost WH, Vieregge P, et al. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q10 in Parkinson disease. Arch Neurol 2007;64:938-44. DOI
- Digiesi V, Cantini F, Oradei A, et al. Coenzyme Q10 in essential hypertension. Mol Aspects Med 1994;15 Suppl:s257-63. PubMed
- Yamagami T, Takagi M, Akagami H, et al. Effect of coenzyme Q10 on essential hypertension, a double blind controlled study. In: Folkers KA, Yamamura Y, eds. Biomedical and Clinical Aspects of Coenzyme Q, Vol. 5. Amsterdam: Elsevier Science Publications, 19
- Ho MJ, Bellusci A, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension (review). Cochrane Database Syst Rev 2009;(4):CD007435. PubMed
- Rosenfeldt, F. L., Haas, S. J., Krum, H., Hadj, A., Ng, K., Leong, J. Y., and Watts, G. F. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum.Hypertens. 2007;21(4):297-306. PubMed
- Stamelou, M., Reuss, A., Pilatus, U., Magerkurth, J., Niklowitz, P., Eggert, K. M., Krisp, A., Menke, T., Schade-Brittinger, C., Oertel, W. H., and Hoglinger, G. U. Short-term effects of coenzyme Q10 in progressive supranuclear palsy: a randomized, place DOI
- Keogh A, Fenton S, Leslie C, et al. Randomised double-blind, placebo-controlled trial of coenzyme Q, therapy in class II and III systolic heart failure. Heart Lung Circ. 2003;12:135-41.
- Gane, E. J., Weilert, F., Orr, D. W., Keogh, G. F., Gibson, M., Lockhart, M. M., Frampton, C. M., Taylor, K. M., Smith, R. A., and Murphy, M. P. The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C
- Lynch, D. R., Perlman, S. L., and Meier, T. A phase 3, double-blind, placebo-controlled trial of idebenone in friedreich ataxia. Arch Neurol. 2010;67(8):941-947. PubMed
- Young, J. M., Florkowski, C. M., Molyneux, S. L., McEwan, R. G., Frampton, C. M., Nicholls, M. G., Scott, R. S., and George, P. M. A randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the me
- Ishiyama, T., Morita, Y., Toyama, S., Yamagami, T., and Tsukamoto, N. A clinical study of the effect of coenzyme Q on congestive heart failure. Jpn.Heart J 1976;17(1):32-42. PubMed
- Matthews, P. M., Ford, B., Dandurand, R. J., Eidelman, D. H., O'Connor, D., Sherwin, A., Karpati, G., Andermann, F., and Arnold, D. L. Coenzyme Q10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease. Neurology 1993;43(5
- Malm, C., Svensson, M., Sjoberg, B., Ekblom, B., and Sjodin, B. Supplementation with ubiquinone-10 causes cellular damage during intense exercise. Acta Physiol Scand. 1996;157(4):511-512. PubMed
- Singh, R. B., Wander, G. S., Rastogi, A., Shukla, P. K., Mittal, A., Sharma, J. P., Mehrotra, S. K., Kapoor, R., and Chopra, R. K. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc. PubMed
- Digiesi V, Cantini F, and Brodbeck B. Effect of coenzyme Q10 on essential arterial hypertension. Current Therapeutic Research 1990;47(5):841-845.
- Parkinson Study Group QE3 Investigators, Beal MF, Oakes D, et al. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. JAMA Neurol. 2014;71(5):543-52.
- Alehagen U, Johansson P, Bjornstedt M, et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citi
- Ho MJ, Li EC, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. Cochrane Database Syst Rev. 2016 Mar 3;3:CD007435. doi: 10.1002/14651858.CD007435.pub3. PubMed
- Tabrizi R, Akbari M, Sharifi N, Lankarani KB, Moosazadeh M, Kolahdooz F, et al. The effects of coenzyme Q10 supplementation on blood pressures among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. PubMed
- Tsai IC, Hsu CW, Chang CH, Tseng PT, Chang KV. Effectiveness of coenzyme Q10 supplementation for reducing fatigue: A systematic review and meta-analysis of randomized controlled trials. Front Pharmacol 2022;13:883251. PubMed
- Yaghini O, Hoseini N, Ghazavi MR, et al. A comparative study on the efficacy of coenzyme Q10 and amitriptyline in the prophylactic treatment of migraine headaches in children: A randomized controlled trial. Adv Biomed Res 2022;11:43. PubMed
- Hansen KS, Mogensen TH, Agergaard J, et al. High-dose coenzyme Q10 therapy versus placebo in patients with post COVID-19 condition: A randomized, phase 2, crossover trial. Lancet Reg Health Eur 2022. PubMed
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