Major interaction on record — check this product against your medications before combining. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Collagen Peptides Vanilla Ingredients & Drug Interactions

by Purely Inspired

Collagen Peptides Vanilla label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Collagen Peptides Vanilla against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Collagen Peptides Vanilla is a dietary supplement by Purely Inspired with 5 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 296 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sodium, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Collagen Peptides Vanilla by Purely Inspired

Ask about any prescription or over-the-counter medication and we check it for interactions with Collagen Peptides Vanilla by Purely Inspired — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Collagen Peptides Vanilla by Purely Inspired

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 4 active ingredients. Sodium is an electrolyte essential in small amounts for nerve and muscle function, but the supplement form raises some caution because your diet likely already provides enough.

Calcium supports bone health and muscle function. Biotin is a B vitamin that your body needs to convert food into energy and maintain skin and hair.

Collagen peptides are broken-down collagen protein — collagen is the most abundant protein in your body and is found in skin, joints, and connective tissue.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: skin health, joints, bones and nails.
  • We looked for evidence on: Aging skin, Brittle nails, Joint pain, Osteoarthritis, Exercise-induced muscle damage, Exercise-induced muscle soreness — and 4 related terms.
  • The strongest evidence on file: Collagen Peptides is rated "Possibly Effective" for Aging skin (Natural Medicines).
  • Also on file: Calcium is rated "Possibly Ineffective" for Fractures.
  • Also on file: Collagen Peptides is rated "Possibly Ineffective" for Muscle strength.

The evidence here is mixed. Calcium is effective for low blood calcium (hypocalcemia) and likely effective for osteoporosis.

Biotin is likely effective for biotin deficiency but was found possibly ineffective for multiple sclerosis and seborrheic dermatitis. Collagen peptides appear possibly effective for aging and dry skin, but possibly ineffective for muscle strength — the evidence for athletic performance and acne isn't established in the data we hold.

Sodium's effectiveness ratings relate to medical conditions like cystic fibrosis and bipolar disorder, not to the cosmetic or joint benefits often marketed for collagen products.

The evidence, ingredient by ingredient Sodium Calcium Biotin Collagen Peptides

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium and biotin are generally well tolerated at recommended doses. Calcium may cause belching, constipation, or stomach upset in some people.

Biotin is considered very safe because your body excretes excess amounts in urine. Collagen peptides are generally well tolerated as a protein source; nausea, heartburn, and diarrhea are rare.

Sodium, however, requires caution: too much is linked to high blood pressure and heart strain. Normal dietary sodium is fine, but you should avoid sodium supplements or very high intake without medical advice.

The safety data for collagen peptides in pregnancy and breastfeeding is limited — talk with your doctor before use. For biotin, amounts from food and prenatal vitamins are appropriate, but check before taking high-dose supplements.

Side effects, ingredient by ingredient Sodium Calcium Biotin Collagen Peptides

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Calcium, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 296 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications if you take blood pressure pills (antihypertensives), HIV integrase inhibitors like dolutegravir or elvitegravir, thyroid hormone (levothyroxine), lithium, corticosteroids, the antibiotic ceftriaxone, heart medications like sotalol or diltiazem, or any other sodium-containing drugs or supplements. The Major interactions with certain HIV and antibiotic drugs mean timing or dose adjustments may be needed.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is a protein-based collagen supplement with added minerals and a B vitamin. If you take blood pressure medications, lithium, levothyroxine, or HIV drugs — especially dolutegravir or elvitegravir — check with your pharmacist before starting it.

The sodium content is worth flagging if you're sodium-sensitive or have heart or kidney concerns. Otherwise, it's generally well tolerated.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Collagen Peptides Vanilla, straight from the product label.

Brand Purely Inspired
Barcode (UPC) 631656714609
Net contents 1.15 Pound(s); 524 Gram(s)
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 264435
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Collagen Peptides Vanilla by Purely Inspired, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
23 Gram(s)
Maximum serving Sizes:
23 Gram(s)
Servings per container
23
UPC/BARCODE
631656714609
IngredientAmount% DV
Calories80 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Sodium20 mg5%
Calcium270 mg21%
Biotin300 mcg1000%
Added Sugars0 Gram(s)--
Total Sugars0 Gram(s)--
Total Fat0.5 Gram(s)1%
Protein18 Gram(s)--
Collagen Peptides20 Gram(s)--

Other ingredients: Coconut Oil, Rice syrup solids, Pea Protein, Sodium Citrate, Tricalcium Phosphate, Sunflower Lecithin, Natural Flavors, Calcium Carbonate, Guar Gum, Acacia Gum, Xanthan Gum, Silicon Dioxide, Rebaudioside A

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

20g Collagen Peptides 18 Amino Acids 18g Protein Collagen Types I & III

Keto Friendly

18g of Clean Protein Not only is this supplement keto friendly, but it also contains 18g of clean protein, is free from recombinant growth hormone (rBGH), and is sourced from grass-fed and pasture-raised bovine.

Purely Inspired uses 100% hydrolyzed Collagen Peptides, which are easy to digest and mix well in both hot and cold liquids.

Grass Fed & Pasture Raised Collagen Shake with Biotin 20g of Collagen Peptides Vanilla Natural Flavors

From collagen peptides.

Formulation

Easy to digest

No rBGH Non GMO Gluten Free No Sugar Added

Easy to Digest and Mixes Easily

Not a low-calorie product. See supplement facts for more information.

Made in the U.S.A. from international ingredients.

General Statements

Living a Radiant & Vital Life We understand your needs to feel empowered, to be happy - to live a good life. Purely Inspired Collagen Peptides helps you get there with a value-packed, enhanced formula - to help you live your most radiant and vital life.

For more information, including recipes, nutrition and motivational tips, visit us at Purelyinspired.com Find us on Facebook@purelyinspirednutrition Instagram@purelyinspirednutrition Twitter@PIsupplements

Typical Amino Acid Profile (Average mg/serving naturally occurring in collagen peptides) Aspartic Acid 1,086mg Glutamic Acid 2,200mg Serine 662mg Histidine 90mg Glycine 4,664mg Threonine 400mg Arginine 1,398mg Alanine 1,702mg Tyrosine 30mg Cysteine 8mg Valine 474mg Methionine 152mg Phenylalanine 224mg Isoleucine 272mg Leucine 548mg Lysine 810mg Hydroxyproline 1,958mg Proline 1,490mg

100% Money-Back Guarantee Return to the place of purchase within 30 days with original receipt for a refund.

Suggested/Recommended/Usage/Directions

Options to Enjoy Purely Inspired Collagen Peptides is easy to mix in any drink or food. Water Add 1 scoop to hot or cold water or juice. Smoothies Mix 1 scoop of Collagen Peptides and 1 scoop of Purely Inspired Organic Protein Oatmeal Stir into oatmeal or a breakfast cereal Cooking Add 1 scoop to hot or cold beverages

Directions: Mix 1 serving (1 scoop) with 8 oz. of water or a beverage of choice and take once daily. Read the entire label before use and follow directions provided.

Brand IP Statement(s)

Purely Inspired Vitality Series

Twitter, Tweet, Retweet and the Twitter logo are trademarks of Twitter, Inc. or its affiliates.

FDA Statement of Identity

Dietary Supplement

Precautions

Contains coconut ingredients. Processed in a facility that also processes milk, soy, egg, wheat, peanut, tree nut, fish and shellfish ingredients.

Warning: For adult use only.

Do not use if pregnant or nursing.

Consult a medical doctor before use if you have a medical condition and before starting a diet or exercise program.

Keep out of reach of children.

Notice: Use this product as a food supplement only. Do not use for weight reduction.

Do not use if packaging has been tampered with.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place (60 degrees F to 80 degrees F).

Seals/Symbols

Made in the USA from international ingredients

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Collagen Peptides Vanilla by Purely Inspired label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Collagen Peptides Vanilla label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Collagen Peptides Vanilla by Purely Inspired

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size23 Gram(s) Dosage formPowder Servings per container23 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
20 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Calcium

Interacts with
168 drugs
270 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Biotin

No known
interactions
300 mcg per serving

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...

Biotin monograph & interactions

Protein

18 Gram(s) per serving

Collagen Peptides

No known
interactions
20 Gram(s) per serving Form: Bovine Collagen Peptides, Hydrolyzed

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is...

Collagen Peptides monograph & interactions

Other (inactive) ingredients: Coconut Oil, Rice syrup solids, Pea Protein, Sodium Citrate, Tricalcium Phosphate, Sunflower Lecithin, Natural Flavors, Calcium Carbonate, Guar Gum, Acacia Gum, Xanthan Gum, Silicon Dioxide, Rebaudioside A. These complete the product’s ingredient list but are not active constituents.

Interaction report

Collagen Peptides Vanilla by Purely Inspired Drug Interactions

Want to check YOUR meds against Collagen Peptides Vanilla?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
296Drugs
7 Major 287 Moderate 2 Minor

Ingredients driving the most interactions

Sodium 205
Calcium 168

Individual Drug Interactions

The ingredients in Collagen Peptides Vanilla interact with 296 drugs. Click any drug to see the details.

2 of the 5 ingredients in Collagen Peptides Vanilla interact with drugs. Each result below shows which ingredient is responsible. Sodium Calcium

Each ingredient & the kinds of drugs it affects

For each ingredient in Collagen Peptides Vanilla with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Collagen Peptides Vanilla, from the product label.

Purely Inspired

See all Purely Inspired products
Name
Iovate Health Sciences U.S.A. Inc.
Street Address
1105 North Market Street Suite 1330
City
Wilmington
State
DE
ZipCode
19801
Web Address
www.purelyinspired.com
Pharmacist Counseling Corner

Collagen Peptides Vanilla by Purely Inspired: Common Questions

Does Collagen Peptides Vanilla by Purely Inspired interact with any medications?
Yes. Based on its ingredients, Collagen Peptides Vanilla has a known interaction with 296 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Collagen Peptides Vanilla contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this collagen powder actually work for skin or joints?
Collagen peptides show possibly effective evidence for aging and dry skin. For joint health, muscle strength, and athletic performance, the evidence isn't established in the data we hold — you may see claims about those benefits, but they're not backed by our current evidence ratings.
Is the sodium content a problem?
Normal dietary sodium is fine, but because this product contains added sodium, it's not ideal if you're sodium-sensitive, have high blood pressure, heart disease, or kidney problems, or take blood pressure medications. Talk to your doctor or pharmacist about whether the amount is right for you.
Can I take this while pregnant or breastfeeding?
Biotin is likely safe in pregnancy, and calcium is likely safe at recommended amounts — adequate calcium matters during pregnancy. However, safety data for collagen peptides in pregnancy and breastfeeding is limited. Talk with your doctor or pharmacist before using, especially if you're pregnant or nursing.
What side effects might I notice?
Calcium may cause belching, constipation, or stomach upset. Collagen peptides can rarely cause nausea, heartburn, diarrhea, or gas. Biotin is very safe and side effects are extremely rare. These are all uncommon at normal doses.
Does biotin in this product do anything special?
Biotin is likely effective for biotin deficiency, but it was found possibly ineffective for multiple sclerosis and seborrheic dermatitis. In this collagen product, it's a small added ingredient — don't count on it for those uses.
Can I take this with my HIV medication?
If you take dolutegravir (Tivicay) or elvitegravir (Vitekta), calcium in this product can significantly reduce how much drug gets into your blood. Talk to your pharmacist — you may need to separate doses by several hours or switch products.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Collagen Peptides Vanilla label
Go deeper

The Full Monographs Behind Collagen Peptides Vanilla’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Biotin

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get plenty from a normal diet, and true defi...

Read the full Biotin monograph → Herb & supplement monograph

Collagen Peptides

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is still developing and results vary. They...

Read the full Collagen Peptides monograph →
Sources

Sources & How We Checked

Collagen Peptides Vanilla's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 106 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
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See these in context on the Sodium monograph →

Calcium 62 references
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See these in context on the Calcium monograph →

Biotin 4 references
  1. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
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See these in context on the Biotin monograph →

Collagen Peptides 2 references
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  2. Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021;20(3):825-834. PubMed

See these in context on the Collagen Peptides monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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